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Advances in Data Analytics for Continuous Manufacturing

Laura Wareham, MerckEmily Johnston, Seeq

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Advances in Data Analytics for CM

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Laura Wareham• Senior Scientist at Merck & Co., Inc.• Laura.Wareham@merck.com

Emily Johnston• Analytics Engineer at Seeq• Emily.Johnston@seeq.com

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Agenda• Welcome and Introductions• Challenge – Maximize Value from Data• Solution – Process Characterization with PI & Seeq

• Use Case 1: Loss-in-Weight Feeder Dashboards• Use Case 2: Film Coating Parameter Analysis

• Results – Process Optimization & Shared Insights• Future Opportunities

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About Our Company

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About Our Company

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AUTOMATION/CONTROL SYSTEMS NEW SENSOR TECHNOLOGY REMOTE AND MOBILE ASSETS

EnterpriseInfrastructure

Advanced analytics: application of big data, machine learning, and other innovations to derive insights and improve outcomes

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PI VisionPI NotificationsEvent FramesPI AFPI Data Archive

Advanced Analytics for OSIsoft PI System

OSIsoft Cloud Services

Industrial A Service Provider

MQTT Service Provider

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Continuous Manufacturing“Material is fed through an

assembly line of fully integrated components. This

method saves time, reduces the likelihood for

human error, and can respond more nimbly to

market changes.”Sau (Larry) Lee, Ph.D.

Chair of the Emerging Technology Team Office of Pharmaceutical Quality, CDER

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https://www.thomasnet.com/articles/machinery-tools-supplies/overview-of-food-processing-equipment/

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Goal: Maximize Value from Data

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Process Data

Contextual Data

BusinessSystems

Manufacturing Systems

Subject MatterExperts

Data Access and Manipulation

Algorithms andTools

Process Visualization

Data Analytics

Operationalize normal production behavior to proactively identify trends or process deviations

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Loss-in-Weight Feeders

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https://www.youtube.com/watch?v=BqDdkMMQR9k

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Feeder Challenge

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2 3 4

6 7 8 Modes of OperationProcess TrendsPerformance Statistics

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DEMOFeeder Dashboard

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Feeder Dashboards

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Film Coating

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https://www.youtube.com/watch?v=FXRjt1RZ3CQ

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Coater Challenge

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Identify Operating Mode Create KPIs

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DEMOCoater Dashboard

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Coater Analyses

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Results: Analytics Strategy

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LeverageHistorical Data

Apply Advanced Analytics

Enable Personnel

Optimize Business

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Looking Ahead

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Expand AnalysesStatistical Process ControlCondition Based Maintenance

Integrate with PI System Features

Event Frames

Asset Framework

“With enough information and quality content, these technologies can transform data into knowledge that supports critical activities,

including process optimization, continuous improvement, operational excellence, and even real-time release.”

Pharmaceutical Engineering, Sep/Oct 2018

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CHALLENGES SOLUTION BENEFITS

Accessing large CM data sets for rapid process analysis

Sharing analysis and insights across the broader team

Applying learnings and analysis proactively to future lots

Utilize PI DataLink, PI ProcessBook, and Seeq to characterize the process

Calculate statistics to understand normal process variability

Generate reports for process visualization and performance analysis

Greater insight into real-time process performance

Visual feedback during operation using monitoring dashboards

Rapid analysis summarized in performance reports for broader team distribution

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“Modern data analysis tools like SEEQ enable new ways for SMEs to interact with their data including rapid insights into process performance.”

Justin Moser, Merck, Advanced Manufacturing Technology

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Advances in Data Analytics for CM

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Laura Wareham• Senior Scientist at Merck & Co., Inc.• Laura.Wareham@merck.com

Emily Johnston• Analytics Engineer at Seeq• Emily.Johnston@seeq.com

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