2.an evaluation of the efficacy of trans dermal continuous oxygen therapy in patients with...
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8/3/2019 2.an Evaluation of the Efficacy of Trans Dermal Continuous Oxygen Therapy in Patients With Recalcitrant Diabetic
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8/3/2019 2.an Evaluation of the Efficacy of Trans Dermal Continuous Oxygen Therapy in Patients With Recalcitrant Diabetic
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diabetes mellitus in the adult population,years, with the highest rate found in the North
, withfoot ulcer in the course of their life. Diabetic foothave high levels of morbidity and mortality and
related to diabetes and the economic cost ofcountries is estimated at $7,000 - $10,000, with4. In2007, the world was estimated to spend at least4
While prevention of the development of a
different options for treatment of a diabeticproper glucose management, off-loading, thetreatment of infection including osteomyelitis,surgical correction of a Charcot foot, vascularreconstruction, proper debridement and otheraspects of wound care.
thereby preventing wound healing. Importantly,
a central and crucial role.8 It is crucial in mostcellular functions associated with wound healing,-9that occurs to kill microorganisms. bactericidal activity of granulocytes depends on
tensile strength of incisional wounds wasconcentrations, with optimal wound healingpressure
vasculature, is a key factor that limits woundhealing.healing process to progress, but the macro- andmicroangiopathy occurring in diabetes maypressure.
Open access publishingThe Journal of Diabetic Foot Complications 2011, Volume 3, Issue 1; No.2, Pages 6-12
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8/3/2019 2.an Evaluation of the Efficacy of Trans Dermal Continuous Oxygen Therapy in Patients With Recalcitrant Diabetic
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Open access publishingThe Journal of Diabetic Foot Complications 2011; Volume 3, Issue 1, No.2, Pages 6-12
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to-heal diabetic foot ulcers in a Canadian out-patient clinic. Patients with a diabetic foot ulcerthat previously had been treated with standardof care methods, without success with regard towere included in the evaluation.
and when necessary, and including osteomyelitis-ed, off-loading, and local wound management,as well as proper diabetes management.
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directed onto the center of the wound. A smallfoam dressing was placed beneath the cannula
cannula from pitting the skin.
-gical tape and covered with an absorbent dress-dressing and the outside of the dressing wasto the study device and this was then usuallywere evaluated at least on a weekly basis for as-sessment of healing progress.
S
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-glycosaminoglycan production, and collagensynthesissetting, allowing the patient to be ambulatory.
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about two-ounces and can be attached to cloth-ing by a tape or strap, worn on a belt, or stored-
ode of the device is delivered to the wound siteend of the cannula is placed onto the wound site
and covered with an occlusive or compressiondressing. Additional dressings may be used,depending upon wound conditions such as theand/or maceration, and the depth and site of thewound. Dressing changes usually take place
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8/3/2019 2.an Evaluation of the Efficacy of Trans Dermal Continuous Oxygen Therapy in Patients With Recalcitrant Diabetic
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Open access publishingThe Journal of Diabetic Foot Complications 2011; Volume 3, Issue 1, No.2, Pages 6-12
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Eleven patients with an average ageaverage duration of the ulcers prior to enrollment
2
prior to enrollment in this evaluation, with
application of low intensity laser and hyperbaric
Many patients suffered from seriousco-morbidities, including peripheral vascular
compliance in these two patients was poor withregard to following off-loading guidelines.
R
Plantar surface 21
Heel 2
Distal leg 1 7
Meta-tarsal 2 14
Peripheral vascular disease 2
End stage renal disease 2
27
Edema 1 9
Coronary arterial disease 1 9
Smoking habit 1 9
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8/3/2019 2.an Evaluation of the Efficacy of Trans Dermal Continuous Oxygen Therapy in Patients With Recalcitrant Diabetic
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8/3/2019 2.an Evaluation of the Efficacy of Trans Dermal Continuous Oxygen Therapy in Patients With Recalcitrant Diabetic
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Open access publishing
is used in many different ways, including hyper-
-respiratory and relies on systemic perfusion anddays per week. Wound dressings are changedfor certain diabetic foot ulcers, particularly those
However,although cost effective -sivecan severely limit mobility.
disposable or reusable limb chamber connected
therapy, in combination with low level laser
However, as mentioned, both therapiesseverely restrict patient mobility. In addition, the
these types of treatment.
delivery device is small and portable, patients
possibilities to continue regular activities of daily
living, including work.
More important than continued mobility, theresults found in this study indicate the high leveldiabetic foot ulcers with a complete re-epithelial-one patient had an untreated contralateral
treated ulcer healed. When the second ulcer wastwo patients in whom healing was not complete,in spite of the fact that they were non-compliantwith regard to prescribed off-loading.
In addition to the positive healing results, the use
by promoting faster healing and reducing costscompared to both ways of delivering alternativemorbidity may also lead to a reduction of
day per bed. When the costs of medical care,such as nursing time, physician consultation,cost savings are even more substantial.
The Journal of Diabetic Foot Complications 2011; Volume 3, Issue 1, No.2, Pages 6-12
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8/3/2019 2.an Evaluation of the Efficacy of Trans Dermal Continuous Oxygen Therapy in Patients With Recalcitrant Diabetic
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8/3/2019 2.an Evaluation of the Efficacy of Trans Dermal Continuous Oxygen Therapy in Patients With Recalcitrant Diabetic
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wound healing. Annales Chirugiae et Gynaecologia. 90
pressure measurements in type I diabetic patients for early
microvascular complications among patients with type 2diabetes in Iran: a systematic review. Diabetes Res Clin Pract
diabetes mellitus. I. Its relation to the early functional changes
epithelial healing in a rabbit ear wound model. Arch Surg
investigating advanced treatment modalities in healing
and low energy laser therapy for chronic diabetic foot
containing ionic silver or calcium alginate dressingsin non-ischaemic diabetic foot ulcers. Diabet Med
controlled trial of autologous platelet-rich plasma gel for the
Comparison of negative pressure wound therapy usingvacuum-assisted closure with advanced moist woundtherapy in the treatment of diabetic foot ulcers: a multicenter
Surrogate end points for the treatment of diabetic neuropathic
neuropathic foot ulcers receiving standard treatment. A
Open access publishingThe Journal of Diabetic Foot Complications 2011, Volume 3, Issue 1, No.2, Pages 6-12
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