biomedical engineering and biomedical informatics program
Post on 03-Jan-2016
111 Views
Preview:
DESCRIPTION
TRANSCRIPT
Presented by
Biomedical Engineering and Biomedical Informatics Program
Barbara BeckermanModeling and Simulation Group
Computational Sciences and Engineering Division
Beckerman_0611
2 Beckerman_Biomed_0611
Biomedical engineering and biomedical informatics research at ORNL Biokinetic and biotransport modeling
Three-dimensional organ and tissue modeling using CT or other imagery (pulmonary, arterial, musculoskeletal)
Prediction of outcomes based on biomedical models
Knowledge discovery and intelligent agents for data mining and analysis
Integration of models at multiple temporal and spatial scales
Computer environments (data repositories, search tools, visualization, etc.) in support of biomedical and medical applications
ORNL HotBox integrates all the DARPA Virtual Soldier windows
HotBox interfaceHotBox interface
Anatomical ontology:Foundational model
of anatomy
Anatomical ontology:Foundational model
of anatomy
Predicted locationof wound
SCIRun Net
Physiology display
Geometry window with thorax model
3 Beckerman_Biomed_0611
Beckerman_0611
4 Beckerman_Biomed_0611
*Funded by National Library of Medicine–NLM-N01-LM-0-1-3512 and LM-0018-01 (1998–2003); PI–Mitch Schnall, University of Pennsylvania; Co-PI/Technical Director–B. Beckerman, Oak Ridge
Biomedical applications for thenext-generation Internet (NIH/NLM)*
NationalDigital
MammographyArchive
NationalDigital
MammographyArchive
Beckerman_0611
5 Beckerman_Biomed_0611
Goal: Predict migration of smooth muscle cells from mediato intima due to inflammatory response after injury
Model for predictingvascular disease
Predictive multi-scale modeling
Spatial modelingof cell migration
Kinetic modelingof biochemicals
Result: A multi-scale hybrid continuous-discrete predictive model for tissue pathology
Atherosclerotic artery
MMP3
proMMP9
TIMP1 TIMP1proMMP9
MMP3MMP3proMMP9
TIMP1
TIMP1 TIMP1
TIMP3TIMP3
TIMP2
TIMP2 TIMP2
MMP9
MMP9
MMP9
MMP9
MMP9
MMP9 MMP9
MMP9
Collagen IV
Collagen IV
MMP3
Inhibited
Inhibited
Inhibited
Activation of MMP-9
Inhibition of MMP-9
MMP-9-inducedcollagenolysis
ACTIVE
Matrix metalloproteinases (MMPs)
Beckerman_0611
6 Beckerman_Biomed_0611
Dorsal view Ventral view
Metrics for tissue anatomy
Temporal measurement of lumenal diameter
Imaging of vascular wall perturbations after injury due to balloon angioplasty
Biological modeling and simulation environments (cellular, tissue, and multi-scale kinetics models)
Discrete event simulationsto predict resultsof vascular wall injury
Thoracic and neck vasculature seen in the microCAT scanner using the vascular
contrast agent Fenestra VC(Images courtesy of J. Wall,
University of Tennessee Medical Center)
Computational modelingfor vascular systems:Collaboration with the UT Medical Center Mammalian models Computational models
Beckerman_0611
7 Beckerman_Biomed_0611
Orthopedics research at UTK/ORNL:Dynamic and kinematic models of motion for knees, hips, and spine
Cervical SpineDynamic ModelCervical SpineDynamic Model
Beckerman_0611
8 Beckerman_Biomed_0611
Computational modeling of pre- and post-operative lumbar spine system
In vivo imaging and analysis of lumbar spine system (Komistek, Mahfouz)
Finite-element mesh models of the spine (Nukala)
Constitutive modeling of intervertebral discs (Nukala)
Two vertebrae and a discTwo vertebrae and a disc
Beckerman_0611
9 Beckerman_Biomed_0611
Seizalert on PDA:2005 R&D 100 award*
Non-linear analysis approach predicts onset of epileptic seizure
Implemented in software on a PDA or wearable device to alert wearer to occurrence of seizure
Protected by five patents and two pending
Licensed to Hercules Development Corporation
*Hively, Protopopescu, Munro, Kruse (2005)
9 Beckerman_Biomed_0611
ORNL solves biomedical problems
Convert CT slice data to finite-element mesh
Abdominal aneurysms
Prediction of wounds
Data repositories
Parallel computations
Computational tools for toxicants
Agent technologies
Ontologies and informatics
10 Beckerman_Biomed_0611
Beckerman_0611
11 Beckerman_Biomed_0611
Contacts
Barbara BeckermanProgram Manager, Biomedical EngineeringComputational Sciences and Engineering Division(865) 576-2681beckermanbg@ornl.gov
Brian WorleyDirector, Computational Sciences and Engineering Division(865) 574-4837worleyba@ornl.gov
Richard WardSenior Research ScientistComputational Sciences and Engineering Division(865) 574-5449wardrc@ornl.gov
11 Beckerman_Biomed_0611
Beckerman_0611
12 Beckerman_Biomed_0611
top related