2015 innovation day_hyperspectral camera_verhaert & lambda-x
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Hyperspectral camera technology & applications
Template Innovation Day presentationCONFIDENTIAL
HYPERSPECTRAL CAMERA: HOW TO GROW IN THE MEDICAL MARKET AS AN OUTSIDER ?
Olivier DUPONT Thierry EMERAUDCEO Lambda-X Business Developer Verhaertodupont@lambda-X.com thierry.emeraud@lverhaert.com
MEDICAL: CONVERGENCE IN HEALTH CARE
Hyperspectral camera technology & applications
2CONFIDENTIAL
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CONTENT
Medical market for an outsider
Lambda-X context
Hyperspectral at Lambda-X: a 13 years journey from space
Landing onto the medical ecosystem
Towards a Proposition Value
Conclusion
Hyperspectral camera technology & applications
CONFIDENTIAL3
MEDICAL MARKET: MULTIFACETED & MULTIPLE TRENDS
140 million people with Alzheimer in 2050
Age related macular degeneration
8% of the WW population having diabetes …50% not aware of it!
Infectious diseases (Ebola) H1N1 pandemic
Early cancer detection
Personalized Healthcare
Surgery guidance
Point-Of-Care testing (near patient testing)
Prevention instead of healing
Tele monitoring
Gene therapy
Hyperspectral camera technology & applications
5CONFIDENTIAL
• Belgian Company founded in 1996
• 100% Private Belgian shareholders
• Established in Nivelles since 2004
• Member of the Verhaert Group since 2014
LAMBDA-X CONTEXT
Hyperspectral camera technology & applications
6CONFIDENTIAL
LAMBDA-X BUSINESS MODEL
• Concept & Design• Prototyping• Serial Production
• Scientific instruments• Earth observation• Space exploration• Solar pointers
• Metrology tailored to ophthalmic markets
• Spectacles• Contact lenses• Intraocular lenses
AEROSPACE OPTICS SUPPORT TO INDUSTRY OPHTHALMICS
CONCEPT / PROJECTSSERIAL PRODUCTS
Hyperspectral camera technology & applications
7CONFIDENTIAL
SOME LAMBDA-X CUSTOMERS
Confidential
SPACE DEFENSE
INDUSTRY
OPHTHALMICS
Hyperspectral camera technology & applications
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HYPERSPECTRAL TECHNOLOGY
1. Acquiring the 3D data cube (XY) at once
2. Hyperspectral = high spatial & spectral resolutions simultaneously • detectors are 2D only…
Hyperspectral camera technology & applications
9CONFIDENTIAL
HYPERSPECTRAL AT LAMBDA-XA 13 YEARS JOURNEY FROM SPACE2002 ESA: explore future biological Lab in Space.
Conclusion: go “confocal” and enable “fluorescence studies”
2005 Miniaturized confocal microscope (AMME project).Excite biological tissues at 1 & measure at 2 & 3
2007 Hyperspectral function for confocal microscope (ACMO)
2009 New ESA project “Intelligent spectroscopic device coupled with high-speed cameras” forchemical analysis of the re-entry of space (ISDE)
2012 HYPE camera HYPEMI project (UCL, de Duve)
2014 Collaboration with GIGA/ULg
2015 Doing business in biology
3µM BODIPY-GlcCer
Hyperspectral camera technology & applications
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FUNDAMENTAL LEARNINGS FROM THE SPACE ODYSSEY
1. Miniaturization(3 steps optics development)
A compact, flexible and robust imaging instrument that can adapt to microscopes for biology applications.
Footprint / 3.5 (m²)/ 8 (m³)
3. Reliability
2. Modularity
Hyperspectral camera technology & applications
11CONFIDENTIAL
Diagnostics / point-of-care
Patient(Home)
Anatomo-pathologists Hospital
Doctor
Academicresearch
IVD companies
Pharmaceu-ticals
Centers forhuman
genetics
LANDING WITH HYPE IN THE MEDICAL ECOSYSTEM
Hyperspectral camera technology & applications
12CONFIDENTIAL
HYPERSPECTRAL FOR THE BIOLOGIST RELATES TO FLUORESCENCE
• Fluorescence: absorbing light at exc and re-emitting light at em
• Fluorescent molecules: auto fluorescent proteins (GFP) or
organic probes that are used as biomarkers for• Cell nucleus (DAPI)
• Cell parts (cytoplasmic membrane)
• Antibodies primary and secondary (AlexaFluor 488)
• Proteins
• DNA/chromosomes (FISH), etc…
• Fluorescence is impacted by environmental factors enabling
advanced studies on bio-organisms
• Fluorescence is a reference technique for biologists:
epifluorescence microscopes
Hyperspectral camera technology & applications
CONFIDENTIAL13
HOW TO TACKLE THE EXPECTATIONS IN THE BIOLOGY MARKET ?
Hyperspectral camera technology & applications
14CONFIDENTIAL
INTEGRATED PRODUCT INNOVATION
Technology & IP development
Proof of principle
Prototype development
Demonstration
First series
Validating process
Product & business strategy
Directing innovation
Strategic design
Value capturing
Product documentation training
Product launch
Strategic innovation services FEI
Product development services NPD
Pre-launch services NPI
Hybrid collaboration
models
CONSULTANCY
INSOURCING
OUTSOURCING
TRAINING
TECHNICAL TRACK
BUSINESS TRACK
USE
RCE
NTE
RED
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15CONFIDENTIAL
PRODUCT SHARPENING: MANY POTENTIAL DIFFERENTIATORS
HIGHLOWLO
WH
IGHmust haves rivals
indifferent outperformers
DESIRABILITY
High spectral resolution
Ease-of-use
Flexiblecan be mounted on any microscope
Affordable
UTILITY
Fast enoughfor vital imaging
Photoncontrast
Accreditation
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16CONFIDENTIAL
TOWARDS AN INNOVATIVE VALUE PROPOSITION ?
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3affordability
ease-of-use
acrreditationSpectral resolution
photon contrast
Epifluorescence microscope Confocal microscope (laser scan)
HYPE camera (Lambda-X)
Value againstconfocal
Value againstepifluo
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17CONFIDENTIAL
GO TO MARKET STRATEGY
1. Biological market: largest growth for optical microscopy
2. Make the story happen…
• Find the appropriate niche where to anchor (identified)
• Leverage on killer applications (FISH, protein colocalisation,…)
• Work closely with the academic world: UCL, ULg, ULB, UGent, UHasselt,… (on-going)
3. Build our own learning curve
• Fail fast
• Learn fast
• Reduce uncertainties
• Manage the risk
4. Market creation: barriers ?
Hyperspectral camera technology & applications
18CONFIDENTIAL
DEVELOP ON THE APPLICATION SIDE
Pharma-ceuticals
Ex-Vivo analysis
Surgery tissue imaging
Protein co-localisation
Cancer detection
Cell therapies
Geneticanalysis
Molecularinteractions
FISH
Hyperspectral camera technology & applications
19CONFIDENTIAL
LANDING SOMEWHERE ELSE WITH HYPE IN THE FUTURE ?
Food sorting
Cropspathogens
Paint Plastic manufacturing
Water treatment
Gas combustion
flame
Recycling (plastic)
UAV (agriculture)
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CONCLUSION
Tech transfer from space
Numerous applications in the biological world
Usage aspects are value drivers beyond technology
Several market spots next to biology
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Develop in a non existing market
Is our vision on user value correct ? (assessment)
Next market spot besides biology ?
Open innovation model of Verhaert + Lambda-X hyperspectral technology = USP ?
What did we learn?
Unknowns and potential pitfalls
Hyperspectral camera technology & applications
KruibekeBelgiumVerhaert New Products & Services Hogenakkerhoekstraat 21B-9150 KruibekeT +32 3 250 19 00E info@verhaert.com
www.verhaert.com
NivellesBelgium
NoordwijkNetherlands
Lambda-XAvenue Robert Schuman 102B-1400 NivellesT +32 67 47 57 10E info@lambda-x.com
www.lambda-x.com
Verhaert NetherlandsKapteynstraat 12201 BB NoordwijkT +31 71 760 05 50E info@verhaert.com
connect.verhaert.com
INDUSTRYFMCGCONNECT
MEDICAL TECHXFER
MEDICALAEROSPACE
TECHXFER
FMCGCONNECT
TECHXFER
AveiroPortugalLoad InteractiveAv. Dr. Lourenço Peixinho 153800-159 AveiroT +351 234 604 088E info@load-interactive.com
www.load-interactive.com
CONNECT
Masters in Innovation is the innovation platform of Verhaert to inspire and coach professionals on product and business development and management.
Innovation Day is an initiative of Verhaert Masters in Innovation.
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