05 gaba-extra slide propofol
Post on 16-Nov-2015
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gaba receptors
TRANSCRIPT
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HowdoesPropofol causeHypnotic/Amnesic/AnestheticEffects?
Propofol isashortactingIVadministeredhypnotic/amnesic/anesthetic
Usedforinductionandmaintenanceofanesthesia;worldsmosthighlyusedIVgeneralanesthetic
Usedforshorttermproceduralsedation,e.g.endoscopicprocedureswherefastrecoverytimeisdesirable
PotentiatestheeffectofGABAbyincreasingGABAaffinityandincreasingGABAefficacy
BindingsiteisdistinctfromGABAanddistinctfrombenzodiazpines.
Bindstothemainligandbindingsubunit( subunit)inthePreM1regionthatisinvolvedincouplingligandbindingintheNterminalextracellulardomaintochannelopeninginthetransmembraneporeformingdomain
FacilitatescouplingofGABAbindingtochannelopening
Yipetal,2013
Propofol
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