bioss pathways - stratech.co.uk fileck-1 ca2+ β-catenin β-catenin β-catenin rac dvl daam1 rho...

Kinase Phosphatase Ligand Transcription Factor Other Receptor Phospho Activation

Membrane Cell Function Binding/Association

Activation Inhibition Indirect Effect Dissociation

P

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Beta catenin FZD3 / Frizzled 3 DKK3 SFRP1 PLCZ1

IF | Rat brain WB | Mouse pancreas IHC-P | Rat mucosa cancer WB | Rat brain IF | Rat testis

B I O S S P AT H W AY S

TCFWNT target genese:

MYC, TCF-1, Cyclin-D1, MMP-7, Axin-2, CD44, etc.

PP2A

Ca2+

GSK3 DVLDVL

APC Axin

B-cateninWTX

B-catenin

B-Tvcp

UbUb

Ub

TCFHDAC

Groucho

CREB

Cdk8

CBP β-catenin

BCL-9 Pygo

RA Chibby

DVL

CK-1 Ca2+

β-catenin

β-cateninβ-catenin

RAC

DVL

Daam1

Rho

ROCK

RAC

JNK

Proflin

G-protein

PLC

Ca2+

Ca2+

Ca2+

Ca2+

Wnt

WntLRP5/6

Axin

Wnt

LRP516

26S proteosome

degradation

WNT target genes

Frizzled

NFATpathway

Wnt target genes

cytoskeletal rearrangement

Proliferation, differentiation, adhesion and survival

SFRPDKK

GBP

CK-1

GSK3

SFRP

WIF

P

P Ca2+Naked

PAR-1

β-catenin

RAR

ICAT

Calcineurin

NFAT

NLK

TAK1

NLK

CamKII

PKC pathway

PKC

Cell survival, gene expression,

cytoskeleton arrangement

ONOFF

TCFWNT target genese:

MYC, TCF-1, Cyclin-D1, MMP-7, Axin-2, CD44, etc.

PP2A

Ca2+

GSK3 DVLDVL

APC Axin

β-cateninWTX

β-catenin

β-Trcp

UbUb

Ub

TCFHDAC

Groucho

CREB

Cdk8

CBP B-catenin

BCL-9 Pygo

RA Chibby

DVL

CK-1 Ca2+

B-catenin

B-cateninB-catenin

RAC

DVL

Daam1

Rho

ROCK

RAC

JNK

Proflin

G-protein

PLC

Ca2+

Ca2+

Ca2+

Ca2+

Wnt

WntLRP5/6

Axin

Wnt

26S proteosome

degradation

WNT target genes

Frizzled

NFATpathway

Wnt target genes

cytoskeletal rear-rangement

Proliferation, differentiation, adhesion and survival

SFRP

DKK

GBP

CK-1

GSK3

SFRPWIF

P

P Ca2+Naked

PAR-1

B-catenin

RAR

ICAT

Calcineurin

NFATNLK

TAK1

NLK

CamKII

PKC pathway

PKC

Cell survival, gene expression,

cytoskeleton arrangement

LRP5/6

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