Advancing Science and Understanding of

Human Microbiome, Diet and Health relationships

Sandrine Miller-Montgomery, PharmD, PhDProfessor of Practice – BioEngineeringExecutive Director of Center for Microbiome Innovation

IndustryPartner

s

Center for Microbiome Innovation

IP

Collab.Projects

Start-ups

External Educ.

Talent Promotion

and Education

Who are we?

Why do we care so much about Microbiome?

Life is Microbial

Brock Biology of Microorganisms, 13th Edition, 2012

• Only microbes for ~90%of history of life onEarth

Life is Microbial• Only microbes for ~90%of

history of life onEarth

• Vast majority of genetic diversity is microbial

YOU ARE HERE

YOU ARE HERE

Life is Microbial• Only microbes for ~90%of

history of life on Earth

• Vast majority of genetic diversity is microbial

• We are mostly microbial

~43%

Cells

• 3.0x 1013 human• 3.9 × 1013 microbial

Genes

• 2.0 x 104human• 2.0 × 106-7 microbial

~1%

We have been neglecting 99% of the genes that we can easily change!

The Gut is Not Vegas…

…what happens in the gut,

… does not stay in the gut

Example of the Gut Brain Axis

CMI generate Synergies between UC San Diego Labs and Industry partners to accelerate Microbiome discoveries

Resourceso Metagenomicso Metabolomicso Metatranscriptomicso Genomicso Multiplexing Proteomicso Flow Cytometryo Gnotobiotic animal modelso Wearable sensorso Teaching Hospital – access to patients

(cancer center, kids, VA…)

Applications exampleso Pharmaceutical (Oncology, Metabolic

disorders, CNS disorders…)

o Nutraceutical (pre and/or probiotics)

o Wellness (Aging)

o Food (Analysis and Personalized)

o Cosmetics

o Energy (renewable, optimization)

o Environment monitoring and remediation

o Agro-Biome

Algorithm and Analysis Powerhouse

Oral

Fecal

Vaginal

Skin

SPAdes &metaSPAdes

BiGG Models

CMI and the 4S of Food

SECURE SAFETY SATISFACTION SUSTAINABLE

The ins and outs Microbiome Science

Food

Gut

Insight

Global FoodOmicsMetabolomics: 2269 samples

Plant

Animal

Fungus

Complex

PCoA on MS2 data, Jaccard

Global FoodOmics ProjectMetabolomics data: 2269 food samples

Plant

Animal

Fungus

Complex

PCoA on MS2 data, Jaccard

Lauric acid

What goes in must come out

Xanthohumol

11-hydroxyl-THC11-Nor-9-carboxy-Delta-9-THC

Vaccenic acid

Riboflavin

Riboflavin Sclareol

Capsaicin

Dihydrocapsaicin

Xanthohumol Piperine

Vaccenic acid

Piperine

Roquefortine C

DioctylPhthalate

Vaccenic acid

Global Foodomic Project and GNPS – 88 AGP samples

Food

Gut

InsightAntimicrobials

Diet-related

Environmental

45,708

26,449

4,075

Advancing the Science and Understanding of the Human Microbiome, Diet and Health

SECURE SAFETY SATISFACTION SUSTAINABLE