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AP-.���HIV������������ !Transcriptional Repression of Human Immunodeficiency

Virus Type + by AP-.

� � � �Kenichi IMAI

������������ �������Department of Molecular and Cellular Biology,

Nagoya City University Graduate School of Medical Sciences

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AP-.�HLH-Zip%��78JK� NLM�DNA

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The Journal of AIDS Research Vol. 2 No. , ,**0

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�� AP-.�����?@'�6=$%� W7�8@1=�AP-.� TBP�()*+,WX��� Y=1�Z[\]^�HIV���3&�0���_�'`a#$%�bc� ���&�de� ��HDAC���fg(h

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K Imai : Transcriptional Repression of Human Immunodeficiency Virus Type + by AP-.

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����� AP-.���HIV���� ������ �� -B��

HIV������ LTR�� AP-.�� ����

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pol IIK LTR�S/TUV��.W�X ! �M�YZV3�[\2T]KDX^.-�X KL'M�� ��.A�� AP-.�>J_`V$ab�c� LTR$���de</01234567$9^�>?! S/TUV���HDAC+Kfg<�X OM! AP-.KHDAC+$ LTR�S/TUV<.-�X Khi��� �� .B��

HIV������ AP-.����

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pol IIK LTR�S/TUV��.W�X ! �M�YZV3�[\2T]KDX^.-�X KL'M��� B. AP-.�>J_`V$ab�c� LTR$ -� ChIP assay��! S/TUV���HDAC+Kfg<��

The Journal of AIDS Research Vol. 2 No. , ,**0

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������������� ������������������ ������HIV� T��� HDAC+ !" valproic acid 3#$ IL-1 +*#���%&'( �)�*+,-������.�/0 %����1 ���� 2 3�4( HAART5���6789:"*;<=�3>*?@A*BC�D53� EFGHIJKL# ��24( �*��3��5=%�M�NO *789:��/4����5P�-( 2M����*HIV

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AIDS�=HAART���YZ%3�[�\M��]�%�( HIV=�^*_����� `a�Sb�cd%T( ef*��� AIDS�g���� �-��U�V5������h=3<( i%�j�$�"kS789:*le3>;<*m��n���oY( pqr*AIDS����g���*s��t��3����� �43�HIV*�u vwx*y!=( Z%3 AIDS��*s��d3������z5P��

�� : �*"= ECC{|}~LK9�8����#��������%�P�Y������i %� $�*���*��%(&����'���%�$����=�T������%�o(� ��i��

� �

+ # Price DH : P-TEFb, a cyclin-dependent kinase control-

ling elongation by RNA polymerase II. Mol Cell Biol ,* :

� / HIV)����� AP-.**�V'A. Jurkat T�� pNL.--�'+ ELISA�� p,.���, %� B. ,3-�� AP-. siRNA�'+ %&'( HIV*)���� %�

� 0 AP-.��� HIV�e**�}� �¡-¢£¤¥*�5=( NF-kB p/*( YY-+� HDAC

� LTR�LH9¦§������1������AP-.= TBP*��� HDAC*LH9¦§��Y¨.� HIV*�e�/��© ����ªM4��� TNF-a3>*¢£�+�� NF-kB0*«S¬�1�LH9¦§���<�­KHI®¦¯¦3>*j���Y( H°±IG*²³�o�Y LTR24 AP-.� HDAC�23��� ´*µ( TBP3>*¶$�u·¸¹�º�»i� HIV*�u�¼i��ªM4���

K Imai : Transcriptional Repression of Human Immunodeficiency Virus Type + by AP-.

E ,. #3*

,0,3�,0-., ,***.

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deacetylation and histone deacetylase occupancy at the

integrated promoter of human immunodeficiency virus

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actions with the HIV-+ LTR promoter. Nucleic Acids

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+,.3/�+,/*/, ,**0

/ � Imai, K, Nakata K, Kawai K, Hamano T, Mei N, Kasai

H, Okamoto T : Induction of OGG+ gene expression by

HIV-+ Tat. J Biol Chem ,2* : ,01*+�,01+-, ,**/.

0 � Mermod N, Williams TJ, Tjian R : Enhancer binding

factors AP-. and AP-+ act in concert to activate SV.*

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Transcription factor AP-. contains multiple dimerization

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2 � Stevenson M : HIV-+ pathogenesis. Nat Med 3 : 2/-�20*, ,**-.

3 � Lehrman G, Hogue IB, Palmer S, Jennings C, Spina CA,

Wiegand A, Landay AL, Coombs RW, Richman DD,

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+*� Wang FX, Xu Y, Sullivan J, Souder E, Argyris EG,

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The Journal of AIDS Research Vol. 2 No. , ,**0

� ,/ �3+

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