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Page 1: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention
Page 2: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

AF Suppression™

Algorithm Overview

Page 3: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

AF Suppression™ Algorithm Overview

•The goal is to keep atrial arrhythmias from occurring

• Prevention of atrial fibrillation• A fib begets A fib!

•Solution: An algorithm designed to keep the atrial pacing rate just above the patient’s changing intrinsic atrial rate, resulting in constant atrial pacing

Page 4: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

> 90% Atrial Pacing

AFx ensures a high percentage of atrial stimulation at a rate following the patients natural circadian variations, thereby maintaining control of the atrium, reducing ectopy, and suppressing atrial tachyarrhythmias

AF Suppression, AFx

Page 5: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

MSR

Basic Rate

AFx

Intrinsic Rate

AF Suppression, AFx

Page 6: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

AF Suppression, AFx

AFx

Page 7: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

Search for intrinsic activity

67 66 65

Activity found(two P-waves)

64 65

Increase stimulation rate

74 74 7474

AF Suppression, AFx

ASAP AP ASAP APAP APVPVP VPVPVP VPVP VPVP

Page 8: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

… and to programme:

ON / OFF !AF Suppression, AFx

Page 9: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

AF Suppression™ Algorithm Overview

• Programmable: • ON• OFF (nominal)

• Screen: Parameters-Brady, AT/AF Detection & Response

• Only available in the following modes• DDD/R• AAI/R

Page 10: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

AF Suppression™ Algorithm Overview

Page 11: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

AF Suppression™ Algorithm Overview

Page 12: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

AF Suppression™ Algorithm Overview

•When the algorithm is activated, the device looks for

• 2 P-waves within 16 cycles• Only P-waves in the alert period will be used

• If 2 P-waves within 16 cycles are seen, the device will increase the atrial pacing rate

Page 13: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

AS AP AP AP AP AP AP AP AP AP AP AP AP AP AP AP AP0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Start 16-cycle counter

AS = P-waveAP = Atrial pacing

Only 1 P-wave was seen. Therefore, NO Overdrive occurs

End 16-cycle counter

Note: Notice how the algorithm starts with a “0” not a “1”

AF Suppression™ Algorithm Overview

Page 14: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

AF Suppression™ Algorithm Overview

AS AP AP AP AP AP AP AP AP AP AP AP AP AP AP AS0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15

Start 16-cycle counter

2 P-waves were seen therefore, Overdrive occurs

Start Overdrive

AS = P-waveAP = Atrial pacing

Page 15: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

AS AS

Overdrive Rate

Pacing Rate

2 P-waves were seen therefore, Overdrive occurs

AF Suppression™ Algorithm Overview

Page 16: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

AF Suppression™ Algorithm Overview

• A look-up table within the device determines the Overdrive rate

• The current atrial pacing rate is used to determine the increase in atrial rate

• The Maximum AF Suppression rate is the maximum rate for atrial overdrive pacing when AF Suppression is programmed on

Page 17: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

AF Suppression™ Algorithm Overview

• Once the atrial Overdrive rate is determined, the device will pace at this rate for a programmable number of cycles

• 15 (nominal), 20, 25, 30, 35 or 40 cycles

• When AF suppression is programmed ON, the Overdrive Pacing Cycles is the only programmable parameter

• Cycle count of 15 was programmed most often during the Adopt-A clinical trial

Page 18: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

AF Suppression™ Algorithm Overview

• Once the number of Overdrive cycles has been completed the Rate Recovery phase will start

• If the Overdrive rate is 100 ppm - 12 ms will be added to each cycle, resulting in a lower rate

• If the Overdrive rate is >100 ppm - 8 ms will be added to each cycle, resulting in a lower rate

Page 19: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

AS AS

Overdrive Rate

Pacing Rate

2 P-waves were seen therefore, Overdrive occurs followed by Rate Recovery

Pacing Rate

AF Suppression™ Algorithm Overview

Rate Recovery

Page 20: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

AF Suppression™ Algorithm Overview

What if there are additional P-waves sensed during the Overdrive portion?

Page 21: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

AF Suppression™ Algorithm Overview

• If 1 P-wave is sensed during the Overdrive portion, the 16 cycle counter will start

• If 2 P-waves are sensed within 16 cycles, the device will increase the atrial rate and Overdrive will start

Page 22: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

AS AS

Overdrive Rate

Pacing Rate Pacing Rate

AS AS

Overdrive Rate

AF Suppression™ Algorithm Overview

Rate Recovery

Page 23: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

AF Suppression™ Algorithm Overview

What if 1 P-wave is sensed in the Rate Recovery portion?

Page 24: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

AF Suppression™ Algorithm Overview

• If 1 P-wave is sensed during the Rate Recovery portion, the 16 cycle counter will start

• If 2 P-waves are sensed within 16 cycles, the device will increase the atrial rate and Overdrive will start

Page 25: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention

for internal use only

AS AS

Overdrive Rate

Pacing Rate Pacing Rate

ASAS

Overdrive Rate

Rate Recovery

Rate Recovery

AF Suppression™ Algorithm Overview

Page 26: AF Suppression Algorithm Overview for internal use only AF Suppression Algorithm Overview The goal is to keep atrial arrhythmias from occurring Prevention