(12) united states patent us 8,644,912 b2 bambot et a...
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(12) United States Patent Bambot et a].
US008644912B2
US 8,644,912 B2 Feb. 4, 2014
(10) Patent N0.: (45) Date of Patent:
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SYSTEM AND METHOD FOR DETERMINING TISSUE CHARACTERISTICS
Inventors: Shabbir Bambot, Suwanee, GA (US); Mark L. Faupel, Alpharetta, GA (US); Anant AgraWal, Atlanta, GA (US); Keith D. Ignotz, Duluth, GA (US); Andrew Fordham, Sugar Hill, GA (US)
SpectRx, Inc., Norcross, GA (US) Subject to any disclaimer, the term of this patent is extended or adjusted under 35 USC 154(b) by 0 days.
Appl. No.: 13/214,638
Assignee: Notice:
Filed: Aug. 22, 2011
Prior Publication Data
US 2011/0306887 A1 Dec. 15,2011
Related US. Application Data
Continuation of application No. 12/099,876, ?led on Apr. 9, 2008, noW abandoned, and a continuation of application No. 10/647,222, ?led on Aug. 26, 2003, noW abandoned, and a continuation-in-part of application No. 10/611,917, ?led on Jul. 3, 2003, noW Pat. No. 7,006,220, and a continuation-in-part of application No. 10/603,597, ?led on Jun. 26, 2003, noW Pat. No. 6,975,899, and a continuation-in-part of application No. 10/446,857, ?led on May 29, 2003, noW Pat. No. 6,870,620, and a continuation-in-part of application No. 10/337,687, ?led on Jan. 8, 2003, noW abandoned, and a continuation-in-part of application No. PCT/US02/06350, ?led on Mar. 1, 2002, and a continuation of application No. 09/786,781, ?led on Mar. 9, 2001, noW abandoned, application No. 13/214,638, Which is a continuation of application No. 09/700,538, ?led on Nov. 16, 2000, noW Pat. No. 6,590,651, and a division of application No. 09/533,817, ?led on Mar. 24, 2000, noW Pat. No. 6,577,391, and a continuation of application No. 09/434,518, ?led on Nov. 5, 1999, noW abandoned, Which is a continuation-in-part of application No. PCT/US99/20646, ?led on Sep. 10, 1999, and a continuation-in-part of application No. PCT/US99/10947, ?led on May 19, 1999.
(60) Provisional application No. 60/272,458, ?led on Mar. 2, 2001, provisional application No. 60/126,056, ?led on Mar. 23, 1999.
Int. Cl. A61B 6/00 US. Cl. USPC .......... .. 600/476; 600/407; 600/473; 600/478 Field of Classi?cation Search USPC ................................ .. 600/407, 473, 476, 478 See application ?le for complete search history.
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(52) (2006.01)
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(56) References Cited
U.S. PATENT DOCUMENTS
4,534,360 A * 6,364,829 B1 6,571,118 B1
8/1985 Williams .................... .. 600/473
4/2002 Fulghum 5/2003 UtZinger et al.
FOREIGN PATENT DOCUMENTS
W0 WO 00/15101 3/2000 OTHER PUBLICATIONS
Shabbir B. Bambot et al., “Sensing oxygen through skin using a red diode laser and ?uorescence liftetimes”, Biosens and Bioelectronics, vol. 10, Nov. 6/7, pp. 643-652, 1995. Kevin T. Shoemacher et al., “Ultraviolet Laser-Induced Fluorescence of Colonic Tissues: Basic Biology and Diagnostic Potential”, Laser in Surgery Medicine, vol. 12, pp. 63-78, 1992.
(Continued) Primary Examiner * Peter Luong
(74) Attorney, Agent, or Firm * Altera LaW Group, LLC
(57) ABSTRACT An apparatus to interrogate, receive, and analyze full emis sion spectra for at least one ?uorescence excitation Wave length and for at least one re?ectance measurement to deter mine tissue characteristics. The apparatus includes a base unit having illumination, detection and control sub-units, the illu mination sub-unit providing illumination optical energy for illuminating a target tissue and the detection sub-unit detect ing tissue characteristics of a target tissue, a separate tissue interface unit, and a pathWay coupling the base unit and the tissue interface unit. The system and apparatus may also include a tube for maintaining the distance between the tissue and units and for surrounding the tissue to prevent patient movement from being transmitted to the tissue.
25 Claims, 24 Drawing Sheets
80a
US 8,644,912 B2 Page 2
(56) References Cited
OTHER PUBLICATIONS Charles E. Alpers et al., “The Prevalance of Carcinoma in Situ in Normal and Cancer Associated Breasts”, Human Pathology, vol. 16, No. 8, pp796-807, Aug. 1985.
Danely Slaughter et al., Field CanceriZation in Oral Strati?ed Squamour Epithelium: Clinical Implication of Multicentric Origin Cancer, vol. 6, No. 4, pp. 963-968, 1953. Cancer Diagnostics: The World Markets, Clinical Reports, PJB Pub lications, p. 72, 1997.
* cited by examiner
US. Patent Feb. 4, 2014 Sheet 2 m4 US 8,644,912 B2
SUB-UNIT DETECTION
2O L-___________________________f
ILLUMINATION SOURCE
ILLUMINATION SUB-UNIT
ELECTRO OPTIC
FIG. 1B
US. Patent Feb. 4, 2014 Sheet 4 m4 US 8,644,912 B2
# Measurement Excitation Collection SpeC’UO— Meas. graph time center A secs
Flourescence 350 nm (10 nm BP) 385 nm LP (66 385) 450nm 2 Flourescence 400 nm (10 nm BF’) 420 nm LP (GG 485) 500nrn 2 Flourescenee 460 nm (10 nm BP) 495 nm LP ((56 495) 560nm 4 Reflectance OD1.5 ND filter 300-700 nm DD (56 26) 500nm 0.2
BPzbandpass LP=Long-pass
FIG. 6
US. Patent Feb. 4, 2014 Sheet 7 m4 US 8,644,912 B2
170 199 \—l w SYSTEM '
POWER INTERFACE I MONITOR AND I
re?ected/ 1 78b CONTROLLER
emitted ' 1I78 178a 1I87 I light T“ — F FVIDEO
% fig) VIDEO CONTROLLER 1% ' I 173a 1730 175 .
159 I57 j I58 1I58a W T m _ r 4 ‘CAMERA I '
,lj 41w CAMERA CONTROLLER I 100 I 156 155 (130 I
Z ' m- LIGHT GUIDE 4 I
light M - —~ — -
‘1313 131 173b,173d I
M7721 I
k LITTb
K1770 183
IMAGE J r __________ L1
DOCKING I I STATION I I REDCEORDING I MONITOR I
182 182a VICE I I
120) (1823 ““““ FIG. 7B
US. Patent Feb. 4, 2014 Sheet 8 m4 US 8,644,912 B2
177 177
[120
POWER PROCESSOR SUPPLY
\ L 190 191 182
ILLUMINATION ILLUMINATION VID’EO SOURCE SOURCE OUT
CONTROLLER
\I 32 \132A
DOCKINC UNIT
FIG. 8A
US. Patent Feb. 4, 2014 Sheet 9 m4 US 8,644,912 B2
1953
503
501 DATA ) TRANSMITTER j |NTERFACE / APERTURE/ UNIT
FILTER MOTOR CONTROLLER
504 502 SHUTTER ) llgll'sEiiigEE /
CONTROLLER UNIT
505
ANALOG ) INTERFACE /'
UNIT
FIG. 8B
US. Patent Feb. 4, 2014 Sheet 12 0f 24 US 8,644,912 B2
[186 ’\
(172 ( 130
u g D O i
1 74
170
FIG. 11
US. Patent Feb. 4, 2014 Sheet 16 m4 US 8,644,912 B2
-1 Order Spectra 0th ?irx<+1 Order Spectra
CCD Camera ——> + / 0c
COG)
(DOC)
CDOCD
CDOQ
(:06
CO6
|——+ @OQ Virtual Area of 0C Cervix as
projected on CCD
FIG. 15
US. Patent Feb. 4, 2014 Sheet 17 m4 US 8,644,912 B2
CCEQWay [ Virtual Area of Cervix
210\ /21O Cb <50
<30 06
C00 COG
(I) <:> O CID
CID O 0CD (Dd
CD Cl) (:3 CD
CD06 (DOC;
O0 0CD
O0 ——-——————> 0O
FIG. 16
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