cancer is heterogeneous disease! -> enabled characterization of new tumor subtypes for improving...

Cancer is heterogeneous disease!

-> enabled characterization of new tumor subtypes for improving personalized

treatment and ultimately achieving better patient outcomes.

To address these challenges,

Combined ‘StratomeX’, an interactive visualization tools to efficiently com-

pare multiple patient stratifications, to correlate patient sets with clinical informa-

tion or genomic alterations and to view the differences between molecular profiles

across patient sets.

Interactive visualization tool

“StratomeX”

http://www.caleydo.org

Core projects

OS: Window 7,8 , Mac, Linux / Java 7

K: knowledge-driven approaches

D: data-driven approaches

Input data class / type

Seamless integration of visual and computational components in the extended StratomeX tool.

1) Based on Similarity to a selected stratification

2) Based on Overlap with selectec patient set

3) Based on Logrank test for patient survival (Mantel-Haenszel test)

4) Based on Gene Set enrichment for a selected patient set

StratomeX user interface

StratomeX complements the network viewers, heat maps and genome browsers typically used in cancer genomics

-The wider the bands, the higher the correlation between

patient sets.

-The results of queries are lists of elements ranked by a

score, which are shown in the LineUp view

-Elements selected in the LineUp view are immediately vi-

sualized in the StratomeX view