alcohol abuse and alcoholism in china jian-hui liang md, ph.d national institute on drug dependence...
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![Page 1: Alcohol Abuse and Alcoholism in China Jian-Hui Liang MD, Ph.D National Institute on Drug Dependence Peking University, Beijing, 100083, P.R.China](https://reader036.vdocuments.site/reader036/viewer/2022070413/5697bfa31a28abf838c96789/html5/thumbnails/1.jpg)
Alcohol Abuse and Alcoholism in China
Jian-Hui Liang MD, Ph.D
National Institute on Drug Dependence
Peking University, Beijing, 100083, P.R.China
![Page 2: Alcohol Abuse and Alcoholism in China Jian-Hui Liang MD, Ph.D National Institute on Drug Dependence Peking University, Beijing, 100083, P.R.China](https://reader036.vdocuments.site/reader036/viewer/2022070413/5697bfa31a28abf838c96789/html5/thumbnails/2.jpg)
China has a long history of drinking alcohol
Drinking alcohol in Chinese society acts as a “bridge” in inter-personal communication
With the rapid development of economy, the production and consumption of alcohol in China have greatly increased
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Epidemiology on alcohol abuse
in China
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23513 subjects in six regions of Chin
a were investigated
DSM- -R criteria and structural quⅢestionairs were used
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The drinking-related subjects were divided into three groups:
Alcohol intoxication in the past six months Problem drinking subjects Alcohol dependence subjects
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Prevalence of alcohol intoxication in the past six months
The total : 2.637% ( 620/23513 )
The male : 5.162% ( 618/11972 )
The female : 0.017% ( 2/11541 )
The male > the female
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Problem drinking prevalence
The total : 7.03% ( 1653/23513 )
The male : 13.6% ( 1629/11972 )
The female : 0.208% ( 24/11541 )
The male > the female
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Alcohol dependence prevalence
The total : 3.428% ( 806/23513 )
The male : 6.632% ( 794/11972 )
The female : 0.104% ( 12/11541 )
The male > the female
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Comparison of alcohol dependence between 1982 and 1998
0
1
2
3
4
3.428%
0.018%
Pre
vale
nce
of a
lcoh
olde
pend
ence
(%
)
1982 1998
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Alcohol-related damage
in alcohol dependence subjects
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Physical damage
Gastrointestinal disorders 18.9% Sexual dysfunction 7.3 % Liver diseases 6.1 % Cardiovascular diseases 5.8 % Chronic pancreatitis 3.9 % Peripheral neuropathy 2.0 %
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Social damage
Marital and family tension 57.8% Co-worker’s tension 49.0% Accidents 17.5% Violent behavior 16.9% Unemployment 7.3%
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Alcohol-related psychiatric disorders Acute intoxication 2.637% Alcoholic withdrawal syndrome 0.434% Delirium tremens 0.043% Dementia 0.072% Amnesia 0.128% Personal disorders 0.119% Alcoholic hallucinosis 0.077%
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Summary ( )Ⅰ The total prevalence of alcohol dependence
in Chinese population : 3.428% Physical damage :
gastrointestinal disorders (18.9%) Social damage:
marital and family tension (57.8%) Mental damage:
acute alcohol intoxication (2.637%)
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Alcohol drinking behavior
in Chinese adolescents
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Comparison of drinking alcohol over the past month in the students of different
schools
0
10
20
30
40
50
60
70
80
90
100
42.6%
63.8%
42.0%
58.5%
26.8%
39.9%
occupational school
Highschool
Middleschool
Dri
nkin
g p
rop
ort
ion
(%
) Male Female
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Comparison of drinking alcohol in the past month in the students of different schools
0
10
20
30
40
50
15.8%
29.2%
12.7%
24.6%
9.1%
14.8%
occupational school
Highschool
Middleschool
Dri
nkin
g p
rop
ort
ion
(%
) Male Female
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Comparison of drinking alcohol to intoxication in the past month in the students of different schools
0
2
4
6
8
10
12
4.9%
10.5%
3.1%
5.7%
2.0%
4.7%
occupational school
Highschool
Middleschool
Dri
nki
ng
pro
po
rtio
n (
%)
Male Female
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Summary ( )Ⅱ
The students in occupational schools are the most important target crew to control drinking alcohol behavior.
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Alcohol dependence and
gene-related polymorphism
in Chinese population
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Ethanol
Acetaldehyde
Acetate
*ADH : alcohol dehydrogenase
**ALDH : acetaldehyde dehydrogenase
ADH *
ALDH **
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The phenotype of ADH geneADH1ADH2 ( polymorphism )ADH3 ( polymorphism )ADH4ADH5
The phenotype of ALDH geneALDH1ALDH2 ( polymorphism )
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Alcohol dependence and ADH polymorphism in Han ethnic group
0.0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1.0
0.1150.083
0.8850.917
0.567
0.677
0.433
0.323
ADH3/2ADH3/1ADH2/2ADH2/1
Alle
le
fre
qu
en
cy
of
AD
H Normal contral Alcohol dependence
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Alcohol dependence and ALDH polymorphism in Han ethnic group
0.0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1.0
0.019
0.229
0.981
0.771
ALDH2/2ALDH2/1
Alle
le f
requ
ency
of
ALD
H Normal contral Alcohol dependence
P < 0.01
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Alcohol dependence and ADH polymorphism in Mongolian ethnic group
0.0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1.0
0.1940.160
0.806
0.900
0.403
0.6290.597
0.371
ADH3/2ADH3/1ADH2/2ADH2/1
Alle
le
fre
qu
en
cy
of
AD
H Normal contral Alcohol dependence
P < 0.01
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Alcohol dependence and ALDH polymorphism in Mongolian ethnic group
0.0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1.0
0.0320.086
0.9680.914
ALDH2/2ALDH2/1
Alle
le f
requ
ency
of
ALD
H
Normal contral Alcohol dependence
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Alcohol dependence and ADH polymorphism in Korea ethnic group
0.0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1.0
0.100.05
0.900.95
0.680.71
0.320.29
ADH3/2ADH3/1ADH2/2ADH2/1
Alle
le
fre
qu
en
cy
of
AD
H
Normal contral Alcohol dependence
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Alcohol dependence and ALDH polymorphism in Korea ethnic group
0.0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1.0
0.05
0.36
0.95
0.64
ALDH2/2ALDH2/1
Alle
le f
requ
ency
of
ALD
H
Normal contral Alcohol dependence
P < 0.01
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Alcohol dependence and ADH polymorphism in Elunchun ethnic group
0.0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1.0
0.32
0.14
0.68
0.86
0.340.38
0.660.62
ADH3/2ADH3/1ADH2/2ADH2/1
Alle
le
fre
qu
en
cy
of
AD
H
Normal contral Alcohol dependence
P < 0.01
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Alcohol dependence and ALDH polymorphism in Elunchun ethnic group
-0.1
0.0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1.0
0
0.08
1.000.92
ALDH2/2ALDH2/1
Alle
le
fre
qu
en
cy
of
AL
DH
Normal contral Alcohol dependence
P < 0.05
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Correlation between alcohol dependence and ADH/ALDH genes in different ethnic population of China
Ethnic group ADH ALDH
Han _ ALDH2
Mongolian ADH2 _
Korea _ ALDH2
Elunchun ADH3 ALDH2
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Conclusion
Alcohol abuse and alcoholism in
China have increasingly become a
very serious social and important
public health problem.
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AcknowledgementA/Prof. Xian-xiang Lv
Ms Rong Han
Ms Yan-ping Sun
Prof. Wei Hao
Prof. Yu-cun Shen
A/Prof. Jian-hua Fang
Dr. Feng Wei
Dr. Chun-yan Luo
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Thank you for your attentionThank you for your attention