Activities ofEORTCBTGCNSMetastases Committee

EmilieLeRhunLille,France

http://www.eortc.org/research_field/brain/

BTGcommittees

• Translational Research &Pathobiology• Quality Assurance• Quality ofLife• Imaging• SPECTA• Meningioma• CNSmetastasis

Missionstatement

• TheCNSMetastasis Committee orchestratesexperimental andclinical research activities withintheEORTCBrainTumor Group.• Scientificprojects focusonthepathogenesis ofbrain andLMmetastasis from solid tumors.• Clinical projects encompass neuroimagingapproaches andCSFstudies,specifically withregardstoresponse assessment.• Thecommittee seeks todevelop clinical trialprotocols exploring newagents.

Members ofthegroup

EmilieLeRhun,Lille(FR)

MartinBendzus,Heidelberg(DE)

FredericDhermain,Paris(FR)

MatthiasPreusser,Vienna(AT)

RiccardoSoffietti,Torino(IT)

Joerg-ChristianTonn,Munich (DE)

PieterWesseling,Nijmegen (NL)

FrankWinkler,Heidelberg(DE)

• Coordinator:ELeRhun(Zurich,Switzerland;Lille,France)• Co-coordinator:MBendszus (Heidelberg,Germany)

• ValidationoftheLANOgrid by10neuro-oncologistsand10neuroradiologists• Firstresults will be presented atthenext BTG(October20,2017)

ValidationofMRIRANOleptomeningeal metastases criteria

joined project with theBTGimaging group

PhaseIItrialofPembrolizumab withstereotacticradiosurgeryorPembrolizumab alonefortheTreatmentofPatientswithBrainMetastasisfromMelanomaorNon-SmallCellLung

Cancer(NSCLC)

• Studycoordinator:GMinniti,Milano,Italy• Study co-coordinator:ELeRhun,Lille,France

• Primary objective:CNS-specific PFSrateat6months

PatientswithBrainMetastasisfromMelanoma

PatientswithBrainMetastasisfromNon-SmallCellLungCancer(NSCLC)

R

R

single-fractionSRSpluspembrolizumab

pembrolizumab alone

single-fractionSRSpluspembrolizumab

pembrolizumab alone

Newproposals

• Newprojects arewelcome!• RequestsforsuchprojectsshouldbesubmittedtotheChairoftheEORTCBTGCNSMetastasisCommittee.• Funding:attheresponsability ofthecoordinator ofthestudy,with thehelpoftheEORTCandtheCNSmetastases committee.