Allows a new type of organ transplantation› Living organ transplant

Maintains organs in warn functioning state outside of the body› Hearts beat› Lungs breath› Kidneys produce urine› Livers produce bile

Simulates conditions of the human body and allows the organ to function as it normally would› Donor blood› Warms the organ as needed› Protects against contamination

House all elements of the system› Oxygen supply› pump

Battery (transportation)

Digital screen for monitoring› Aortic pressure› Heart rate

Sterile chamber› Protects the

heart› Maintain

temperature and humidity

Enables sterile ultrasound and blood sampling

Provides nutrients to the organ they would normally receive in the body› Keeps the organ healthy during transplant

Ischemic organs are cooled below normal temperature with fluids and ice to minimize cell death

The more times that passes the more damage

After certain time the organ becomes unusable› Most hearts

transplanted in four hours

• Many organs go unused because of this

• Because organs are transplanted non-functioning underlying diseases or damage due to transplantation can not be detected

Around 2,000 people receive heart transplants every year

400 will die while waiting for a transplant

Donor hearts can last roughly four hours before they become unusable

Two catheters are inserted into the heart› Aorta (blood enters)› Pulmonary artery

Aorta is attached to inflow Inferior and superior vena cava, all

other veins and arteries are all stitched closed so all the blood leaves through the pulmonary artery

Blood leaves through the pulmonary artery › Passes through the oxygenator› Pumped through the heating element

Enters the heart through the aorta

Increase the amount of time the organ can maintain outside of the body

Provides surgeons the opportunity to assess the organ outside of the body

Improve function of the organ after removal

Typically, 92 to 95 percent of heart transplant patients are alive and their new heart is working after 30 days

Clinical trials in Europe, which concluded four years ago, showed 30-day survival rates for patients who received beating heart transplants were almost 98 percent.

Primary outcomes› Increase 30 day survival rate of heart

transplant patients Secondary outcomes

› Decreased ICU stay› Heart related adverse events

Rejection Heart defects

"Enabling the Functional Assessment of Organs for the First Time outside of the Body." How It Works: TransMedics, Inc. N.p., 2012. Web. 15 Oct. 2012. <http://www.transmedics.com/wt/page/how_works>.

"Frequently Asked Questions: TransMedics, Inc." Frequently Asked Questions: TransMedics, Inc. N.p., 2012. Web. 16 Oct. 2012. <http://www.transmedics.com/wt/page/faq>.

Kowalczyk, Liz. "Metro." BostonGlobe.com. N.p., 11 Jan. 2012. Web. 16 Oct. 2012. <http://bostonglobe.com/metro/2012/01/11/beating-heart-transplants-could-boost-success-rate/XG4Jzwy4ER9K1rIvGZfGyM/story.html>.

"Visual Dictionary Online." HUMAN BEING. N.p., 2012. Web. 18 Oct. 2012. <http://visual.merriam-webster.com/human-being/anatomy/blood-circulation/heart.php>.

"Randomized Study of Organ Care System Cardiac for Preservation of Donated Hearts for Eventual Transplantation (PROCEEDII)." Randomized Study of Organ Care System Cardiac for Preservation of Donated Hearts for Eventual Transplantation. N.p., 27 Sept. 2012. Web. 18 Oct. 2012. <http://clinicaltrials.gov/ct2/show/record/NCT00855712>.

Yeter, R., M. Hübler, M. Pasic, I. Grunwald, B. Youssef, M. Dandel, H. Lehmkuhl, R. Hetzer, and C. Knosalla. "Initial Single Center Experience with the Organ Care System for Heart Preservation." The Thoracic and Cardiovascular Surgeon 58.S 01 (2010): n.

Laliberte, Jennifer. "UK Surgeons Transplant Still-beating Heart." National Review of Medicine 3.12 (2006): n. pag. NRM: UK Surgeons Transplant Still-beating Heart. Web. 21 Oct. 2012. <http://www.nationalreviewofmedicine.com/issue/2006/06_30/3_advances_medicine02_12.html>.