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DTU Kemiteknik22. marts 2019 Annual Polymer Day 2
Advanced Wound Care Adhesives with ImprovedMoisture Handling Capabilities
Valeria Chiaula1,2, Piotr Mazurek1, Anders C. Nielsen2, Anne L. Skov1
1. DTU – Chemical Engineering – The Danish Polymer Centre
2. Coloplast A/S – GRD, TECH- Adhesives
Annual Polymer Day – 22/03/2019
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 3
Chronic wounds
Significant disability
Amputation
Increased mortality
Elderly and/or diabetic patients
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 4
Incorrect wound healing process
Chronic wounds stall in inflammatory/proliferative phases
Hyperproliferation
Chronic inflammation
Infections
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 5
Correct wound healing process
Moist, warm and clean wound’s bed
Moist wound bed promotes wound’s closure
Wound’s environment control
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 6
Allows moisture transmission
Mantains correct moisture in the wound bed and skin
Dressing for appropriate wound environment
GOAL
Wounded skin
Liquids/sweat from wound and skin
Dressing
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 7
Silicone adhesives
Low degree of cross-linkingdensity
Great potential in wound care applications due to its gentle skin adhesion properties
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Limited moisturetransportation due to hydrophobicity
Low absorption and incompatibility with high exudingwounds and/or large amount of sweat from skin
Silicone adhesives
Risk of failure prematurely
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 9
Current solutions on the market
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Mechanical holes in the border region of the silicone adhesive layer
Issues related to making holes
• Manufacturing
• Minor flexibility
• Risk of holes’ closure
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 11
PDMS
Glycerol
Development of novel, skin-friendly glycerol-silicone hybrid adhesives
Our solution13-12-2019
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 12
PDMS
Hydrophobic and nowater transport, but
permeable to gas (oxygen, water vapor)
Glycerol
Hydrophilic and causesthe water to be
absorbed in significantamounts
Improved moisture handling properties
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 13
SA* Part A SA* Part B
1:1
Glycerol: X phr*
SpeedMixer DAC 150 FVZ-K
3500 rpm, 1 min
Glycerol-in-silicone emulsion
SA*: S stands for silicone, A for adhesive
GX*: G stands for glycerol, X for glycerol phr*, which is glycerol weight amount per hundred parts of silicone
High shear forces to immiscible mixtures of hydrophilic glycerol and hydrophobic silicone
GX*_SA
Experimental
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 14
100 µm 100 µm
G20_SA t = 0 min G20_SA t = 60 min
Stability and morphology of the emulsions
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 15
100 µm
µm100 µm
0
2
4
6
8
0 60
aver
age
size
(µ
m)
t (min)
G20_SA t = 0 min G20_SA t = 60 min
Stability and morphology of the emulsions
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 16
Glycerol-in-silicone emulsion
Curing
80 ˚C, 1h
Hybrid adhesive
From emulsions to adhesives
Thickess 0.3 mmRelease liner: PET
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 17
Water absorption + permeability after 24h –TM0291
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DTU Kemiteknik22. marts 2019 Annual Polymer Day
0
0.2
0.4
0.6
0.8
1
1.2
1.4
SA G10 G20 G30 G40 G50 G60 G70
Ab
s +
Perm
g/c
m2
Composition
18
Water Absorption Permeability
Water absorption + permeability after 24h –TM0291
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 19
Ability to resist separation from skin surface after a period of application – long-term measurement
Maximum adhesion upon initial application to skin
Gradually decreases due to transdermal waterevaporation
Peel adhesion
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 20
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Peel test – TM0037
Substrate: stainless steelplates
Peel temperature: 32 C
Peel rate: 5 mm/s
Peel angle: 180°
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 22
Peel force vs glycerol loading
0
0.5
1
1.5
2
2.5
3
3.5
4
4.5
Pure SA G10 G20 G30 G40 G50 G60 G70
Peel
Fo
rce
(N)
Composition
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G70G60
After peel test… cohesive failure13-12-2019
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Peel test
Substrate: skin-like material
Peel temperature: 32 C
Peel rate: 5 – 1 – 0.1 mm/s
Peel angle: 180°
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DTU Kemiteknik22. marts 2019 Annual Polymer Day
0
0.5
1
1.5
2
2.5
3
3.5
Pure SA G10 G20 G30 G40 G50
Peel
Fo
rce
(N)
Composition
Peel force vs peel rate on skin-like substrate
26
1
Peel rate 5 mm/s Peel rate 1 mm/s Peel rate 0,1 mm/s
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 27
Tack
Short-term measurement
Shows initial tendency of adhesives to stick to the skin
High level of tack required to hold adhesives in position
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 28
Tack test – ASTM 6195-D03
Tack vs glycerol loading
0
2
4
6
8
10
Pure SA G10 G20 G30 G40 G50 G60 G70
Tack
Fo
rce
(N)
Composition
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 29
G70G60
After tack test… cohesive failure13-12-2019
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 30
Conclusions
Simple manufacturing and possibility of glycerol domains’ size control– no holes-related issues
Improved moisture handling capabilities compared to pure silicone
Versatile system, tunable according to patients’ requirements – extentof liquids that need to be absorbed
Adhesion and tack not compromised
Glycerol-silicone adhesives
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 31
Collaboration and support of Piotr Mazurek, Anne L. Skov and Anders C. Nielsen
The Danish Polymer Centre
Acknowledgements13-12-2019
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DTU Kemiteknik22. marts 2019 Annual Polymer Day 32
Thank you!
13-12-2019
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