Alzheimers disease (AD) is one of the most devastating human pathologies. AD is the leading cause of age-related dementia and currently afflicts more than 44 million persons worldwide (World Alzheimer Report 2014). It is characterized by a cognitive decline and memory loss and by the appearance of two pathological hallmarks: beta amyloid plaques and cytoskeletal pathology.Figure 1. Alzheimers disease pathological hallmarks and spatio-temporal progression of the disease. | Credit: Wonders Our knowledge of the causes and mechanisms of Alzheimers disease are still limited, partly because no non-invasive and ethical methods currently exist to access brain tissue of human patients. To date, several mice models recapitulates diverse symptoms of AD but it does not exist a single model (in vivo or in vitro) showing all the pathophysiological changes occurring in the human disease (A overproduction and accumulation in plaques and tau hyperphosphorylation and formation of neurofibrillar tangels). Here is where Choi and colleagues 1 has brought some light to AD research. The authors have developed a new procedure to grow neurons in a 3D gel matrix that mimics all the pathological alterations induced in human patients.