acqua e sale aghe (ago) e saal - sito acemc · 2015-01-23 · aghe (ago) e saal. mi raccomando,...
TRANSCRIPT
![Page 1: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/1.jpg)
Acqua e sale
Aghe (ago) e saal
![Page 2: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/2.jpg)
Mi raccomando, beva molto!
![Page 3: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/3.jpg)
Bruera E et alParenteral Hydration in Patients With Advanced Cancer: A Multicenter, Double-Blind, Placebo-Controlled RandomizedTrial
JCO January 1, 2013 vol. 31 no. 1 111-118
Hydration at 1 L per day did notimprove symptoms, quality of life, or survival compared with placebo
![Page 4: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/4.jpg)
• …common, particularly in hospital patients and elderlypeople
• …mild disorders may be asymptomatic and self limiting, but severe disorders are associated with considerablemorbidity and mortality
• …causes are often iatrogenic and therefore avoidable
BMJ 2006;332:702-705
![Page 5: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/5.jpg)
Whelan B et al. Serum sodium as a risk factor for in-hospital mortality in acute unselected general medical patients.
QJM. 2009;102:175–82
14,239 emergency medical patients over a 5-year period, mortality was the highest in patients whoseNa level was <125 or >140 mmol/L
99 192
![Page 6: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/6.jpg)
![Page 7: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/7.jpg)
TBW(Total Body Water)
60% of body weight
2/3 ICF 1/3 ECF
Water…
![Page 8: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/8.jpg)
Osmolality is a physical property dependenton the total number of solute particles presentin a solution
Tonicity is a physiological processdependent upon the selectively permeablecharacteristics of a membrane
![Page 9: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/9.jpg)
[Na]p is the main determinant of plasma
osmolality and therefore of the total water
balance among the body fluid compartments
2 Na+ + Glucose + BUN18 2.8
Posm =
![Page 10: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/10.jpg)
RELATIVE PERMEABILITY ACROSS MEMBRANES
Na 1
GLUCOSE 104
UREA 106
WATER 1010
![Page 11: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/11.jpg)
Water moves from solution with the lower concentration to the
solution with the higherconcentration: this is
OSMOSIS
From the lower to the higher
![Page 12: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/12.jpg)
TBW(Total Body Water)
60% of body weight
2/3 ICF 1/3 ECF
Na
H20
![Page 13: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/13.jpg)
ECF ICF
H2O
ECF Osm <= > ICF Osm
![Page 14: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/14.jpg)
High[Na+]
ECF
H20
ICF
CELLSHRINKAGE
![Page 15: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/15.jpg)
Low[Na+]
ECF
CellSwelling
H20
CELL SWELLING
ICF
![Page 16: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/16.jpg)
TBW(Total Body Water)60% of body weight
2/3 ICF 1/3 ECF
Na
H20
¾ INT1/4 PL
![Page 17: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/17.jpg)
EABV
Tissues Perfusion
(700 ml)
* large molecules
![Page 18: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/18.jpg)
Evaluate volume status
ECF volume
EABV
![Page 19: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/19.jpg)
ECF
EABV
ECF
EABV
ECF
EABV
ECF
EABV
1 2
3 4
ECF EABV
ECF EABV
ECF EABV
![Page 20: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/20.jpg)
cell
inter‐stitium
plasma
0,8 – 0,75
0,2 – 0,25
edema
Raghunathan K et al. Curr Opin Crit Care 2012, 18:350–357
However, this model is
not consistent with the observed effects
![Page 21: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/21.jpg)
Gluc. 5% 0
NaCl 0,45% 77
Ringer 130
NaCl 0,9 % 154
![Page 22: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/22.jpg)
![Page 23: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/23.jpg)
GIFTAHo; an improvement on GIFTASuP? New
NICE guidelines on intravenous fluids
Woodcock T Anaesthesia 2014, 69, 399–419
![Page 24: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/24.jpg)
The pathophysiology of the host response to stress includes activation of the neurohumoral system that is targeted atconserving both sodium and water through the renin–angiotensin–aldosterone axis, natriuretic peptides, the sympathetic nervoussystem and antidiuretic hormone.
The amount and type of fluid administered by cliniciansto critically ill patients affects this acute adaptativeresponse and , through this, may affect subsequent survivaland recovery.
Saxena MK Crit Care Res 2013 15; 2:75-76
![Page 25: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/25.jpg)
RSE&GM
Revised Starling equation (RSE) and the
glycocalyx model (GM) of transvascular fluid
exchange: an improved paradigm for
prescribing intravenous fluid therapy
Bye, bye Starling?
![Page 26: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/26.jpg)
There are three intravascular volumes:
plasma volume
red cell volume
circulating blood volume
non-circulating intravascular
volume
glycoclaix*
glycocalix*
* 1.5 litres of the intravascular volume in health
o plasma volume
o red cell volume
o glycocalix
red cell
Woodcock TE, Woodcock TM British Journal of Anaesthesia 108 (3): 384–94 (2012) (modified)
![Page 27: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/27.jpg)
Fluid Expansion as Supportive
Therapy
(FEAST) trial
Maitland K, Kiguli S, Opoka RO, et al. Mortality after fluid bolus in African children with severe infection
N Engl J Med 2011, 64:2483-2495.
![Page 28: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/28.jpg)
bolus
no bolus
the trial was stopped after the recruitment of
3141 patients when bolus-fluid resuscitation with
albumin or saline was shown to increase the
absolute risk of death at 48 hours by 3.3 % and the risk
of death, neurologic sequelae, or both at 4 weeks by 4%.
![Page 29: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/29.jpg)
“Should we just carry on doing what we have alwaysdone, which is essentially giving too much fluid?”
“Or should we make some effort to be a bit more thoughtful in what we are doing and reduce the amount of fluid?
Finfer S Issue 1 18 March 2014 ISICEM News
![Page 30: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/30.jpg)
To the Executive Director of the European Medicines Agency
We are concerned that the European Medicines Agency’s
(EMA) Pharmacovigilance Risk Assessment Committee’s
(PRAC) recent conclusions on the use of hydroxyethyl starch
(HES) will result in harm to patients.
R. BellomoJ. Bion*S. FinferJ. MyburghA. PernerK. Reinharton behalf of all co-signatories
Br J Anaesth 2014 Mar;112(3):595-600
![Page 31: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/31.jpg)
The end of saline solutions?
I think its only real role is in replacing sodium and chloride in patients that are both volume depleted and have a deficit in sodium and chloride.
Lactated Ringer’s solution is perfectly reasonable as an alternative, and if clinicians were to make that change, one would expect to see a drop in the rate of AKI and dialysis.
J.Kellum
![Page 32: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/32.jpg)
![Page 33: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/33.jpg)
Humans evolved as long distance persistence hunters on
the arid savannahs of south and east Africa.
Because of our evolutionary history, we are delayed
drinkers and correct the fluid deficits generated by
exercise at, for example, the next meal, when the
electrolyte (principally sodium but also potassium) deficits
are also corrected.
As a result, there is no need to completely replace any fluid
deficit as it develops either at rest or during exercise.
Instead people optimise their hydration status by
drinking according to the dictates of thirst.
Noakes TD BMJ 2012;344:e4171
![Page 34: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/34.jpg)
Mythbusters
![Page 35: Acqua e sale Aghe (ago) e saal - Sito AcEMC · 2015-01-23 · Aghe (ago) e saal. Mi raccomando, beva molto! Bruera E et al Parenteral Hydration in Patients With Advanced Cancer: A](https://reader031.vdocuments.site/reader031/viewer/2022011911/5f8e4ef60f427a1d1a78f968/html5/thumbnails/35.jpg)
Dar da bere agli assetati.
Soprattutto quelli che non possono farlo e non possono chiederlo.