biotech in animal production
Post on 01-Oct-2015
24 Views
Preview:
DESCRIPTION
TRANSCRIPT
-
CNG NGH SINH HC
NG DNG TRONG
CHN NUI V TH Y
PGS. TS. Dng Thanh Lim
B mn Dinh dng
Khoa Chn nui Th Y
Trng i hc Nng Lm
-
Cng ngh sinh hc
trong chn nui ng vt
1. Cng ngh sinh hc trong sinh sn vt nui.
2. Cng ngh sinh hc trong k thut di truyn.
3. Cng ngh sinh hc trong sn xut thc n
chn nui v thc phm.
-
Cng ngh sinh hc
trong sinh sn
ng vt
-
Bioscope II
Atomic Force MicroscopeMultiMode
scanning probe microscope
Knh hin vi quan st c phng i ln c kh nng
quan st v chp ct lp cu trc t bo
-
Knh hin vi
thao tc c
th ht ly
nhn v cy
chuyn
nhn t bo
-
Cng ngh sinh hc ng dng trong sinh
sn v tnh vt nui sn xut sinh
phm dc v thc phm chc nng
-
Hai trng hp nhn dng
thnh cng trn th gii
- Sinh sn v tnh cu Dolly
- Sinh sn v tnh chut Cumulina.
- Sinh sn v tnh ng vt chuyn gen
Ngi ta hy vng vi k thut ny, c th to ra
nhiu con ging sn xut dc phm trong thi
gian ngn, hoc to t bo gc cung cp cc
c quan b phn cho c th ngi.
-
Cu Dolly ra i bng
phng php sinh sn v tnh
-
Chut Cumulina ra i bng
phng php sinh sn v tnh
-
1. To ra ging ng vt c kh nng khng bnh tt:
Bnh b in: Trc ht cn to ra ging ng vt c kh nng chng li bnh b in BSE (bovine spongiform encephalopathy).
To ra ging chut chuyn gen nhn bit nhanh PrP Pht hin sm nhng triu chng bnh l no Chn, nhn ging n dng khng li prion (PrPR).
Bnh vim v:
Th sn xut protein sa c cha lysostaphin, mt loi protein enzyme c kh nng chng li staphylococcus, vi khun gy vim m trong v. y l hng nghin cu rt kh thi.
Nhn v tnh ging t cha bnh (Therapeutic breeds). Nhng ging ny c kh nng sn xut protein khng sinh chng khun. tng t nghin cu kh nng t khng ca trn t?
Mc tiu ca nghin cu chuyn gen, sinh sn v
tnh l to nhng ng vt c nhiu u th
-
To ra ging heo thi t phosphate ra mi trng.
To ging heo cho tht c cht lng tt trong ba n.
To thnh phn dinh dng sa v tht tt cho sc khe.
Xy dng ging trang tri c cht lng tt
-
C kh nng khng khunThay i nhng thuc tnh ch bin:
- Gim thi gian lm kt vn
- Tng sc kt vn ng cc
Sa c hot cht chng khun gy bnh
v vi khun lm cho sa mau h hng.
-10
-5
0
5
10
15
20
25
30
#34 #37 #53
SFA
MFA
PUFA
Cht bo sa thay i c li cho sc khe con ngi:Gim thp acid bo no,
Lm tng acid CLA, linoleic
bin i do vi khun d c,
chng vim, chng ung th.
Ging d sa chuyn gen
-10
-5
0
5
10
15
20
25
30
#34 #37 #53
-
Loi Protein dc phm Chc nng cha bnh Loi th
-1 - antitrypsin C chc nng chng vim D, Cu
Anti-thrombin III Chng s nhim trng v x cng D
nghn mch, cc mu ng.
C1 inhibitor Cha ph huyt qun do di truyn Th
Collagen Cha bng, gy xng, incon B
Factor IX & VIII Bnh a chy mu C r phi
Cu, heo
Fibrinogen cha fibrin glue, bng, phu thut, Heo, cu
trong ha tr liu, trong dc phm
Human fertility hormones Trit sn, vaccin nga thai D, b
Human hemoglobin Thay th mu ngi, truyn mu Heo
Human serum albumin Cha bng, shock, chn thng, D, b
phu thut
Lactoferrin Tr vi khun gy bnh ng rut B
LAtPA Tissue Plasminogen Activator (t-PA) Cha lot do mu tnh mch D
Monoclonal antibodies (Mab) Chng ung th kt trng D
anti-TNF IgG1 (monoclonal) Chng li c au tim D
Tissue plasminogen activator t qu, deep vein D
thrombosis, pulmonary embolism
Trang tri nui ging ng vt cng ngh sinh hc dc phm
Table modified from GEN Co.
-
Loi sn phm chuyn gen N sn xut Th trng. Giai on TN
h- Collagen Cattle** Pharming $500 M (+) Sng ch
h- Fibrinogen Cattle** Pharming $600 M (+) Cha ng k
h- Esterase Inhibitor **/ Cattle Rabbits Pharming $150 M Cha ng k
h- Factor VIII Pigs ProGenics* $300 M (+) Cha ng k
h- Alph- glucosidase Rabbits/ Cattle** Pharming $300 M (+) Phase II (Eur)
h- AT- III Goats GTC ? Phase II (US)
h- SA Cattle** GTC $1B Cha ng k
h- SA Cattle** Argentina Cha ng k
Spider Silk Goats** Nexia Huge Device
h- AAT Goats PPL/ Bayer ? Phase II
h- Factor IX Sheep PPL ? Cha ng k
h- Lactoferrin Cattle Pharming ? Cha chc chn
** Animals made using nuclear transfer.
Nhng nghin cu ng vt chuyn gen c nhiu tm nng
dc ng dng vo sn xut
-
Table modified from GEN
ng vt chuyn gen v sn lng Protein sinh phm ca n
c tnh sn lng protein sinh phm trong sa v qui m n th chuyn gen trn Th gii
Loi Protein sinh phm c tnh hng nm cn, kg c tnh qui m th Loi th
Protein C 100 33 B1,100 Heo
tPA 75 600 DCu
1-anti-trypsin 5,000 33,000 Cu42,000 D
Factor IX 2 13 Cu
22 Heo
Human serum albumin 1,000 300 B8,300 D
The number of lactating animals may be calculated as: (expression in g/L) x (annual milk
production in L) x (purification efficiency)
-
t-PA
BloodClot
C ch ph hy huyt khi trong c th bi sinh phm t-PA (Tissue Plasminogen Activator)
t-PA l mt enzyme, n c th ph tan huyt khi ng
lm tt nghn mch mu
PlasminogenS hot ha
Plasmin
B gySi Fibrin
Ph tan huyt khiT chc
Thng tn t-PA
StreptokinaseFrom Bacteria
UrokinaseFrom the Kidneys
-
To ra con d nhn gen ti t hp 1:Vector cu trc (Construction)
Murine Way Acid Protein Promoter
LAtPA cDNA
SV40 Poly A Signal
Murine Way Acid Protein Promoter, tn hiu biu l
gen trong nhng t bo thuc ng vt c v.
Qui tc sp xp LAtPA cDNA cho im bin i t tPA (asn glu AA 117) c glycosylated vi longer
acting (LA) tPA
SV40 l virus c cung cp poly A (on cui gen), tn
hiu t bo mRNA kt thc.
Promoter
sequenceGene
Poly A
sequence
-
Hp t
Zygote
Nucleus
Suctio
n
Suction Pipit
Vector
Micro-injector
To ra con d ti t hp 2:Vector lng ghp (Insertion)
-
To ra con d ti t hp 2:Vector lng ghp (Insertion)
Nucleus
Zygote Vector
-
To ra con d ti t hp 2:Vector lng ghp (Insertion)
Nucleus
ZygoteNhiu phin bn ca vector b b
gyMt s vo ctrong nhn
-
To ra con d ti t hp 2:Vector lng ghp (Insertion)
Chromosome
Nucleus Vector
-
To ra con d ti t hp 2:Vector lng ghp (Insertion)
Vector lng ghp vo cchromosome
-
Sinh sn v tnh to ra con d ti t hp 3: D con ln ln cho sa c cha tPA
Hp t ti t hp hoc
phi
Thu hoch sa
tPA tinh ch
-
Nhn v tnh b chuyn gen c kh nng
sn xut protein chng bnh vim vTransgenic Cow Clone for
Mastitis Disease Resistance
By Jan SuszkiwJanuary 10, 2001 BELTSVILLE, Md., Jan. 10--U.S. Department of Agriculture and University of Vermont (UV) Cc nh khoa hc trng i hc Vermont sn xut dng thun v tnh b Jersey cung cp gen chng bnh vim v cho ngnh Cng ngh sinh hc to ging b sa c kh nng chng li bnh vim v do vi khun.
T bo tuyn v b Jersey ny c kh
nng sn xut Lysostaphin, l mt loi
protein endopeptidase c hiu l h
mng t bo ca vi khun gy vim v
http://www.ars.usda.gov/is/pr/2001/010110.2.htm
-
Nhng con b chuyn gen ny c nhn ging v tnh, n c kh nng tng hp ra mt loi men c tc dng ph hy mng t bo vi khun gy vim v. Do vy b t bnh nn t dng khng sinh iu tr vim v, t t to ra dng vi khun khng thuc.
-
B Holstein bin i gen c kh nng
sn xut protein lysostaphin khng t
cu khun Staphylococcus aureus
gy bnh vim v b
-
Nhng con b sa sn xut sa giu
lysostaphin c gi tr nh mt loi
thc phm chc nng.
-
Cng ngh chuyn gen
to ra ging gia sc c
kh nng sn xut protein
c tc dng cha bnh v
phng chng bnh tt
-
To ra ging ng vt sn xut thucTrang tri dc phm sinh hc phn t
http://muextension.mi
ssouri.edu/xplor/regp
ubs/ncr552.htm
To ra phi t th tinh
trong ng nghim.
a gen DNA c
kh nng tng hp
ra dc phm vo
phi th tinh.
Cy phi chuyn
Gen vo cu ci cho
mang thai phi c
chuyn gen
Cu con chuyn gen
sn xut thuc tr
bnh trong sa
-
Nhng Protein c tc dng cha bnh trong sa
c sn xut ra bi th cho sa chuyn gen.
Sn xut ch Y khoa siu nh, siu chc, siu mnhDSpider silk
protein
Hp cht khng khun phng bnh vim v b.BLysostaphin
Cha bnh x u nang v kh thng.CuAlpha-1-
antitrypsin
Khng sinh t nhin c s dng trong phu thut tim BLactoferrin
Cha bnh x u nang (cystic fibrosis)CuCFTR (cystic fibrosis
transmembrane
conductance regulator
Cha bnh a chy mu (hemophilia)D, Heo,
Cu
Factor VIII,
Factor IX
Lm gim s lng mu cn thit trong mt s trng
hp phu thutD
Antithrombin
III
ng dng trong iu tr bnhng vtTn Protein
http://www.ext.vt.edu/pubs/biotech/443-003/443-003.html#L3
-
Sn xut sa b giu lactoferrin
c gi tr phng chng bnh tt.
Lactoferrin ti t hp ca ngi (rhLF), mt loi phc glucoprotein-Fe. Protein lactoferin ti t hp ngi (rhLF) c trong sa b chuyn gen ging vi lactoferrin t nhin ca ngi (hLF t nhin), u c v tr gn Fe v phng thch Fe ging nhau.
Lactoferrin c kh nng khng khun, khng nm, khng ni c t, v khng hoat ng ca cc virus. Lactoferrin tng tc vi t bo ch, iu bin tin trinh vim ty, v t bo v ca t bo ch. Lactoferrin trong sa c vai tr hp thu Fe, c th coi y l mt loi sa dc phm chc nng.
-
Sn xut trng g cha bnh ung th
Mt nhm cc nh khoa hc Anh
pht trin thnh cng loi g
Chuyn trng bin i gen c kh
nng ra nhng qu trng cha
cc loi protein chng ung th.
Trung tm sng to ra cu Dolly
bng sinh sn v tnh nm 1997,
lai to thnh cng khong
500 con g bin i gen c kh
nng trng chng ung th.
Loi protein cha bnh nm trong
lng trng trng, c th chit xut
sn xut thuc cha ung th c
hiu qu v tn t chi ph.
-
Loi trng g ny c cha protein miR24
(mt loi khng th cho php cha tr bnh
ung th da) c kh nng ngn chn s tng
sinh ca virus trong t bo. Cc nh nghin
cu vn cn phi mt khong 10 nm na
cung ng i tr cho th trng mt loi
protein chng ung th gi r.
68-nucleotide miRNA precursor, t y sn xut
ra 2 miRNA, vi 2 miRNA ny s tng hp ra
2 loi protein: smiR189 v miR24. Trong ny c
protein miR24 tn cng t bo ung th
-
Trng g bin i gen c kh nng cha bnh ung th
-
Chuyn gen tng hp protein ca loi
nhn vo trong gen tng hp sa ca loi
d ni, n sn xut ra mt loi protein
sa c bit c th ko ra si t lm ch
khu Y khoa, tan c trong c th.
-
D sa Biosteel ca Cng ty
Nexia Biotechnologies In C.
Qubec, Canada.
-
Sn phm ch yu ca Cng ty Nexia ca Canada l dc phm
v cht liu sinh hc. Protein ti t hp trong sa d BELE c
c tnh ging nh si t ca nhn ni. V si nh, chc nh thp
nn ngi ta cn gi sn phm l BioSteel, Vi phng php
ny Cng ty Nexia sn xut trn 80 loi sinh phm dc.
Chuyn on gen
nhn ni vo dGing d cho
Sa ko si
-
D BELE s dng trong nghin cu
chuyn gen ca Cng ty Nexiabiotech.
D BELE c c im l thnh thc rt sm, do
rt thun tin trong cng tc nghin cu di truyn.
Sn xut sa
Sn xut sa
Mang thai
Gieo tinh
-
Thnh phn Amino Acids
trong sa d chuyn gen
1. Glycine2. Alanine 3. Valine4. Leucine5. Isoleucine6. Serine 7. Threonine 8. Phenylalanine 9. Tyrosine 10.Tryptophan
1. Aspartate 2. Glutamate 3. Asparagine 4. Glutamine 5. Cysteine 6. Methionine 7. Lysine 8. Arginine 9. Histidine 10.Proline
Khng khc g khi so snh vi protein truyn thng
-
Sa d chuyn gen ca nhn ni c s dng
lm ch khu tan, siu chc dng trong Y khoa
-
Ch khu Y khoa rt cht, c th cu c ln c
-
Th nghim ch khu Y khoa trong phng TN
-
Kt qu nhng th nghim ch khu
Y khoa lm t sa d nhn gen nhn ni
-
Nhm cc nh khoa hc tho lun
cc tng ng dng cng ngh mi ny
-
Cng ngh sinh hc ng dng trong s sinh sn Th tinh nhn to trong ng nghim
Chuyn cy phi, nhn ging qu
http://www.scienceatstmarys.net/KS3 computer work/Variation/Selecting the best IV.ppt
Chuyn cy phi iu tr him mun
-
Thit b knh hin vi thao tc
s dng trong cng ngh sinh hc
Micromanipulation
http://www.cvm.tamu.edu/CollegeHour/02 Spring 2005/08 Reproductive Sciences.ppt
Knh hin vi thao tc ly nhn v bm nhn t bo
-
Thao tc vi tim di
knh hin vi thao tc c phng
i ln chuyn nhn t bo
-
Chuyn nhn t bo
Nucleus Transfer
Khot ly nhn t bo
(removing the nucleus)
-
Bm nhn vo trong t bo
Chuyn nhn t bo
Nucleus Transfer
-
a tinh trng vo bn trong t bo trng
Sperm Injection
Tim tinh trng vo trong
t bo cht ca trng, nui
trng trong ng nghim
thnh phi v cy vo t
cung
K thut ny p dng cho
sinh sn th qu him, n
ng v sinh khng c kh
nng th tinh
http://ims.cos.edu:8081/Jim Sellers/Bio 20 PP-Frontiers in Biology Fall 2005/Weathers_Amanda.ppt
-
Giao tTrng Tinh trng
Tin nhn
cTin nhn
ci
Vi pipet
Tim gen
Chuyn gen
Trng
th tinh
Gen tim vo trng
Th tinh bng phng php vi tim
-
Ci thin ngun gen
Kim tra nh gi
Ph bin sn xut
Cng ngh sinh hc c th rt ngn m hnh
nhn ging, khng cn tri nhn ging b m?
Ging
Ht nhn
Ging thng phm
Thp ging Phn bit gii tnh, nhn v tnh
AI, MOET, JIVET
p dng cho ging cao sn, nhng kh nng
sinh sn, nhn ging t nhin thp.
Artificial insemination (AI)
In Vitro Fertilisation (JIVET)
Embryo transfer (MOET)
-
Tng nhanh i sau t mt gia nh
Pht huy c tnh tt t gc cha m tt chn la k lng, tn km
Nhn nhanh c th c c tnh tt t gc cha m phc v sn xut.
http://centaur.vri.cz/docs/CENTAUR_3.PPT
-
http://www.cvmbs.colostate.edu/bms/640_RM_endangsld.ppt
-
TLHFSH
GnRH
T = Testosterone
LH = Leuteinizing Hormone (regulates T secretion)
FSH = Follicle Stimulating Hormone (regulates seminiferous tubule function)
GnRH = Gonadotropin Releasing Hormone (regulates LH & FSH secretion)
INHIBIN from Sertoli cells feedsback on the pituitary to regulate FSH secretion
PITUITARY/TESTIS
FEEDBACK SYSTEM
TIME
CO
NC
EN
TR
AT
ION
INHIBIN
http://www.umanitoba.ca/womens_health/rp017c.ppt
-
http://depts.washington.edu/cfas/WHIN/2005_sanjuan/Bardeguez.ppt
-
HYPOTHALAMUS
GnRH (Gonadotropin releasing hormone)
PITUITARY
LH (Luteinizing hormone)
FSH (Follicle stinulating hormone)
TESTIS
Leydig cells (produce Testosterone)
Sertoli cells (produce Inhibin)
Nhng hormon s dng trong
k thut sinh sn nhn to
-
Cng ngh sinh hc ng dng
trong sn xut hormon
1. Sn xut hormon ti t hp: rBST, rBGH
2. Sn xut Hormon IGF iu tr bnh ln.
3. Sn xut Insulin ti t hp: rInsulin
-
Cng ngh sinh
hc sn xut
Insulin
Nguyn l:- Ly on plasmid tng hp insulin trong t bo ngi chuyn vo plasmid E. Coli
- E.Coli tng hp ra Insulin
ng dng:- Thuc tr tiu ng- Lm vaccine ch khng huyt thanh insulin.
- Chn on bnh
http://www.idrc.ca/uploads/user-S/11095853171RabihTalhouk-AsPresented-IDRC-Sep29-04.ppt
-
Cu trc ca Insulin
C 2 chui polypeptide; chui th nht c 21
acid amin v chui th hai c 30 acid amin.
Hai chui lin kt vi nhau qua cu disulfide
Gene m ha protein insulin tim thy trong
chromosome 11, da vo cu trc ca gen
ny, ngi ta ti t hp DNA tng hp insulin
http://www.life.umd.edu/grad/MLfsc/res/RecombomamtDNA&Medicine.ppt
-
Cu trc ca Insulin
http://www.fda.gov/cder/meeting/followOn/Ahn.ppt
-
K thut ti t hp DNA
Nhng Enzyme gii
hn c s dng
ct gen insulin v ct
plasmid ca vi khun
(E. coli) cng ging
nhau u cui nn
dnh li c sticky
ends
-
K thut ti t hp DNA
Dng bin i ca E. coli c s dng
trnh s tn cng gen l (foreign genes)
Gen insulin gn vo E. coli l
B-galactosidase, n kim sot s sao chp.
Nhng t bo vi khun s ti to v sao
chp bn sao ca gen insulin.
-
K thut ti t hp DNA
Protein Insulin c tinh ch
(B-galactosidase thc hin)
Nhng chui peptide hn hp v ni li vi
nhau bi cu disulfide.
Sn phm cui cng c tn goi l Humulin
tn ha hoc ni ln insulin ca ngi.
-
S dng insulin ngi chng
bnh tiu ng
Trn th gii c hn 150.000.000 ngi mc chng bnh tiu ng. Hu qu ca n rt nghim trng, gy ra nhng bin chng phc tp,nguy him n tnh mng.
Tng chi ph cho cha tr bnh tiu ng ch ring cho nc Php c n 5,7 t Euro trong nm trong 2002
Insulin ti t hp ln u tin xut hin trn th trng nm 1982
Nhng dng sn phm insulin pht trin nhanh chng v a dng (insulin tc dng nhanh- hoc tc dng ko di, hoc insulin dng ht)
Trong nm 2002 tng s bn ra l 4.2 t Euro
-
Bin chng c th xy ra khi
s dng Insulin ngi
Hypoglycemia (thp ng huyt) xy ra vi
insulin ngi nhiu hn so vi insulin ng vt.
S dng insulin h ng huyt ngi tiu
ng nn c s khm bnh v hng dn ca
Bc s iu tr. Khng nn t tin dng rt nguy
him.
-
Sn xut bovin somatotropin (bST)http://www.monsantodairy.com/about/history/
Qu trinh sn xut
somatotropin v
ng dng trong
chn nui b sa,
nng nao nng
sut, cht lng sa
-
Sn xut bST bng con ng cng ngh sinh hc
-
Ti t hp sn xut bST v ng dng nng cao nng sut sahttp://www.extension.umn.edu/distribution/livestocksystems/DI6337.html
Hot ng ca BST t nhin
Sn xut BST tng hp
1.Thy trc tuyn yn tit ra BST, l
mt hormon c cu trc nh 1 peptid,
c tc dng ln s tng hp sa.
2.Hormon ny vo mu i khp c th.
3.BST tc ng n gan sn xut ra mt
protein quan trong IGF-1 (Insulin like
Growth Factor-1).
4.IGF-1 tc ng ln tuyn v, phn ct
cht bo sinh nng lng cho sn xut sa..
A.Gen p ng cho sn xut BST c
c lp t DNA ca b. B.Gen ny c
a vo vi khun E. Coli bng k thut
c bit. C. Vi khun E.Coli c gen tng
hp BST c nhn ln trong mi trng
nui cy. D.Thu nhn BST trong mi trng
E.Tinh loc BST t VK to ra BST tng hp.
-
http://www.avs.uidaho.edu/avs221-bio212/Past Team Presentations/Recombinant Bovine Somatotropin.ppt
B sa c chch
Kch t ti t hp rbST
-
B c chch
hormon BST
c g c bit
trong nui
dng khng?
C, l nhu cu
dinh dng cao
hn, nhng tiu
hao dinh dng
cho sn xut1 kg
sa thp hn b
bnh thng.
-
Cc vn rc ri
c lin quan vi rBGH hay rBST
Lm tng 16 vn th y xy ra trn b sa dng rBST: Gim t l u thai v trong lng s sinh ca b,
Tng t l tiu chy,
H hi chn,
Thng tn t bo somatic (c m),
Gy vim v.
Vim v v khng thuc lin quan n sc khe ngi
C s lin quan gia IGF-1 v bnh ung th trn ngi
trn b sa c s dng rBST.
-
CHA BN CI
IGF-1 hin din v ging nhau trn b v ngi
rBGH lm tng IGF-1 trong sa b
IGF-1 tng cao kch thch t bo ung th trn ngi
rBST, IGF-1 v UNG TH
rBGH
Kch thch ung th
trn ngi
IGF-1 tiu ha nh th no?!
Tng IGF-1
Trong sa b
IGF-1 tng
trn ngi
-
CASEIN BO V IGF-1
Casein nh hng trn ton b cu trc IGF-1 (80%) v receptor kt dnh hot tnh. . .Ngun ti liu: (C.J. Xian et al, Degradation of IGF-1 in the adult rat gastrointestinal tract is limited by a specific antiserum or the dietary protein casein, Journal of Endocrinology, v. 146, 1995.)
T bo ny cho thy IGF-1 c th tiu ha cn st li (67%) khi c s hin din ca casein.Ngun ti liu: (Michael Hansen, Consumer Policy Institute, Letter to Maine Attorney General G. Steven Rowe, Feb. 11, 2003, citing T. Kimura et al, Journal of Pharmacology and Experimental Therapeutics, v. 283, 1997.))
Casein tng cng cao, cng lm cho IGF-1 tr nn n nh hn, kh b men tiu ha phn giiNgun ti liu: (P. Anderle et al, In Vitro Assessment of Intestinal IGF-1 Stability, Journal of Pharmaceutical Sciences, v. 91, 2002.)
-
S dng GH iu tr bnh lnng dng trong iu tr bnh ln bm sinh.
http://arbl.cvmbs.colostate.edu/hbooks/pathphys/endocrine/hypopit/gh.html
(Insulin like
grower factor)
-
Somatotropin c an ton thc phm
cho ngi tiu dng khng?
L mt Protein hormon
1. C cc m vi s lng nht nh.
2. Khng tch ly trong m m.
3. L mt protein c cu to t cc acid amin.
4. Gii hn tc ng theo loi.
5. Khng c hot tnh nu s dng qua ng ming, v n b tiu ha nh nhng protein khc trong thc n
L mt Steroid hormon
C th tch ly trong c th ng vt v ngi.
C nhiu trong cc m m, kh loi ra ngoi.
L phn t hu c c ngun gc cholesterol.
Khng gii hn tc ng theo loi, k c ngi.
C hot tnh khng i khi s dng qua ng ming.
-
Posilac l sn phm thng mi
c cha rBST c s dng M
Posilac c sn xut bi cng ty Monsanto
Ch c FDA chp nhn cho s dng nng cao
sc sn xut sa ca b.
L ch phm s dng chch vo c bp
9 triu b sa cc nc th gii th ba s
dng ch phm Posilac ca Monsanto.
-
Nhng
Canada CHA (Canadas health
administration) khng chp nhn cho s dng
Posilac
EU (European Union) cm s dng rbST
Nht bn, c v New Zealand cm s dng
Posilac
-
Mt s kch t tng hp thuc steroid
b cm s dng trn th v VN.
S TT Tn ho cht, kch t S TT Tn ha cht, kch t
1 Carbuterol 9 Metronidazole
2 Cimaterol 10 19 Nor-testosterone
3 Clenbuterol 11 Ractopamine
4 Diethylstilbestrol (DES) 12 Salbutamol
5 Dimetridazole 13 Terbutaline
6 Fenoterol 14 Stilbenes
7 Isoxuprin 15 Terbolone
8 Methyl-testosterone 16 Zeranol
-
Nhng loi kch t Steroid hormon b cm s dng
OH
H
H
H
CH3OH
O
CH3
H
H
H
CH3OH
O
CH3
H
H
H
CH3C
CH3
O
Beta-estradiol TestosteroneProgesterone
O
H
CH3OH
H
CH3
CH3
OH
OHO
OH
CH3HOOH
OHHTrenbolone Zeranol Diethylstibestrol
NH2
Cl
Cl
CH CH2NH C(CH3)3OH
Clenbuterol
OH
HOH2C
CH CH2NH C(CH3)3OH
Salbutamol
H2N
F3C
CH CH2NH C(CH3)3OH
ClMabuterol
H2N
NC
CH CH2NH C(CH3)3OH
Cimaterol
-
Cng ngh sinh hc vi sinh
ng dng sn xut thc n b sung
1. Thng qua t bo nm men sn xut
Selenium hu c ng dng trong thc n
chn nui v phng bnh thoi ha c.
2. S dng vi khun hu ch ng rut
sn xut Probiotic phng chng bnh
ng rut thay th khng sinh.
-
Selenium
Vai tr sinh hc ca Se: Phng chng nhng bnh c lin quan vi thiu Se nh:
Bnh teo c trn cu, b v g (thng xy ra trn th nui theo li CN) Bnh hoi t gan trn chut v heo do thiu Se Bnh th tng tit dch trn g v g Ty (tch nc xong bng) Bnh a thoi ha hoi t tim, gan, c v thn trn chut.
Chc nng trong trao i cht ca Se: Selenium cu to enzyme glutathione peroxidase, ph hy cc gc t do peroxides trong cytosol, gc ny c nguy c gy ung th.
C th coi Se c hot tnh chng oxyha (vi vy c mi quan h vi vitamin E trong hot ng chng oxyha).
Mui selenium v c tng i c, selenium hu c c nhiu trong t bo nm men khng c, s dng an ton hn. V vy cng ngh sinh hoc tng hp selen hu c.
-
Selenium tham gia trong enzyme Glutathione Oxidation thc hin
chu trnh phn ng oxyha kh, bin H2O2 thnh H2O, chng li
s hnh thnh cc gc t do trong c th http://lpi.oregonstate.edu/infocenter/minerals/selenium/gsh.html
-
Selenium hu c v chc nng sinh hc
-
Cng ngh sinh hc sn xut
Selenium hu c bi
t bo nm men
Video clips: 1, 2.
-
Cng ngh sinh hc ng dng trong sn
xut Probiotics, Prebiotic v Synbiotics
Probiotics = L nhng vi sinh vt hu ch, sng c trong mi trng ng rut, ci thin sc khe ng rut vt ch. Tm kim VSV probiotic trong ng rut vt ch khe mnh, nh danh, nui thun hoc hn hp.
Prebiotics = Ngun thc n cho vi sinh vt sng hu ch trong ng rut vt ch (khng phi cho vt ch). Prebiotics thng l cc cht x tan khng tiu ha on trn ca rut, c kh nng ln men su\inh acid hu c bi VSV probiotics.
Synbiotics = Hn hp probiotics v prebiotics c tc dng:Ci thin kh nng sng v chim ng trong ng rut caprobiotics. Cho nhiu nh hng tt hn s dng probiotics n thun. Prebiotics bao bc xung quanh VSV probiotics.
-
C ch hot ng ca
Probiotics, prebiotic v synbiotics
(S khng chim lnh hay s cnh tranh loi b)
1. Sn xut cc cht khng vi khun gy bnh.
2. Gi cn bng pH thp bi nhng acid bo mch ngn v acid lactic do vi khun hu dng ln men sinh ra.
3. Nng cao hot ng ca i bch cu, thc bo VK gy bnh
4. c ch cnh tranh v tr bm dnh ca vi khun gy bnh.
5. Cnh tranh ngun dinh dng vi vi khun gy bnh.
6. iu chnh khng th, tng cng khng th khng c hiu.
7. Gim thp s chuyn i yu t tin ung th thnh ung th bi nh hng ca hot ng enzyme.
8. Gim chng to bn, t gim c t sinh ra trong rut.
9. Gim cholesterol ti hp thu, t gim cholesterol mu.
-
89
Thnh rut
T bo nim mc rut
VK c li (Probiotics)
VK gy bnh
A.
B.VK gy bnh
VK c li (Probiotics)
Thnh rut
T bo nim mc rut
Hng ro phng ng t nhin
-
90
Bacillus subtilis/cereus/mesentericus
Clostridium butyricum, Bifidobacterium
Lactobacillus acidophilus
Enterococcus faecium..
S DNG VI KHUN C CH
TR SINH (PROBIOTIC)
Saccharomyces cerevisiae/boulardii..
Aspergillus oryzae
-
c im chung ca
probiotics l:
Tng i thch nghi trong ng rut ng vt
C kh nng chng li stress trong d dy, rut
khng li vi cc yu t ch bin thc n
Phi t cc yu cu, qui nh ca lut l an
ton sinh hoc v c hiu qu ln sc khe.
-
Ny chi trong ng rut
hiu qu hng ro sinh hc
Tng cng ti hp thu Nit
Sn xut cc enzyme
Sn xut cc acid hu c
Kch thch min dch cc b
1
Enzymes
2
N
3
5
acid hu c4
C ch tc ng cu
Probiotic
Video clips 1, 2
-
T l tiu ha hi trng (Ileal)
G 21 ngy tui
+15.9%
+18.9%
+17.9%
+3.8%
+3.5%
+7.9%
+12.8%
+12.2%
+15.1%
70
75
80
85
90
95
100
MET LYS ARG THR VAL LEU ILE PHE HIS
Essential Amino Acids
CONTROL ESPORAFEED
-
50%
60%
CaCONTROL ESPORAFEED
50%
60%
Mg
CONTROL ESPORAFEED
10%
15%
20%
K
CONTROL ESPORAFEED
Ca
K
Mg
nh hng dng tnh ca Probiotics
trn s tch ly khong
+9.1%
+12.0%
+28.6%
-
S QUI TRNH SN
XUT PROBIOTICS
Nhn ging a vo b Ly tm tch Sn phm th
trong ng ln men ln lp t bo t cui cng
nghim Sy phun loc
bao sp, hoc
cht x tan
New!
-
S QUI TRNH SN
XUT PROBIOTICS (TT)
Sn phm th
(do Norel sn xut)
Sn phm hot ng ng gi Sn phm
thng mi
Cht mang
New!
-
Sn xut trng g giu khng th phng chng
bnh ng rut cho ngi v ng vt
-
Trng g giu khng th phng v chng
bnh do vi khun v virus gy bnh
-
Vi khun gy bnh tn cng t bo nim mc rut v
gy mt nhiu nc, tiu chy, gim hp thu.
-
Vi khun bnh b khng th c hiu trong lng
kt dnh v lm v hot chng
-
Virus gy bnh tn cng nim mc rut
l cho t bo nim mc v tung, gy tiu chy
-
n lng trng c khng th c hiu s lm
v hot cc virus gy bnh ng rut
-
Trng g giu khng th chng bnh c
sn xut Nht Bn bi Cng ty GHENhttp://www.ghen.co.jp/en/ingredients/index.html
-
ELISA
QUY TRNH SN XUTPROTIMAX
PROTIMAX
ProtimaxProtimax
G mi nui trong tri SPFChng vaccin c kim Sot g sn xut khng Th lng cao
Trng g giu khng th c kim tra hm lngkhng th cn thn
Nghin cu to ra ch phm p dngVo sn xut
Th nghim khNng phng hTrn heo con
-
Cc loi khng th c hiu c
sn xut t lng trng g
Salmonella typhimurium
Salmonella cholaraesuis
Salmonella enteriditus
Salmonella dublin
Salmonella heidleberg
lostridium perfringens
Rotavirus
TGE
E.coli 987P
E.coli F41
E.coli K88
E.coli K99
E.coli 1362
E.coli 2134* ( 2134 is an 18
E. Coli)
E.coli 263
E.coli J5
-
C ch tc ng ca Protimax
PROTIMAX cn c kh nng
kt dnh cc vi khun gy bnh
v virus, khng cho chng bm
vo thnh rut v nhn ln
trong ng tiu ha ca heo
con, nh vy gip cho heo con
trnh c cc bnh nhim
trng gy tiu chy.
IgG
IgG
-
Nhng kt qu th nghim Protimax M
1.441.39Ch s bin chuyn thc n, FCR
+ 13.64%1.351.19Lng thc n tiu th bnh quan,
/heo/ngay (lb.)
5548.4Tng lng thc n tiu th / heo (lb.)
+ 9.46%0.940.86Bnh qun tng trng / ngy/heo, (lb.)
40.740.7S ngy nui
38.234.9Tng trng bnh qun / heo, (lb.).
51.747.4Trng lng bnh qun u ra(,lb.)
13.512.5Trng lng bnh qun u vo,( lb.)
- 29.92%1.462.09%T l t vong
4563S heo cht
30312955S heo u ra
30763018S heo u vo
% Khc bitProtimaxi chng
-
10.39%1.381.54Ch s bin chuyn T, FCR
- 9.40%1.061.17Lng thc n bnh qun /
heo/ngy (lb.)
46.953.1Tng thc n / heo (lb.)
+1.31%0.770.76Tng trng/ ngy/con,lb.
4445S ngy nui
34.134.6Tng tng trng / heo,(lb.)
45.145.6P bnh qun u ra, (lb.)
1111P bnh qun u vo, (lb.)
- 45.50%4.728.66%T l t vong
72131S heo cht
14551382S heo u ra
15271513S heo u vo
% Khc bitProtimaxi chng
Hiu qu s dng Protimax trn heo min Nam Carolina.
-
Thank you for
Your attention
top related