adderall analysis: a comparison

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Adderall Analysis: A Comparison EJ Habina and Dan Palumbo

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Adderall Analysis: A Comparison. EJ Habina and Dan Palumbo. Purpose. Using FT-IR and NMR spectroscopy, evaluate an amphetamine salt isomer from a generic, prescription-brand adderall. - PowerPoint PPT Presentation

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Page 1: Adderall Analysis: A Comparison

Adderall Analysis:A Comparison

EJ Habina and Dan Palumbo

Page 2: Adderall Analysis: A Comparison

Purpose

• Using FT-IR and NMR spectroscopy, evaluate an amphetamine salt isomer from a generic, prescription-brand adderall.

• Compare results and structure of the generic brand to a name brand adderall and see if any difference exists.

Page 3: Adderall Analysis: A Comparison

Background• Adderall is a combination

of amphetamine salts used as medication to treat ADHD and narcolepsy

• Once Adderall enters the bloodstream, the amphetamines stimulate the brain's production of norepinephrine and dopamine

Page 4: Adderall Analysis: A Comparison

Adderall Composition

Page 5: Adderall Analysis: A Comparison

More Information

• Detection and analysis of amphetamine salts is important in forensic science due to their widespread abuse

• In non-ADHD users, Adderall produces a surge of focus and energy and an accompanying loss of appetite

Page 6: Adderall Analysis: A Comparison

Method 1: FT-IR

1. Crush tablet of dextroamphetamine sulfate to a fine powder

2. Run an IR scan in Organic Lab3. Determine structure based on peak reading4. Follow procedure above for generic and

name brand and compare peaks

Page 7: Adderall Analysis: A Comparison

FT-IR Spectra – Generic

Page 8: Adderall Analysis: A Comparison

FT-IR Spectra – Generic and Dextro salt

Page 9: Adderall Analysis: A Comparison

FT-IR Spectra – All three samples

Page 10: Adderall Analysis: A Comparison

Method 2: NMR

1. Dissolve 20mg of dextroamphetamine sulfate in 1mL D2O in an NMR tube

2. Run 13C-NMR 10k scans overnight3. Collect spectra and determine peaks4. Repeat for generic and name brand and

compare results

Page 11: Adderall Analysis: A Comparison

NMR Spectra – Dextro salt

Page 12: Adderall Analysis: A Comparison

NMR Spectra – Generic

Page 13: Adderall Analysis: A Comparison

NMR Spectra – Name Brand

Page 14: Adderall Analysis: A Comparison

Results

• We were able to produce successful spectra from both FT-IR and NMR for all three samples

• Comparatively, we found the peaks were virtually identical for the name brand and generic brand on both instruments

• We were also able to use the pure Dextro salt to identify specific peaks of interest as well as to prove our method was successful

Page 15: Adderall Analysis: A Comparison

Discussion

• Our original goal was to isolate one of the amphetamine salts and use it to spike a sample of pure Adderall

• However, the isolation process requires dangerous chemicals and lengthy procedures

• The one synthetic route we found is not stereo-selective so we could not tell which isomer we were isolating which set us up for error

Page 16: Adderall Analysis: A Comparison

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