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    ORIGINAL ARTICLE

    Novel method of 3-dimensional soft-tissueanalysis for Class III patients

    Marko Bozic,a Chung How Kau,b Stephen Richmond,c Maja Ovsenik,d and Natasa Ihan Hrene

    Ljubljana, Slovenia, Houston, Tex, and Cardiff, United Kingdom

    Introduction:The aim of this study was to evaluate 3-dimensional facial shells by incorporating a population-

    specific average template with a group of Class III subjects preparing to have orthognathic surgery. Methods:

    The Class III group included 14 male (MCIII) and 15 female (FCIII) subjects. We used 43 male and 44 female

    Class I subjects to construct average male (AvM) and female (AvF) faces. Coordinates of 3 points on the facial

    templates of groups MCIII and FCIII and the templates AvM and AvF were compared. MCIII-AvM and

    FCIII-AvF superimpositions were evaluated for differences. Results: Vertical distances (sella to soft-tissue

    pogonion) were statistically significantly higher for the AvM (9.1%) and MCIII (10.1%) than for the AvF and

    FCIII, respectively (P\0.05). The distances of soft-tissue pogonion in the horizontal x-axis were positive in

    80% of the FCIII group and 85.7% of the MCIII group. The Class III subjects differed from the average face

    in the lower two thirds, but, in 50% (MCIII) and 60% (FCIII), they differed also in the upper facial third.Conclusions: (1) The average and Class III Slovenian male morphologic face heights are statistically signifi-

    cantly higher than those of the female subjects. (2) The Slovenian Class III male and female subjects tend to-

    ward a left-sided chin deviation. (3) Differences between Class III patients and a normative data set were

    determined. (Am J Orthod Dentofacial Orthop 2010;138:758-69)

    Three-dimensional (3D) imaging in maxillofacial

    surgery and orthodontics is a fast developing

    field. Several noninvasive and radiographic

    methods have been introduced in the last 20 years, and

    they have proved valid and reliable compared with direct

    anthropometry.1 The methods that render 3D imaging

    possible are photogrammetry, laser acquisition systems,structured light systems, video imaging, computerized

    tomography, cone-beam computerized tomography,

    magnetic resonance imaging, and ultrasound.2 Because

    of ever improving techniques, the acquisition of 3D data

    today is safe, affordable, and precise. The software

    applications are also being reengineered to efficiently

    handle and analyze these highly precise 3D data

    formats.3

    Three-dimensional imaging is now being used for var-

    ious orthodontic and maxillofacial assessments: 3D

    treatment planning, preorthodontic and postorthodontic

    evaluations, preoperative and postoperative evaluations,

    3D prefabricated archwires, research, distinction between

    syndromes involving craniofacial deformities, and more.4-6

    Soft-tissue prediction software has also been usedsuccessfully in patients with skeletal Class III

    malocclusion treated with bimaxillary surgery.7

    Three-dimensional imaging with a laser scanning sys-

    tem has proven to be reliable, with accuracy within

    0.85 mm.8 A study with a photogrammetric tool for

    3D acquisition showed a lower system error: within

    0.2 mm.9 On the other hand also, a recent study

    showed that the 3D cone-beam computerized tomog-

    raphy measurements were statistically significantly

    different from measurements performed on ex-vivoskulls in two thirds of the measurements, but the

    authors concluded that this statistical significancewas probably not clinically relevant.10

    Despite the favoring trends in 3D imaging, 2-dimen-

    sional diagnostic methods are still the main tools (lateral

    and frontal cephalograms, dental panoramic tomograms,

    intraoral and extraoral photographs) in maxillofacial

    surgery and orthodontics. This might be a direct result

    of the lack of 3D evaluation tools to accompany newer

    imaging modalities.

    A Class III malocclusion is a common condition

    that, along with Class I and Class II malocclusions,

    has physical, psychological, and social effects on

    aResident and Fulbright scholar, Clinical Department of Maxillofacial and Oral

    Surgery, University Medical Center Ljubljana, Ljubljana, Slovenia.bAssociate professor, University of Texas Health Science Center at Houston,

    Houston, Tex.cProfessor, Dental Health and Biological Sciences, Cardiff University, Cardiff,

    United Kingdom.dAssistant professor and chair, Department of Orthodontics, Division of Stoma-

    tology, University Medical Center Ljubljana, Ljubljana, Slovenia.eAssistant professor, Clinical Department of Maxillofacial and Oral Surgery,

    University Medical Center Ljubljana, Ljubljana, Slovenia.

    The authors report no commercial, proprietary, or financial interest in the

    products or companies described in this article.

    Reprint requests to:ChungHowKau, University of Texas HealthScience Center

    at Houston, 6516 M. D. Anderson Blvd, Ste 371, Houston, TX 77030; e-mail,

    [email protected].

    Submitted, November 2008; revised and accepted, January 2009.

    0889-5406/$36.00

    Copyright 2010 by the American Association of Orthodontists.

    doi:10.1016/j.ajodo.2009.01.033

    758

    mailto:[email protected]:[email protected]:[email protected]
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    quality of life.11 Class III patients most common fea-

    tures are retrusive maxilla, protrusive maxillary inci-

    sors, retrusive mandibular incisors, protrusive

    mandible, and long lower facial height.

    12

    Facial asym-metry is a 3D problem that often accompanies other fa-

    cial deformities. Many analyses compare right and left

    measurements with a constructed midline reference

    plane for the estimation of asymmetries.13 This method,

    however, has raised concerns, and new methods of

    asymmetry evaluation are still emerging.14

    The aim of this study was to evaluate 3D facial

    shells by incorporating a population-specific average

    template with a group of Class III subjects preparing

    for orthognathic surgery. To date, 3D data of such nature

    have not been used to determine differences between

    Class III patients and a normative data set.

    MATERIAL AND METHODS

    Two groups from the University Medical Center in

    Ljubljana, Slovenia, were included in the study. The

    first group consisted of normal subjects (Class I) at

    the Division of Stomatology, and the second group

    consisted of Class III subjects who came for surgery

    at the Department of Maxillofacial and Oral Surgery.

    The inclusion criteria for the Class I group were (1)

    white descent, (2) between 18 and 30 years of age, (3)

    no adverse skeletal deviations (a basic orofacial

    examination was performed to exclude them), (4) nor-

    mal body mass index of 18.5 to 25, and (5) no gross cra-

    niofacial anomalies.

    The inclusion criteria for the Class III group were (1)

    white descent, (2) normal body mass index of 18.5 to 25,(3) diagnosed Class III condition that required combined

    orthodontic and surgical treatment, and (4) no other

    forms of pathology (eg, condylar hypolasia). The Class

    III group was further divided into subgroups by sex.

    The study was approved by the Slovenian National

    Medical Ethics Committee. It was conducted accordingto the principles of the Helsinki-Tokyo declaration.

    Informed consent was obtained from all subjects.

    The laser scanning system consisted of 2 high-

    resolution Vivid VI900 3D cameras (Konica Minolta,

    Tokyo, Japan) with a reported manufacturing accuracy

    of 0.1 mm, operating as a stereo pair. Each camera emitsan eye-safe Class I laser, 690 nm at 30 mW, with an

    object-to-scanner distance of 600 to 2500 mm and

    a fast mode scan time of 0.3 seconds. The system uses

    a one half frame transfer charged couple device and

    can acquire 307,000 data points. The scanners output

    data are 640 3480 pixels for 3D and red, green, and

    blue color data. The data were recorded on a desktop

    workstation, and, for surface capture, a medium-range

    lens (Konica Minolta) with a focal length of 14.5 mm

    was used. The cameras were placed 1350 mm from thesubjects. The scanners were controlled with multi-scan

    Fig 1. An average facial template showing the locations

    of sella (S), subspinale (A), and Pog (P).

    Table I. Class III female subgroup coordinates of Pog

    (px, py, and pz) and subspinale (ax, ay, and az), with

    S as the zero point (0, 0, 0)

    Subject/coordinate px py pz ax ay az

    1 1.68 103.98 2.01 0.89 51.15 3.64

    2 8.70 103.35 0.45 1.24 56.14 0.98

    3 0.13 97.18 4.50 0.81 50.74 4.80

    4 5.49 99.47 5.73 0.44 48.94 4.03

    5 2.56 100.79 0.90 1.24 54.17 2.04

    6 6.72 100.88 0.59 0.90 48.47 1.07

    7 4.33 93.23 0.14 0.31 52.03 0.44

    8 0.23 103.04 2.18 2.22 54.04 3.17

    9 4.07 86.81 5.78 0.59 50.24 2.24

    10 1.18 103.33 0.08 0.64 59.73 0.34

    11 2.70 98.15 1.28 0.76 48.49 0.76

    12 9.78 97.67 2.53 0.71 51.64 1.39

    12 1.51 104.79 0.34 2.35 59.80 0.49

    14 1.85 97.70 0.88 1.64 52.89 0.57

    15 6.53 103.65 1.77 1.37 56.87 0.28Average* 3.83 99.60 1.95 1.07 53.02 1.75

    Mean 1.92 99.60 0.96 0.58 53.02 1.19

    AvF 1.18 95.21 4.09 1.54 55.05 2.83

    Mean direction Left Down Forward Left Down Forward

    *Represents the average value of the absolute values (distance from 0)

    of the coordinates; Average female facial template.

    American Journal of Orthodontics and Dentofacial Orthopedics Bozic et al 759Volume138,Number6

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    software (Cebas Computer, Eppelheim, Germany), and

    data coordinates were saved in a vivid file format. Infor-

    mation was transferred to a reverse modeling software

    package, Rapidform 2006 (RF6) (INUS Technology,

    Seoul, Korea), for analysis.

    The images were acquired with the subjects in naturalheadposture. NHP has proven to be clinically reproduc-

    ible.15 The subjects sat on an adjustable chair and were

    asked to look at an object located centrally between the

    cameras. Adjustments to the height and angle were

    made to achieve the NHP and appropriate positioning.

    The subjects were asked to keep their facial musculature

    as relaxed as possible and to remain as still as possible

    during the scan. The image acquisition took approxi-

    mately 10 seconds for every patient and was repeated if

    any movement in the head position or mimics wasnoted.8

    The images were analyzed by using the RF6 software.

    Absolute mean shell deviations, standard deviations oferrors during shell-to-shell overlaps, maximum and mini-

    mum range maps, histogram plots, and color maps weregenerated. The data were furtherprocessed before analysis

    to obtain an image with preserved shape, surface, and vol-

    ume by using custom-made macros for the RF6.16 Surface

    defects were filled automatically or manually without loss

    of raw data. The result was 1 composite shell per subject.

    The construction of an average face was performed

    by using a previously validated software subroutine

    available in the RF6. The Class I group was divided by

    sex. The results were an average male (AvM) shell and

    an average female(AvF) shell. The steps required to pro-

    duce an average face have already been described and

    are summarized as follows: (1) the images are

    prealigned to determine the principal axes of rotation;

    (2) manual corrections are made to positioning;

    (3) best-fit alignment is done with the built-in algorithm

    Table II. Class III male subgroup coordinates of Pog

    (px, py, and pz) and subspinale (ax, ay, and az), with

    S as the zero point (0, 0, 0)

    Subject px py pz ax ay az

    1 1.27 105.54 5.52 0.24 55.93 5.81

    2 1.90 102.43 0.85 0.70 52.41 2.38

    3 1.28 102.23 10.81 0.47 58.73 1.12

    4 2.04 115.68 8.69 1.03 56.48 3.81

    5 1.89 111.53 6.15 0.72 58.40 6.66

    6 2.41 129.64 2.08 0.81 71.47 4.83

    7 2.15 112.53 0.62 0.00 58.60 5.03

    8 0.40 103.14 0.47 1.90 64.58 2.45

    9 2.16 103.66 2.86 0.86 60.43 1.48

    10 5.48 114.50 1.93 3.32 61.00 3.36

    11 2.52 114.14 2.57 1.77 58.82 4.98

    12 7.12 108.13 0.09 2.27 55.57 2.08

    13 2.01 114.58 3.60 0.99 64.42 0.42

    14 4.48 97.94 4.48 3.16 54.33 2.35

    Average* 2.65 1 09.69 3.62 1.30 5 9.37 3.34Mean 2.32 109.69 0.67 1.27 59.37 0.84

    Value on AvM 0.83 103.96 5.49 0.37 55.60 3.33

    Mean direction Left Down Forward Left Down Forward

    *Represents the average value of the absolute values (distance from 0)

    of the coordinates; Average male facial template.

    Table III. The difference of Pog (px, py, and pz) and

    subspinale (ax, ay, and az) of the average female tem-

    plate and the female Class III subjects

    Subject Diff px Diff py Diff pz Diff ax Diff ay Di ff az

    1 0.50 8.77 6.10 2.43 3.89 0.81

    2 9.88 8.14 3.64 2.78 1.09 1.85

    3 1.32 1.97 8.59 2.35 4.31 1.97

    4 6.68 4.26 9.82 1.98 6.11 1.20

    5 1.38 5.57 4.10 0.31 0.88 4.87

    6 5.54 5.67 4.68 0.65 6.58 3.90

    7 3.15 1.99 3.95 1.85 3.02 2.40

    8 0.96 7.83 6.27 0.67 1.00 0.34

    9 2.89 8.40 9.87 0.96 4.81 0.59

    10 0.01 8.11 4.17 0.90 4.69 2.49

    11 1.51 2.94 2.81 0.79 6.56 2.07

    12 8.59 2.46 1.56 0.84 3.41 1.45

    13 0.32 9.58 3.75 0.81 4.76 3.32

    14 0.67 2.48 3.21 0.10 2.16 3.40

    15 5.34 8.44 2.32 0.17 1.82 2.55Average* 3.25 5.77 5.05 1.17 10.90 2.21

    Mean 0.74 4.39 5.05 0.96 2.03 1.64

    Direction Left Down Forward Right Down Back

    Diff,Difference.

    *Represents the average of absolute differences.

    Table IV. The difference of Pog (px, py, and pz) and

    subspinale (ax, ay, and az) of the average male template

    and the male Class III subjects

    Subject Diff px D iff py Diff pz D iff ax D iff ay Di ff az

    1 2.10 1.57 11.02 0.61 0.33 2.49

    2 1.07 1.54 4.64 0.33 3.19 5.71

    3 2.11 1.74 16.31 0.10 3.13 2.20

    4 2.87 11.71 3.19 0.65 0.88 7.14

    5 2.72 7.57 11.65 0.35 2.80 3.34

    6 3.23 25.68 7.58 0.44 15.87 1.51

    7 2.98 8.57 4.87 0.37 2.99 8.36

    8 0.43 0.83 5.02 1.53 8.98 5.77

    9 2.99 0.30 8.35 0.49 4.83 4.81

    10 6.31 10.54 3.57 2.95 5.40 0.04

    11 3.35 10.18 8.06 1.40 3.21 1.66

    12 7.95 4.16 5.58 1.89 0.03 1.25

    13 2.84 10.62 1.89 0.62 8.81 2.91

    14 5.31 6.02 1.02 2.79 1.28 5.67

    Average* 3.30 7.22 6.62 1.04 4.41 3.77Mean 3.15 5.73 6.17 0.90 3.77 2.49

    Mean direction Left Down Forward Left Down Back

    Diff,Difference.

    *Represents the average of absolute differences.

    760 Bozic et al American Journal of Orthodontics and Dentofacial OrthopedicsDecember 2010

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    in RF6; (4) the z-coordinates of the images are averaged

    based on normals to a facial template; (5) the point cloud

    is triangulated to obtain an average face; (6) defects

    and unwanted areas are removed, and holes are filled;

    (7) color texture is applied; and (8) shells are created

    with 1 positive and 1 negative standard deviation.17

    All images were oriented in the virtual space to have

    a NHP before analysis. Sella (S), subspinale (A), and

    soft-tissue pogonion (Pog) were chosen as described

    before and shown inFigure 1.18 The surface shell was

    translated in the 3D space so that S represented thezero point (x, y, and z values were 0, 0, and 0). The values

    of the other points coordinates therefore representeddistances from S in the chosen axis in millimeters, and

    their corresponding positive or negative value sign (the

    plus sign was omitted for positive values) indicated the

    directions (ie, positive x, left; positive y, up; positive z,

    to the front). The coordinates of points A and Pog

    were summated in the following manner. (1) As absolute

    values to demonstrate the absolute differenceie, dis-

    tance from S not taking the direction into account; in

    this way, by dividing the sum by the number of subjects,

    average distances of points A and Pog from S (zero) for

    the male and female Class III groups were calculated.

    (2) With their positive and negative values and divided

    by the number of subjects to give the mean value of

    the coordinate, showing also the direction. The differ-

    ences of the A and Pog coordinates of the template

    AvM and group MCIII (AvM MCIII) and the differ-

    ences of thetemplateAvFand group FCIII (AvF FCIII)

    were also summated and divided in these 2 ways to give

    the average distances regarding the average face and the

    means showing also the direction of the points in theClass III groups compared with the average facial

    templates (AvM and AvF). Means of the coordinates

    and means of their differences (AvM MCIII and

    AvF FCIII) were compared and tested for significant dif-

    ferences between thesexes.The differences (AvM MCIII,

    AvF FCIII) of coordinates of points A (ax) and Pog (px)

    were also compared for significant differences.

    Superimpositions of the shells from the Class III

    group were performed with the AvM and AvF shells

    by using a previously described technique.19 The mor-

    phologic differences between the shells were depicted.

    Fig 2. Coordinates px (Pog) of the male and female Class III (MCIII and FCIII) patients compared with

    the px of the average female (AvF) and male (AvM) patients.

    American Journal of Orthodontics and Dentofacial Orthopedics Bozic et al 761Volume138,Number6

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    The process of comparing the facial average shells

    involved a manual alignment of the 5 points on the facial

    scans (4 points at the outer and inner canthus of the eyes

    and 1 point on the nasal tip) followedby fine alignment

    performed automatically by the RF6.19 Color histogram

    andsurface areas andshapes were theparameters used in

    the study. The color histogram indicates the difference

    between the average facial shells: the blue areas show

    negative values, and the red areas show positive values.

    Surface areas and shapes were automatically generated

    by theRF6. These shapeswere obtained when a previous

    tolerance of 0.85 mm was applied to the paired surface

    shell studies.8 The areas corresponding to 0.85 mm

    were deemed to be similar between the 2 shells, whereas

    the shapes above this tolerance represented differences

    and were shown as surface shapes and color deviations.

    The percentage of the areas corresponding to the

    tolerance of 0.85 mm was calculated by the RF6 and

    represented the similarity of 2 shells.

    Statistical analysis

    The data were tested for significant differences

    by using the independent-samples 2-tailed Student

    t test in SPSS for Windows (version 11.0.0, SPSS,

    Chicago, Ill).

    RESULTS

    One hundred sixteen subjects were included in this

    study; 43 male and 44 female subjects constituted the

    normal group that made up the average templates, and

    14 male and 15 female subjects constituted the Class

    III group.

    Coordinates of the points Pog (px, py, and pz) and A

    (ax, ay, and az) with the average distance from S

    (average of the absolute values) for the groups FCIIIand MCIII as well as for the AvM and AvF facial tem-

    plates are presented in Tables I and II, respectively.

    Their mean values and corresponding directions are

    also shown. Tables III and IV show the differences

    between the coordinates Pog and A chosen on the

    AvF and AvM templates and the coordinates of Pog

    and A chosen on the subjects of groups FCIII and

    MCIII, respectively. The values of the coordinates of

    points A and Pog of FCIII and MCIII and values of

    the A and Pog coordinates of the average facial

    templates (AvF and AvM) are also presented in

    Fig 3. Coordinates py (Pog) of the male and female Class III (MCIII andFCIII) patients compared with

    the py of the average female (AvF) and male (AvM) patients.

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    Figures 2 to 7. Coordinates py and ay of the groups

    MCIII and FCIII were statistically significantly

    different (P \0.05). The other coordinates did not

    show statistical significance.

    The average distances of Pog from S in the vertical

    dimension (ie, y-axis) were 109.69 mm (103.96 on

    AvM) for the MCIII subjects and 99.60 mm for the

    FCIII subjects (95.21 on AvF). The distance differences

    were 10.09 mm between MCIII and FCIII and 8.75 mm

    between AvM and AvF.

    The subtractions of the female ax and ay coordinates

    (AvF FCIII) were statistically significantly (P\0.05)different from the subtractions of the male ax and ay

    coordinates (AvM MCIII).

    Differences of the px were statistically significantly

    higher than differences of the ax (P \0.05).

    In the template analysis, the results of differences

    between the average faces (AvM and AvF) and Class

    III patients (MCIII and FCIII) are shown with color

    histograms inTable V. The similarities to the average

    face ranged from 21.30% to 46.07% among the MCIII

    subjects and from 23.71% to 52.02% among the FCIII

    subjects. The average percentages of similarity were

    38.34% for FCIII to AvF and 32.85% for MCIII to

    AvM. The differences were mainly in the lower facial

    two thirds. However, in 50% (MCIII) to 60% (FCIII),

    there were also differences in the upper facial third.

    Figure 8shows a face with a protruded mandible, with

    the upper two thirds mostly within the accepted

    0.85-mm tolerance when superimposed on the corre-

    sponding average face. Asymmetry can also easily be

    noted from the image. Figure 9 shows a subject with

    mandibular prognathism and maxillary retrognathism,

    whereas the upper facial third is mostly within the

    accepted 0.85-mm tolerance when superimposed onthe corresponding average face.Figure 10shows a sub-

    ject whose mandible is protruded and whose maxilla is

    retruded, and there is also a significant difference from

    the average face in the upper third of the face: the area

    around the eyes and forehead.

    DISCUSSION

    Three-dimensional imaging is a fast developing

    field of medical diagnostics. It was shown that 3D im-

    aging with laser scanning devices can be used reliably

    Fig 4. Coordinates pz (Pog) of the male and female Class III (MCIII andFCIII) patients compared with

    the pz of the average female (AvF) and male (AvM) patients.

    American Journal of Orthodontics and Dentofacial Orthopedics Bozic et al 763Volume138,Number6

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    and with great accuracy.20,21 A 3D average face has

    been used in several studies: to distinguish people

    with Noonans syndrome,4 to compare different

    groups of orthodontic patients (postextraction to non-

    extraction groups),22 to distinguish growth changes

    among children,23 and to compare distinct geographi-

    cally remote white populations (Slovenian and

    Welsh).24

    In our study, the 3D data were obtained with a nonin-

    vasive laser scanning device. A previously described

    method of averaging faces was used.17 Differences and

    asymmetry of Class III patients and their comparisonsto average female and male facial templates of their pop-

    ulation were noted. To our knowledge, previous studieshave not used an average face for the objective of linear

    measurement.

    Symmetry and averageness were considered in this

    study, since they play important roles in a faces

    attractiveness, although extraordinary beauty probably

    depends on the addition of special characteristics

    (child-like and mature characteristics and expressive-

    ness) for the females, whereas male attractiveness is

    more controversial, depending on the great influence

    of the menstrual cycle and the environment on female

    observers. The ideal of beauty is also subject to fluctu-

    ations in fashion.25

    Our findings show that the male and female faces of

    Class III patients in Slovenia are statistically signifi-

    cantly different in the vertical (y) direction. This agrees

    with a recent international anthropometric study where

    the mean morphologic face height was determined as

    the distance from nasion to gonion. Thirty male and

    30 female subjects from Slovenia were included, and,

    for the males, the mean morphologic face height

    was 7.1% higher than for the females (116.6 mm vs108.8 mm).26 In our study, the morphologic face height

    was estimated as the distance between S and Pog inthe y-axis. On the AvM facial template, the Pog dis-

    tance in the y-axis was 9.1% higher than on the AvF,

    and, in the MCIII group, it was 10.1% higher than in

    the FCIII.

    Asymmetry makes the human face less attractive,

    and its objective estimate is therefore important.25 In

    FCIII, the deviation of Pog to the left or right was on

    average 3.8 mm (2.65 mm in MCIII), whereas on the

    AvF template it was 1.18 mm (0.83 mm on AvM).

    Fig 5. Coordinates ax (point A) of the male and female Class III (MCIII and FCIII) patients compared

    with the ax of the average female (AvF) and male (AvM) patients.

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    This could lead to a conclusion that Class III patients are

    more likely to have a deviation of the chin than the

    Class I population. Differences of the px were statisti-cally significantly higher than differences of the ax,

    meaning that the mandible deviates in the x-axis more

    than the maxilla. It has been previously shown that

    asymmetry among Class III patients is seen frequently

    and not by chance and is more pronounced in the

    mandible than in the maxilla.27

    The px values were positive in 12 of 15 (80.0%) sub-

    jects of the FCIII group and in 12 of 14 (85.7%) subjectsin the MCIII group. A positive px value means left-sided

    chin deviation; this also agrees with previous studies27

    and probably is a consequence of prenatal (genetic

    and teratogenic) factors.28,29

    The subtraction of the ax (AvM MCIII) that was

    significantly different from the subtraction of the ax

    (AvF FCIII) leads us to conclude that Class III

    men have a maxilla deviated more to the left, whereas

    the women tend to have a maxilla deviated more to the

    right. Considering the small dimensions of these

    means of deviations (10.96 mm and 0.90 mm), it

    is also possible that these can be ascribed to technical

    errors.

    The similarity of the Class III patients and theaverage facial templates was low (FCIII similarity,

    38.3%; MCIII similarity, 32.8%). To our knowledge,

    no previous studies have used 3D digital data to

    show this.

    The data of this study also suggest that the upper fa-

    cial third might be of importance for the final result of

    orthognathic surgery. The upper facial third was differ-

    ent from the average facein 9 of15 (60%) FCIII and in 7of 14 (50%) MCIII patients. Since the upper third is not

    surgically corrected, these patients might have a disad-

    vantage when compared with those whose upper third is

    more similar to the average face.

    This study included average faces built only from

    our small database; larger studies are needed and

    ongoing. Further 3D imaging studies will help to cre-

    ate 3D norms that will eventually replace the tradi-

    tional 2-dimensional cephalometric norms and lead

    to better surgical and orthodontic corrections of facial

    irregularities.

    Fig 6. Coordinates ay (point A) of the male and female Class III (MCIII and FCIII) patients compared

    with the ay of the average female (AvF) and male (AvM) patients.

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    CONCLUSIONS

    The following can be concluded from this novel

    method of 3D analysis.

    1. Facial morphologic differences between Angle

    Class III patients and average Slovenian male and

    female faces were noted by using commercially

    available laser scanning system and software.

    2. The average and Class III Slovenian male morpho-

    logic face height is statistically significantly higher

    than female.

    3. The Slovenian Class III males and females tend tohave a left-sided chin deviation.

    4. Differences between Class III patients and a norma-tive data set were determined (FCIII similarity,

    38.3%; MCIII similarity, 32.8%).

    Marko Bozic thanks the Fulbright Commision for

    the scholarship that enabled him to work at the Univer-

    sity of Texas Health Science Center at Houston and the

    Slovenian Research Agency.

    Fig 7. Coordinates az (point A) of the male and female Class III (MCIII and FCIII) patients compared

    with the az of the average female (AvF) and male (AvM) patients.

    Table V. Percentages of similarity between the average

    face templates and Class III patients calculated with

    color histograms

    Female subject Similarity (%)* Male subject Similarity (%)*

    1 30.83 1 27.15

    2 47.69 2 39.59

    3 27.18 3 36.10

    4 52.02 4 34.29

    5 26.66 5 38.78

    6 49.05 6 21.43

    7 52.64 7 32.47

    8 28.72 8 34.449 38.46 9 21.30

    10 34.42 10 25.93

    11 41.81 11 35.98

    12 39.26 12 35.85

    13 34.81 13 30.56

    14 23.71 14 46.07

    15 47.84

    Average 38.34 32.85

    *Tolerance 5 0.85 mm (values less than this are deemed similar).

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    Fig 8. A Slovenian female Class III face superimposed on an average Slovenian female face showing

    a protruded mandible, with the upper two thirds mostly within the accepted 0.85-mm tolerance. Note

    the asymmetry of the mandible.

    Fig 9. A Slovenian male Class III face superimposed on an average Slovenian male face showing

    mandibular prognathism and maxillary retrognathism, with the upper facial third mostly within the

    accepted 0.85-mm tolerance.

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    REFERENCES

    1. WongJY, Oh AK,OhtaE, Hunt AT, Rogers GF, Mulliken JB, et al.

    Validity and reliability of craniofacial anthropometric measure-

    ment of 3D digital photogrammetric images. Cleft PalateCraniofac J 2008;45:232-9.

    2. Kau CH, Richmond S, Incrapera A, English J, Xia JJ. Three-

    dimensional surface acquisition systems for the study of facial

    morphology and their application to maxillofacial surgery. Int J

    Med Robot 2007;3:97-110.

    3. Lane C,HarrellW Jr. Completing the3-dimensionalpicture. AmJ

    Orthod Dentofacial Orthop 2008;133:612-20.

    4. Hammond P, Hutton TJ, Allanson JE, Campbell LE,

    Hennekam RC, Holden S, et al. 3D analysis of facial morphology.

    Am J Med Genet A 2004;126A:339-48.

    5. Kau CH, Cronin A, Durning P, Zhurov AI, Sandham A,

    Richmond S. A new method for the 3D measurement of postoper-

    ative swelling following orthognathic surgery. Orthod Craniofac

    Res 2006;9:31-7.6. Ferrario VF, Sforza C, Schmitz JH, Santoro F. Three-dimensional

    facial morphometric assessment of soft tissue changes after or-

    thognathic surgery. Oral Surg Oral Med Oral Pathol Oral Radiol

    Endod 1999;88:549-56.

    7. Koh CH, Chew MT. Predictability of soft tissue profile changes

    following bimaxillary surgery in skeletal Class III Chinese

    patients. J Oral Maxillofac Surg 2004;62:1505-9.

    8. Kau CH, Richmond S,ZhurovAI,KnoxJ, Chestnutt I,Hartles F, etal.

    Reliability of measuring facial morphology with a 3-dimensional

    laser scanning system. Am J Orthod Dentofacial Orthop 2005;128:

    424-30.

    9. Khambay B, Nairn N, Bell A, Miller J, Bowman A, Ayoub AF.

    Validation and reproducibility of a high-resolution three-dimen-

    sional facial imaging system. Br J Oral Maxillofac Surg 2008;

    46:27-32.

    10. Periago DR, Scarfe WC, Moshiri M, Scheetz JP, Silveira AM,

    Farman AG. Linear accuracy and reliability of cone beam CTderived 3-dimensional images constructed using an orthodontic

    volumetric rendering program. Angle Orthod 2008;78:387-95.

    11. Bernabe E, Sheiham A, de Oliveira CM. Condition-specific im-

    pacts on quality of life attributed to malocclusion by adolescents

    with normal occlusion and Class I, II and III malocclusion. Angle

    Orthod 2008;78:977-82.

    12. Guyer EC, Ellis EE 3rd, McNamara JA Jr, Behrents RG. Compo-

    nents of Class III malocclusion in juveniles and adolescents.

    Angle Orthod 1986;56:7-30.

    13. McIntyre GT, Mossey PA. Asymmetry of the parental cranio-

    facial skeleton in orofacial clefting. J Orthod 2002;29:

    299-305.

    14. Ferrario VF, Sforza C, Poggio CE, Tartaglia G. Distance from

    symmetry: a three-dimensional evaluation of facial asymmetry.

    J Oral Maxillofac Surg 1994;52:1126-32.15. Chiu CS, Clark RK. Reproducibility of natural head position.

    J Dent 1991;19:130-1.

    16. Zhurov AI, Kau CH, Richmond S, ed. Computer methods for

    measuring 3D facial morphology. Computer methods in biome-

    chanics & biomedical engineering - 5, ed. M.G.S.a.M.L.J.J. Mid-

    dleton. 2005, FIRST Numerics: Cardiff.

    17. Kau CH, Zhurov A, Richmond S, Bibb R, Sugar A, Knox J, et al.

    The 3-dimensional construction of the average 11-year-old child

    face: a clinical evaluation and application. J Oral Maxillofac

    Surg 2006;64:1086-92.

    18. Swennen GRJ, Schutyser F, Hausamen JE. Three-dimensional

    cephalometry: a color atlas and manual. 1st ed. Berlin, Germany,

    and New York: Springer; 2006. p. xxi, 365.

    Fig 10. A Slovenian female Class III face superimposed on an average Slovenian female face where

    the mandible is protruded, the maxilla is retruded, and there is also a significant difference from the

    average face in the upper third: the area around the eyes and forehead.

    768 Bozic et al American Journal of Orthodontics and Dentofacial OrthopedicsDecember 2010

  • 8/10/2019 ajodo dec 10-14.pdf

    12/12

    19. Kau CH,Richmond S, Savio C, MallorieC. Measuringadult facial

    morphology in three dimensions. Angle Orthod 2006;76:773-8.

    20. Marmulla R, Hassfeld S, Luth T, Muhling J. Laser-scan-based

    navigation in cranio-maxillofacial surgery. J Craniomaxillofac

    Surg 2003;31:267-77.

    21. Kau CH, Zhurov A, Scheer R, Bouwman S, Richmond S. Thefeasibility of measuring three-dimensional facial morphology in

    children. Orthod Craniofac Res 2004;7:198-204.

    22. Ismail SF, MossJP,HennessyR. Three-dimensional assessment of

    the effects of extraction and nonextraction orthodontic treatment

    on the face. Am J Orthod Dentofacial Orthop 2002;121:244-56.

    23. Nute SJ, Moss JP. Three-dimensional facial growth studied by

    optical surface scanning. J Orthod 2000;27:31-8.

    24. Bozic M, Kau CH, Richmond S, Hren NI, Zhurov A, Udovic M,

    et al. Facial morphology of Slovenian and Welsh white popula-

    tions using 3-dimensional imaging. Angle Orthod 2009;79:640-5.

    25. Honn M, Goz G. The ideal of facial beauty: a review. J Orofac

    Orthop 2007;68:6-16.

    26. Farkas LG, Katic MJ, Forrest CR, Alt KW, Bagic I,

    Baltadjiev G, et al. International anthropometric study of facial

    morphology in various ethnic groups/races. J Craniofac Surg

    2005;16:615-46.27. Haraguchi S, Takada K, Yasuda Y. Facial asymmetry in sub-

    jects with skeletal Class III deformity. Angle Orthod 2002;

    72:28-35.

    28. Saijoh Y, Adachi H, Mochida K, Ohishi S, Hirao A, Hamada H.

    Distinct transcriptional regulatory mechanisms underlie left-right

    asymmetric expression of lefty-1 and lefty-2. Genes Dev 1999;13:

    259-69.

    29. Jacobsson C, Granstrom G. Clinical appearance of spontaneous

    and induced first and second branchial arch syndromes. Scand J

    Plast Reconstr Surg Hand Surg 1997;31:125-36.

    American Journal of Orthodontics and Dentofacial Orthopedics Bozic et al 769Volume138,Number6