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12 June 2019 MEDTO19-M-005_ENG v1.0

3 topics of this presentation

① The overview of our product

for COPD patients.

② The medical network

we are building now

③ About our next product that

support patients at home

12 June 2019 MEDTO19-M-005_ENG v1.0

COPD is a global medical problem

COPD( chronic obstructive pulmonary disease) prevalence rate 8.6%

【NICE Study(2001)】

Estimated of patientsTreated patients

Estimated of patients(2014):

Total 5.5 million people

COPD patients (2004):

64 million people

COPD deaths(2005):

>3million people

The 3rd leading cause

of death(2030)

In JAPAN In the world

Medical cost(2014):

146.0 billion yen

Awareness(2018): 28.1%

12 June 2019 MEDTO19-M-005_ENG v1.0

Our Mission

is to raise awareness of health condition and

contribute to extending healthy life.

Awareness and early detectionProviding information to maintain

and not exacerbate the condition

12 June 2019 MEDTO19-M-005_ENG v1.0

4

ATS/ERS

Established

from 1909

The National

Center for Global

Health and

Medicine

IOP-01

Overview of Respiratory Muscle Strength Meter "IOP-01"

The only dedicated measuring device in Japan.

Guidelines of COPD

for Exercise therapy

“Respiratory muscle strength

measurement“ is defined as

a test performed

in the new COPD guidelines.

Recommended

grade A

12 June 2019 MEDTO19-M-005_ENG v1.0

5

IOP-01Class II

medical

device

Features of IOP-01

Launched last November

Pocketable

AnywhereLight

Class Ⅱ medical devicecertified by the Japanese FDA

12 June 2019 MEDTO19-M-005_ENG v1.0

6

Respiratory

CardiovascularIOP-01

COPD・Asthma

Aspiration pneumonia

Tuberculosis

Lung cancer

Rehabilitation/Training for Target Diseases by IOP-01

Cardiac insufficiencyFrail

Sarcopenia

Deglutition disorder

Geriatrics

Otorhinolaryngology

12 June 2019 MEDTO19-M-005_ENG v1.0

7

The medical network we are building now

• Measurement of respiratory muscle strength of healthy

volunteers using ATS / ERS recommended oral pressure

measurement. (Collaborate with University)

• Join a health checkup company. (Coming soon)

• Briefing @ high volume center & University.

• Booth display and seminars @ academic conferences

• Demonstration & Measurement @ Taisho monozukuri festival.

12 June 2019 MEDTO19-M-005_ENG v1.0

8

Business Plan

POST IOP-01

Development of home healthcare equipment (non-medical device)

based on respiratory muscle strength measurement.

@home@clinic

IOP-01

I o T

Network

using our own

patented technology

12 June 2019 MEDTO19-M-005_ENG v1.0

What we offer

① IoT monitoring system of

the respiratory function at home

② Home medication(Medicine / Exercise

/ Nutrition)management system(Collaboration with pharmaceutical manufacturers etc.)

③ Home patient‘s medical information

share system directly with doctors

④ Increase patient’s adherence and motivation

12 June 2019 MEDTO19-M-005_ENG v1.0

Team members

Iwao Kobata (CEO Project Leader)

Director of Medical Device

Development Association.

Working on a number of joint

projects and receiving grants.

Mitsuyoshi Nakaya

Design and development engineer

From Sharp Corporation

Specialized field: Electronic circuit

design

Kenji Nozaki PhD (Engineering)

Sales promotion

From Taiho Pharmaceutical Co., Ltd.

Specialized field: Drug Discovery /

Medical Affaires

Kazuhiro Yoshida

Director

(Leave a Nest Corporation CRO)

Master (Technical Management)

Specialized field: Venture support

Souichi Soroji

Pharmaceutical and marketing

manager

From Roche Diagnostics Ltd.

Yukihiro Ishida

Researcher/Clinical engineer

Taisho Kusunoki Clinic

Deputy General Manager

Medical Presentation Labo

Japan. Representative

Team members

12 June 2019 MEDTO19-M-005_ENG v1.0

CONTACTPresenter : CEO Iwao KobataE-mail :iwao@kobata.co.jpTel : +81-6-6552-0545

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