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CURRICULUM VITAE
Family name: CORSINI First name: EMANUELA Date of birth: May 26th, 1963 Nationality: Italian Civil status: Married Codice Fiscale: CRSMNL63E66F205S Education:
Institution Degree(s) or Diploma(s) obtained:
High school
Date: 1982
Diploma
Institution Degree(s) or Diploma(s) obtained:
University of Milan, Italy
Date: 1987
Degree in Food Science and Technology
Institution Degree(s) or Diploma(s) obtained:
University of Milan, Italy
Date: 1992
PhD in Food and Environmental Toxicology
Membership of professional bodies: Since 1988 ‐ Member of the Italian Society of Toxicology Since 1993 ‐ Member of the American Society of Toxicology 1999‐2005 Treasures of the Italian Association for in vitro Toxicology 2009‐2013 Member of EUROTOX Education Sub Committee 2005‐2011 Chair of the Immunotoxicology and Chemical Specialty Section at EUROTOX 2010‐2016 Member of the IUTOX Executive Committee 2014‐2020 Member of the EUROTOX Executive Committee 2017‐2018 President elect of the Immunotoxicology Specialty Section at SOT 2017‐2019 Member of the Award Committee at SOT Present position: Professor of Toxicology at the School of Pharmacy at the Università degli Studi di Milano, Italy Years within the organisation: 26 years Key qualifications: At present, the primary focus of her laboratory centres on the refinement of alternative in vitro tests to identify and discriminate contact allergens from irritants and respiratory sensitizers, based on the
use of DC‐like cells and keratinocytes, and to classify allergens according to their potency. The other area of research centres on the understanding at the molecular level the mechanism of action of immunotoxic/immunomodulatory compounds (i.e. perfluorinated compounds, pesticides, vegetal extracts) on innate and adaptive immunity. Finally, immunosenescence represents the other area of interest of her laboratory. Specifically, studies are being conducted to define the role of RACK1 and protein kinase C in the decline or remodelling of the immune responses associated with aging, and to identify compounds able to reverse such changes (i.e. DHEA, natural extracts). She is author of more than 174 publications in peer‐reviewed journals and 25 book chapters. H‐index 42 (Web of Sciences). She is the recipient of several awards and honours, including Award for the best paper published in Fundamental and Applied Toxicology (21: 71‐81, 1993); Outstanding Young Investigator Award from the Immunotoxicology Specialty Section of the SOT (2004); Recipient of the EUROTOX/P&G "Animal Alternatives Award 2008”. Professional Experience Record:
Date: From 8/1989 to 3/1992
Location USA
Company NIEHS
Position Post doctoral fellow
Date: From 11/1994 to 3/1995
Location UK
Company AstraZeneca
Position Visiting scientist
Date: From 7/1995 to 8/1995
Location USA
Company Bowman Gray School of Medicine
Position Visiting scientist
Selected publications in the last four years: 1: Buoso E, Galasso M, Ronfani M, Papale A, Galbiati V, Eberini I, Marinovich M, Racchi M, Corsini E. The scaffold protein RACK1 is a target of endocrine disrupting chemicals (EDCs) with important implication in immunity. Toxicol Appl Pharmacol. 2017 Jun 15;325:37‐47. doi: 10.1016/j.taap.2017.04.011. 2: Buoso E, Galasso M, Ronfani M, Serafini MM, Lanni C, Corsini E, Racchi M. Role of spliceosome proteins in the regulation of glucocorticoid receptor isoforms by cortisol and dehydroepiandrosterone. Pharmacol Res. 2017 Jun;120:180‐187. doi:10.1016/j.phrs.2017.03.019. 3: Corsini E, Vecchi R, Marabini L, Fermo P, Becagli S, Bernardoni V, Caruso D, Corbella L, Dell'Acqua M, Galli CL, Lonati G, Ozgen S, Papale A, Signorini S, Tardivo R, Valli G, Marinovich M. The chemical composition of ultrafine particles and associated biological effects at an alpine town impacted by wood burning. Sci Total Environ. 2017 Jun 1;587‐588:223‐231. doi: 10.1016/j.scitotenv.2017.02.125. 4: Buoso E, Galasso M, Serafini MM, Ronfani M, Lanni C, Corsini E, Racchi M. Transcriptional regulation of RACK1 and modulation of its expression: Role of steroid hormones and significance in health and aging. Cell Signal. 2017 Jul;35:264‐271. doi: 10.1016/j.cellsig.2017.02.010. 5: Galbiati V, Papale A, Marinovich M, Gibbs S, Roggen E, Corsini E. Development of an in vitro method to estimate the sensitization induction level of contact allergens. Toxicol Lett. 2017 Apr 5;271:1‐11. doi: 10.1016/j.toxlet.2017.01.016. 6: Kavasi RM, Berdiaki A, Spyridaki I, Corsini E, Tsatsakis A, Tzanakakis G, Nikitovic D. HA metabolism in skin homeostasis and inflammatory disease. Food Chem Toxicol. 2017 Mar;101:128‐138. doi:
10.1016/j.fct.2017.01.012. 7: Corsini E, Ozgen S, Papale A, Galbiati V, Lonati G, Fermo P, Corbella L, Valli G, Bernardoni V, Dell'Acqua M, Becagli S, Caruso D, Vecchi R, Galli CL, Marinovich M. Insights on wood combustion generated proinflammatory ultrafine particles (UFP). Toxicol Lett. 2017 Jan 15;266:74‐84. doi:10.1016/j.toxlet.2016.12.005. 8: Ardolino LI, Meloni M, Brugali G, Corsini E, Galli CL. Preclinical Evaluation of Tolerability of a Selective, Bacteriostatic, Locally Active Vaginal Formulation. Curr Ther Res Clin Exp. 2016 Jul 25;83:13‐21. eCollection 2016. 9: Zucca E, Corsini E, Galbiati V, Lange‐Consiglio A, Ferrucci F. Evaluation of amniotic mesenchymal cell derivatives on cytokine production in equine alveolar macrophages: an in vitro approach to lung inflammation. Stem Cell Res Ther. 2016 Sep 20;7(1):137. doi: 10.1186/s13287‐016‐0398‐9. 10: Papale A, Kummer E, Galbiati V, Marinovich M, Galli CL, Corsini E. Understanding chemical allergen potency: role of NLRP12 and Blimp‐1 in the induction of IL‐18 in human keratinocytes. Arch Toxicol. 2017 Apr;91(4):1783‐1794. doi:10.1007/s00204‐016‐1806‐8. 11: Galbiati V, Papale A, Kummer E, Corsini E. In vitro Models to Evaluate Drug‐Induced Hypersensitivity: Potential Test Based on Activation of Dendritic Cells. Front Pharmacol. 2016 Jul 12;7:204. doi: 10.3389/fphar.2016.00204. eCollection 2016. 12: Andres E, Barry M, Hundt A, Dini C, Corsini E, Gibbs S, Roggen EL, Ferret PJ. Preliminary performance data of the RHE/IL‐18 assay performed on SkinEthic(™) RHE for the identification of contact sensitizers. Int J Cosmet Sci. 2017 Apr;39(2):121‐132. doi: 10.1111/ics.12355. 13: Corsini E, Galbiati V, Papale A, Kummer E, Pinto A, Serafini MM, Guaita A, Spezzano R, Caruso D, Marinovich M, Racchi M. Role of androgens in dhea‐induced rack1 expression and cytokine modulation in monocytes. Immun Ageing. 2016 May 29;13:20. doi: 10.1186/s12979‐016‐0075‐y. 14: Corsini E, Galbiati V, Papale A, Kummer E, Pinto A, Guaita A, Racchi M. The role of HSP27 in RACK1‐mediated PKC activation in THP‐1 cells. Immunol Res. 2016 Aug;64(4):940‐50. doi: 10.1007/s12026‐016‐8802‐1. 15: Wallace H, Roberts R, Corsini E, Bonefeld‐Jorgensen E, Orhan H, Mach M, Weiser T, Carvalho F, Iscan M, Tsatsakis A. Toxicology as an academic discipline in European Universities. Toxicol Lett. 2016 Jul 8;254:63. doi: 10.1016/j.toxlet.2016.04.024. 16: Gennari CG, Franzè S, Pellegrino S, Corsini E, Vistoli G, Montanari L, Minghetti P, Cilurzo F. Skin Penetrating Peptide as a Tool to Enhance the Permeation of Heparin through Human Epidermis. Biomacromolecules. 2016 Jan 11;17(1):46‐55. doi: 10.1021/acs.biomac.5b01524. 17: Lourenço AC, Galbiati V, Corti D, Papale A, Martino‐Andrade AJ, Corsini E. The plasticizer dibutyl phthalate (DBP) potentiates chemical allergen‐induced THP‐1 activation. Toxicol In Vitro. 2015 Dec;29(8):2001‐8. doi:10.1016/j.tiv.2015.08.011. 18: Goodson WH 3rd, Lowe L, Carpenter DO, Gilbertson M, Manaf Ali A, Lopez de Cerain Salsamendi A, Lasfar A, Carnero A, Azqueta A, Amedei A, Charles AK, Collins AR, Ward A, Salzberg AC, Colacci A, Olsen AK, Berg A, Barclay BJ, Zhou BP, Blanco‐Aparicio C, Baglole CJ, Dong C, Mondello C, Hsu CW, Naus CC, Yedjou C, Curran CS, Laird DW, Koch DC, Carlin DJ, Felsher DW, Roy D, Brown DG, Ratovitski E, Ryan EP, Corsini E, Rojas E, Moon EY, Laconi E, Marongiu F, Al‐Mulla F, Chiaradonna F, Darroudi F, Martin FL, Van Schooten FJ, Goldberg GS, Wagemaker G, Nangami GN, Calaf GM, Williams G, Wolf GT, Koppen G, Brunborg G, Lyerly HK, Krishnan H, Ab Hamid H, Yasaei H, Sone H, Kondoh H, Salem HK, Hsu HY, Park HH, Koturbash I, Miousse IR, Scovassi AI, Klaunig JE, Vondráček J, Raju J, Roman J, Wise JP Sr, Whitfield JR, Woodrick J, Christopher JA, Ochieng J, Martinez‐Leal JF, Weisz J, Kravchenko J, Sun J, Prudhomme KR, Narayanan KB, Cohen‐Solal KA, Moorwood K, Gonzalez L, Soucek L, Jian L,
D'Abronzo LS, Lin LT, Li L, Gulliver L, McCawley LJ, Memeo L, Vermeulen L, Leyns L, Zhang L, Valverde M, Khatami M, Romano MF, Chapellier M, Williams MA, Wade M, Manjili MH, Lleonart ME, Xia M, Gonzalez MJ, Karamouzis MV, Kirsch‐Volders M, Vaccari M, Kuemmerle NB, Singh N, Cruickshanks N, Kleinstreuer N, van Larebeke N, Ahmed N, Ogunkua O, Krishnakumar PK, Vadgama P, Marignani PA, Ghosh PM, Ostrosky‐Wegman P, Thompson PA, Dent P, Heneberg P, Darbre P, Sing Leung P, Nangia‐Makker P, Cheng QS, Robey RB, Al‐Temaimi R, Roy R, Andrade‐Vieira R, Sinha RK, Mehta R, Vento R, Di Fiore R, Ponce‐Cusi R, Dornetshuber‐Fleiss R, Nahta R, Castellino RC, Palorini R, Abd Hamid R, Langie SA, Eltom SE, Brooks SA, Ryeom S, Wise SS, Bay SN, Harris SA, Papagerakis S, Romano S, Pavanello S, Eriksson S, Forte S, Casey SC, Luanpitpong S, Lee TJ, Otsuki T, Chen T, Massfelder T, Sanderson T, Guarnieri T, Hultman T, Dormoy V, Odero‐Marah V, Sabbisetti V, Maguer‐Satta V, Rathmell WK, Engström W, Decker WK, Bisson WH, Rojanasakul Y, Luqmani Y, Chen Z, Hu Z. Assessing the carcinogenic potential of low‐dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis. 2015 Jun;36 Suppl 1:S254‐96. doi: 10.1093/carcin/bgv039. 19: Corti D, Galbiati V, Gatti N, Marinovich M, Galli CL, Corsini E. Optimization of the THP‐1 activation assay to detect pharmaceuticals with potential to cause immune mediated drug reactions. Toxicol In Vitro. 2015 Oct;29(7):1339‐49. doi: 10.1016/j.tiv.2015.04.012. 20: Kravchenko J, Corsini E, Williams MA, Decker W, Manjili MH, Otsuki T, Singh N, Al‐Mulla F, Al‐Temaimi R, Amedei A, Colacci AM, Vaccari M, Mondello C, Scovassi AI, Raju J, Hamid RA, Memeo L, Forte S, Roy R, Woodrick J, Salem HK, Ryan EP, Brown DG, Bisson WH, Lowe L, Lyerly HK. Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions. Carcinogenesis. 2015 Jun;36 Suppl 1:S111‐27. doi: 10.1093/carcin/bgv033. 21: Corsini E, Galbiati V, Pinto A, Davin A, Polito L, Guaita A, Racchi M. Immunostimulatory effects of RACK1 pseudosubstrate in human leukocytes obtained from young and old donors. Oncotarget. 2015 Mar 30;6(9):6524‐34. 22: Pinto A, Malacrida B, Oieni J, Serafini MM, Davin A, Galbiati V, Corsini E, Racchi M. DHEA modulates the effect of cortisol on RACK1 expression via interference with the splicing of the glucocorticoid receptor. Br J Pharmacol. 2015 Jun;172(11):2918‐27. doi: 10.1111/bph.13097. 23: Rovida C, Alépée N, Api AM, Basketter DA, Bois FY, Caloni F, Corsini E, Daneshian M, Eskes C, Ezendam J, Fuchs H, Hayden P, Hegele‐Hartung C, Hoffmann S, Hubesch B, Jacobs MN, Jaworska J, Kleensang A, Kleinstreuer N, Lalko J, Landsiedel R, Lebreux F, Luechtefeld T, Locatelli M, Mehling A, Natsch A, Pitchford JW, Prater D, Prieto P, Schepky A, Schüürmann G, Smirnova L, Toole C, van Vliet E, Weisensee D, Hartung T. Integrated Testing Strategies (ITS) for safety assessment. ALTEX. 2015;32(1):25‐40. doi:http://dx.doi.org/10.14573/altex.1411011. 24: Nikitovic D, Berdiaki A, Galbiati V, Kavasi RM, Papale A, Tsatsakis A, Tzanakakis GN, Corsini E. Hyaluronan regulates chemical allergen‐induced IL‐18 production in human keratinocytes. Toxicol Lett. 2015 Jan 5;232(1):89‐97. doi: 10.1016/j.toxlet.2014.09.026. 25: Andreoli C, Bassi A, Gregg EO, Nunziata A, Puntoni R, Corsini E. Effects of cigarette smoking on circulating leukocytes and plasma cytokines in monozygotic twins. Clin Chem Lab Med. 2015 Jan;53(1):57‐64. doi: 10.1515/cclm‐2013‐0290. 26: Galbiati V, Papale A, Galli CL, Marinovich M, Corsini E. Role of ROS and HMGB1 in contact allergen‐induced IL‐18 production in human keratinocytes. J Invest Dermatol. 2014 Nov;134(11):2719‐27. doi: 10.1038/jid.2014.203. 27: Teunis MA, Spiekstra SW, Smits M, Adriaens E, Eltze T, Galbiati V, Krul C, Landsiedel R, Pieters R, Reinders J, Roggen E, Corsini E, Gibbs S. International ring trial of the epidermal equivalent sensitizer potency assay: reproducibility and predictive‐capacity. ALTEX. 2014;31(3):251‐68. doi:http://dx.doi.org/10.14573/altex.1308021.
28: Corsini E, Luebke RW, Germolec DR, DeWitt JC. Perfluorinated compounds: emerging POPs with potential immunotoxicity. Toxicol Lett. 2014 Oct 15;230(2):263‐70. doi: 10.1016/j.toxlet.2014.01.038. 29: Corsini E, Pinto A, Galbiati V, Viviani B, Galli CL, Marinovich M, Racchi M. Corticosteroids modulate the expression of the PKC‐anchoring protein RACK‐1 and cytokine release in THP‐1 cells. Pharmacol Res. 2014 Mar;81:10‐6. doi: 10.1016/j.phrs.2014.01.002. 30: Boverhof DR, Ladics G, Luebke B, Botham J, Corsini E, Evans E, Germolec D, Holsapple M, Loveless SE, Lu H, van der Laan JW, White KL Jr, Yang Y. Approaches and considerations for the assessment of immunotoxicity for environmental chemicals: a workshop summary. Regul Toxicol Pharmacol. 2014 Feb;68(1):96‐107. doi: 10.1016/j.yrtph.2013.11.012. 31: Corsini E, Galbiati V, Esser PR, Pinto A, Racchi M, Marinovich M, Martin SF, Galli CL. Role of PKC‐β in chemical allergen‐induced CD86 expression and IL‐8 release in THP‐1 cells. Arch Toxicol. 2014 Feb;88(2):415‐24. doi: 10.1007/s00204‐013‐1144‐z. 32: Viviani B, Boraso M, Valero M, Gardoni F, Marco EM, Llorente R, Corsini E, Galli CL, Di Luca M, Marinovich M, López‐Gallardo M, Viveros MP. Early maternal deprivation immunologically primes hippocampal synapses by redistributing interleukin‐1 receptor type I in a sex dependent manner. Brain Behav Immun. 2014 Jan;35:135‐43. doi: 10.1016/j.bbi.2013.09.008. 33: Galbiati V, Bianchi S, Martínez V, Mitjans M, Corsini E. NCTC 2544 and IL‐18 production: a tool for the in vitro identification of photoallergens. Toxicol In Vitro. 2014 Feb;28(1):13‐7. doi: 10.1016/j.tiv.2013.06.008. Contact Address: Prof. Emanuela Corsini Department of Environmental Science and Policy Via Balzaretti 9 20133 Milan Italy e‐mail: emanuela.corsini@unimi.it Phone : +390250318214 Fax : +390250318284
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