aiha dr.nyoto
DESCRIPTION
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AIHANYOTO WIDYO ASTOROHEMATOLOGI ONKOLOGIRSGS
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AIHACharacterized by shortened red blood cell survival and autoantibodies directed against red blood cell antigens. 1 in 75.000-80.000 per yearWarm AIHA 60-70% of all AIHA50% Warm AIHA are idiopathic or primary
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CLASIFICATION AIHA
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PATHOPHYSIOLOGYTwo mechanism immune mediated red blood cell destruction :Extravascular hemolysisIntravascular hemolysis
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Extravascular Hemolysis
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Intravascular Hemolysis
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Clinical feanturesFatigue, weakness, malaiseDizzinesFeverBack painDydpnea on exertionJaundiceDiscolored urinePallor
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Physical ExaminationJaundice and or pallorHepatosplenomegalyThromboembolism
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LaboratoryAnemiaElevated reticulosytesElevated BillirubinElevated LDHElevated urobilinCoombs test positive
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PERIPHERAL BOOD SMEAR
- TratmentCorticosteroid 60mg-100mg/day for 1-3 weekSplenectomy with low dose prednison (