agen infevi : ruolo eziologico primario o solo trigger?...priyanka sharma roberto benigni -99.5% of...

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Agen% infe)vi: ruolo eziologico primario o solo trigger? Roberto Furlan M

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Page 1: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

Agen%infe)vi:ruoloeziologicoprimarioosolotrigger?RobertoFurlan

Monza,5giugno2017

Page 2: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

Infec%onsinMS(andautoimmunity):-  Causal-  Co-factor-  Protec%ve

Page 3: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

Page 4: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

Page 5: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

Page 6: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

Causal:EBV

Page 7: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

Page 8: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

Page 9: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

Page 10: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

PerronFerranteSotgiuDolei

Page 11: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

Sriram

Page 12: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

Page 13: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

Page 14: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

Page 15: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

Prototypicalinfec0ousdiseasesandimmunedisorders

BachJF.NEnglJMed2002

Page 16: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

Bacteriaandparasiteswithprotec0veeffectsinautoimmunedisease

Page 17: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

Helminththerapy

KhanandFallon.IntJParasitol2013

Page 18: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

Page 19: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

Malariaandautoimmunediseases

•  Thepresenceofaspa0alandtemporalclusterofMSoccurredaJermalariaeradica0on

•  Correla0onbetweenA30-B18-DR3HLAhaplotype,MSandhighmalariaprevalenceareas

•  SomeTNFpolymorphismsintheTNF-promoterregionalreadyassociatedwithbothmalariaandMSareupto100meselevatedamongstSardiniansascomparedtoSiciliansandanyotherpopula0onworldwide

PugliaSetal.Neurology2002Wirzetal.2004Fernandez-Arqueroetal.Neurology1999Knightetal.NatGenet1999McGuireetal.JInfectDis1999

Page 20: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

Page 21: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

Page 22: Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of adult MS patients EBV+, 94% of adult controls -98.6% of children with MS EBV+, 72.1%

Horubatoslidesa:MauraPuglia)MichelBrahicPriyankaSharmaRobertoBenigni

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artus® EBV LC PCR - rcostoya.comrcostoya.com/uploads/galerias/con817/hb-artus-ebv-lc-pcr-kit-ce-24-96.pdf · artus EBV LC PCR Kit 03/2015 5 artus EBV LC PCR Kit Para utilizar con

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