algorithms organization ross whitaker – utah polina golland – mit (kayhan b.) guido gerig –...
TRANSCRIPT
Algorithms Organization
• Ross Whitaker – Utah
• Polina Golland – MIT (Kayhan B.)
• Guido Gerig – Utah
• Martin Styner – UNC
• Allen Tannenbaum – Georgia Tech
Presentations
• Highlights from the 10-year project
• Recent advances
• Clinical/biomedical impact
Diffusion Tensor Imaging
• Structure, function, connectivity, and schizophreniao Shenton/Harvardo Potkin/Irvine
• Technical challengesoData preprocessingoRobust tools for analysis
DTI Technical Development
• Denoisingo Basu, et al., MICCAI, 2006
• Susceptibility artifactso Tao, et al., IPMI 2009
• Segmentationo Fletcher et al., IPMI, 2007
DTI Segmentation
• Volumetric tractography
• Volumetric paths between ROIsoA collection of shortest pathsoUser interaction, visualization, GPU
implementations
NA-MIC DTI Analysis• Ancillary grant:
Lainhart/Fletcher – DTI analysis in autismo Scientific results
– Arcuate fasciculus in autism, Fletcher et al, Neuroimage, 2010.
– Longitudinal Heschl's gyrus in autism, Prigge et al., 2013.
o Software pipeline
• Broader impact– Cardenas et al., J Neuroimaging,
2013. (UCSF)
Statistical Shape Modeling
• DBPso Shenton/Schizophreniao Piven/AutismoMacLeod/Marrouche
• Robust, general methods for shape analysis
• Softwareo ShapeWorks
Technology for Shape Analysis
• Correspondence/parameterization
• Hypothesis testing
• Regression
• Longitudinal analysis
• Scientific resultso Harris et al., J. of Ortho. Res., 2013o Jones et al., J. of Ortho. Res., 2013
NA-MIC Ancillary Grant
• Anderson: shape analysis in hip pathoanatomy (ongoing)o Shape analysis in hip biomechanicsoDiagnosis and treatment planningoDatabase of parameterized hip models
Segmentation
• DBPso Sharp/Chen, Head and Neck CanceroMacLeod/Marrouche, Afib
• Robust tools for “difficult” segmentation problemso Low SNRoHigh shape variability
Bayesian Formulation of LA Segmentation (DCE-MRI)
LA Segmentation Results
Slicer Module