Upload File

amino acids met dank aan dr. detke. most amino acids are chiral all naturally occuring amino acids...

  • Home
  • Documents
  • Amino acids Met dank aan Dr. Detke. Most amino acids are chiral All naturally occuring amino acids except Gly are the L isomer L & D amino acids are stereoisomers
16
Amino acids Met dank aan Dr. Detke

Upload: katrina-rich

Post on 03-Jan-2016

215 views

Category:

Documents


0 download

Report

Tags:

TRANSCRIPT

Page 1: Amino acids Met dank aan Dr. Detke. Most amino acids are chiral All naturally occuring amino acids except Gly are the L isomer L & D amino acids are stereoisomers

Amino acids

Met dank aan Dr. Detke

Page 2: Amino acids Met dank aan Dr. Detke. Most amino acids are chiral All naturally occuring amino acids except Gly are the L isomer L & D amino acids are stereoisomers

Most amino acids are chiral All naturally occuring amino acids

except Gly are the L isomer L & D amino acids are stereoisomers

Page 3: Amino acids Met dank aan Dr. Detke. Most amino acids are chiral All naturally occuring amino acids except Gly are the L isomer L & D amino acids are stereoisomers

Most amino acids are zwitterions amino acids

are zwitterions at neutral pH (contains negative and positive charged groups)

Page 4: Amino acids Met dank aan Dr. Detke. Most amino acids are chiral All naturally occuring amino acids except Gly are the L isomer L & D amino acids are stereoisomers

Small aliphatic amino acids Glycine

non-chiral smallest most flexible in

polypeptides less hydrophobic

Alanine chiral next smallest less hydrophobic

Page 5: Amino acids Met dank aan Dr. Detke. Most amino acids are chiral All naturally occuring amino acids except Gly are the L isomer L & D amino acids are stereoisomers

Other aliphatic amino acids

Val, Leu, Ile Highly hydrophobic branched side-chains

Page 6: Amino acids Met dank aan Dr. Detke. Most amino acids are chiral All naturally occuring amino acids except Gly are the L isomer L & D amino acids are stereoisomers

Yet another aliphatic amino acid

Proline imino acid rigid ring structure puts kinks in

polypeptides

Page 7: Amino acids Met dank aan Dr. Detke. Most amino acids are chiral All naturally occuring amino acids except Gly are the L isomer L & D amino acids are stereoisomers

Aromatic amino acidsPhenylalanine•Absorbs UV•Very hydrophobic

Tyrosine•Absorbs UV•less hydrophobic•H-bonds•OH can ionize•OH can be modified

Tryptophan•Really absorbs UV!•less hydrophobic•H-bonds

Page 8: Amino acids Met dank aan Dr. Detke. Most amino acids are chiral All naturally occuring amino acids except Gly are the L isomer L & D amino acids are stereoisomers

Sulfur-containing amino acids

Methionine highly hydrophobic initiator amino acid

Cysteine less hydrophobic forms disulfide bonds SH group can ionize

Page 9: Amino acids Met dank aan Dr. Detke. Most amino acids are chiral All naturally occuring amino acids except Gly are the L isomer L & D amino acids are stereoisomers

Oxidation of cysteine to cystine

Disulfide bond formation is reversible

Disulfide bonds form in proteins and help stabilize their structures

Page 10: Amino acids Met dank aan Dr. Detke. Most amino acids are chiral All naturally occuring amino acids except Gly are the L isomer L & D amino acids are stereoisomers

Alcoholic amino acids

Ser, Thr less hydrophobic H-bonding potential can be modified Thr is an isostere of

Val

Page 11: Amino acids Met dank aan Dr. Detke. Most amino acids are chiral All naturally occuring amino acids except Gly are the L isomer L & D amino acids are stereoisomers

Acidic amino acids

Asp, Glu highly

hydrophilic negatively

charged at neutral pH

Page 12: Amino acids Met dank aan Dr. Detke. Most amino acids are chiral All naturally occuring amino acids except Gly are the L isomer L & D amino acids are stereoisomers

Basic amino acids Highly hydrophilic Lys and Arg are positively charged at neutral pH His is partially charged at neutral pH

Page 13: Amino acids Met dank aan Dr. Detke. Most amino acids are chiral All naturally occuring amino acids except Gly are the L isomer L & D amino acids are stereoisomers

Amide-containing amino acids

Asn, Gln highly hydrophilic H-bonding potential isosteres of Asp and

Glu

Page 14: Amino acids Met dank aan Dr. Detke. Most amino acids are chiral All naturally occuring amino acids except Gly are the L isomer L & D amino acids are stereoisomers

Peptide bond formation

Page 15: Amino acids Met dank aan Dr. Detke. Most amino acids are chiral All naturally occuring amino acids except Gly are the L isomer L & D amino acids are stereoisomers

The peptide bond is planar

Fig. 4.6

Page 16: Amino acids Met dank aan Dr. Detke. Most amino acids are chiral All naturally occuring amino acids except Gly are the L isomer L & D amino acids are stereoisomers

Aspartame – a dipeptide

200X Sweeter than Sucrose !!!

aspartylphenylalanine methyl ester


Amino Acids And Protein...α Amino acids --- Natural amino acids β – Amino acids -- β alanine, β taurine γ -- Amino acids --- GABA, L Amino acids - normal present in Human1

Amino Acids, Peptides & Proteins -amino acid:. Amino Acids Are >500 naturally occurring amino acids identified in living organisms Humans synthesize

BIOCHEMISTRY Amino Acids and Proteins · Amino Acid Function and Protein Classification • Amino acids are the building block of proteins, support metabolism and are important energy

Proteins. WHAT IS PROTEIN? n Proteins are a sequence of amino acids n Of the 20 amino acids that exist, 9 are essential amino acids, and 11 are non- essential

Amino Acids Metabolism : Disposal of Nitrogen. No No Storage Amino Acids of Amino Acids in the body No No Storage Amino Acids of Amino Acids in the body

DISORDERS OF AMINO Acids Metabolism€¦ · disorders of amino & imino acids 1. aromatic amino acids 2. sulphur containing amino acids 3. branched –chain amino acids

PROTEINS The Science of Food. What are Proteins? Amino Acids Amino Acids Essential amino acids Complimentary proteins Specific chemical properties (charge,

Amino Acids - NOW Foods · 2019-08-07 · amino acids and needs to obtain them from the diet. These amino acids are also referred to as conditionally non-essential amino acids. There

2. AMINO ACIDS, PEPTIDES AND PROTEINS amino acids. Amino acids, peptides... · 1 2. AMINO ACIDS, PEPTIDES AND PROTEINS amino acids functional groups: NH 2 COOH amino acids bound by

Amino Acids, Peptides, Proteins and Enzymes Peptides and proteins are encoded by DNA and are built from amino acids

AMINO ACIDS II: CLASSIFICATION AND CHEMICAL ......AMINO ACIDS II: CLASSIFICATION AND CHEMICAL CHARACTERISTICS OF EACH AMINO ACID: -The “R” group side chains on amino acids are

Proteins are polymers of amino acids. There are 20 unique amino acids that make up proteins in general. Each of the 20 different amino acids has a different

Proteins are made by linking amino acids

Amino&Acids - Oregon State Universityoregonstate.edu/instruct/bb450/450material/Keynotes/03AminoAcids.pdf · • Proteins$comprised$of$2021 $amino$acids. Amino&Acids Essential$Amino$Acids

What are amino acids? - PSAU · PDF fileAll amino acids found in proteins are of the L-configuration. However, D-amino acids are found in some ... amines left over from proteins sloughed

Amino Acids Lecture (1): Amino Acids are the building units of proteins. Proteins are polymers of amino acids linked together by what is called “ Peptide

2. AMINO ACIDS, PEPTIDES AND PROTEINS amino acidsdolezala/FCHS/2. Amino acids, peptides... · 1 2. AMINO ACIDS, PEPTIDES AND PROTEINS amino acids functional groups: NH 2 COOH amino

AMINO ACID Amino acids are critical to life, and have many functions in metabolism. Amino acids are organic compounds that combine to form proteins. Our

325 Chapter 25: Amino Acids, Peptides, and Proteins. monomer unit: -amino acids Biopolymer: the monomeric amino acids are linked through an amide bond

Amino Acid Analyzer Nashwa Othman. What are Amino Acids Amino acids are organic compounds containing an amine group, a carboxylic acid group and a side

27.1: Classification of Amino Acids.Chapter 27: Amino Acids, Peptides, and Proteins. monomer unit: α-amino acids Biopolymer: the monomeric amino acids are linked through an amide

Amino acids and proteins … for AS Biology. Amino acids Proteins are macromolecules consisting of long unbranched chains of amino acids. All amino acids

Proteins are built of L-amino acids. 20 different amino acids are encoded by specific

What are Proteins? Amino Acids

AMINO ACIDS Jana Novotná Dept. of Biochemistry. AMINO ACIDS Amino acids are building blocks of proteins. Proteins are composed of 20 different amino acid

Amino Acids ( 9/08/2009) 1. What are Amino Acids, and what is their 3-D structure? 2. What are the structures & properties of the individual amino acids?

Amino Acids, Peptides, and Proteins. Introduction to Amino Acids There are about 26 amino acids, many others are also known from a variety of sources

Amino Acids & Protein. Amino Acids What are amino acids? Structure Classification Understand pK Peptides and Peptide bond Examples of related compounds

Gel Electrophoresis of Proteins - Chemistry | … amino acids. There are 20 common amino acids. The sequence and interaction between these different amino acids determine the function

Chapter 4 Amino Acids. Amino acids -20 common amino acids there are others found naturally but much less frequently Common structure for amino acid COOH,

Amino acids structure. Configuration of Amino Acids

Proteins and Amino Acids. Proteins Proteins are large molecules present in all cells. They are made up of -amino acids. There are two forms of an amino

Proteins. Protein is made of amino acids Amino acids are the building blocks of protein- they are organic acids Contain nitrogen Each amino acid has side

Proteins Enzymes are Proteins. Proteins Proteins: a chain of amino acids 20 different amino acids are found in proteins

Proteins. Building Blocks of Protein: Amino Acids All protein is composed of Amino Acids Amino Acids are Nitrogen bearing compounds that form the structural