corpus callosum
Post on 01-Jun-2015
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Corpus Callosum - History
In the 18th century, the corpus callosum was considered the site of the soul (Maurice Ptito), and in the early 20th it was assigned the mere role of preventing the cerebral hemispheres from collapsing onto each other
It was only in the 1950's that the corpus callosum, in the pioneering work of Myers and Sperry, was attributed the function of transferal of information between the two hemispheres
This was followed by the development, in the early 1960's, of a surgical intervention aimed at reducing the interhemispheric transmission of abnormal electrical discharges in epileptic patients
Corpus CallosumFrontal Forceps
Commissural fibersShort
Arcuate FibersOccipital forceps
Industium grisium
Medial Longitudinal stria
Lateral Longitudinal stria
Corpus Callosum - Parts
Rostrum
Genu Body
Splenium
Motor
Somatosensory Auditory
Visual200,000,000 Neurons connect each hemisphere
Agenesis of corpus callosum
ACC Clinical
• Partial or complete• Prtial Rostrum is
always missing• Delay in development
at 18-20 weeks to compensate formation of midline structure
• Associated anomalies– Hetrotopias– Lissencephaly, Schizencephaly– Chiari II– Cephalocele– Dandy Walker– Holoporencephaly– Lipomas– Azygous anterior cerebral
artery– Midline facial and skeletal
abnormality– Aicardi Syndrome
ACC - Gross
Coronal section at the level of midbrain
17-year-old female with developmental delays
The corpus callosum, cingulate gyrus, and sulcus are absent or malformed
there is a high-riding third ventricle that is open superiorly to the interhemispheric fissure
The sulci and gyri on the medial hemispheric surface have a radial or "spoke-like" configuration around the third ventricle
Agenesis of corpus callosum
Agenesis of corpus callosum CT
ACC – MR
ACC
Acardi Syndrome
• Agenesis of corpus callosum (ACC)
• Cortical heterotopia,• Infantile spasm, • Chorioretinopathy, • Mental retardation with
or without associated vertebral anomalies.
• X Linked Recessive
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