cheminform abstract: synthesis and biological evaluation of conformationally restricted gabapentin...
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1999 amino acids, peptides
amino acids, peptidesU 0400
45 - 234Synthesis and Biological Evaluation of Conformationally RestrictedGabapentin Analogues. — Conformationally restricted gabapentinanalogues, e.g. (III), (VII), (IX), and (XIII), are prepared. Compound (R)-(IX)and gabapentin have similar in vitro and in vivo biological activities at thegabapentin binding site and in the carrageenan-induced thermal hyperalgesiamodel. — (RECEVEUR, JEAN-MARIE; BRYANS, JUSTIN S.; FIELD,MARK J.; SINGH, LAKHBIR; HORWELL, DAVID C.; Bioorg. Med. Chem.Lett. 9 (1999) 16, 2329-2334; Parke-Davis Neurosci. Res. Cent., Univ. ForvieSite, Cambridge CB2 2QB, UK; EN)
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