Agilent 7890B- 5977A

MSD Introduction

ASTS

March 15, 2013

Graham Robinett

GC-MS Product Specialist

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240 IT 7890 GC

7000 TQ 7890 GC

5975E SQ 7820 GC

5975T LTM SQ

5977A SQ 7890B GC

7200 Q-TOF 7890GC

More Choices – Better Solutions

Agilent GC/MS/MS

Agilent GC/MS

Today’s Challenges Economic Backdrop: Tension and Uncertainty

March 18, 2013 3

• Operating expenses increasing

• Capital Budgets decreasing

• Asset management and protection a priority Operations

• Regulations, compliance and technology driving need for lower level detection

• Sample complexity increasing

• Many analytes are labile

Technology

•Skill reduction at local level; expertise often sequestered at COE •Lean operation drives cross-training •Higher staff turnover

Human Resources

Agilent Response Solutions to Assure Business Continuity & Reduce Uncertainty

March 18, 2013 4

Reduced operating

expenses: gas use

Improved asset

utilization & protection:

maintenance feedback &

improved GC:MSD

communication

Increased productivity:

fast MSD vent mode &

Rapid consumables

Parts Finder tool

Economic

A more facilitated user

experience

Powerfully Intuitive

Software Solutions:

New OpenLAB CDS

MassHunter for MSD

Integrated Intelligence

Analyzer Solutions

Execution

Better analyte detection:

Improved performance

specifications

Better protection of

labile compounds:

Agilent Inert Flow Path

Expanded lab

capabilities:

improved FPD, ECD as

3rd detector, dual MMI

Technical

Innovations in Hardware, Software, Chemistries and Workflows

Improve Asset Utilization Leverage and Protect Your Investment Better

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Economic

5977A 7890B

During MSD vent… Increases GC carrier gas flows,

Cools MSD faster

40% Faster Vent Times

(280C 100C)

In event of MSD Failure… Stops GC Flows

Don’t waste expensive He

Don’t build-up H2

5977A 7890B

GC monitors GC/MSD

connection.

If communication lost… GC shuts down various

(GC) thermal zones

Integrated GC-MSD Communication

Faster Maintenance, better asset protection, safer H2 use

Reducing Operating Expenses Reducing Dependence on He

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Economic

Can save as much as 15% in gas usage – up to $4,000 per year per instrument for many labs

Sleep-Wake Function

Manage He Use Optimally

• Set time to sleep

• Set time to wake

• Choose to condition GC before first run

• Use only the gas you need

Increase Productivity Faster and easier method development

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Economic

Bar Code Scanning Option

AutoInput column, liner and septum information into method. Integrated with Parts Finder for seamless consumables management.

Improved Asset Utilization Avoid Unplanned Downtime

March 18, 2013

Confidentiality Label

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Economic

Optimize your maintenance plan

• You determine your maintenance schedule,

not your instrument

• Use only the consumables you need, when

you need them

• A maintenance SOP built into your GC

When production or shipment decisions are on the line,

unplanned downtime can cost $1000’s

Early Maintenance Feedback

Saving Energy and Time

Agilent Confidential Tonga Project Definition Check Point

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350

400

NormalOp

Standby

Power Consumption - 5977

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250

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Vent Fast

Vent

Power

saved

Time saved

Po

we

r( V

A)

So

urc

e T

em

p

Time(min)

Time saved using Fast Vent

Economic

Reducing Operating Expenses Reducing Dependence on He

March 18, 2013 10

Economic

Switching to N2 gas overnight and on weekend downtime can save up to 180 days of He per

GC instrument

He Conservation Module

Manage He Use Optimally

• Use He only when needed

• Extend He tank usage

• Reduce operating costs

• Reduce gas supply uncertainty

Improved Performance Deliver better results

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UltiMetal – TCD,

FPD, NPD/FID Jets

UltiMetal Capillary Flow Technology

Devices, Ultimate Union

UltiMetal Inlet Weldment, Shell

and Transfer Lines

Ultra Inert GC Column

Ultra Inert Gold Seal

Ultra Inert Inlet

Liner

New UltiMetal

FlexiMetal Ferrules

Technical …now from a single supplier

Agilent Inert Flowpath SSL Inlet Option Proprietary UltiMetal-Plus Treatment

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Enhanced performance for trace GCMS and

GC-ECD analysis of pesticides and drugs of

abuse

Protects labile analytes contacting injector

metal structure during high volume injections

Available as 7890B Inert Flowpath option #114

or upgrade G3453B for 7890A/B

Technical

Improved Performance Deliver better results

March 18, 2013 13

Technical

Detector Performance

MSD Scan 1500:1 S/N; SIM 10 fg IDL

FID <1.4 pg C/sec

ECD <4.4 fg/sec

FPD <2.5 pg S/sec; <45 fg P/sec

SCD <0.5 pg S/sec

NPD <0.01 pg P/sec, 0.08 pg N/sec (Blos bead)

TCD 400 pg/mL

New Extractor Ion Source for 5977

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Why the Extractor EI Source?

Increase in ion count

True increase in sensitivity

Better trace level precision

Lower IDL and MDL

Proven in the 7000 Series GC/TQ!

Technical

Comparison of Inert and Extractor Ion Source

Agilent Confidential

Page 15

Repeller

(Push)

Drawout Plate

Ion Focus Lens

Entrance Lens

Ionization area

Ions

Inert Ion Source

Extractor Lens

(Pull)

Extractor Source

More ions to

Mass Filter

Mass Filter

January 8, 2013

Extractor Source “Etune” Sensitivity Increase

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Blue – Extractor 40ppb solution (SVOC)

Red – Standard 40ppb solution (SVOC)

5977 Extractor Source: Improved Thermal Profile

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Better performance of high boilers

i.e. PAH even at lower concentration!

5ppb PAH

Top of the peak shows

expected imprecision, but no

response trending with new

5977 Extractor Source

GC Conditions:

80 minute separation

Longer than normal

to enhance visibility

of trending

Technical

Brochure Example of S/N Specification

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Technical

Better Specs for Working Methods:

Instrument Detection Limit (IDL)

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More ions = Better precision = Better IDL = Better MDL

10 fg Extractor EI (24 fg Inert EI/TP)

Method conditions

TESTED at INSTALLATION (factory spec even lower)

Technical

European Pharmacopoeia 6.2 Council of Europe, Strasbourg, France, 2008

20x pk width half

height

LCGC Europe, Vol 22 (2), Feb 2009; R Boqué, Y Vander Heyden

S/N = 2H

h

H is measured from

mid-point of baseline

immediately before

and after peak (not

mid-point of h)

Noise time segment

carefully defined

IDL 2-page Flyer

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Three Improved Specifications

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Market’s ONLY SQ IDL < 10 fg

Market’s Best S/N (SNR) > 1500:1

Technical

Better HW Features: Agilent Turbo Pump (V304)

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Agilent Quality Standard

TwisTorr 304 FS Innovation for:

•Higher pumping performance

• especially for He and H2

•High reliability

• lower cost of operation

Technical

Economic

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TwisTorr 304 FS: Vacuum Design

8 EDM turbo stages

(rotor) designed to

optimize pumping

speed for light gases

8 Turbo stators

made by pressed

SST sheet

technology

3 TwisTorr drag stages (spiral

channels) designed for high

compression ratio performances

Agilent’s new patent-

pending Floating

Suspension for robust,

low noise operation

255 L/s helium

220 L/s hydrogen

Technical

Better HW Features: Agilent Rough Pumps

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New DS42i New IDP-3c

High performance

Energy saving design “Inverter” not compatible with diff pump

High performance

Oil-free scroll pump

NH3 CI compatible

with Agilent Quality Standards

MassHunter GC/MS Acquisition for GC/MSD

Unified GC/MS Acquisition and

MassHunter Data Analysis; with

MSD ChemStation workflow for GC/MSD

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Economic

The Value of G1701FA Software

All Inclusive G1701FA Software Package

• Acquisition, Quant, Qual, MSD ChemStation

• 21CFR11 Compliance tools (Acquisition and

Quant)

• GC/MS and LC/MS Translators

Collated User Information

• Workflow guides, Video Tutorials, all in one

location

Support

• 1yr Upgrade, Updates, and Phone Support

• Installation and Familiarization options

• New Familiarization material for GC/MSD

users

MSD ChemStation DA

MassHunter Qual

MassHunter Quant

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GC/MSD Software MassHunter Qual

MassHunter Quant MH

CS

MassHunter GC/MS Acquisition

And Use Either

MassHunter Data Analysis

OR

MSD ChemStation Data Analysis MSD ChemStation DA

G1701FA

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GC/MSD Acquisition Methods

MSD Productivity ChemStation MassHunter GC/MS Acquisition

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GC/MS Acquisition Methods are Transparent

from MSD ChemStation to MassHunter GC/MS (Except PAL)

Moving from MSD Productivity ChemStation EA to

MassHunter with MSD ChemStation Data Analysis (FA)

GC & GC/MS Acquisition data is compatible with both

MSD Productivity ChemStation EA

MSD ChemStation Data Analysis FA (MassHunter)

MSD Productivity ChemStation (EA)

MSD ChemStation DA (FA)

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Migrate Data to MassHunter Format

Data

Data

Data

MassHunter Quant

MassHunter Unknowns Analysis

MassHunter Qual

ChemStation (.D)

WorkStation (.SMS)

Generic (.CDF)

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Migrate Quantitative Methods to

MassHunter Format

MSD ChemStation (QDB.MTH)

WorkStation (.mth)

MassHunter Quant

Method

Method

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MSD Productivity ChemStation OR MassHunter?

MSD ChemStation

Established Agilent GC/MSD User

• Adding instrument to routine production

• Established workflows

• Macros, Macros, Macros

DRS or Screener DB

EnviroQuant User

• Uses the US EPA workflow, especially

reports and QA/QC criteria.

• MassHunter EnviroQuant targeted for

late 2013

MassHunter

Look and feel of modern software

Superior Quantitation

21CFR11 & Other Regulated Labs

Multi disciplinary MS lab

• Have Agilent Triple Quad or (Q-)TOF

• LC/MS, ICP-MS, & GC/MS

• MS and MS/MS

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1-Year Software Maintenance Agreement

Supported Add-on Software

DRS and Analyzers

DRS is for MSD Productivity

ChemStation mode ONLY

Headspace PAL

Fully supported in GC/MS Acquisition

Mass Profiler Professional GC/MS Libraries & RTL Database

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Flexibility: Performance and Budget

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Lowest Price

Performance Meets

Method Requirement

5977E Turbo MS

5977E Diff MS

7820A

Stainless source

Highest

GC Performance

& MS Performance

5977A EI

5977A EI/CI

7890B GC

Extractor source

DS42i

Balance of Price,

GC performance,

& MS performance

5977A Turbo MS

5977A Diff MS

7890B GC

Inert source

Introducing the 5977A Series GC/MSD Re-defining Premium Single Quad GC/MS

Improved Performance Specifications Best-in-class Single Quadrupole Performance

New & Expanded Accessories & Options Agilent Turbomolecular and Roughing pumps

New Inert Flowpath option

Dual MMI inlets

Improved non-MS detectors

ChemStation AND MassHunter Data Handling

Integrated Intelligence Functions GC-MSD communication

Sleep-wake function

Method development calculators

3D Interactive Graphical Parts Finder

Early Maintenance Feedback

Barcode Scanning with Auto-Input

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7890B/5977A GC/MS Solution Portfolio Driving Business Value and Success

Proven 7890 and 5977 Reliability

MassHunter & ChemStation SW

Integrated Intelligence

Improved Performance

Greater Operating Efficiency

Expanded Accessories and Options

MassHunter Superior Quantitative Analysis

• Batch Design for Comprehensive Data Review

• Automated Quality Checking and Outlier

display

• Interactive Calibration Results

Unified Agilent MS solution

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MassHunter Qualitative Analysis

• Comprehensive Display and Review Options

• Multi-Library GC/MS Spectral Searching of

all Agilent libraries

• Integrated Deconvolution and Other

Compound Finding Tools

Unified Agilent MS solution

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