aes biomedical capabilities & case studies · case studies on biomedical pharmaceutical and...

ADVANCED ENGINEERING SOLUTIONS INC.

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AES Biomedical Capabilities

AES Biomedical Capabilities & Case Studies




AES Biomedical Capabilities11/14/07

Advanced Engineering Solutions Inc. (AES), is one of the leading product design and engineering

consulting company providing product development and engineering solutions to major global companies.

• Aerospace

• Automotive

• Biomedical

• Chemical Industries

• Consumer Goods

• Electronic

• Environmental

• Energy

• Gas Turbine

• HVAC

• Industrial

• Oil & Gas

• Power Generation

• Process Industries

• Pumps

• Semiconductor

• Steam Turbine

• Turbo-machinary





Flow Modeling Solutions for the Biomedical, Healthcare & Pharmaceutical Industries

• Visualization and prediction of physical phenomena for crucial information.

• Understanding the physics into delicate and often inaccessible areas

• Helping the designer in design and development of bio-medical systems.

• System studies include: Respiratory, Pharmaceutical, breath-activated device, Drug

delivery (inhalers, etc.), Blood handling (pumps, separators), In vivo blood and non-

blood flow etc.





a. Troubleshooting: Diagnosing the problem and defects will be done faster, safer at less

cost.

b. Analyzing: Statically and Graphical data will reveal the cause/effect relationships to

improve performance and effectiveness.

c. Optimizing: Project viability and accuracy can be enhanced by doing number of changes

prior to laboratory testing to save time and money.

d. Understanding: Evaluate implications of changes in process variables to rapidly gain a

wider knowledge base at a low cost.

e. Reducing Development Time (Turn-around Time): Understanding the changes and

modifications for unsuccessful attempts before conducting time-consuming laboratory tests

and validations will be come down drastically and results in faster progress.

e. Reducing Development Cost

CFD Benefits





AES CFD Services

• Steady & Transient Flows

• Flow Distribution (Laminar & Turbulent ) using Different Turbulent Methods

• Incompressible and Compressible

• Swirling & Rotating Flows

• Conjugate Thermal Analysis

• Flow Through Porous Media

• Rotating Frames of Reference

• Multiple Species Transport,

• Multi-component & Multi Phase Flow- Mixing, Flashing, Reacting Evaporation

• Mixing

• Multiphase

• Fluid Structure Interaction (Including Deforming Grid),

• Radiation Modeling

• Cavitations

• Lagrangian Particle Tracking

• Forced & Natural Convection Heat Transfer

• Free Surfaces by VOF Method

• Deformable Meshes

• Design Optimization studies





Inhaler Performance

Design/Prototype Testing

Needles

Blood Processing Devices

Micro-Fluidic Diagnostic Devices

Manufacturing Process Optimization

Blood Pumps

Artificial Organs

CFD Applications -Medical Device Design & Performance

Inhaler

Inspiratory flow

Blood Pump





Medical Tubing Extrusion

Blow Molding of Medical Balloons

Micro-Electro-Mechanical Devices (MEMS)

3D Injection Molding

Compression Molding

Magnetic Drug Targeting

Blood flow within aneurysms Compression MoldingInjection

CFD Applications - Device Manufacturing Process





Diagnostic and Therapeutic Methods

Drug Delivery Modeling

Blood and Other Physiological Flows

Arteriosclerosis

Pathologies

Toxicology Research

Air Flow in Physiological Passages

Fluid Structure Interaction

Valve Modeling

Surgical Analysis

Complex Rheologies

Oxygenation

Multiphase Flow

Aerosol inhaler

Heart Throb

Bronchial tubes

CFD Applications - Physiological Transport Modeling





Presen

ted

to

Case Studies

on

Biomedical Pharmaceutical and healthcare





Case Study for real-time visualization of tissue viability and function

Objective :

• Real-time visualization of tissue viability and function based on computer simulations that will provide a new tool for

doctors to help them in planning.

• Pressure load calculations on the tissue walls and flow paths and directions at different locations of blood vessel (arteries)

CFD Modeling :

• Flow is 3D laminar, Steady and Incompressible & Conjugate heat transfer problem.

Task Executed:

• The model is created in Unigraphics. Tetrahedral meshing is carried out using ICEM. Analysis is carried out in CFX after

applying the material properties and different boundary conditions. Different plots are provided in the technical report using

CFX- Post-processing.

Conclusion & Reliability :

• our 3-D simulation models employing computational fluid dynamics (CFD) calculations of flow in blood vessels and

facilitates by improving our whole organ thermal modeling by developing an improved understanding of tissue perfusion,

metabolism, and vasculature blood flow under surgical or emergency conditions. .

CAD Model MeshPressure Contours for the blood vessel





CAD ModelMesh

Case Study for High Pressure Gas & Low Quantity Fluid Nozzle StudyObjective :

• CFD analysis to predict the flow pattern in the nozzle system.

• To predict the static pressure & total pressure distribution , velocity and mass flow distribution of liquid in the nozzle

system.

• To optimise the design.

CFD Modeling :

• Isothermal, Turbulent and steady incompressible flow in 3D Domain is solved in Ansys CFX 11 parallel solver.

Task Executed:

• The model is created in Unigraphics. Hexahedral meshing is carried out using ICEM. Analysis is carried out in CFX after




•From the Analysis, the static pressure, total pressure, mach number, static temperature, mass fractions of fluids at different

location and velocity components are plotted. Based on the analysis, the liquid gas ratio and performance are optimized

for the given design as per the SOW. Customer verified the initial results as well as optimized results obtained by CFD

analysis with the experimental data.

Contours : Stream lines, Velocity and mass fraction





Case Study for MEB mobile charger head coil assembly thermal analysisObjective :

• Neuro-modulation CFD Analysis describing the transient thermal performance of the MEB mobile charging head coil assembly in

multiple simulated cases is to simulate test conditions used during design verification testing. .

• Thermal performance includes the temperature distribution throughout the entire assembly to outer surface temperature.

• To estimate response times to reach the specified temperature by the sensors

CFD Modeling :

• Flow is 3D laminor, Steady and Incompressible & Conjugate heat transfer problem.

•Natural convection has been accounted.

Task Executed:

• The model is created in Unigraphics. Tetrahedral meshing is carried out using ICEM. Analysis is carried out in CFX after




• Performance of MEB mobile charging head coil assembly was estimated and suggestions on design changes made for the

improvement.

Cost Savings :

• Performance of MEB mobile charging head coil assembly validated before incurring heavy cost of prototyping and testing.

CAD ModelMesh

Surface Temperature Contours for the individual parts





Case Study for Vacuum Pressure Syndion Chamber Reactive Flow StudyObjective :

• Side injection simulation for predicting the flow patterns in the vacuum pressure chamber with reactions of SiF4 and F2.

• Realize the flow pattern and pressure distribution in the Syndion chamber.

• Use the simulation data as a tool to design and optimize gas injection and chamber geometry.

• Forecast the etch uniformity with the simulated data.

CFD Modeling :

• Flow is 3D Turbulent , Steady and Incompressible & reactive and species transport problem.• Chemistry: Si + 4F SiF4 & F+F F2 (All Walls)• Low pressure gas flow between 20 to 300 mTorr.

Task Executed:

• The model is created in Unigraphics. Hexahedral meshing is carried out using ICEM. Analysis is carried out in Fluent after


Fluent Post processing.


• Optimization was achieved for the uniform etching by doing iterative flow studies by varying the angle of flow, flow rate and

chamber operative pressure .

Cost Savings :

• Performance Syndion chamber validated before incurring heavy cost of multiple cases of testing.

CAD Model Mesh Surface Mass Fraction , Reaction , Velocity vectors and Stream lines




AES Biomedical Capabilities11/14/07

aes biomedical capabilities & case studies · case studies on biomedical pharmaceutical and...

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