5.1 proteins are linear polymers of amino acids

Biochemistry 2/e - Garrett & Grisham

Copyright © 1999 by Harcourt Brace & Company

5.1 Proteins are Linear Polymers of Amino Acids

Biochemistry 2/e - Garrett & Grisham

Copyright © 1999 by Harcourt Brace & Company

Biochemistry 2/e - Garrett & Grisham

Copyright © 1999 by Harcourt Brace & Company

The Coplanar Nature of the Peptide Bond

Six atoms of the peptide group lie in a plane!

Biochemistry 2/e - Garrett & Grisham

Copyright © 1999 by Harcourt Brace & Company

Biochemistry 2/e - Garrett & Grisham

Copyright © 1999 by Harcourt Brace & Company

“Peptides”

• Short polymers of amino acids

• Each unit is called a residue

• 2 residues - dipeptide

• 3 residues - tripeptide

• 12-20 residues - oligopeptide

• many - polypeptide

Biochemistry 2/e - Garrett & Grisham

Copyright © 1999 by Harcourt Brace & Company

Biochemistry 2/e - Garrett & Grisham

Copyright © 1999 by Harcourt Brace & Company

Biochemistry 2/e - Garrett & Grisham

Copyright © 1999 by Harcourt Brace & Company

The sequence of ribonuclease A

Biochemistry 2/e - Garrett & Grisham

Copyright © 1999 by Harcourt Brace & Company

Biochemistry 2/e - Garrett & Grisham

Copyright © 1999 by Harcourt Brace & Company

Biochemistry 2/e - Garrett & Grisham

Copyright © 1999 by Harcourt Brace & Company

Biochemistry 2/e - Garrett & Grisham

Copyright © 1999 by Harcourt Brace & Company

Configuration and conformation are not the same

Biochemistry 2/e - Garrett & Grisham

Copyright © 1999 by Harcourt Brace & Company

The tetrameric structure of hemoglobin