acquired heart disease prof. abdullah al-jarallah, md. pediatric cardiologist
TRANSCRIPT
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Acquired Heart Disease
Prof. Abdullah Al-Jarallah, MD.Pediatric Cardiologist
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Acquired Heart disease
• Disease affecting cardiac tissue and function which does not have its inception at birth and usually is secondary to an extraneous agent.
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Types of Acquired Heart Disease
• Ischemic / hypoxic• Hypertensive• infectious• Inflammatory• Metabolic• Nutritional• Traumatic
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Ischemic / Hypoxic
• Coronary occlusiono Atherosclerosiso Kawasaki Diseaseo Sickle cell anemia
• Hypoperfusiono Surgical ischemic arresto severe hypotension
• Asphyxia
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Hypertensive
• Systemic hypertension• Pulmonary hypertension
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Infectious
• Pericarditis• Myocarditis• Endocarditis
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Inflammatory
• Post-pericardiotomy Syndrome• Rheumatic fever• Collagen vascular Diseases
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Metabolic
• Endocrine adenopathyo Adrenalo Pituitaryo Pancreatico Thyroido Parathyroid
• Storage diseaseso Glycogeno Mucopolysacchrides
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Nutritional
• Nutritional deficiencieso Starvationo Vitamino Mineralo Carnitine
• Nutritional Excesseso Obesityo Vitamino Mineral
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Traumatic
• Penetrating• Blunt
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• Kawasaki Disease• Pericarditis and post-pericardiotomy
syndrome• Myocarditis / congestive Cardiomyopathy• Infectious Endocarditis• Rheumatic heart disease
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Kawasaki Disease
• Recognized in 1970’s• Inflammatory disease of unknown etiology• 9.2/100,000 cases per year; usually <4 y/o• Winter and spring; 3yr”epidemics”• Asiatics and blacks > white: 9&1.5/1
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Kawasaki’s Disease Pathophysiology
• Immunoregulatory anomalieso Activation of T and B lymphocyteso Production of immunoglobulins and cytokineso wide spread immune reaction
• Generalized microvasculitis• Myocardial and pericardial inflammation• Coronary vasculitis
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Kawasaki’s Disease Clinical Manifestations• Fever of 5 + days duration• Physical findings
o Polymorphous rasho Non-purulent conjunctivitiso Erythema of oral membranes including tongueo Indurative edema of hands and feeto Cervical lymphadenopathy
• Acute and often severe toxic presentation• multi-organ involvement
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Kawasaki’s Disease Laboratory Findings
• Elevated acute phase reactants• Elevated ESR• Elevated Platelets• Myocardial dysfunction• Pericardial effusion• Coronary thickening ---> coronary
dilatation and aneurysm
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Kawasaki's Disease- Cardiovascular Stages
• 20% of untreated; 2-4% with treatment• Stage1: Week 1-2
o Microvasculitiso Peri, myo, and endocarditiso endocarditis and perivasculitis of coronaries
• Stage 2: Week 1.5-3o Vasculitis of coronaries with aneurysms and thrombio intimal proliferation of coronarieso peri, myo-, and endocarditis
• Stage 3: Week 4-5o Scaring and intimal thickening of Coronarieso Myocardial infarction
• Stage 4: >2m0o Advanced coronary artery diseaseo Myocardial Fibrosis
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Echocardiographic Findings
• Acute phase:o Pericardial effusiono LV dysfunctiono Diffuse coronary artery wall thickening and
dilatation in 30-50%• Coronary dilatation
o <5y/o, lumen >3 mmo Sacular or fusiform
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Treatment
• IVGG: 2g/kg over 24 hrs• ASA:
o 20-25 mg/kg/dose, q 6 hrs until afebrile 2-3 days
o 3-5 mg/kg/day 6-8 weeks, until ESR and plt count normal Indefinitely if coronary artery anomalies
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Pericarditis / post-pericardiotomy Syndrome
• Inflammation(infection) of pericardial space• Chest pain• Friction rub• Pericardial effusion• Fever• Elevated ESR
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Pericarditis
• Viral• Purulent• Tuberculous• Rheumatic• Kawasaki• Uremic
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Post - pericardiotomy Syndrome
• 30%, if pericardium opened• 1-2 weeks post surgery• Etiology??
o Viral Autoimmune• Symptoms:
o Fevero Chest paino Friction rubo Pericardial effusion
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Post - pericardiotomy syndrome
• Treatment:o ASA: 50-75 mg/kg/day; 4-6 weekso Steroids: 2mg/kg/day; taper over 3-4 weekso Diuretics (cautiously)
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Cardiac tamponade
• Pathophysiologyo Increase in pericardial fluid which elevates
filling pressures, impedes ventricular filling and decreases cardiac output
o Rapid small volume increase versus large chronic volume
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Cardiac Tamponade
• Physical findingso Decreased heart soundso Distended jugular veinso Pulsus paradoxus
>10 mmHg decrease in SBP with inspiration Increased pooling of blood in pulmonary bed due to
decreased LV filling
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Cardiac tamponade• ECG:
o Low voltageo ST - T wave changeso Electrical alternans
• CXRo “Water - bottle” heart, if large volumeo Normal, if acute
• ECHOo space between heart and pericardiumo Swinging hearto Inspiratory variation in Doppler flows
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Myocarditis / Congestive Cardiomyopathy
• Infection of myocardium with lymphocytic infiltration
• Degenerative process affecting myocytes• Impairment of myocardial function
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Myocarditis - Etiology
• Viral - Coxackievirus, ECHO, adeno, etc.• Bacterial - Tuberculosis, strep, etc.• Fungal - unusual• Protozoan - Chaga’s disease (T.cruzi),
malaria, toxoplasmosis• Rickettsial• Spirochetal• metazoal - trichinosis, echinococcosis, etc.
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Congestive Cardiomyopathy - Etiology
• Infectious - viral• familial - duchenne’s• Metabolic - glycogen storage• Ischemic - Kawasaki• Toxic - anthracyclines• Nutritional - carnitine
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Clinical Manifestation
• General malaise or viral syndrome• low cardiac output state (Shock)• Gallop rhythm (mitral insufficiency)• ST - T wave changes• ECHO:
o Reduced shortening fractiono Segmental wall motion anomalieso Valvar insufficiency
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CourseMyocarditis
70-80% 20-30%Mild-Mod CHF Severe CHF
60-70% 10-20% 10%Recovery Dil.Cardiomyo Death/Trans
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Diagnosis
• Clinical findings• Identification of etiologic agent• Endomyocardial biopsy
o Lymphocytic infiltrateo Etiologic agento Necrosiso “Staging”
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Treatment• Symptomatic
o inotropeso Diureticso afterload reduction
• Correction of etiology• Immunosupression
o Steroidso Anti-viralso Cyclosporino Interferon
• Transplantation
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Infective Endocarditis• Microbial infection of endocardial surface of heart
- valves or wall• “Acute” (virulent) / “subacute” (prolonged)• 1:1800 to 1:4500 ped cases: admissions• Any age; greater in 5th decade• Pre-v. post-antibiotic era - no change• Factors:
o Better diagnosiso Drug abuseo Treatment modalities
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Etiology
• Alpha hemolytic strep: most common (>60%); prolonged
• Staph aureus: 2nd most common (20%); virulent
• Beta hemolytic strep: uncommon• Coagulase negative Staph: increasing• Candida
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Risk Factors
• High Risko Prosthetic valveso Surgical shuntso Indwelling catheterso Previous SBE
• Moderate Risko PDAo VSDo ASD (not secondum)o Bicuspid aortic valve o RHDo MVP with MR
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Clinical Manifestations
• Fevero High (Staph)o Low (Strep)
• “Viral syndrome”• New murmur• CHF• Petechiae• Inc ESR, anemia, hematuria
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Diagnosis
• Blood Cultureo Positive off antibioticso 5-8% negative cultureso 2-3 sets over 24 hrs; (as much as possible)
• ECHO:o Vegitationso Valve insufficiency
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Treatment
• Specific anti-microbial• 4-6 weeks IV• 2 weeks w/wo P.O.• Surgery, esp. prosthetic valves
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Prophylaxis
• AHA guidelineso Amoxicillin - oral, upper resp procedureso Clindamycin (penicillin allergic)o Amp and gent or vancomycin - GU or GI
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Rheumatic Fever
• Most common cause of acquired heart disease in children (5-15 y peak of 8 y)
• USA: 0.5-3.0/100,000 (1900: 100-200/100,000)
• Post- infectious connective tissue response in susceptible host
• Group A beta- hemolytic streptococcus infection of the pharynx
• F/H of RHD and low socioecnomic status.
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Pathophysiology
• 1960 Kaplan and coworkers- show an antigenic “similarity” between strep cell walls and myocardium.
• An autoimmune response to strep group A with cross reaction to myocardium.
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Jones Criteria• Major
o Carditis: 40-50%o Arthritis: 60-85%o Chorea; 15%o Erythema marginatum: 10%o Subcutaneous nodules; 2-10%
• Minoro Clinical: Arthralgia, fever and H/O RF or RHDo Laboratory:Elevated ESR, C-reactive protein and
Prolonged PR interval• Must have evidence for strep infection (Inc ASO,
+ve culture or recent scarlet fever).
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Arthritis
• Most common manifestation• Monoarticular, usually large joints• Migratory or Fleeting• Good response to ASA• No residual effect
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Carditis
• 1-2 weeks after Strep; may be delayed• Inflammation of:
o Endocardium: Valveso Myocardium (Tachycardia,cardiomegally and
Heart failure).o Pericardium: Rub or PE ( rare)
• Prior attack predisposes to recurrence• The only feature which cause permanent
damage.
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Valvular Involvement
• Mitralo Insufficiency; mild to severe (Carey-Coombs)o Congestive heart failureo Stenosis, late
• Aortico Insufficiencyo Less common but more severe
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Chorea
• Sydenham’s chorea or St. Vitus’ dance• Prepubertal girls (8-12y)• First emotional lability and personality
changes• Followed by loss of motor coordination -
characteristic spontaneous, purposeless movement and motor weakness
• It is often an isolated manifestation.
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Erythema Marginatum
• Nonpruritic serpiginous or annular erythematous rashes.
• Most prominent on the trunk and inner proximal portions of the extremities.
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Subcutaneous Nodules
• Hard, painless, nonpruritic, freely movable, swelling, 0.2-2.0 cm in diameter.
• Symmetrical, single or clusters• On the extensor surfaces of both large and
small joints, scalp or along the spine.
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Investigations
• Elevated ESR• ASO > 333 Todd units• Throat culture• Leukocytosis• Hypochromic microcytic anemia• ECG: first degree heart block, arrhythmia.• CXR: progressive cardiac enlargement.• ECHO.
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Treatment
• Cardiac supportiveo Bed rest 1-2 Wo Immobilise inflammed jointso ASA 100 mg/kg/d (level 20 mg/100 ml) - side
effects (after diagnosis of RF is made)o Benz Penicillin G 0.6-1.2 million U for
eradicationo Steroids Prednisone (severe carditis) 2 mg/kg /d
2-4 W ???o Treatment of CHF- Digoxin toxisity
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Prevention
• Any pt with documented H/O RF• Prophylaxis after attack: until 21-25y of age• Benzathine Penicillin 1.2 million U IM q 28
d. or Erythromycin 250 mg BID for penicillin allergics