ACKNOWLEDGMENT

The Editors of the Journal of Clinical Investigation gratefully acknowledge the assistance of the followingreviewers:'°

Nabih I. AbdouHerbert AbelsonGeorge AbrahamJohn W. AdamsonRobert S. AdelsteinSiamak AdibiSheldon AdlerVincent AgnelloZalman AgusGail AhumadaGerard AilhaudPhilip AisenAlan C. AisenbergQais Al-AwqatiJohn J. AlbersAl AlbertsEdward A. AlexanderR. Wayne AlexanderCharles A. Alford, Jr.Norma AlkjaersigJulius C. AllenRobert H. AllenChester A. AlperLeonard C. AltmanConstantine AnastRobert AndersonThomas E. AndreoliReubin AndresNickolas R. AnthonisenMichael AntonaccioNobuo AokiThomas T. AokiCarl S. ApsteinAllen I. ArieffAkira ArimuraClaude ArnaudBarry ArnasonPeter S. AronsonEdward R. ArquillaJose ArrudaRobert F. AshmanG. AssmanRichard AsterJohn W. AthensKen AultDennis A. AusielloFrank AustenMary Ellen AveryLouis V. AvioliBernard M. BabiorMichael K. BachHoward P. Baden

Robert L. BaehnerJacques U. BaenzigerNancy BaenzigerCarol J. BakerJohn R. BakerPhilip L. BallardArthur BankRobert S. BarJose BarbosaClyde Wayne BardinWilliam H. BarryPhilip J. BarterDavid BassPaul BassRobert BastFrederick C. BattagliaEugene BauerJohn BaxterSteven BaylinDavid BaylinkJohn W. BaynesE. H. BeachyArthur BeaudetM. A. BeavenWilliam S. BeckElmer L. BeckerMichael A. BeckerJose BeharPaul BeigelmanElliot BellNorman BellWilliam R. BellGeorge BellerElsa Bello-ReussEarl P. BendittRuth BeneschVann BennettWilliam M. BennettCostan BerardHarvey BergerNathan BergerM. G. BergeronSteve BergmanPaul D. BerkTomas BerlRichard BerlinRobert BerlinerHenry R. Besch, Jr.Dan BestenPiero BaincaniCelso BiancoWilliam Biddison

John BienenstockDennis BierG. BieseckerJohn P. BilezikianDavid BilheimerHenry J. BinderStanley BirgeLutz BirnbaumerAlan BisnoDwight BisselRobert BittmanWilliam G. BlackardR. Michael BlaeseRoland C. BlantzBennett L. BlitzerColin BloorConrad BlumThomas F. BoatRichard BockmanGunter BodenEdgar C. BoedekerDavid H. BoldtGerald BonaHerbert L. BonkowskyRobert J. BonneyJoseph V. BonventreWayne A. BorderPaul BornsteinJames E. BourdeauHenry R. BourneLaurence A. BoxerJames L. BoyerThomas BracialeRalph A. BradshawRoscoe 0. BradyAllen BrashGlenn BraunsteinLewis BravermanGeorge A. BrayPeter BrecherJan L. BreslowRubin BresslerBryan BrewerKenneth L. BrighamMichael BristowArthur BroadusJohn BrockmanSamuel BroderJerome BrodyMichael BrodyMichael BrookeBarbara Brown

Edward M. BrownElmer B. BrownMarvin R. BrownMichael BrownWilliam R. BrownMichael J. BrownsteinHal E. BroxmeyerGeorge BrozeJohn D. BrunzellThomas M. BuchananPat BuckleyRebecca H. BuckleyJohn E. BuerkertBernadine BulckleyRuth E. BulgerH. Franklin BunnSteven J. BurakoffJohn BurchIan M. BurrMaria BuseWilliam W. BusseVincent P. Butler, Jr.William T. ButlerJean-Claude BystrynEdward CadmanMichael E. CainEdward J. CampbellRobert CampbellGeorge CannellosHarvey CantorJ. Donald CapraMartin C. CareyRobert M. CareyBernard CarpenterCharles B. CarpenterOscar A. CarreteroEdgar S. CathcartKevin CattJames CavellAnthony CeramiBruce A. ChabnerT. J. ChambersLawrence ChanHugh ChaplinHarold ChapmanSamuel CharacheAlan N. CharneyLewis R. ChaseNeil S. CherniakAlan CherringtonPaul A. ChervenickLeonard Chess

' These reviewers served 1 August 1981 through 31 July 1982.

i

William L. ChickKenneth ChienJohn ChirgwinFrancis V. ChisariInder ChopraAndreas C. ChrambachJames ChristensenW. H. ChurchillHenry N. ClamanJerry ClamonJames H. ClarkMargaret R. ClarkRobert A. ClarkThomas B. ClarksonJohn A. ClementsBrian Lee CevingerR. E. ClouseWilliam E. ClutterFrederick R. CobbJack CoburnCharles G. CochraneEd CodmanFredric L. CoeMartin G. CoganAllen B. CohenHarvey J. CohenMargo P. CohenR. D. CohenSidney CohenFrances S. ColeBarry CollerRobert W. ColmanWilson S. ColucciWilliam E. ConnorG. ControniNeil R. CooperRichard A. CooperPeter CorrRamzi S. CotranRichard CoulsonWilliam CouserJames W. CovellJoseph CoylePhilip R. CraddockJ. E. CraigheadJames CrapoCarroll E. CrossWilliam F. CrowleyPhilip CryerRonald G. CrystalCharlotte Cunningham-

RundlesSamuel W. CushmanMichael P. CzechDavid C. DaleEdwin E. DanielDavid R. DantzkerJohn DavidEugene DavidsonEarl DavieJoseph M. DavieAlbert 0. DaviesBernard B. DavisPamela DavisChristopher A. DawsonHaile T. DebasWilliam M. Deen

Ralph A. DeFronzoLeonard J. DeftosLeslie J. DeGrootRalph B. DellJay DelmezAlfred DeMariaLawrence DenBestenVincent DennisJoseph D'ErcoleReed DetarThomas DetwilerThomas DeuelRichard D. DiamondGerald Di BonaJohn DietschyCharles DinarelloWarren F. DivenG. Robert DluhyJohn DobbinsWilliam 0. Dobbins, IIIRobert M. Donaldson, Jr.Russel F. DoolittleMartin E. DorfSteven D. DouglasThomas DousaJeffrey DrazenMarc DreznerWilliam C. DuaneThomas D. DuBose, Jr.Lewis DubroffMaria DuFauMichael J. DunnHarriet DustanPeter James DyckR. Philip EatonDwain L. EckbergNorman EdelmanThomas S. EdgingtonNeil EdwardsRichard EffrosE. N. EhrlichMichael G. EhrlichAli EhsaniArthur Z. EisenHerman N. EisenGeorge S. EisenbarthShlomo EisenbergGerald ElfenbeinKlaus D. ElgertWilliam H. ElliottPeter ElsbachJohn W. EnsinckWilliam D. EnsmingerMark EntmanFranklin EpsteinLois B. EpsteinMurray EpsteinRichard W. ErbeAllan J. ErslevCharles EsmonAlfred F. EsserMarilynn E. EtzlerJohn H. ExtonAlan I. FadenJohn L. FaheyJohn N. FainStefan Fajans

Harold J. FallonBarry L. FanburgDarrell D. FanestilJoseph C. FantoneMarilyn FarquharAnthony S. FauciMurray J. FavusDouglas T. FearonMark FeldmanPhilip FeligVictor J. FerransThomas F. FerrisMichael FieldChristopher J. FieldingBernard N. FieldsLaurence FinbergClement A. FinchMichael FinchSteven R. FindlayLeon G. FineAlan FinkelsteinBarry FirkinMichael FischbachJ. E. FischerAron B. FisherM. M. FisherRobert FisherRonald FisherRobert FishmanWilliam H. FishmanCoy Dean FitchGarret A. FitzgeraldHerbert FleischJohn R. FletcherJeffrey FlierJohn C. FloydAlan M. FogelmanJohn FoltsJohn FordtranE. Lee ForkerM. L. ForslingRobert E. ForsterGordon ForstnerCynthia Foss-BowmanDaniel FosterIrving H. FoxJoan E. B. FoxKeith FoxHarry A. FozzardLinda FranciscoRoberto Franco-SaenzMichael M. FrankAndrew G. FrantzDonald S. FredricksonFrank FrenchEugene FrenkelWalter FriedCarl FriedenRobert FriedlerHenry G. FriesenGottlieb FriesingerLarry A. FrohmanHarold M. FrostDavid W. FryJames E. GadekJohn I. GallinGloria Gallo

Robert C. GalloAlan GarberJerry GardnerJames GavinHaralambos GavrasHoward M. GebelBernard GeeMarlys H. GeeRaif S. GehaLarry GelbErwin W. GelfandF. John GennariSaul M. GenuthMichael C. GeokasJames N. GeorgeWilliam J. GeorgeJohn GergelyJohn E. GerichRichard K. GershonDavid GewirtzAllan GibofskyKenneth GibsonStephen J. GiddingsIrma GigliJoan GilMichael Gimbrone, Jr.Ronald GingerichF. Ginsberg-FellnerDavid GlassJonathan GlassRichard GlassockM. P. GlauserGerald J. GleichRobert GlewRobert GlickmanJohn A. GlomsetLouis GluckC. J. GlueckR. Jon GoerkeEdward J. GoetzlWarren GoldAlfred L. GoldbergAndrew GoldbergStanley GoldinI. David GoldmanMichael D. GoldmanPeter GoldmanRalph GoldsmithGideon GoldsteinIra M. GoldsteinJ. H. GoldsteinJoseph L. GoldsteinMilton N. GoldsteinBoaz GonenRobert A. GoodTheodore L. GoodfriendDeWitt S. GoodmanH. M. GoodmanLawrence T. GoodnoughKenneth GoodrumJames S. GoodwinSherwood L. GorbachPhillip GordenJeff GordonCarl GoreskyArnold Bernard GorinRobert R. Gorman

ii

Emil C. GotschlichAntonio M. Gotto, Jr.Carl W. GottschalkRaj K. GoyalDavid GrahamRichard GrandDaryl GrannerJared J. GranthamGary M. GrayR. W. GrayMelvin F. GreavesHoward GreenIra GreenWilliam GreenJoel Steven GreenbergerDavid J. GreenblattWarner GreeneMel GreenesJoseph C. Greenfield, Jr.Paul GreengardHoward GreyJames E. GriffinOwen W. GriffithRogers GriffithGerold M. GrodskyJerome GroopmanJerome GrossWilliam GrossmanScott GrundyVictor GuerievichGuido GuidottiLarry GuilbertRobert B. GunnSudhir GuptaPaul H. GuthJohn HaddadJim HagbergBevra HahnTheodore J. HahnRaymond M. HakimCharles A. HalesCharles A. HallDan HalmPerry V. HalushkaPavel HametDale HammarschmidtMarc R. HammermanMargit HamoshRobert I. HandinJoseph S. HandlerJacques HanouneRussell F. HansonW. G. M. HardisonLaurence A. HarkerDonald R. HarknessPeter C. HarpelEdward D. HarrisT. R. HarrisTed HarrisHerschel HarterL. Howard HarleyMark HausslerRichard J. HavelJack HawigerWilliam H. HayMorey W. HaymondBurton Haynes

John P. HayslettWilliam R. HazzardRobert P. HeaneyHunter Heath IIISteven HebertAaron HeifitzWilliam C. HeirdDonald D. HeistadWilliam D. HeizerAri HeleniasSandy I. HelmanCraig HendersonR. I. HenkenChristopher HenneyHelen HenryPhilip HenryMichael HershfieldRon HerbermanGeoffrey HerzigMichael HessScot HickmanJacob HildebrandtHarry R. HillDavid HillisRichard E. HillmanRobert HillmanPatricia M. HinkleRaymond L. HintzJack HirschMartin S. HirschKurt HirschhornRochelle HirschhornJohn C. HoakW. Alan HodsonA. V. HoffbrandBrian HoffmanSandy HoffmanAlan F. HofmannT. HokfeltMichael F. HolickSally HolickWilliam HollanderHolm HolmsenJohn 0. HolloszyPeter R. HoltRichard HongWilliam B. Hood, Jr.John J. HooksPeter HoonMartin I. HorowitzRichard HortonDavid A. HorwitzMarcus A. HorwitzThomas H. HostetterDavid HowseRalph R. HonellRodney R. HowellStephen HowellJohn R. HoyerLeon W. HoyerAnastacio M. Hoyumpa, Jr.Keith HruskaBernadette HughesTony E. HugliTitus HuismanDavid HumesGary Hunninghake

John HuttonRichard W. HydeRichard 0. HynesIekuni IchikawaTadashi InagamiRoland IngramJoanne IngwallT. L. InnerarityPaul A. InselKimishige IshizakaH. IsraelMervyn IsraelKurt J. IsselbacherSeiki ItoJoel L. IveyCraig JacksonRichard L. JacksonH. S. JacobLaurence JacobsHarry R. JacobsonWilliam E. JacobusAllan JaffeBernard M. JaffeEric A. JaffeBarbara A. JakschikRobert JamesW. P. T. JamesRex L. JamisonCharles A. Janeway, Jr.Aaron JanoffLeonard JarettHugo E. JasinK. N. JeejeebhoyJohn JeffreyMarty JendrisakR. G. JensenRobert T. JensenAlan JohnsonLeonard R. JohnsonRobert L. JohnsonC. Conrad JohnstonRichard B. JohnstonKeith JoinerAlbert L. JonesPatricia JonesCraig JordanRobert E. JordanMark E. JosephsonMartin KagnoffC. Ronald KahnRonald Kenneth KalkhoffGeorge KaloyanidesDonald L. KaminskiYuet Wai KanJohn P. KaneA. H. KangFred S. KantorAllen P. KaplanKaren KaplanManuel E. KaplanMelvin H. KaplanNorman M. KaplanSolomon A. KaplanNeil KaplowitzA. KappasJohn H. KaramIrene Karl

Manfred L. KarnovskyRichard E. KatholiArnold KatzDavid H. KatzPaul KatzWilliam F. KeaneHarry R. KeiserVicki E. KelleyClaudia KentJohn H. KerseyKenneth KiddYoung S. KimRichard J. KingMadeleine KirchbergerManfred KirchgessnerJohn M. KissaneAhmed KissebachAbbas E. KitabchiA. KitaharaCraig KitchensRobert KlauerSeymour KlebanoffCharles R. KleemanJohn KlockFrancis J. KlockeRobert A. KlockeRobert A. KlonerPhilip KnaufFranklyn G. KnoxGeorge KobayashiH. Phillip KoefflerPeter F. KohlerJuha KokkoFred Kolhouse0. G. KoltermanValentina KonTetsuro KonoIrwin J. KopinJoel D. KoppleStanley KrenmanDavid R. KostrevaTheodore A. KotchenStephen M. KraneNicholas KredichAlan KrenskeyNorman KretchmerDorothy T. KriegerDavid KritchevskyDonald KrogstadRonald J. KroneOtto KuchelAnthony Kulczycki, Jr.Rajiv KumarCalvin KuninHenry KunkelNeil A. KurtzmanKiyoshi KurokawaJames P. KushnerWilliam W. LacyJack LadensonJ. Thomas LamontLewis LandsbergM. Daniel LaneLouis LangeGlenn A. LangerKathryn F. LaNoueMichael La Posata

iii

John H. LaraghP. Reed LarsenSamuel LattBernhard H. LauterburgAlexander LawtonSandy LawtonHerbert LazarusAlexander LeafHarold E. LebovitzBrenda LeckieJohn P. LeddyWilliam Jonathan LedererBen I. LeeCarroll M. LeevyAlan R. LeffRobert J. LefkowitzMarianne J. LegatoRobert LehrerDavid E. LeithLoretta LeiveJacob LemannKathy LeonardsonA. Martin LernerRichard A. LernerE. Carwile LeRoyRoger LesterJohn A. Leutscher, Jr.Richard LevereGerald LeveyEugene LevinDavid Z. LevineJoel S. LevineLawrence LevineShirley LevineNorman LevinskyD. Michael LevittMortimer LevitzUrban J. LewisChiang-seng LiangLawrence M. LichtensteinDavid A. LightnerStuart LindMarc LippmanMortimer B. LipsettPeter LipskyJ. Russell Little, Jr.John W. LittlefieldPeter I. LoboAlbert F. LoBuglioAlan H. LockwoodDean H. LockwoodJohn LoebGerald LogueChristopher LongcopeWilliam J. LongmoreA. J. LonigorLaszlo LorandD. Lynn LoriauxxRuy V. LourencoWalter M. LovenbergN. LoveridgeJohn M. LowensteinOliver LowryPhilip LudbrookRichard LynchRichard MacDermottPeter T. Macklem

Noel MacLarenDavid A. MaddoxNicholas MadiasRose MageRobert W. MahleyA. A. F. MahmoudCarlo L. MainardiPhilip W. MajerusW. J. MalaisseR. MalleyAlberto MallianiGerald L. MandellHenry J. MankinDean MannKenneth G. MannMart MannikVincent T. MarchesiAaron MarcusDonald MarcusFrank L. MarcusJay MarionAllyn L. MarkPeter R. MarokoJoseph MarrDonald J. MarshGarland MarshallRonald MarshallDavid W. MartinGeorge R. MartinJoseph B. MartinKevin J. MartinJose MartinezStephen MarxRobert J. MasonDonald J. MassaroGloria De Carlo MassaroThomas E. MasseyBarry MassieShaul G. MassryJohn R. MathiasFrank M. MatschinskyDwight E. MatthewsAlvin M. MauerW. Lowell MaughamMichael M. MaurerJohn MaxonRobert MayerRobert T. McCluskeyJoe M. McCordMichael L. McDanielHugh 0. McDevittJay McDonaldJohn McDonaldRodger P. McEverEdward R. McFadden, Jr.Donald McFarlaneJohn Denis McGarryJohn C. McGiffDouglas McGregorJames E. McGuiganPatrick A. McKeeJere MeadRobert MechamGerald MedoffElias MeezanJames C. MelbyKenneth L. Melmon

Victor MeltzerJohn MendelsohnCarole MendelsonThomas C. Merigan, Jr.Thomas J. MerimeeEzlo MerlerAllen MerrittH. A. MessnerRonald MessnerRichard S. MetzgarBoyd MetzgerHenry MetzgerAlfred F. Michael, Jr.Joseph MiletichGeorge MillerJames MillerMyron MillerJ. Philip MillerDavid MilstoneRichard C. MinickRobert I. MisbinWilliam MitchBeverly MitchellJere H. MitchellJerry R. MitchellJoel MoakeStanley MogelsonCharles F. MoldowWilliam MonafoAnne MooreMalcolm MooreFrancois MorelEugene MorkinJeremiah MorrisseyAubrey MorrisonKenneth M. MoserAlan C. MosesArnold M. MosesMichael W. MosessonH. David Mosier, Jr.Joel MossUrsula Muller-EberhardPatrick J. MulrowGregory R. MundyFerid MuradPatrick MurphyJames Fraser MustardN. B. MyantCharles E. MyersRalph L. NachmanLee NadlerRonald L. NagelMoon NahmCarl NathanDavid G. NathanG. J. NaylorPhilip NeedlemanJames R. NeelyHugh N. NellansSteven NellisD. L. NelsonYale NemersonPaul J. NestelEllis NeufeldHarold NeufeldPeter E. NewburgerJulian Niemetz

Arthur W. NienhuisAlan S. NiesAlfred NisonoffS. Peter NissleyDavid NjusConstance NoguchiNadia NogueiraKarl NolphAnthony W. NormanHymie L. NosselAbner L. NotkinsWilliam L. NyhanRobert OcknerRichard OdesseyStella R. O'DonnellJoseph T. O'FlahertyMichael B. A. OldstoneJerrold M. OlefskyWard A. OlsenJoost OppenheimJack H. OppenheimerStuart OrkinRobert A. O'RourkeEugene P. OrringerDavid OrthC. Kirk OsterlandRichard OstlundJ. Donald OstrowOliver E. OwenRobert L. OwenGary K. OwensCarolyn S. PaceCharles Y. C. PakRobert H. PalmerWilliam M. PardridgeA. Michael ParfittJohn C. ParkerWilliam W. ParmleyJanet V. PassonneauMark PasternackYogesh C. PatelCarlo PatronoJosef R. PatschWolfgang PatschRichard PearsonRobert C. PedersenJames PenningtonJohn T. PennistonJames F. PerdueJulio E. PerezR. Perez-PoloPaul PerlsteinM. Alan PermuttSolbert PermuttTheodore Peters, Jr.T. E. PetersenCharles M. PetersonKirk L. PetersonRalph E. PetersonRobert PetersonM. A. PettySharron PfuellerDavid R. PhillipsGordon PhillipsLarry PhillipsSidney F. PhillipsGordon Philpott

iv

John A. PierceR. Neal PinckardStephanie PincusHenry PitotBertram PittConstance S. PittmanS. V. PizzoMarshall PlautEdward F. PlowYeshayau PockerStephen L. PohlThomas D. PollardGeorge PopjakGeorge A. PorterRobert L. PostWilliam John Powell, Jr.Stephen PrescottPaul A. PriceDarwin J. ProckopJules B. PuschettSteven H. QuarfordtPeter J. QuesenberryPaul QuieMichel RabinovitchEfraim RackerCharles RackleyMarcus RaichleL. RaijLawrence G. RaiszStanley I. RapaportPhilip RaskinHoward RasmussenOscar D. RatnoffL. RayElliot J. RayfieldEve P. ReavenGerald M. ReavenMatthew RechlerFloyd C. Rector, Jr.Richard N. RedingerCharles ReedJohn T. ReevesJens F. RehfeldJuerg ReichenMorris ReichlinSeymour ReichlinLynne ReidKeith ReimerMichael ReinJohn ReinickEllis L. ReinherzEric ReissJack S. RemingtonHeinz RemoldHelmut G. RennkePeter RentrapJohn E. RepineHerbert ReynoldsRobert R. RichCharles T. RichardsonGeorge RichardsonE. Chester RidgewayDaniel RifkinLee RiggB. L. RiggsDavid L. RimoinJ. J. Rinehart

Susan RittenhouseR. A. RizzaJacob RobbinsJohn B. RobbinsKenneth C. RobbinsHarold RobertsRobert RobertsDonald L. RobertsonGary RobertsonEugene D. RobinA. G. RobinsonAllen RobinsonAlan RobsonRoss E. RocklinJoseph RodarteGlen RodneyHector RodriguezJohn RogersAlan D. RogolF. J. RollSeamus A. RooneyDirk RoosRichard K. RootFred RosenHenry RosenMichael R. RosenSaul RosenIrwin H. RosenbergIsadore N. RosenbergRobert RosenbergJerry RosenbloomC. RosendorffRobert L. RosenfieldA Catherine RossGordon D. RossRussell RossWendell F. RosseG. RosselinRoger D. RossenAldo A. RossiniJerry RothNathan RothSheldon RothenbergJack RoweArun K. RoyArthur H. RubensteinCharles S. RubinCyrus RubinEmanuel RubinFrank RuddleShaun RuddyNeil B. RudermanDaniel RudmanGary RudnickAbraham M. RudolphMichael RytelSeymour M. SabesinSami SaidLester B. SalansDavid SalantGerald SalenSydney E. SalmonJohn SalvaggioEdwin W. SalzmanHerbert SamuelsMerle SandeHarold H. Sandstead

Richard J. SantenJulio SantiagoClifford SaperShigeru SassaWilbur H. SawyerWilliam D. SawyerAndrew SaxonAngelo M. ScanuBrent SchacterJames SchaferA. SchaferDon S. SchalchMorris SchambelinMatthew D. ScharffBruce ScharschmidtAlan N. SchechterCharles ScherJames ScheuerElliot SchiffmanJohn R. SchiltzDetlef SchlondorffStuart F. SchlossmanJerry Allen SchneiderGustav SchonfeldAnton SchoolwerthGeorge F. SchreinerRobert W. SchrierStanley G. SchultzPeter H. SchurDaniel P. SchusterArnold SchwartzBen SchwartzElias SchwartzRobert SchwartzWalter N. ScottWilliam ScottCharles R. ScriverBellur SeetharamStanton SegalGeorge B. SegelGino SegrePaul SeligmanRobert SeniorRamadan Sha'afiDavid ShafritzDavid G. ShandLarry ShapiroSandy ShapiroS. S. ShapiroSardos ShapiroArjun D. SharmaGeoffrey W. G. SharpGordon SharpSanford J. ShattilJ. Stephen ShawWilliam T. ShearerWilliam E. ShellAlbert P. Shepherd, Jr.James ShepherdPeter SherlineBarry ShermanLarry ShermanDon SherrardRobert S. SherwinLouis SherwoodEthan M. ShevachKenneth I. Shine

Steven B. ShohetMarc ShumanMarvin I. SiegelHelmut SiesPennti K. SiiteriDavid F. SilbertJeremiah SilbergWilliam SilenMelvin Joel SilverFrederick SilverblattEmanuel SilversteinSamuel SilversteinLouis SimchowitzFranz SimonFrancis SimonLawrence SimonFrederick SingerJack W. SingerReuben P. SiraganianLeonard T. SkeggsLarry A. SklarK. L. SoreckiEduardo SlatopolskyArt SlutskyLeon SmallDonald SmileyCarl Hugh SmithD. J. SmithDavid SmithJ. Bryan SmithKendall A. SmithThomas SmithermanWilliam J. Snape, Jr.Fred L. SnyderPeter J. SnyderRalph SnydermanBurton E. SobelKonrad SoergelAndrew SollDavid H. SolomonRoger SolowayNicholas SoterFred SouthwickJ. W. SpaldingHarvey SparksRobert B. Sparks, Jr.Arthur A. SpectorAllen M. SpiegelHans SpiegelbergIsaias SpilbergRobert G. SpiroJohn K. SpitznagelJerry SpivakMichael B. SpornPhilip StahlGeorge StamatoyannopoulosE. R. StanleyGeorge R. StarkPeter StastnyNorman C. StaubThomas H. SteeleWilliam J. SteeleRoy T. SteigbigelHanley SteinJay Stein0. SteinAlfred D. Steinberg

v

A. H. SteinbergDaniel SteinbergEmil SteinbergerDonald F. SteinerGeorge SteinerRalph SteinmenMichael B. StemermanWilliam F. StensonNewman L. StephensKenneth SterlingCarleton StewardGwendolyn StewartJohn D. StoboJeffrey StoffJohn StokesViktor StolcB. David StollarRainer StorbArnold StraussWarren StroberJohn A. SturmanBrian K. SuarezWadi N. SukiLawrence P. SullivanTimothy SullivanJohn S. SundsmoMartin I. SurksHoward H. SussmanJohn W. SuttieLawrence SweetmanLeon SwellJoseph H. SzurszewskiHoward S. TagerNorman TalalAlan R. TallEng TanKay TanakaRichard L. TannenMarvin L. TanzerStephan TarganArmen H. Tashjian, Jr.A. S. TavillAubrey E. TaylorJohn M. TaylorSteven L. TeitelbaumPaul I. Terasaki

Luther Cass TerryBradley ThachMarc D. ThamesJames TheodoreArgyrios N. TheofilopoulosJess G. ThoeneDavid Thorley-LawsonM. 0. ThornerR. TimplCraig TisherF. Gary TobackDouglas TollefsonSherri TollefsonAlexander TomaszBryan P. TooleJohn S. TordayJames TravisDavid TrenthamJerry S. TrierIan TrowbridgeRobert F. TroxlerJohn TurkLeslie A. TurnbergJerry J. TwomeyFrank TylerJouni UittoRichard J. UlevitchStanley UlickLouis UnderwoodRoger UngerFerdinand UrthalerG. UtermannRobert D. UtigerJudith VaitukaitisWilliam N. ValentineFrederick A. ValerioteJudith Van LiewAjit VarkiStephen F. VatnerJohn H. VaughanRichard L. VeechM. A. VenkatachalamZ. R. VlahcevicJohn H. K. VogelJoseph J. VolpeRobert Volpe

Mladen VranicConrad WagnerPeter WagnerLarry M. WahlJ. Herbert WaiteThomas A. WaldmannW. Allen WalkerMacKenzie WalserJohn H. WalshPatrick WalshPeter N. WalshJ. R. WandsLewis WannamakerPeter WardDavid WarnockJames C. WarrenStephen WassermanAugust WatanabeJohn WatkinsKarl T. WeberH. James WednerDavid WeinsteinGordon C. WeirNorman WeisbrodtMilton WeiserHarvey J. WeissStephen J. WeissSigmund WeitzmanBabette WekslerMarc E. WekslerZena WerbElliot WeserCharles D. WestJackie Whang-PengDabney WhiteMichael WhyteWalter WiestJack WilberC. Kern WildenthalJ. M. WilhelmMitch WilliamGordon H. WilliamsLewis WilliamsM. C. WilliamsR. Sanders WilliamsRalph Williams

John R. WilliamsonJoseph R. WilliamsonGeorge D. WilnerBarry W. WilsonChris WilsonCurtis B. WilsonFred WilsonJean D. WilsonRobert J. WinchesterH. G. WindmuellerMyron WinickAlan WinkelsteinJerry WinkelsteinJoseph WitztumJan WolffAllen WolkoffGlenda WongErnest M. WrightFred S. WrightKenneth K. WuRosalyn S. YalowK. YamadaJohn YardleyWilliam E. YargerLewis YeciesPaul YeeS. C. YenFrank YinMitsuhiro YokoyomaLowell S. YoungNeal YoungVernon YoungKarir M. YounoszaiPaul YuAbel A. YunisEsmail ZanjaniHarold ZarkowskyKenneth L. ZierlerJacob ZighelboimDonald B. ZilversmitBen C. ZimmermanT. S. ZimmermanDavid ZopfKenneth S. ZuckermanRobert ZurierRandall M. Zusman

vi

ABBREVIATION S

(material in parenitheses for explatnationi only)

ADPAMPATP

ACTHA

MAmAA

BMR°CCr

CpiliCpS

MCiCinc

cycle/mmiicycle/s

dDNADEAEdpmieVkeVMeV

EDTAEGTA

OFFFAGSHGSSG

gkg

Mg (niot v)Ing

mng/100 imlmg/10() mg *mg/100 g(niot mg %) J

fgngpgcal

g-cmgti

Hepes

'Ui.m.I.p.i.y.

kcalkcyclekg-n

liter(s)MAI (not X)

mlnlpimcmkmmmcm2

cm3 (not cc)geq

adenosine diphosphateadenosine monophosphateadenosine triphosphateadrenocorticotropinampere(s)

microampere(s)milliampere(s)

angstrom (10-8 cm)basal metabolic ratedegree Celsiuscorrelation coefficientcounts per minutecounts per secondcurie(s)

muicrocurie(s)millicurie(s)

cycle(s) per minutecycle(s) per seconddensitydeoxyribonucleic aciddiethylaminoethyldisintegrations per miniuteelectron volt(s)

103 electron volt(s)10' electron volt(s)

ethyleniediaminetetraacetateethyleneglycol-bis(f3-aminioethyl

ether)-N,N'-tetraacetic aciddegree Fahrenheitfree fatty acidsglutathione, reducedglutathione, oxidizedgram(s)

kilogram(s)microgram(s)milligram(s)

complete "milligramn(s) percent"as appropriate*

femtogram(s)nanogram(s) (mnillimicrograin)picogram(s) (micromicrogram)

gram-calorie(s); convert to jouiles( J)gram-centimeter(s)unit of gravityhalf-lifeN-2-hydroxyethylpiperazitne-N '-2-

ethane sulfonic acidinternational unit(s)intramuscularintraperitonealintravenousdegree kelvinkilocalorie(s)kilocycle(s)kilogram-meter(s)liter(s)

microliter(s)milliliter(s)nanoliter(s) (millimicroliter)picoliter(s) (micromicroliter)

meter(s)centimeter(s)kilometer(s)millimeter(s)square centimeter(s)cubic centimeter(s)

microequivalent(s)

meq,im or 10-6 m

(not M)pmnimAs

MfMmMAMnMpMmolfmolMirnolmmolnmolpmol

mol wtNNS

Negative exponentsNo.(s)GDosM

osmolMosmolmosmol% (with

numeral)p

POPOPPPORQrpmRNA

s

sp actSDSE

SEMS

t testNAD

NAD+

NADH

NADP+

NADPH

TrisU

MUmUUDP

dyn-s-cm-sVkVMVmVVolwkWwt

milliequivalent(s)micrometer(s) (micron)

picometer(s) (micromicron)nanometer(s) (millimicron)

microsecond(s)millisecond(s)molar

femtomnolarmillimolarmicromolarnanomolar (millimicromolar)picomolar (micromicromolar)

mole(s)femtomole(s)micromole(s)millimole(s)nanomole(s) (millimicromole)picomole(s) (micromicromole)

molecular weightnormal (concentration)not significantdo niot usenumber(s)optical densityosmolarosmnole(s)

microosmole(s)milliosmole(s)

percent

probability1,4-bis[2-(5-phenyloxazolyl)]benzene2,5-diphenyloxazolerespiratory quotientrevolutions per minuteribonucleic acidsedimentation coefficientspecific activitystandard deviationstandard errorstandard error of the meanSvedberg unit of sedimenitation

coefficient (10-'3 s)Student's t testnicotinamide adenine dinucleotidereduced form

nicotinamide adenine dinucleotide,oxidized form

nicotinamide adenine dinucleotide,reduced form

nicotinamide adenine dinucleotidephosphate, oxidized form

nicotinamide adenine dinucleotidephosphate, reduced form

tris(hydroxymethyl)aminomethaneunit(s)

microunit(s)milliunit(s)

uridine 5'-diphosphateunits of peripheral vascular resistancevolt(s)

kilovolt(s)microvolt(s)millivolt(s)

volume(s)watt(s) (voltampere)

kilowatt(s)weight

* Apply same principle to gram(s) percent, microgram(s) percent, etc.t Use SI symbols instead of negative exponents:

Multiplication Factors Prefix SI Symbols Multipli4

decicentimillimicro

dc

m

IL

cation Factors

0.000 000 001 = 10-90.000 000 000 001 = 10- 2

0.000 000 000 000 001 = 10-150.000 000 000 000 000 001 = 10-28

Prefix

nanopicofemtoatto

0.1 = 10-'0.01 = 10-2

0.001 = 10-30.000 001 = 10-6

SI Symbols

npfa

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AUTHOR INDEX

A

Abo, T., Roder, J. C., Abo, W., Cooper, M. D., and Balch, C. M.Natural killer (HNK-l+) cells in Chediak-Higashi patients arepresent in normal numbers but are abnormal in function andmorphology. 193.

Abo, W., See Abo, Roder, Abo, Cooper, and Balch.Abraham, P. A., Perejda, A. J., Carnes, W. H., and Uitto, J. Marfan

syndrome. Demonstration of abnormal elastin in aorta. 1245.Abumrad, N. N., Jefferson, L. S., Rannels, S. R., Williams, P. E.,

Cherrington, A. D., and Lacy, W. W. Role of insulin in theregulation of leucine kinetics in the conscious dog. 1031.

Adams, G. K., III, See MacGlashan, Schleimer, Peters, Schulman,Adams, Newball, and Lichtenstein.

Aden, D. P., See Morris, Aden, Knowles, and Colten.Aikawa, M., See Schmidt, Udeinya, Leech, Hay, Aikawa, Barnwell,

Green, and Miller.Allen, C. L., See Rittenhouse and Allen.Allen, R. H., See Kondo, Binder, Kolhouse, Smythe, Podell, and

Allen.Alloisio, N., See Dhermy, Lecomte, Garbarz, Bournier, Galand,

Gautero, Feo, Alloisio, Delaunay, and Boivin.Amado, C., See Massaro, Amado, Clerch, and Massaro.Amuro, V., Tanaka, M., Higashino, K., Hayashi, E., Endo, T.,

Kishimoto, S., Nakabayashi, H., and Sato, J. Bile acid synthe-sis by long-term cultured cell line established from a humanhepatoblastoma. 1128.

Anderson, K. C., See Nadler, Ritz, Bates, Park, Anderson, Sallan,and Schlossman.

Andersson, S. M., See Ohisalo, Laskowska-Klita, and Andersson.Angelin, B., Bjorkhem, I., Einarsson, K., and Ewerth, S. Hepatic

uptake of bile acids in man. Fasting and postprandial concen-trations of individual bile acids in portal venous and systemicblood serum. 724.

Arieff, A. I., See Park and Arieff.Asseff, S., See Myers, Okarma, Friedman, Bridges, Ross, Asseff,

and Deen.Aster, R. H., See Christie and Aster.

B

Bach, M.-A., See Cashman, Martin, Eizenbaum, Degos, and Bach.Bachmann, F., See Tissot, Schneider, Hauert, Ruegg, Kruithof, and

Bachmann.Baehner, R. L., See Boxer, Haak, Yang, Wolach, Whitcomb, But-

terick, and Baehner.Baggiolini, M., See Dewald, Bretz, and Baggiolini.Bailey, B. D., See Jolivet, Schilsky, Bailey, Drake, and Chabner.Balasingam, M., See Hebbel, Eaton, Balasingam, and Steinberg.Balch, C. M., See Abo, Roder, Abo, Cooper, and Balch.Bard, H., and Prosmanne, J. Postnatal fetal and adult hemoglobin

synthesis in preterm infants whose birth weight was less than1,000 grams. 50.

Barnwell, J., See Schmidt, Udeinya, Leech, Hay, Aikawa, Barnwell,Green, and Miller.

Bates, M. P., See Nadler, Ritz, Bates, Park, Anderson, Sallan, andSchlossman.

Battaglia, F. C., See Sparks, Hay, Bonds, Meschia, and Battaglia.Beaudet, A. L., See Su, Bock, Beaudet, and O'Brien.Beer, D. J., Dinarello, C. A., Rosenwasser, L. J., and Rocklin, R.

E. Human monocyte-derived soluble product(s) has an acces-sory function in the generation of histamine- and concanavalinA-induced suppressor T cells. 393.

Berger, C. L., Morrison, S., Chu, A., Patterson, J., Estabrook, A.,Takezaki, S., Sharon, J., Warburton, D., Irigoyen, O., andEdelson, R. L. Diagnosis of cutaneous T-cell lymphoma by useof monoclonal antibodies reactive with tumor-associated an-tigens. 1205.

Berman, M., See Schwartz, Berman, Vlahcevic, and Swell., See Schwartz, Vlahcevic, Berman, Meadows, Nisman, and

Swell.Berry, C. A., See Sasaki, Berry, and Rector.Bier, D. M., See Bougneres, Karl, Hillman, and Bier.Bijvoet, 0. L. M., See Reitsma, Teitelbaum, Bijvoet, and Kahn.Binder, M. J., See Kondo, Binder, Kolhouse, Smythe, Podell, and

Allen.Bissell, D. M., See Hartmann and Bissell.Bitterman, P. B., Rennard, S. I., Hunninghake, G. W., and Crystal,

R. G. Human alveolar macrophage growth factor for fibro-blasts. Regulation and partial characterization. 806.

Bjorkhem, I., See Angelin, Bjorkhem, Einarsson, and Ewerth.Blum, C. B., Deckelbaum, R. J., Witte, L. D., Tall, A. R., and

Cornicelli, J. Role of apolipoprotein E-containing lipoproteinsin abetalipoproteinemia. 1157.

Bock, H.-G. O., See Su, Bock, Beaudet, and O'Brien.Boggs, D. R., Boggs, S. S., Saxe, D. F., Gress, L. A., and Canfield,

D. R. Hematopoietic stem cells with high poliferative potential.Assay of their concentration in marrow by the frequency andduration of cure of W/W' mice. 242.

Boggs, S. S., See Boggs, Boggs, Saxe, Gress, and Canfield.Boivin, P., See Dhermy, Lecomte, Garbarz, Bournier, Galand,

Gautero, Feo, Alloisio, Delaunay, and Boivin.Bonds, D., See Sparks, Hay, Bonds, Meschia, and Battaglia.Bone, R. C., See Jacobs, Soulsby, Bone, Wilson, and Hiller.Bongiovanni, A. M., See Witkin, Zelikovski, Bongiovanni, Geller,

Good, and Day.Borcherding, W., See Finlay, Shahidi, Horowitz, Borcherding, and

Hong.Borgstrom, B., and Erlanson-Albertsson, C. Hydrolysis of milk fat

globules by pancreatic lipase. Role of colipase, phospholipaseA2, and bile salts. 30.

Borregaard, N., and Herlin, T. Energy metabolism of humanneutrophils during phagocytosis. 550.

Bougneres, P. F., Karl, I. E., Hillman, L. S., and Bier, D. M. Lipidtransport in the human newborn. Palmitate and glycerol turn-over and the contribution of glycerol to neonatal hepaticglucose output. 262.

Bournier, O., See Dhermy, Lecomte, Garbarz, Bournier, Galand,Gautero, Feo, Alloisio, Delaunay, and Boivin.

Boxer, L. A., Haak, R. A., Yang, H.-H., Wolach, J. B., Whitcomb,J. A., Butterick, C. J., and Baehner, R. L. Membrane-boundlactoferrin alters the surface properties of polymorphonuclearleukocytes. 1049.

Bradley, W. A., See Gianturco, Bradley, Gotto, Morrisett, andPeavy.

Brazy, P. C., Gullans, S. R., Mandel, L. J., and Dennis, V. W.Metabolic requirement for inorganic phosphate by the rabbitproximal tubule. Evidence for a Crabtree effect. 53.

Bretz, U., See Dewald, Bretz, and Baggiolini.Brewer, H. B., Jr., See Ghiselli, Schaefer, Zech, Gregg, and Brewer.-, See Schaefer, Kay, Zech, and Brewer.

The Journal of Clinical Investigation 1343

Bridges, C., See Myers, Okarma, Friedman, Bridges, Ross, Asseff,and Deen.

Brown, W. V., See Goldberg, Le, Paterniti, Ginsberg, Lindgren,and Brown.

Broze, G. J., Jr., Binding of human Factor VII and Vlla tomonocytes. 526.

Brun, A., See Sandberg and Brun.Buerkert, J., Martin, D., and Trigg, D. Ammonium handling by

superficial and juxtamedullary nephrons in the rat. Evidencefor an ammonia shunt between the loop of Henle and thecollecting duct. 1.

Burch, W. M., and Lebovitz, H. E. Triiodothyronine stimulatesmaturation of porcine growth-plate cartilage in vitro. 496.

Burke, J. F., See Gelfand, Donelan, Hawiger, and Burke.Buse, M. G., See Gandy, Buse, and Crouch.Butterick, C. J., See Boxer, Haak, Yang, Wolach, Whitcomb,

Butterick, and Baehner.

C

Campbell, E. J., Senior, R. M., McDonald, J. A., and Cox, D. L.Proteolysis by neutrophils. Relative importance of cell-sub-strate contact and oxidative inactivation of proteinase inhibi-tors in vitro. 845.

Canfield, D. R., See Boggs, Boggs, Saxe, Gress, and Canfield.Canfield, W. M., and Kisiel, W. Evidence of normal functional

levels of activated protein C inhibitor in combined Factor V/VIII deficiency disease. 1260.

Capasso, J., See Scheuer, Malhotra, Hirsch, Capasso, and Schaible.Carnes, W. H., See Abraham, Perejda, Carnes, and Uitto.Carraway, R. E., See Hammer, Carraway, and Leeman.Cartron, J.-P., See Nurden, Dupuis, Pidard, Kieffer, Kunicki, and

Cartron.Casey, M. L., and MacDonald, P. C. Metabolism of deoxycorticos-

terone and deoxycorticosterone sulfate in men and women.312.

, See Gal, Casey, Johnston, and MacDonald.Cashman, N., Martin, C., Eizenbaum, J.-F., Degos, J.-D., and Bach,

M.-A. Monoclonal antibody-defined immunoregulatory cellsin multiple sclerosis cerebrospinal fluid. 387.

Celada, A., See Huebers, Uvelli, Celada, Josephson, and Finch.Chabner, B. A., See Jolivet, Schilsky, Bailey, Drake, and Chabner.Chang, H., See Fabry, Kaul, Raventos-Suarez, Chang, and Nagel.Chaplinski, T. J., and Niedel, J. E. Cyclic nucleotide-induced

maturation of human promyelocytic leukemia cells. 953.Cherrington, A. D., See Abumrad, Jefferson, Rannels, Williams,

Cherrington, and Lacy.Cheung, R. K., Grinstein, S., and Gelfand, E. W. Volume regulation

by human lymphocytes. Identification of differences betweenthe two major lymphocyte subpopulations. 632.

Chikkappa, G., See Mangan, Chikkappa, and Farley.Chiorazzi, N., See Posnett, Chiorazzi, and Kunkel.Christian, C. L., See Inman, Redecha, Knechtle, Schned, van de

Rijn, and Christian.Chrstie, D. J., and Aster, R. H. Drug-antibody-platelet interaction

in quinine- and quinidine-induced thrombocytopenia. 989.Chu, A., See Berger, Morrison, Chu, Patterson, Estabrook, Take-

zaki, Sharon, Warburton, Irigoyen, and Edelson.Chused, T. M., See Luger, Smolen, Chused, Steinberg, and Oppen-

heim.Cicala, M., See Sacca, Cicala, Trimarco, Ungaro, and Vigorito.Clark, M. R., Mohandas, N., and Shohet, S. B. Hydration of sickle

cells using the sodium ionophore Monensin. A model fortherapy. 1074.

Clemetson, K. J., McGregor, J. L., James, E., Dechavanne, M.,and Luscher, E. F. Characterization of the platelet membraneglycoprotein abnormalities in Bernard-Soulier syndrome andcomparison with normal by surface-labeling techniques andhigh-resolution two-dimensional gel electrophoresis. 304.

Clerch, L., See Massaro, Amado, Clerch, and Massaro.

Cleveland, R. P., See Radoiu, Cleveland, and Leon.Colten, H. R., See Morris, Aden, Knowles, and Colten.Comp, P. C., Jacocks, R. M., Ferrell, G. L., and Esmon, C. T.

Activation of protein C in vivo. 127.Conway, R. S., and Weiss, H. R. Role of propranolol in improve-

ment of the relationship between 02 supply and consumptionin an ischemic region of the dog heart. 320.

Cooper, M. D., See Abo, Roder, Abo, Cooper, and Balch.Cooper, N. R., See Nemerow, Jensen, and Cooper.Cornicelli, J., See Blum, Deckelbaum, Witte, Tall, and Cornicelli.Cox, D. L., See Campbell, Senior, McDonald, and Cox.Cronin, M. J., See Thorner, Perryman, Cronin, Rogol, Draznin,

Johanson, Vale, Horvath, and Kovacs.Crouch, R. K., See Gandy, Buse, and Crouch.Crump, M. A., Scearce, R., Dobersen, M., Kortz, W., and Eisen-

barth, G. S. Production and characterization of a cytotoxicmonoclonal antibody reacting with rat islet cells. 659.

Crystal, R. G., See Bitterman, Rennard, Hunninghake, and Crystal.Currie, M. S., See Rustagi, Currie, and Logue.Cushman, S. W., See Hissin, Foley, Wardzala, Karnieli, Simpson,

Salans, and Cushman.

D

Davis, G. R., See Schiller, Davis, Santa Ana, Morawski, andFordtran.

Day, N. K., See Witkin, Zelikovski, Bongiovanni, Geller, Good,and Day.

Dechavanne, M., See Clemetson, McGregor, James, Dechavanne,and Luscher.

Deckelbaum, R. J., See Blum, Deckelbaum, Witte, Tall, and Cor-nicelli.

Deen, W. M., See Myers, Okarma, Friedman, Bridges, Ross, Asseff,and Deen.

Degos, J.-D., See Cashman, Martin, Eizenbaum, Degos, and Bach.Delacroix, D. L., Hodgson, H. J. F., McPherson, A., Dive, C., and

Vaennan, J. P. Selective transport of polymeric immunoglob-ulin A in bile. Quantitative relationships of monomeric andpolymeric immunoglobulin A, immunoglobulin M, and otherproteins in serum, bile, and saliva. 230.

Delaunay, J., See Dhermy, Lecomte, Garbarz, Bournier, Galand,Gautero, Feo, Alloisio, Delaunay, and Boivin.

Dennis, V. W., See Brazy, Gullans, Mandel, and Dennis.DeSantis, N. M., See Nakagawara, DeSantis, Nogueira, and Na-

than.Dewald, B., Bretz, U., and Baggiolini, M. Release of gelatinase

from a novel secretory compartment of human neutrophils.518.

Dhermy, D., Lecomte, M. C., Garbarz, M., Bournier, O., Galand,C., Gautero, H., Feo, C., Alloisio, N., Delaunay, J., and Boivin,P. Spectrin fl-chain variant associated with hereditary ellipto-cytosis. 707.

Dietschy, J. M., See Munford, Hall, Lipton, and Dietschy.Dinarello, C. A., See Beer, Dinarello, Rosenwasser, and Rocklin.Dive, C., See Delacroix, Hodgson, McPherson, Dive, and Vaerman.Dluhy, R. G., See LeBoff, Dluhy, Hollenberg, Moore, Koletsky,

and Williams.Dobersen, M., See Crump, Scearce, Dobersen, Kortz, and Eisen-

barth.Donelan, M., See Gelfand, Donelan, Hawiger, and Burke.Drake, J. C., See Jolivet, Schilsky, Bailey, Drake, and Chabner.Draznin, M., See Thorner, Perryman, Cronin, Rogol, Draznin,

Johanson, Vale, Horvath, and Kovacs.Dunn, J. T., and Kaplan, A. P. Formation and structure of human

Hageman factor fragments. 627.Dunn, W. L., See Riggs, Wahner, Seeman, Offord, Dunn, Mazess,

Johnson, and Melton.Dupuis, D., See Nurden, Dupuis, Pidard, Kieffer, Kunicki, and

Cartron.Durrington, P. N., Newton, R. S., Weinstein, D. B., and Steinberg,

1344 Author Index . Volume 70, 1982

D. Effect of insulin and glucose on very low density lipoproteintriglyceride secretion by cultured rat hepatocytes. 63.

DuVall, E. M., See Slater, Murray, Wetzel, Wisdom, and DuVall.

E

Eaton, J. W., See Hebbel, Eaton, Balasingam, and Steinberg.Eby, B. K., See Lau and Eby.Edelson, R. L., See Berger, Morrison, Chu, Patterson, Estabrook,

Takezaki, Sharon, Warburton, Irigoyen, and Edelson.Edmonds, K. L., See Ellner, Olds, Lee, Kleinhenz, and Edmonds.Einarsson, K., See Angelin, Bjorkhem, Einarsson, and Ewerth.Einarsson, M., See Gonias, Einarsson, and Pizzo.Eisenbarth, G. S., See Crump, Scearce, Dobersen, Kortz, and

Eisenbarth.Eizenbaum, J.-F., See Cashman, Martin, Eizenbaum, Degos, and

Bach.Elmner, J. J., Olds, G. R., Lee, C. W., Kleinhenz, M. E., and

Edmonds, K. L. Destruction of the multicellular parasite Schis-tosoma mansoni by T lymphocytes. 369.

Endo, T., See Amuro, Tanaka, Higashino, Hayashi, Endo, Kishi-moto, Nakabayashi, and Sato.

Erlanson-Albertsson, C., See Borgstrom and Erlanson-Albertsson.Esmon, C. T., See Comp, Jacocks, Ferrell, and Esmon.Estabrook, A., See Berger, Morrison, Chu, Patterson, Estabrook,

Takezaki, Sharon, Warburton, Irigoyen, and Edelson.Ewerth, S., See Angelin, Bjorkhem, Einarsson, and Ewerth.

F

Fabry, M. E., Kaul, D. K., Raventos-Suarez, C., Chang, H., andNagel, R. L. SC erythrocytes have an abnormally high intra-cellular hemoglobin concentration. Pathophysiological conse-quences. 1315.

Falcone, D. J., See Hajjar, Weksler, Falcone, Hefton, Tack-Gold-man, and Minick.

Falk, J. A., See Falk, Hardy, Makowka, Teodorczyk-Injeyan, andFalk.

Falk, R. E., Hardy, M., Makowka, L., Teodorczyk-Injeyan, J., andFalk, J. A. Sensistization to low dose 5-fluorouracil. Subse-quent enhancement of its systemic antitumor effect in the rat.558.

Farley, P. C., See Mangan, Chikkappa, and Farley.Feo, C., See Dhermy, Lecomte, Garbarz, Bournier, Galand, Gau-

tero, Feo, Alloisio, Delaunay, and Boivin.Ferrell, G. L., See Comp, Jacocks, Ferrell, and Esmon.Finch, C., See Huebers, Uvelli, Celada, Josephson, and Finch.Fine, L. G., See Kirschenbaum, Lowe, Trizna, and Fine.Finlay, J. L., Shahidi, N. T., Horowitz, S., Borcherding, W., and

Hong, R. Lymphocyte dysfunction in congenital hypoplasticanemia. 619.

Fishman, A. P., See Pack, Hertz, Ledlie, and Fishman.Foley, J. E., See Hissin, Foley, Wardzala, Karnieli, Simpson,

Salans, and Cushman.Fordtran, J. S., See Schiller, Davis, Santa Ana, Morawski, and

Fordtran.Fraillon, D. R., See Khalid, Lim, Fraillon, and Funder.Frangione, B., See Solomon, Frangione, and Franklin.Franklin, E. C., See Solomon, Frangione, and Franklin.Frederiksen, K., See Steinberg, Smathers, Frederiksen, and Stein-

berg.Friedman, S., See Myers, Okarma, Friedman, Bridges, Ross, Asseff,

and Deen.Funder, J. W., See Khalid, Lim, Fraillon, and Funder.

, See Krozowski and Funder.-, See Mendelsohn, Lloyd, Kachel, and Funder.Furie, B., See Shoenfeld, Hsu-Lin, Gabriels, Silberstein, Furie,

Furie, Stollar, and Schwartz.

Furie, B. C., See Shoenfeld, Hsu-Lin, Gabriels, Silberstein, Furie,Furie, Stollar, and Schwartz.

G

Gabriels, J. E., See Shoenfeld, Hsu-Lin, Gabriels, Silberstein, Furie,Furie, Stollar, and Schwartz.

Gal, D., Casey, M. L., Johnston, J. M., and MacDonald, P. C.Mesenchyme-epithelial interactions in human endometrium.Prostaglandin synthesis in separated cell types. 798.

Galand, C., See Dhermy, Lecomte, Garbarz, Bournier, Galand,Gautero, Feo, Alloisio, Delaunay, and Boivin.

Gandy, S. E., Buse, M. G., and Crouch, R. K. Protective role ofsuperoxide dismutase against diabetogenic drugs. 650.

Garbarz, M., See Dhermy, Lecomte, Garbarz, Bournier, Galand,Gautero, Feo, Alloisio, Delaunay, and Boivin.

Gautero, H., See Dhermy, Lecomte, Garbarz, Bournier, Galand,Gautero, Feo, Alloisio, Delaunay, and Boivin.

Gelfand, E. W., See Cheung, Grinstein, and Gelfand.Gelfand, J. A., Donelan, M., Hawiger, A., and Burke, J. F. Alter-

native complement pathway activation increases mortality ina model of burn injury in mice. 1170.

Geller, N., See Witkin, Zelikovski, Bongiovanni, Geller, Good, andDay.

Gepts, W., See Van De Winkel, Smets, Gepts, and Pipeleers.Gerich, J., See Gottesman, Mandarino, Verdonk, Rizza, and Ger-

ich.Ghiselli, G., Schaefer, E. J., Zech, L. A., Gregg, R. E., and Brewer,

H. B., Jr. Increased prevalence of apolipoprotein E4 in type Vhypolipoproteinemia. 474.

Gianturco, S. H., Bradley, W. A., Gotto, A. M., Jr., Morrisett, J.D., and Peavy, D. L. Hypertriglyceridemic very low densitylipoproteins induce triglyceride synthesis and accumulation inmouse peritoneal macrophages. 168.

Giffels, J., See Griffin and Giffels.Gigliotti, F., and Insel, R. A. Protective human hybridoma antibody

to tetanus toxin. 1306.Ginsberg, H. N., See Goldberg, Le, Paterniti, Ginsberg, Lindgren,

and Brown., Jacobs, A., Le, N.-A., and Sandier, J. Effect of somatostatin-

induced suppression of postprandial insulin response upon thehypertriglyceridemia associated with a high carbohydrate diet.1225.

Gluck, L., See Hallman, Spragg, Harrell, Moser, and Gluck.Goldberg, I. J., Le, N.-A., Paterniti, J. R., Jr., Ginsberg, H. N.,

Lindgren, F. T., and Brown, W. V. Lipoprotein metabolismduring acute inhibition of hepatic triglyceride lipase in thecynomolgus monkey. 1184.

Gonias, S. L., Einarsson, M., and Pizzo, S. V. Catabolic pathwaysfor streptokinase, plasmin, and streptokinase activator complexin mice. In vivo reaction of plasminogen activator with a2-macroglobulin. 412.

Gonzalez, M., See Simon, Sutherland, and Gonzalez.Good, R. A., See Witkin, Zelikovski, Bongiovanni, Geller, Good,

and Day.Goodwin, B. J., and Weinberg, J. B. Receptor-mediated modulation

of human monocyte, neutrophil, lymphocyte, and plateletfunction by phorbol diesters. 699.

Goresky, C. A., See Huet, Goresky, Villeneuve, Marleau, andLough.

Gorman, R. R., See Lin, Morton, and Gorman.Gottesman, I., Mandarino, L., Verdonk, C., Rizza, R., and Gerich,

J. Insulin increases the maximum velocity for glucose uptakewithout altering the Michaelis constant in man. Evidence thatinsulin increases glucose uptake merely by providing addi-tional transport sites. 1310.

Gotto, A. M., Jr., See Gianturco, Bradley, Gotto, Morrisett, andPeavy.

Green, I., See Schmidt, Udeinya, Leech, Hay, Aikawa, Barnwell,Green, and Miller.

The Journal of Clinical Investigation 1345

Greene, D. A., and Lattimer, S. A. Sodium- and energy-dependentuptake of myo-inositol by rabbit peripheral nerve. Competitiveinhibition by glucose and lack of an insulin effect. 1009.

Gregg, R. E., See Ghiselli, Schaefer, Zech, Gregg, and Brewer.Gress, L. A., See Boggs, Boggs, Saxe, Gress, and Canfield.Griffin, D. E., and Giffels, J. Study of protein characteristics that

influence entry into the cerebrospinal fluid ofnormal mice andmice with encephalitis. 289.

Griffin, G. L., See Senior, Griffin, and Mecham.Grinstein, S., See Cheung, Grinstein, and Gelfand.Grundy, S. M., See Kesaniemi and Grundy.Gullans, S. R., See Brazy, Gullans, Mandel, and Dennis.

H

Haak, R. A., See Boxer, Haak, Yang, Wolach, Whitcomb, Butterick,and Baehner.

Hajar, D. P., Weksler, B. B., Falcone, D. J., Hefton, J. M., Tack-Goldman, K., and Minick, C. R. Prostacyclin modulates cho-lesteryl ester hydrolytic activity by its effect on cyclic adenosinemonophosphate in rabbit aortic smooth muscle cells. 479.

Hall, C. L., See Munford, Hall, Lipton, and Dietschy.Hallman, M., Spragg, R., Harrell, J. H., Moser, K. M., and Gluck,

L. Evidence of lung surfactant abnormality in respiratoryfailure. Study ofbronchoalveolar lavage phospholipids, surfaceactivity, phospholipase activity, and plasma myoinositol. 673.

Halper, J., Kabat, E. A., Osserman, E. F., Tonda, P., and Pernis, B.Spontaneous in vitro differentiation of antigen-specific lym-phocytes from a patient with immunoglobulin M gammopathy.1292.

Hammer, R. A., Carraway, R. E., and Leeman, S. E. Elevation ofplasma neurotensinlike immunoreactivity after a meal. Char-acterization of the elevated components. 74.

Hardin, J. A., Rahn, D. R., Shen, C., Lerner, M. R., Wolin, S. L.,Rosa, M. D., and Steitz, J. A. Antibodies from patients withconnective tissue diseases bind specific subsets of cellularRNA-protein particles. 141.

Hardy, M., See Falk, Hardy, Makowka, Teodorczyk-Injeyan, andFalk.

Harrell, J. H., See Hallman, Spragg, Harrell, Moser, and Gluck.Hartmann, F., and Bissell, D. M. Metabolism of heme and bilirubin

in rat and human small intestinal mucosa. 23.Hauert, J., See Tissot, Schneider, Hauert, Ruegg, Kruithof, and

Bachmann.Hawiger, A., See Gelfand, Donelan, Hawiger, and Burke.Hawley-Nelson, P., See Stanley, Yaar, Hawley-Nelson, and Katz.Hay, R. J., See Schmidt, Udeinya, Leech, Hay, Aikawa, Barnwell,

Green, and Miller.Hay, W. W., Jr., See Sparks, Hay, Bonds, Meschia, and Battaglia.Hayashi, E.s See Amuro, Tanaka, Higashino, Hayashi, Endo, Kish-

imoto, Nakabayashi, and Sato.Hebbel, R. P., Eaton, J. W., Balasingam, M., and Steinberg, M. H.

Spontaneous oxygen radical generation by sickle erythrocytes.1253.

Hechtman, H. B., See Utsunomiya, Krausz, Levine, Shepro, andHechtman.

Hefton, J. M., See Hajjar, Weksler, Falcone, Hefton, Tack-Gold-man, and Minick.

Henson, P. M., See Webster, Larsen, and Henson.Herd, J. E., See Phillips, Parks, Hjelle, Herd, Plotnick, Migeon, and

Seeburg.Herlin, T., See Borregaard and Herlin.Hertz, B. C., See Pack, Hertz, Ledlie, and Fishman.Higashino, K., See Amuro, Tanaka, Higashino, Hayashi, Endo,

Kishimoto, Nakabayashi, and Sato.Hiller, F. C., See Jacobs, Soulsby, Bone, Wilson, and Hiller.Hillman, L. S., See Bougneres, Karl, Hillman, and Bier.Hirsch, C., See Scheuer, Malhotra, Hirsch, Capasso, and Schaible.Hissin, P. J., Foley, J. E., Wardzala, L. J., Karnieli, E., Simpson,

I. A., Salans, L. B., and Cushman, S. W. Mechanism of insulin-

resistant glucose transport activity in the enlarged adipose cellof the aged, obese rat. Relative depletion of intracellularglucose transport systems. 780.

Hjelle, B. L., See Phillips, Parks, Hjelle, Herd, Plotnick, Migeon,and Seeburg.

Hodgson, H. J. F., See Delacroix, Hodgson, McPherson, Dive, andVaerman.

Hollenberg, N. K., See LeBoff, Dluhy, Hollenberg, Moore, Kolet-sky, and Williams.

Holman, H. R., See Okarma, Krueger, and Holman.Holmberg, L., See Ruggeri, Nilsson, Lombardi, Holmberg, and

Zimmerman.Hong, R., See Finlay, Shahidi, Horowitz, Borcherding, and Hong.Horowitz, S., See Finlay, Shahidi, Horowitz, Borcherding, and

Hong.Horvath, E., See Thorner, Perryman, Cronin, Rogol, Draznin,

Johanson, Vale, Horvath, and Kovacs.Horwitz, A. L., See Smith, Murata, Horwitz, Philipson, and Refe-

toff.Howard, B. V., See Reitman, Kosmakos, Howard, Taskinen, Kuusi,

and Nikkila.Hsu-Lin, S. C., See Shoenfeld, Hsu-Lin, Gabriels, Silberstein,

Furie, Furie, Stollar, and Schwartz.Huebers, H., Uvelli, D., Celada, A., Josephson, B., and Finch, C.

Basis of plasma iron exchange in the rabbit. 769.Huet, P.-M., Goresky, C. A.Vileneuve, J.-P., Marleau, D., and

Lough, J. 0. Assessment of liver microcirculation in humancirrhosis. 1234.

Hunninghake, G. W., See Bitterman, Rennard, Hunninghake, andCrystal.

Husted, R. F., and Steinmetz, P. R. Mechanisms of K' transport inisolated turtle urinary bladder. Induction of active K' secretionin a K'-absorbing epithelium. 832.

Ingbar, S. H., See Segal and Ingbar.Inman, R. D., Redecha, P. B., Knechtle, S. J., Schned, E. S., van de

Rijn, I., and Christian, C. L. Identification of bacterial antigensin circulating immune complexes of infective endocarditis. 271.

Insel, R. A., See Gigliotti and Insel.Irigoyen, O., See Berger, Morrison, Chu, Patterson, Estabrook,

Takezaki, Sharon, Warburton, Irigoyen, and Edelson.

J

Jacobs, A., See Ginsberg, Jacobs, Le, and Sandler.Jacobs, E. R., Soulsby, M. E., Bone, R. C., Wilson, F. J., Jr., and

Hiller, F. C. Ibuprofen in canine endotoxin shock. 536.Jacobson, H. R., See Wingo, Seldin, Kokko, and Jacobson.Jacocks, R. M., See Comp, Jacocks, Ferrell, and Esmon.Jaffe, B. M., See Yeo, Jaffe, and Zinner.James, E., See Clemetson, McGregor, James, Dechavanne, and

Luscher.Javid, J., See Macklis, Javid, Lipton, Kudisch, Pettis, and Nathan.Jefferson, L. S., See Abumrad, Jefferson, Rannels, Williams, Cher-

rington, and Lacy.Jensen, F. C., See Nemerow, Jensen, and Cooper.Johanson, A., See Thorner, Perryman, Cronin, Rogol, Draznin,

Johanson, Vale, Horvath, and Kovacs.Johnson, K. A., See Riggs, Wahner, Seeman, Offord, Dunn, Mazess,

Johnson, and Melton.Johnston, J. M., See Gal, Casey, Johnston, and MacDonald.Jolivet, J., Schilsky, R. L., Bailey, B. D., Drake, J. C., and Chabner,

B. A. Synthesis, retention, and biological activity of metho-trexate polyglutamates in cultured human breast cancer cells.351.

Jordan, M. C., and Mar, V. L. Spontaneous activation of latentcytomegalovirus from murine spleen explants. Role of lym-

1346 Author Index. Volume 70, 1982

phocytes and macrophages in release and replication of virus.762.

Josephson, B., See Huebers, Uvelli, Celada, Josephson, and Finch.

K

Kabat, E. A., See Halper, Kabat, Osserman, Tonda, and Pernis.Kachel, C., See Mendelsohn, Lloyd, Kachel, and Funder.Kahn, A. J., See Reitsma, Teitelbaum, Bijvoet, and Kahn.Kane, W. H., Mruk, J. S., and Majerus, P. W. Activation of

coagulation Factor V by a platelet protease. 1092.Kaplan, A. P., See Dunn and Kaplan.Karl, I. E., See Bougneres, Karl, Hillman, and Bier.Karnieli, E., See Hissin, Foley, Wardzala, Karnieli, Simpson, Sal-

ans, and Cushman.Kasper, D. L., See Rice and Kasper.Katz, S. I., See Stanley, Yaar, Hawley-Nelson, and Katz.Kaul, D. K., See Fabry, Kaul, Raventos-Suarez, Chang, and Nagel.Kawashima, H., Kraut, J. A., and Kurokawa, K. Metabolic acidosis

suppresses 25-hydroxyvitamin D3-la-hydroxylase in the ratkidney. Distinct site and mechanism of action. 135.

Kay, L. L., See Schaefer, Kay, Zech, and Brewer.Kelsen, S. G., See Supinski and Kelsen.Kesaniemi, Y. A., and Grundy, S. M. Significance of low density

lipoprotein production in the regulation of plasma cholesterollevel in man. 13.

Khalid, B. A. K., Lim, A. T., Fraillon, D. R., and Funder, J. W.Mineralocorticoid and glucocorticoid effects on 31,000- and29,000-dalton proopiomelanocortin in rat anterior pituitaryand neurointermediate lobe. 443.

Kieffer, N., See Nurden, Dupuis, Pidard, Kieffer, Kunicki, andCartron.

Kirschenbaum, M. A., Lowe, A. G., Trizna, W., and Fine, L. G.Regulation of vasopressin action by prostaglandins. Evidencefor prostaglandin synthesis in the rabbit cortical collectingtubule. 1193.

Kishimoto, S., See Amuro, Tanaka, Higashino, Hayashi, Endo,Kishimoto, Nakabayashi, and Sato.

Kisiel, W., See Canfield and Kisiel.Klein, R., See Weiss, Klein, Slivka, and Wei.Kleinhenz, M. E., See Ellner, Olds, Lee, Kleinhenz, and Edmonds.Knechtle, S. J., See Inman, Redecha, Knechtle, Schned, van de

Rijn, and Christian.Knowles, B. B., See Morris, Aden, Knowles, and Colten.Kokko, J. P., See Wingo, Seldin, Kokko, and Jacobson.Koletsky, R. J., See LeBoff, Dluhy, Hollenberg, Moore, Koletsky,

and Williams.Kolhouse, J. F., See Kondo, Binder, Kolhouse, Smythe, Podell, and

Allen.Kondo, H., Binder, M. J., Kolhouse, J. F., Smythe, W. R., Podell,

E. R., and Allen. Presence and formation of cobalamin ana-logues in multivitamin-mineral pills. 889.

Kortz, W., See Crump, Scearce, Dobersen, Kortz, and Eisenbarth.Kosmakos, F. C., See Reitman, Kosmakos, Howard, Taskinen,

Kuusi, and Nikkila.Kouttab, N. M., See Twomey, Luchi, and Kouttab.Kovacs, K., See Thorner, Perryman, Cronin, Rogol, Draznin, Jo-

hanson, Vale, Horvath, and Kovacs.Krausz, M. M., See Utsunomiya, Krausz, Levine, Shepro, and

Hechtman.Kraut, J. A., See Kawashima, Kraut, and Kurokawa.Krozowski, Z. S., and Funder, J. W. Rat anterior pituitary. Dis-

tinction of an -8S, corticosterone-preferring species from dex-amethasone-binding glucocorticoid receptors. 899.

Krueger, J. A., See Okarma, Krueger, and Holman.Kruithof, E. K. O., See Tissot, Schneider, Hauert, Ruegg, Kruithof,

and Bachmann.Kudisch, M., See Macklis, Javid, Lipton, Kudisch, Pettis, and

Nathan.Kudoh, T., and Wenger, D. A. Diagnosis of metachromatic leuko-

dystrophy, Krabbe disease, and Farber disease after uptake offatty acid-labeled cerebroside sulfate into cultured skin fibro-blasts. 89.

Kunicki, T. J., See Nurden, Dupuis, Pidard, Kieffer, Kunicki, andCartron.

Kunkel, H. G., See Posnett, Chiorazzi, and Kunkel.Kurokawa, K., See Kawashima, Kraut, and Kurokawa.Kuusi, T., See Reitman, Kosmakos, Howard, Taskinen, Kuusi, and

Nikkila.

L

Lacy, W. W., See Abumrad, Jefferson, Rannels, Williams, Cher-rington, and Lacy.

Lande, W. M., Thiemann, P. V. W., and Mentzer, W. C., Jr.Missing band 7 membrane protein in two patients with highNa, low K erythrocytes. 1273.

Larsen, G. L., See Webster, Larsen, and Henson.Larsen, P. R., See Silva and Larsen.Laskowska-Klita, T., See Ohisalo, Laskowska-Klita, and Anders-

son.Lattimer, S. A., See Greene and Lattimer.Lau, K., and Eby, B. K. Tubular mechanism for the spontaneous

hypercalciuria in laboratory rat. 835.Luscher, E. F., See Clemetson, McGregor, James, Dechavanne,

and Luscher.Lawler, J., Liu, S.-C., Palek, J., and Prchal, J. Molecular defect of

spectrin in hereditary pyropoikilocytosis. Alterations in thetrypsin-resistant domain involved in spectrin self-association.1019.

Le, N.-A., See Ginsberg, Jacobs, Le, and Sandler.Le, N.-A., See Goldberg, Le, Paterniti, Ginsberg, Lindgren, and

Brown.LeBoff, M. S., Dluhy, R. G., Hollenberg, N. K., Moore, T. J.,

Koletsky, R. J., and Williams, G. H. Abnormal renin shortfeedback loop in essential hypertension is reversible with con-verting enzyme inhibition. 335.

Lebovitz, H. E., See Burch and Lebovitz.Lecomte, M. C., See Dhermy, Lecomte, Garbarz, Bournier, Ga-

land, Gautero, Feo, Alloisio, Delaunay, and Boivin.Ledlie, J. F., See Pack, Hertz, Ledlie, and Fishman.Lee, C. W., See Ellner, Olds, Lee, Kleinhenz, and Edmonds.Leech, J. H., See Schmidt, Udeinya, Leech, Hay, Aikawa, Barnwell,

Green, and Miller.Leeman, S. E., See Hammer, Carraway, and Leeman.Leon, M. A., See Radoiu, Cleveland, and Leon.Lerner, M. R., See Hardin, Rahn, Shen, Lerner, Wolin, Rosa, and

Steitz.Leung, L. L. K., and Nachman, R. L. Complex formation of platelet

thrombospondin with fibrinogen. 542.Levine, L., See Utsunomiya, Krausz, Levine, Shepro, and Hecht-

man.Levy, R. A., See Ostlund, Levy, Witztum, and Schonfeld.Lichtenstein, L. M., See MacGlashan, Schleimer, Peters, Schulman,

Adams, Newball, and Lichtenstein.Lim, A. T., See Khalid, Lim, Fraillon, and Funder.Lin, A. H., Morton, D. R., and Gorman, R. R. Acetyl glyceryl ether

phosphorylcholine stimulates leukotriene B4 synthesis in hu-man polymorphonuclear leukocytes. 1058.

Lindgren, F. T., See Goldberg, Le, Paterniti, Ginsberg, Lindgren,and Brown.

Lipton, J. M., See Macklis, Javid, Lipton, Kudisch, Pettis, andNathan.

, See Munford, Hall, Lipton, and Dietschy.Liu, S.-C., See Lawler, Liu, Palek, and Prchal.Lloyd, C. J., See Mendelsohn, Lloyd, Kachel, and Funder.Logue, G. L., See Rustagi, Currie, and Logue.Lombardi, R., See Ruggeri, Nilsson, Lombardi, Holmberg, and

Zimmerman.Lough, J. O., See Huet, Goresky, Villeneuve, Marleau, and Lough.

The Journal of Clinical Investigation 1347

Lowe, A. G., See Kirschenbaum, Lowe, Trizna, and Fine.Luchi, R. J., See Twomey, Luchi, and Kouttab.Luger, T. A., Smolen, J. S., Chused, T. M., Steinberg, A. D., and

Oppenheim, J. J. Human lymphocytes with either the OKT4or OKT8 phenotype produce interleukin 2 in culture. 470.

M

MacDonald, P. C., See Casey and MacDonald.-, See Gal, Casey, Johnston, and MacDonald.MacGlashan, D. W., Jr., Schleimer, R. P., Peters, S. P., Schulman,

E. S., Adams, G. K., III, NewbaUl, H. H., and Lichtenstein, L.M. Generation of leukotrienes by purified human lung mastcells. 747.

Macklis, R. M., Javid, J., Lipton, J. M., Kudisch, M., Pettis, P. K.,and Nathan, D. G. Synthesis of hemoglobin F in adult simianerythroid progenitor-derived colonies. 752.

Majerus, P. W., Fraud in medical research. Presidential addressdelivered before the 74th Annual Meeting of the AmericanSociety for Clinical Investigation, Washington, DC, 8 May1982. 213.

, See Kane, Mruk, and Majerus.Makowka, L., See Falk, Hardy, Makowka, Teodorczyk-Injeyan,

and Falk.Malhotra, A., See Scheuer, Malhotra, Hirsch, Capasso, and Schai-

ble.Mandarino, L., See Gottesman, Mandarino, Verdonk, Rizza, and

Gerich.Mandel, L. J., See Brazy, Gullans, Mandel, and Dennis.Mangan, K. F., Chikkappa, G., and Farley, P. C. T gamma (Ty)

cells suppress growth oferythroid colony-forming units in vitroin the pure red cell aplasia of B-cell chronic lymphocyticleukemia. 1148.

Mar, V. L., See Jordan and Mar.Marleau, D., See Huet, Goresky, Villeneuve, Marleau, and Lough.Martin, C., See Cashman, Martin, Eizenbaum, Degos, and Bach.Martin, D., See Buerkert, Martin, and Trigg.Massaro, D., See Massaro, Amado, Clerch, and Massaro.Massaro, G. D., Amado, C., Clerch, L., and Massaro, D. Studies on

the regulation of secretion in Clara cells with evidence forchemical nonautonomic mediation of the secretory response toincreased ventilation in rat lungs. 608.

Mazess, R. B., See Riggs, Wahner, Seeman, Offord, Dunn, Mazess,Johnson, and Melton.

McDonald, J. A., See Campbell, Senior, McDonald, and Cox.McGregor, J. L., See Clemetson, McGregor, James, Dechavanne,

and Luscher.McPherson, A., See Delacroix, Hodgson, McPherson, Dive, and

Vaerman.Meadows, J. G., See Schwartz, Vlahcevic, Berman, Meadows,

Nisman, and Swell.Mecham, R. P., See Senior, Griffin, and Mecham.Melton, L. J., II., See Riggs, Wahner, Seeman, Offord, Dunn,

Mazess, Johnson, and Melton.Mendelsohn, F. A. O., Lloyd, C. J., Kachel, C., and Funder, J. W.

Induction by glucocorticoids ofangiotensin-convertingenzymeproduction from bovine endothelial cells in culture and ratlung in vivo. 684.

Mentzer, W. C., Jr., See Lande, Thiemann, and Mentzer.Meschia, G., See Sparks, Hay, Bonds, Meschia, and Battaglia.Micksche, M., See Uchida and Micksche.Migeon, C. J., See Phillips, Parks, Hjelle, Herd, Plotnick, Migeon,

and Seeburg.Miller, L. H., See Schmidt, Udeinya, Leech, Hay, Aikawa, Barn-

well, Green, and Miller.Minick, C. R., See Hajar, Weksler, Falcone, Hefton, Tack-Gold-

man, and Minick.Mohandas, N., See Clark, Mohandas, and Shohet.Moore, T. J., See LeBoff, Dluhy, Hollenberg, Moore, Koletsky,

and Williams.

Morawski, S. G., See Schiller, Davis, Santa Ana, Morawski, andFordtran.

Morris, K. M., Aden, D. P., Knowles, B. B., and Colten, H. R.Complement biosynthesis by the human hepatoma-derivedcell line HepG2. 906.

Morrisett, J. D., See Gianturco, Bradley, Gotto, Morrisett, andPeavy.

Morrison, S., See Berger, Morrison, Chu, Patterson, Estabrook,Takezaki, Sharon, Warburton, Irigoyen, and Edelson.

Morton, D. R., See Lin, Morton, and Gorman.Moser, K. M., See Hallman, Spragg, Harrell, Moser, and Gluck.Mruk, J. S., See Kane, Mruk, and Majerus.Munford, R. S., Hall, C. L., Lipton, J. M., and Dietschy, J. M.

Biological activity, lipoprotein-binding behavior, and in vivodisposition of extracted and native forms of Salmonella typhi-murium lipopolysaccharides. 877.

Murata, Y., See Smith, Murata, Horwitz, Philipson, and Refetoff.Murray, S. L., See Slater, Murray, Wetzel, Wisdom, and DuVall.Myers, B. D., Okarma, T. B., Friedman, S., Bridges, C., Ross, J.,

Asseff, S., and Deen, W. M. Mechanisms of proteinuria inhuman glomerulonephritis. 732.

N

Nachman, R. L., See Leung and Nachman.Nadler, L. M., Ritz, J., Bates, M. P., Park, E. K., Anderson, K. C.,

Sallan, S. E., and Schlossman, S. F. Induction of human Bcell antigens in non-T cell acute lymphoblastic leukemia. 433.

Nagel, R. L., See Fabry, Kaul, Raventos-Suarez, Chang, and Nagel.Nakabayashi, H., See Amuro, Tanaka, Higashino, Hayashi, Endo,

Kishimoto, Nakabayashi, and Sato.Nakagawara, A., DeSantis, N. M., Nogueira, N., and Nathan, C. F.

Lymphokines enhance the capacity of human monocytes tosecrete reactive oxygen intermediates. 1042.

Nakahata, T., and Ogawa, M. Hemopoietic colony-forming cells inumbilical cord blood with extensive capability to generatemono- and multipotential hemopoietic progenitors. 1324.

Nathan, C. F., See Nakagawara, DeSantis, Nogueira, and Nathan.Nathan, D. G., See Macklis, Javid, Lipton, Kudisch, Pettis, and

Nathan.Nemerow, G. R., Jensen, F. C., and Cooper, N. R. Neutralization

of Epstein-Barr virus by nonimmune human serum. Role ofcross-reacting antibody to herpes simplex virus and comple-ment. 1081.

Newball, H. H., See MacGlashan, Schleimer, Peters, Schulman,Adams, Newball, and Lichtenstein.

Newton, R. S., See Durrington, Newton, Weinstein, and Steinberg.Niedel, J. E., See Chaplinski and Niedel.Nikkila, E. A., See Reitman, Kosmakos, Howard, Taskinen, Kuusi,

and Nikkila.Nilsson, 1. M., See Ruggeri, Nilsson, Lombardi, Holmberg, and

Zimmerman.Nisman, R. M., See Schwartz, Vlahcevic, Berman, Meadows, Nis-

man, and Swell.Nogueira, N., See Nakagawara, DeSantis, Nogueira, and Nathan.Nurden, A. T., Dupuis, D., Pidard, D., Kieffer, N., Kunicki, T. J.,

and Cartron, J.-P. Surface modifications in the platelets of apatient with a-N-acetyl-D-galactosamine residues, the Tn-syn-drome. 1281.

0

O'Brien, W. E., See Su, Bock, Beaudet, and O'Brien.Offord, K. P., See Riggs, Wahner, Seeman, Offord, Dunn, Mazess,

Johnson, and Melton.Ogawa, M., See Nakahata and Ogawa.Ohisalo, J. J., Laskowska-Klita, T., and Andersson, S. M. Devel-

opment of tyrosine aminotransferase and p-hydroxyphenyl-

1348 Author Index. Volume 70, 1982

pyruvate dioxygenase activities in fetal and neonatal humanliver. 198.

Okarma, T. B., See Myers, Okarma, Friedman, Bridges, Ross,Asseff, and Deen.

, Krueger, J. A., and Holman, H. R. Analysis of speckled flu-orescent antinuclear antibody test antisera using electrofocusednuclear antigens. 296.

Olds, G. R., See Ellner, Olds, Lee, Kleinhenz, and Edmonds.Oppenheim, J. J., See Luger, Smolen, Chused, Steinberg, and

Oppenheim.Osserman, E. F., See Halper, Kabat, Osserman, Tonda, and Pernis.Ostlund, R. E., Jr., Levy, R. A., Witztum, J. L., and Schonfeld, G.

Familial hypercholesterolemia. Evidence for a newly recog-nized mutation determining increased fibroblast receptor affin-ity but decreased capacity for low density lipoprotein in twosiblings. 823.

Otsuki, M., and Williams, J. A. Effect of diabetes mellitus on theregulation ofenzyme secretion by isolated rat pancreatic acini.148.

p

Pack, A. I., Hertz, B. C., Ledlie, J. F., and Fishman, A. P. Reflexeffects of aerosolized histamine on phrenic nerve activity. 424.

Palek, J., See Lawler, Liu, Palek, and Prchal.Park, E. K., See Nadler, Ritz, Bates, Park, Anderson, Sallan, and

Schlossman.Park, R., and Arieff, A. 1. Treatment of lactic acidosis with dichlo-

roacetate in dogs. 853.Parks, J. S., See Phillips, Parks, Hjelle, Herd, Plotnick, Migeon,

and Seeburg.Patel, Y. C., See Zingg and Patel.Paterniti, J. R., Jr., See Goldberg, Le, Paterniti, Ginsberg, Lind-

gren, and Brown.Patterson, J., See Berger, Morrison, Chu, Patterson, Estabrook,

Takezaki, Sharon, Warburton, Irigoyen, and Edelson.Peavy, D. L., See Gianturco, Bradley, Gotto, Morrisett, and Peavy.Pelus, L. M., Association between colony forming units-granulo-

cyte macrophage expression of Ia-like (HLA-DR) antigen andcontrol of granulocyte and macrophage production. A newrole for prostaglandin E. 568.

Perejda, A. J., See Abraham, Perejda, Carnes, and Uitto.Pernis, B., See Halper, Kabat, Osserman, Tonda, and Pernis.Perryman, R. L., See Thorner, Perryman, Cronin, Rogol, Draznin,

Johanson, Vale, Horvath, and Kovacs.Peters, S. P., See MacGlashan, Schleimer, Peters, Schulman,

Adams, Newball, and Lichtenstein.Pettis, P. K., See Macklis, Javid, Lipton, Kudisch, Pettis, and

Nathan.Philipson, L., See Smith, Murata, Horwitz, Philipson, and Refetoff.Phillips, J. A., III., Parks, J. S., Hjelle, B. L., Herd, J. E., Plotnick,

L. P., Migeon, C. J., and Seeburg, P. H. Genetic analysis offamilial isolated growth hormone deficiency type I. 489.

Pidard, D., See Nurden, Dupuis, Pidard, Kieffer, Kunicki, andCartron.

Pipeleers, D., See Van De Winkel, Smets, Gepts, and Pipeleers.Pizzo, S. V., See Gonias, Einarsson, and Pizzo.Plotnick, L. P., See Phillips, Parks, Hjelle, Herd, Plotnick, Migeon,

and Seeburg.Podell, E. R., See Kondo, Binder, Kolhouse, Smythe, Podell, and

Allen.Posnett, D. N., Chiorazzi, N., and Kunkel, H. G. Monoclonal

antibodies with specificity for hairy cell leukemia cells. 254.Pratt, J. H., Role of angiotensin II in potassium-mediated stimula-

tion of aldosterone secretion in the dog. 667.Prchal, J., See Lawler, Liu, Palek, and Prchal.Prosmanne, J., See Bard and Prosmanne.

R

Radoiu, G. N., Cleveland, R. P., and Leon, M. A. Peripheral Tlymphocytes from rheumatoid arthritis patients recognize de-terminants on light chains and/or Fab fragments of immuno-globulin G. 329.

Rahn, D. R., See Hardin, Rahn, Shen, Lerner, Wolin, Rosa, andSteitz.

Rannels, S. R., See Abumrad, Jefferson, Rannels, Williams, Cher-rington, and Lacy.

Ranney, H. M., See Reiss, Ranney, and Shaklai.Raventos-Suarez, C., See Fabry, Kaul, Raventos-Suarez, Chang,

and Nagel.Rector, F. C., Jr., See Sasaki, Berry, and Rector.Redecha, P. B., See Inman, Redecha, Knechtle, Schned, van de

Rijn, and Christian.Refetoff, S., See Smith, Murata, Horwitz, Philipson, and Refetoff.Reiss, G. H., Ranney, H. M., and Shaklai, N. Association of

hemoglobin C with erythrocyte ghosts. 946.Reitman, J. S., Kosmakos, F. C., Howard, B. V., Taskinen, M.-R.,

Kuusi, T., and Nikkila, E. A. Characterization of lipase activ-ities in obese Pima indians. Decreases with weight reduction.791.

Reitsma, P. H., Teitelbaum, S. L., Bijvoet, 0. L. M., and Kahn, A.J. Differential action of the bisphosphonates (3-amino-1-hy-droxypropylidene)-l,l-bisphosphonate (ADP) and disodiumdichloromethylidene bisphosphonate (Cl2MDP) on rat mac-rophage-mediated bone resorption in vitro. 927.

Rennard, S. I., See Bitterman, Rennard, Hunninghake, and Crystal.Rice, P. A., and Kasper, D. L. Characterization of serum resistance

of Neisseria gonorrhoeae that disseminate. Roles of blockingantibody and gonococcal outer membrane proteins. 157.

Riggs, B. L., Wahner, H. W., Seeman, E., Offord, K. P., Dunn, W.L., Mazess, R. B., Johnson, K. A., and Melton, L. J., III.Changes in bone mineral density of the proximal femur andspine with aging. Differences between the postmenopausal andsenile osteoporosis syndromes. 716.

Rittenhouse, S. E., and Allen, C. L. Synergistic activation bycollagen and 15-hydroxy-9a,l la-peroxidoprosta-5, 13-dienoicacid (PGH2) of phosphatidylinositol metabolism and arachi-donic acid release in human platelets. 1216.

Ritz, J., See Nadler, Ritz, Bates, Park, Anderson, Sallan, andSchlossman.

Rizza, R., See Gottesman,Mandarino, Verdonk, Rizza, and Gerich.Rocklin, R. E., See Beer, Dinarello, Rosenwasser, and Rocklin.Roder, J. C., See Abo, Roder, Abo, Cooper, and Balch.Rogol, A. D., See Thorner, Perryman, Cronin, Rogol, Draznin,

Johanson, Vale, Horvath, and Kovacs.Rosa, M. D., See Hardin, Rahn, Shen, Lerner, Wolin, Rosa, and

Steitz.Rosenwasser, L. J., See Beer, Dinarello, Rosenwasser, and Rocklin.Ross, J., See Myers, Okarma, Friedman, Bridges, Ross, Asseff, and

Deen.Ruegg, M., See Tissot, Schneider, Hauert, Ruegg, Kruithof, and

Bachmann.Ruggeri, Z. M., Nilsson, I. M., Lombardi, R., Holmberg, L., and

Zimmerman, T. S. Aberrant multimeric structure of von Wil-lebrand factor in a new variant of von Willebrand's disease(type IIC). 1124.

Rustagi, P. K., Currie, M. S., and Logue, G. L. Activation ofhuman complement by immunoglobulin G antigranulocyteantibody. 1137.

S

Sacca, L., Cicala, M., Trimarco, B., Ungaro, B., and Vigorito, C.Differential effects of insulin on splachnic and peripheralglucose disposal after an intravenous glucose load in man. 117.

Salans, L. B., See Hissin, Foley, Wardzala, Karnieli, Simpson,Salans, and Cushman.

The Journal of Clinical Investigation 1349

SaDlan, S. E., See Nadler, Ritz, Bates, Park, Anderson, Sallan, andSchlossman.

Sandberg, S., and Brun A. Light-induced protoporphyrin releasefrom erythrocytes in erythropoietic protoporphyria. 693.

Sandier, J., See Ginsberg, Jacobs, Le, and Sandler.Santa Ana, C. A., See Schiller, Davis, Santa Ana, Morawski, and

Fordtran.Sasaki, S., Berry, C. A., and Rector, F. C., Jr. Effect of luminal

and peritubular HCO3 concentrations and Pco2 on HCO3reabsorption in rabbit proximal convoluted tubules perfusedin vitro. 639.

Sato, J., See Amuro, Tanaka, Higashino, Hayashi, Endo, Kishi-moto, Nakabayashi, and Sato.

Saxe, D. F., See Boggs, Boggs, Saxe, Gress, and Canfield.Scearce, R., See Crump, Scearce, Dobersen, Kortz, and Eisenbarth.Schaefer, E. J., Kay, L. L., Zech, L. A., and Brewer, H. B., Jr.

Tangier disease. High density lipoprotein deficiency due todefective metabolism of an abnormal apolipoprotein A-I(APOA-ITANGIER). 934.

See Ghiselli, Schaefer, Zech, Gregg, and Brewer.Schaible, T. F., See Scheuer, Malhotra, Hirsch, Capasso, and

Schaible.Scharschmidt, B. F., See Van Dyke, Stephens, and Scharschmidt.Scheuer, J., Malhotra, A., Hirsch, C., Capasso, J., and Schaible, T.

F. Physiologic cardiac hypertrophy corrects contractile proteinabnormalities associated with pathologic hypertrophy in rats.1300.

Schiller, L. R., Davis, G. R., Santa Ana, C. A., Morawski, S. G.,and Fordtran, J. S. Studies of the mechanism of the antidi-arrheal effect of codeine. 999.

Schilsky, R. L., See Jolivet, Schilsky, Bailey, Drake, and Chabner.Schleimer, R. P., See MacGlashan, Schleimer, Peters, Schulman,

Adams, Newball, and Lichtenstein.Schlossman, S. F., See Nadler, Ritz, Bates, Park, Anderson, Sallan,

and Schlossman.Schmidt, J. A., Udeinya, 1. J., Leech, J. H., Hay, R. J., Aikawa,

M., Barnwell, J., Green, I., and Miller, L. H. Plasmodiumfakciparum malaria. An amelanotic melanoma cell line bearsreceptors for the knob ligand on infected erythrocytes. 379.

Schned, E. S., See Inman, Redecha, Knechtle, Schned, van de Rijn,and Christian.

Schneider, P., See Tissot, Schneider, Hauert, Ruegg, Kruithof, andBachmann.

Schonfeld, G., See Ostlund, Levy, Witztum, and Schonfeld.Schulman, E. S., See MacGlashan, Schleimer, Peters, Schulman,

Adams, Newball, and Lichtenstein.Schwartz, C. C., Berman, M., Vlahcevic, Z. R., and Swell, L.

Multicompartmental analysis of cholesterol metabolism inman. Quantitative kinetic evaluation of precursor sources andturnover of high density lipoprotein cholesterol esters. 863.

-, Vlahcevic, Z. R., Bennan, M., Meadows, J. G., Nisman, R. M.,and Swell, L. Central role of high density lipoprotein in plasmafree cholesterol metabolism. 105.

Schwartz, R. S., See Shoenfeld, Hsu-Lin, Gabriels, Silberstein,Furie, Furie, Stollar, and Schwartz.

Seeburg, P. H., See Phillips, Parks, Hjelle, Herd, Plotnick, Migeon,and Seeburg.

Seeman, E., See Riggs, Wahner, Seeman, Offord, Dunn, Mazess,Johnson, and Melton.

Segal, J., and Ingbar, S. H. Specific binding sites for triiodothyro-nine in the plasma membrane of rat thymocytes. Correlationwith biochemical responses. 919.

Seldin, D. W., See Wingo, Seldin, Kokko, and Jacobson.Senior, R. M., See Campbell, Senior, McDonald, and Cox.-, Griffin, G. L., and Mecham, R. P. Chemotactic responses of

fibroblasts to tropoelastin and elastin-derived peptides. 614.Shahidi, N. T., See Finlay, Shahidi, Horowitz, Borcherding, and

Hong.Shaklai, N., See Reiss, Ranney, and Shaklai.Sharon, J., See Berger, Morrison, Chu, Patterson, Estabrook, Tak-

ezaki, Sharon, Warburton, Irigoyen, and Edelson.Shen, C., See Hardin. Rahn, Shen, Lerner, Wolin, Rosa, and Steitz.

Shepro, D., See Utsunomiya, Krausz, Levine, Shepro, and Hecht-man.

Shoenfeld, Y., Hsu-Lin, S. C., Gabriels, J. E., Silberstein, L. E.,Furie, B. C., Furie, B., Stoilar, B. D., and Schwartz, R. S.Production of autoantibodies by human-human hybridomas.205.

Shohet, S. B., See Clark, Mohandas, and Shohet.Silberstein, L. E., See Shoenfeld, Hsu-Lin, Gabriels, Silberstein,

Furie, Furie, Stollar, and Schwartz.Silva, J. E., and Larsen, P. R. Comparison of iodothyronine 5'-

deiodinase and other thyroid-hormone-dependent enzyme ac-tivities in the cerebral cortex of hypothyroid neonatal rat.Evidence for adaptation to hypothyroidism. 1110.

Simon, F. R., Sutherland, E. M., and Gonzalez, M. Regulation ofbile salt transport in rat liver. Evidence that increased maxi-mum bile salt secretory capacity is due to increased cholic acidreceptors. 401.

Simon, L. M., See Suttorp and Simon.Simpson, I. A., See Hissin, Foley, Wardzala, Karnieli, Simpson,

Salans, and Cushman.Slater, L. M., Murray, S. L., Wetzel, M. W., Wisdom, R. M., and

DuVall, E. M. Verapamil restoration of daunorubicin respon-siveness in daunorubicin-resistant Ehrlich ascites carcinoma.1131.

Slivka, A., See Weiss, Klein, Slivka, and Wei.Smathers, P. A., See Steinberg, Smathers, Frederiksen, and Stein-

berg.Smets, G., See Van De Winkel, Smets, Gepts, and Pipeleers.Smith, T. J., Murata, Y., Horwitz, A. L., Philipson, L., and Refetoff,

S. Regulation of glycosaminoglycan synthesis by thyroid hor-mone in vitro. 1066.

Smolen, J. S., See Luger, Smolen, Chused, Steinberg, and Oppen-heim.

Smythe, W. R., See Kondo, Binder, Kolhouse, Smythe, Podell, andAllen.

Solomon, A., Frangione, B., and Franklin, E. C. Bence Jonesproteins and light chains of immunoglobulins. Preferentialassociation of the Vxv, subgroup of human light chains withamyloidosis A I(A). 453.

Soulsby, M. E., See Jacobs, Soulsby, Bone, Wilson, and Hiller.Sparks, J. W., Hay, W. W., Jr., Bonds, D., Meschia, G., and

Battaglia, F. C. Simultaneous measurements of lactate turn-over rate and umbilical lactate uptake in the fetal lamb. 179.

Spragg, R., See Hallman, Spragg, Harrell, Moser, and Gluck.Stanley, J. R., Yaar, M., Hawley-Nelson, P., and Katz, S. I.

Pemphigus antibodies identify a cell surface glycoprotein syn-thesized by human and mouse keratinocytes. 281.

Steinberg, A. D., See Luger, Smolen, Chused, Steinberg, andOppenheim.

, See Steinberg, Smathers, Frederiksen, and Steinberg.Steinberg, B. J., Smathers, P. A., Frederiksen, K., and Steinberg,

A. D. Ability of the xid gene to prevent autoimmunity in (NZBX NZW)F, mice during the course of their natural history,after polyclonal stimulation, or following immunization withDNA. 587.

Steinberg, D., See Durrington, Newton, Weinstein, and Steinberg.Steinberg, M. H., See Hebbel, Eaton, Balasingam, and Steinberg.Steinmetz, P. R., See Husted and Steinmetz.Steitz, J. A., See Hardin, Rahn, Shen, Lerner, Wolin, Rosa, and

Steitz.Stephens, J. E., See Van Dyke, Stephens, and Scharschmidt.Stokes, J. B., Consequences of potassium recycling in the renal

medulla. Effects on ion transport by the medullary thickascending limb of Henle's loop. 219.

Stollar, B. D., See Shoenfeld, Hsu-Lin, Gabriels, Silberstein, Furie,Furie, Stollar, and Schwartz.

Su, T.-S., Bock, H.-G. O., Beaudet, A. L., and O'Brien, W. E.Molecular analysis of argininosuccinate synthetase deficiencyin human fibroblasts. 1334.

Supinski, G. S., and Kelsen, S. G. Effect of elastase-inducedemphysema on the force-generating ability of the diaphragm.978.

1350 Author Index * Volume 70, 1982

Sutherland, E. M., See Simon, Sutherland, and Gonzalez.Suttorp, N., and Simon, L. M. Lung cell oxidant injury. Enhance-

ment of polymorphonuclear leukocyte-mediated cytotoxicityin lung cells exposed to sustained in vitro hyperoxia. 342.

Swell, L., See Schwartz, Berman, Vlahcevic, and Swell.

T

Tack-Goldman, K., See Hajjar, Weksler, Falcone, Hefton, Tack-Goldman, and Minick.

Takezaki, S., See Berger, Morrison, Chu, Patterson, Estabrook,Takezaki, Sharon, Warburton, Irigoyen, and Edelson.

Tall, A. R., See Blum, Deckelbaum, Witte, Tall, and Cornicelli.Tanaka, M., See Amuro, Tanaka, Higashino, Hayashi, Endo, Kish-

imoto, Nakabayashi, and Sato.Taskinen, M.-R., See Reitman, Kosmakos, Howard, Taskinen,

Kuusi, and Nikkila.Teitelbaum, S. L., See Reitsma, Teitelbaum, Bijvoet, and Kahn.Teodorczyk-Injeyan, J., See Falk, Hardy, Makowka, Teodorczyk-

Injeyan, and Falk.Thiemann, P. V. W., See Lande, Thiemann, and Mentzer.Thorner, M. O., Perryman, R. L., Cronin, M. J., Rogol, A. D.,

Draznin, M., Johanson, A., Vale, W., Horvath, E., and Kovacs,K. Somatotroph hyperplasia. Successful treatment of acromeg-aly by removal of a pancreatic islet tumor secreting a growthhormone-releasing factor. 965.

Tissot, J.-D., Schneider, P., Hauert, J., Ruegg, M., Kruithof, E. K.O., and Bachmann, F. Isolation from human plasma of aplasminogen activator identical to urinary high molecularweight urokinase. 1320.

Tonda, P., See Halper, Kabat, Osserman, Tonda, and Pernis.Tremble, P., See Williams and Tremble.Trigg, D., See Buerkert, Martin, and Trigg.Trimarco, B., See Sacca, Cicala, Trimarco, Ungaro, and Vigorito.Trizna, W., See Kirschenbaum, Lowe, Trizna, and Fine.Twomey, J. J., Luchi, R. J., and Kouttab, N. M. Null cell senescence

and its potential significance to the immunobiology of aging.201.

U

Uchida, A., and Micksche, M. Autologous mixed lymphocyte re-action in the peripheral blood and pleural effusions of cancerpatients. 98.

Udeinya, I. J., See Schmidt, Udeinya, Leech, Hay, Aikawa, Barn-well, Green, and Miller.

Uitto, J., See Abraham, Perejda, Carnes, and Uitto.Ungaro, B., See Sacca, Cicala, Trimarco, Ungaro, and Vigorito.Utsunomiya, T., Krausz, M. M., Levine, L., Shepro, D., and Hecht-

man, H. B. Thromboxane mediation of cardiopulmonary ef-fects of embolism. 361.

Uvelli, D., See Huebers, Uvelli, Celada, Josephson, and Finch.

V

Vaerman, J. P., See Delacroix, Hodgson, McPherson, Dive, andVaerman.

Vale, W., See Thorner, Perryman, Cronin, Rogol, Draznin, Johan-son, Vale, Horvath, and Kovacs.

van de Rijn, I., See Inman, Redecha, Knechtle, Schned, van deRijn, and Christian.

Van De Winkel, M., Smets, G., Gepts, W., and Pipeleers, D. Isletcell surface antibodies from insulin-dependent diabetics bindspecifically to pancreatic B cells. 41.

Van Dyke, R. W., Stephens, J. E., and Scharschmidt, B. F. Effectsof ion substitution on bile acid-dependent and -independentbile formation by rat liver. 505.

Verdonk, C., See Gottesman, Mandarino, Verdonk, Rizza, andGerich.

Vigorito, C., See Sacca, Cicala, Trimarco, Ungaro, and Vigorito.Villeneuve, J.-P., See Huet, Goresky, Villeneuve, Marleau, and

Lough.Vlahcevic, Z. R., See Schwartz, Berman, Vlahcevic, and Swell.-, See Schwartz, Vlahcevic, Berman, Meadows, Nisman, and

Swell.

W

Wahner, H. W., See Riggs, Wahner, Seeman, Offord, Dunn, Ma-zess, Johnson, and Melton.

Warburton, D., See Berger, Morrison, Chu, Patterson, Estabrook,Takezaki, Sharon, Warburton, Irigoyen, and Edelson.

Wardzala, L. J., See Hissin, Foley, Wardzala, Karnieli, Simpson,Salans, and Cushman.

Webster, H. K., and Whaun, J. M. Antimalarial properties ofbredinin. Prediction based on identification of differences inhuman host-parasite purine metabolism. 461.

Webster, R. O., Larsen, G. L., and Henson, P. M. In vivo clearanceand tissue distribution of C5a and C5a des arginine comple-ment fragments in rabbits. 1177.

Wei, M., See Weiss, Klein, Slivka, and Wei.Weinberg, J. B., See Goodwin and Weinberg.Weinstein, D. B., See Durrington, Newton, Weinstein, and Stein-

berg.Weiss, H. R., See Conway and Weiss.Weiss, S. J., Klein, R., Slivka, A., and Wei, M. Chlorination of

taurine by human neutrophils. Evidence for hypochlorous acidgeneration. 598.

Weksler, B. B., See Hajar, Weksler, Falcone, Hefton, Tack-Gold-man, and Minick.

Wenger, D. A., See Kudoh and Wenger.Wetzel, M. W., See Slater, Murray, Wetzel, Wisdom, and DuVall.Whaun, J. M., See Webster and Whaun.Whitcomb, J. A., See Boxer, Haak, Yang, Wolach, Whitcomb,

Butterick, and Baehner.Williams, G. H., See LeBoff, Dluhy, Hollenberg, Moore, Koletsky,

and Williams.Williams, J. A., See Otsuki and Williams.Williams, L. T., and Tremble, P. Binding of a calcium antagonist,

[3Hlnitrendipine, to high affinity sites in bovine aortic smoothmuscle and canine cardiac membranes. 209.

Williams, P. E., See Abumrad, Jefferson, Rannels, Williams, Cher-rington, and Lacy.

Wilson, F. J., Jr., See Jacobs, Soulsby, Bone, Wilson, and Hiller.Wingo, C. S., Seldin, D. W., Kokko, J. P., and Jacobson, H. R.

Dietary modulation ofactive potassium secretion in the corticalcollecting tubule of adrenalectomized rabbits. 579.

Wisdom, R. M., See Slater, Murray, Wetzel, Wisdom, and DuVall.Witkin, S. S., Zelikovski, G., Bongiovanni, A. M., Gelier, N., Good,

R. A., and Day, N. K. Sperm-related antigens, antibodies, andcirculating immune complexes in sera of recently vasectomizedmen. 33.

Witte, L. D., See Blum, Deckelbaum, Witte, Tall, and Cornicelli.Witztum, J. L., See Ostlund, Levy, Witztum, and Schonfeld.Wolach, J. B., See Boxer, Haak, Yang, Wolach, Whitcomb, But-

terick, and Baehner.Wolin, S. L., See Hardin, Rahn, Shen, Lerner, Wolin, Rosa, and

Steitz.Wyler, D. J., In vitro parasite-monocyte interactions in human

leishmaniasis. Evidence for an active role of the parasite inattachment. 82.

y

Yaar, M., See Stanley, Yaar, Hawley-Nelson, and Katz.Yang, H.-H., See Boxer, Haak, Yang, Wolach, Whitcomb, Butter-

ick, and Baehner.

The Journal of Clinical Investigation 1351

Yeo, C. J., Jaffe, B. M., and Zinner, M. J. Local regulation ofblood flow in the feline jejunum. A possible role for endolu-minally released substance P. 1329.

z

Zech, L. A., See Ghiselli, Schaefer, Zech, Gregg, and Brewer.-, See Schaefer, Kay, Zech, and Brewer.

Zelikovski, G., See Witkin, Zelikovski, Bongiovanni, Geller, Good,and Day.

Zimmenran, T. S., See Ruggeri, Nilsson, Lombardi, Holmberg,and Zimmerman.

Zingg, H. H., and Patel, Y. C. Biosynthesis of immunoreactivesomatostatin by hypothalamic neurons in culture. 1101.

1352 Author Index. Volume 70, 1982

SUBJECT INDEX

A

Abetalipoproteinemia, role of apolipopro-tein E-containing lipoproteins in,1157

Acetyl glyceryl ether phosphorylcholine,effects on leukotriene B4 synthesis,polymorphonuclear leukocytes,1058

Acidosisammonium, renal tubular handling of,

Ilactic, treatment with dichloroacetate,

853metabolic, 25-hydroxyvitamin D3-la-

hydroxylase suppression, 135Acromegaly therapy, growth hormone-re-

leasing factor-secreting pancreatictumor, removal, 965

Activator, plasminogen, isolation fromplasma, 1320

Adenine nucleotides, energy metabolismof neutrophils, 550

Adipose cell, insulin-resistant glucosetransport activity in, mechanismsof, 780

Adrenalectomy, dietary modulation ofpotassium secretion, cortical col-lecting tubule, 579

Adrenergic blockade: see BlockadeAging

cellular, hematopoietic stem cells andhigh proliferative potential, 242

changes in bone mineral density, proxi-mal femur and spine, 716

immunobiology of, null cell senescenceand, 201

Aldosteronemineralocorticoid-independent potas-

sium secretion, 579secretion stimulation, potassium-angio-

tensin II interaction, 667Alloxan, protective role of superoxide

dismutase against, 650Alveolar macrophage, growth factor for

fibroblasts, 806Amino acid, metabolism, tyrosinemia

and, fetus, 198Ammonium ion, renal tubular handling,

nephrons, 1Amphotericin B, luminal addition, potas-

sium ion secretion, urinary blad-der, 832

Amyloidosis, light chain association with,Bence Jones proteins, 453

Anemiacongenital hemolytic, erythrocyte

membrane proteins, 1273

congenital hypoplastic, lymphocytedysfunction in, 619

Angiotensin-converting enzyme, induc-tion by glucocorticoids, endothe-lium and lung, 684

Angiotensin IIinteraction with potassium, stimulation

of aldosterone secretion, 667renin release suppression by, essential

hypertension, 335Antibodies: see also Autoantibodies

antiislet, diabetes mellitus and, 659antinuclear

cellular RNA-protein particle bind-ing, 141

xid gene and, 587blocking, serum resistance of Neisseria

gonorrhoeae, 157cell surface, binding to pancreatic B

cells, 41IgG antigranulocyte, activation of com-

plement by, 1137interaction with drugs and platelets,

thrombocytopenia, 989monoclonal

cutaneous T-cell lymphoma diagno-sis with, 1205

cytotoxic, reaction with islet cells,659

immunoregulatory cells, multiplesclerosis cerebrospinal fluid, 387

protective, tetanus toxin and, 1306specificity for hairy cell leukemia

cells, 254pemphigus, cell surface glycoprotein

identification by, 281speckled fluorescent antinuclear, anti-

sera analysis, electrofocused nu-clear antigens, 296

sperm-related, sera levels after vasec-tomy, 33

Antigensbacterial, immune complexes in infec-

tive endocarditis, 271B cell, induction in non-T cell acute

lymphoblastic leukemia, 433HLA-DR, colony-forming unit-granu-

locyte macrophage expression and,568

islet cell surface, monoclonal antibodybinding, 659

nuclear, Sm, and ribonucleoprotein,analysis of speckled fluorescentantinuclear antibody antisera, 296

sperm-related, sera levels after vasec-tomy, 33

tumor-associated, reactive with mono-clonal antibodies, T cell lym-phoma diagnosis, 1205

tumor-specific, in hairy cell leukemia,monoclonal antibodies and, 254

Antiislet antibodies: see Antibodiesa-Antitrypsin, neutrophil-derived proteol-

ysis and, 845Aplasia, pure red cell, B cell chronic lym-

phocytic leukemia, 1148Apolipoprotein E, lipoproteins contain-

ing, role in abetalipoproteinemia,1157

Apolipoprotein E4, increased prevalenceof, type V hyperlipoproteinemia,474

Apoliprotein, A-I, Tangier disease, 934Apoprotein, low density lipoprotein,

plasma cholesterol level, 13Arachidonic acid, release, activation in

platelets, 1205Argininosuccinate synthetase, deficiency,

molecular analysis, fibroblast,1334

Arthritis, rheumatoid, peripheral T lym-phocytes, IgG determinants, 329

Asthma, histamine and phrenic nerve ac-tivity, 424

Atherosclerosishigh density lipoprotein and, plasma-

free cholesterol metabolism, 105hypertriglyceridemia and, triglyceride

synthesis and accumulation, 168Autoantibodies: see also Antibodies

disease prevention, xid gene, 587monoclonal, production by human-hu-

man hybridomas, 205Autoimmunity

diabetes mellitus, pathogenesis, 41prevention with xid gene, polyclonal

stimulation or immunization withDNA, 587

B

Band 3, membrane, erythrocyte, 946B cell

activation, xid gene effects, 587antigens, induction in non-T cell acute

lymphoblastic leukemia, 433Bence Jones proteins, light chains of im-

munoglobulins and, 453Bernard-Soulier syndrome, platelet mem-

brane glycoprotein abnormalitiesin, comparison with normal glyco-proteins, 304

Bicarbonateoutput, ion substitution effects on bile

formation, liver, 505reabsorption, determinants of, proxi-

mal convoluted tubules, 639Bile

The Journal of Clinical Investigation 1353

deoxycorticosterone excretion in, liver,sex differences, 312

flow, ion substitution effects, liver, 505monomeric and polymeric proteins in,

selective transport of, 230Bile acids

bile formation, ion substitution effects,505

serum, hepatic uptake, 724synthesis, hepatoblastoma cell line,

1128Bile salts

hepatic, regulation of transport bycholic acid receptors, 401

hydrolysis of milk fat globules, pan-creatic lipase, 30

Bilirubin, conjugation, small intestinalmucosa, 23

Binding'sites, nitrendipine, smooth mus-cle and cardiac membranes, 209

Biosynthesis, immunoreactive somatosta-tin, hypothalmic neurons, 1101

Bisphosphonates, differential action, mac-rophage-mediated bone resorp-tion, 927

Bladder, urinary, isolated, potassium iontransport in, 832

Blast cells, colonies, umbilical cord blood,1324

Blockade, a- and ,8-adrenergic, secretionby Clara cells after lung vential-tion, effects on, 608

Blood-brain barrier, protein entry, cere-brospinal fluid, 289

Blood flowcoronary, oxygen supply and consump-

tion, ischemia, 320mucosal, local regulation, jejunum,

1329B lymphocytes, T lymphocytes and, vol-

ume regulation by, 632Bone

mineral density, changes with aging,proximal femur and spine, 716

resorption, macrophage-mediated, dif-ferential action of biphosphonateson, 927

Bradykinin, glucocorticoid induction ofangiotensin-converting enzyme,684

Breathing, control, histamine and phrenicnerve activity, 424

Bredinin, antimalarial properties of, 461Burns, mortality increases, alternative

complement pathway activation,1170

CC5a, C5a des arginine and, clearance and

tissue distribution, 1177Calcitonin, 25-hydroxyvitamin D3-la-hy-

droxylase activity, stimulation, 135Calcium, transport, tubular mechanism

for spontaneous hypercalciuria,835

Calcium antagonist, nitrendipine and ni-fedipine, binding sites, 209

Cancerautologous mixed lymphocyte reaction,

1354 Subject Index . Volume 11, 1982

peripheral blood and pleural effu-sions, 98

breast, methotrexate polyglutamates incells, 351

Capillarization, liver microcirculation,cirrhosis, 1234

Captoprilangiotensin II and, potassium-mediated

stimulation of aldosterone secre-tion, 667

renin release suppression by, essentialhypertension, 335

Carbohydrates, high levels, postprandialinsulin level and hypertriglyceride-mia, 1225

Cardiopulmonary system, effects of em-bolism, thromboxane mediation,361

Cartilage, growth-plate, maturation, stim-ulation with triiodothyronine, 496

Cationserythrocyte permeability, potassium

and sodium, 1273mean cell hemoglobin concentration

and, sickle cell hydration, 1074Cell line

breast cancer, methotrexate polygluta-mates in, 351

hepatoblastoma, bile acid synthesis by,1128

HepG2, hepatoma-derived, comple-ment biosynthesis by, 906

Cell surface antibodies, binding to pan-creatic B cells, 41

Cerebral cortex, congenital hypothyroid-ism, thyroid hormone-dependentenzyme activities, neonate, 110l

Cerebroside sulfate, fatty acid-labeled,metabolism in cultured cells, 89

Cerebrospinal fluidmultiple sclerosis, T cell subsets in, 387protein entry into, encephalitis, 289

Charge-selective barrier, glomerulone-phritis and, 732

Chediak-Higashi syndrome, natural killercells in, number, function, andmorphology, 193

Chemotaxisfibroblast responses, tropoelastin and

elastin-derived peptides, 614receptors, cyclic nucleotide-induced

maturation of promyelocytic leu-kemia cells, 953

Cholecystokinin, enzyme secretion and,pancreas, diabetes effects, 148

Cholesterolfamilial hypercholesterolemia, fibro-

blast receptor affinity and lowdensity lipoprotein, 823

metabolismapoliprotein E in abetalipoproteine-

mia, 1157multicompartmental analysis, 863role of high density lipoprotein in,

105plasma level, regulation, 13

Cholesteryl ester, hydrolysis, modulationby prostacyclin, 479

Cholesteryl esterase, prostacyclin effectson, 479

Cholic acid, receptors, regulation of bilesalt transport with, 401

Chromatographygas-liquid, bile acid analysis, 1128high'pressure liquid, and gel, plasma

neurotensinlike immunoreactivityand, 74

Circulation, portal and enterohepatic, se-rum bile acids, 724

Cirrhosis, liver microcirculation in, 1234Citrullinemia, argininosuccinate synthe-

tase deficiency, molecular analysis,1334

Clara cells, secretion regulation of, 608Clearance, tissue distribution and, C5a

and C5a des arginine complement,1177

CoagulationFactor V, activation by platelet pro-

tease, 1092Factor V/VIII deficiency disease, acti-

vated protein C inhibitor and,1260

Cobalamin, presence and formation ofanalogues, multivitamin-mineralpills, 889

Codeine, antidiarrheal effects, 989Colipase, hydrolysis of milk fat globules,

pancreatic lipase, 30Collagenabnormal elastin in aorta and, Marfan

syndrome, 1245synergistic activation by, phosphatidyl-

inositol metabolism and arachi-donic acid release, platelets, 1205

Colony-forming unitserythroid, growth suppression, aplasia

of leukemia, 1148granulocyte macrophage and, control

of proliferation, Ia-antigen and,568

Complementactivation by antigranulocyte antibody,

1137alternative pathway activation, in-

creased mortality, burns, 1170C5a and C5a des arginine, clearance

and tissue distribution, 1177herpes simplex virus, cross-reacting an-

tibody role, 1081Contractility, diaphragm, elastase-in-

duced emphysema, 978Corticosterone, binding, anterior pitui-

tary, 899Cryohydrocytosis, erythrocyte membrane

permeability, potassium and so-dium, 1273

Cyclic adenosine monophosphate, prosta-cyclin effects on, cholesteryl esterhydrolysis, 479

Cynomolgus monkey, lipoprotein metab-olism during hepatic triglyceridelipase inhibition, 1184

Cytomegalovirus, latent, spleen explants,spontaneous activation of, 762

Cytoskeleton, hereditary pyropoikilocyto-sis and elliptocytosis, 1019

Cytotoxicity, antibody-dependent cell-mediated, natural killer cells inChediak-Higashi patients, 193

DDaunorubicin, resistance, verapamil ef-

fects, Ehrlich ascites carcinoma,1131

Deformability, sickle cell hydration ef-fects, 1074

Density gradients, continuous, hemoglo-bin concentration, SC disease,1315

Deoxycorticosterone, deoxycorticosteronesulfate and, metabolism, sex dif-ferences, 312

Deoxycorticosterone sulfate, deoxycorti-costerone and, metabolism, sexdifferences, 312

Diabetesdrugs for, protective role of superoxide

dismutase against, 650myo-inositol uptake, peripheral nerve,

1009Diabetes mellitusenzyme secretion regulation and, pan-

creatic acini, 148insulin-dependent, antibody binding to

pancreatic B cells, 41type I, islet cell surface antigens, auto-

immunity and, 659Diamond-Blackfan syndrome, lympho-

cyte dysfunction in, 619Diaphragm, contractility, elastase-in-

duced emphysema, 978Diarrhea, codeine, antidiarrheal effects,

989Dichloroacetate, treatment for lactic aci-

dosis, 853DNA

linkage analysis, familial isolatedgrowth hormone deficiency type 1,489

single strand, autoantibodies to, 205Drugs, interaction with platelets and anti-

bodies, thrombocytopenia, 989

E

Ehrlich ascites carcinoma, daunorubicin-resistant, verapamil effects, 1131

Elastinabnormal, Marfan aorta, 1245fibroblast chemotaxis to, 614

Electrophoresis, high-resolution two-di-mensional, normal and abnormalplatelet membrane glycoproteins,Bernard-Soulier syndrome, 304

Elliptocytosis, hereditary, spectrin ,B-chain variant associated with, 707

Embolism, cardiopulmonary effects,thromboxane mediation, 361

Emphysemaelastase-induced, effects on diaphragm

contractility, 978inflammatory connective tissue injury

modulation, neutrophil-derivedproteolysis, 845

Encephalitis, viral, protein entry into ce-rebrospinal fluid, 289

Endocarditis, infective, bacterial antigensin circulating immune complexesof, 271

Endocytosis, receptor-mediated, hypertri-glyceridemia and foam cell forma-tion in vitro, 168

Endometrium, mesenchyme-epithelial in-teractions in, 798

Endothelial cells, Plasmodiumfalciparum-infected, malaria, 379

Endothelium, angiotensin-converting en-zyme production, induction byglucocorticoids, 684

Endotoxins, lipopolysaccharides and, 877Endotoxic shock, ibuprofen and, 536Energy metabolism, neutrophils, phago-

cytosis, 550Enterogastrone, plasma immunoreactiv-

ity, elevation after meal, 74Enzyme: see also specific enzyme

secretion, regulation, diabetes effects,148

Epidermis, pemphigus antibodies, cellsurface glycoprotein identificationby, 281

Epstein-Barr virus, neutralization by non-immune human serum, 1081

Erythrocytes: see also Red blood cellsmembranes, hemoglobin C and, 946protoporphyrin release from, erythro-

poietic protoporphyria, 693Erythroid colonies, progenitor-derived,

hemoglobin F synthesis, 752Erythropoiesis

pure red cell aplasia in B cell chroniclymphocytic leukemia, 1148

stress, hemoglobin F synthesis, 752Erythropoietic protoporphyria, protopor-

phyrin release from erythrocytesin, 693

Exercise, cardiac overload, physiologicand pathologic cardiac hypertro-phy and, 1300

Exocytosis, neutrophil secretory compart-ment, gelatinase release, 518

F

Fab fragments, determinants on, periph-eral T lymphocytes, rheumatoidarthritis, 329

Factor V, coagulation, activation byplatelet protease, 1092

Factor VII, Factor VIla and, binding tomonocytes, 526

Factor V/VIII deficiency disease, acti-vated protein C inhibitor, func-tional levels, 1260

Farber disease, fatty acid-labeled cere-broside sulfate uptake, diagnosisafter, 89

Fasting, serum bile acids, hepatic uptake,724

Ferrokinetics, plasma iron exchange, 769Fetus, hemoglobin synthesis, 50Fibrinogen receptor, platelet thrombos-

pondin formation, 542Fibrinolysis, protein C activation in vivo,

127Fibroblasts

argininosuccinate synthetase defi-ciency, molecular analysis, 1334

chemotactic responses of, tropoelastinand elastin-derived peptides, 614

cultured skin, fatty acid-labeled cere-broside sulfate uptake, 89

growth factor, alveolar macrophage,806

receptor affmity, increased, familial hy-percholesterolemia, 823

5-Fluorouracil, low dose, sensitization to,558

Foam cell, formation, hypertriglyceride-mia and, 168

Force, generating ability, diaphragm, em-physema effects, 978

Fractional catabolic rate, plasma choles-terol regulation, 13

Fraud in medical research, 213

G

Gammopathy, IgM, antigen-specific lym-phocyte differentiation, 1292

Gelatinase, release, neutrophil secretorycompartment, 518

Glomerular barrier, function, glomerulo-nephritis and, 732

Glomerulonephritis, proteinuria mecha-nisms in, 732

Glucagon, postprandial insulin responsesuppression, hypertriglyceridemia,1225

Glucocorticoidseffects on proopiomelanocortin, pitui-

tary and neurointermediate lobe,443

induction of angiotensin-converting en-zyme, endothelium and lung, 684

receptors, anterior pituitary, 899Gluconeogenesis, calculation from glyc-

erol, newborn, 262Glucose

disposal and output, differential insulineffects, 117

metabolismfluid absorption and, 53insulin effects, 13 10insulin resistant, adipose cell, 780

production, glycerol contribution to,newborn, 262

transport systems, translocation, insulinresistant activity, adipose cell, 780

turnover and uptake, fetus, 179Glycerol flux, palmitate flux and, new-

born, 262Glycolysis, energy metabolism of neutro-

phils during, 550Glycoprotein

Ib, platelet modification, Tn-syndrome,1281

platelet membrane, abnormalities, Ber-nard-Soulier syndrome, 304

Glycosaminoglycan, synthesis, thyroidhormone regulation of, 1066

Granulocyte macrophage, colony-formingunits and, control of proliferation,Ia-antigen and, 568

Granulocytes, lactoferrin binding to, 1049

The Journal of Clinical Investigation 1355

Growth factor, alveolar macrophage, fi-broblast, 806

Growth hormone, deficiency type I, ge-netic analysis, 489

Growth hormone-releasing factor, secre-tion by pancreatic islet tumor, ac-romegaly treatment by removal,965

Guanylates, metabolism, malaria and,bredinin effects, 461

Gut, leucine kinetics, insulin role in regu-lation, 1031

H

Hageman factor, fragments, formationand structure, 627

Hairy cells, leukemia, monoclonal anti-bodies specific for, 254

Hearthypertrophy, physiologic and patho-

logic, 1300oxygen supply and consumption, is-

chemia, propranolol effects, 320Heme, metabolism, small intestinal mu-

cosa, 23Hemichrome, generation by sickle eryth-

rocytes, 1253Hemoglobinoxygen radical generation by sickle

erythrocytes, 1253protoporphyrin and, release, erythropo-

ietic protoporphyria, 693synthesis, preterm infants, 50

Hemoglobin C, erythrocyte ghosts and,946

Hemoglobin F, synthesis, erythroid pro-genitor-derived colonies, 752

Hemoglobinopathy, SC erythrocytes,high hemoglobin concentrations,pathophysiology, 1315

Hemopoiesis, cell colonies, umbilical cordblood, 1324

Henle's loop, potassium ion transport in,219

Hepatoblastoma, cell line, bile acid syn-thesis by, 1128

Hepatocytes, very low density lipoproteintriglyceride secretion by, insulinand glucose effects, 63

Hepatomabile acid studies with, 1128cell line HepG2, complement biosyn-

thesis by, 906HepG2, hepatoma-derived cell line, com-

plement biosynthesis by, 906Hereditary elliptocytosis, hereditary pyro-

poikilocytosis and, molecular de-fect of spectrin in, 1019

Hereditary pyropoikilocytosis, moleculardefect of spectrin in, 1019

Heredity, spontaneous hypercalciuriaand, 835

Herpes simplex virus, neutralization bynonimmune human serum, 1081

Hindlimb, leucine kinetics, insulin role inregulation, 1031

Hip, fracture, bone mineral densitychanges, aging, 716

Histamine

aerosolized, reflex effects on phrenicnerve activity, 424

suppressor T cells, monokine require-ment on, 393

HLA-DR antigen, colony-forming unit-granulocyte macrophage expres-sion and, 568

Hormone: see also under specific namegrowth, deficiency type I, genetic anal-

ysis, 489thyroid, glycosaminoglycan regulation,

1066Hybridomahuman-human, autoantibody produc-

tion by, 205protective antibody, tetanus toxin, 1306

Hydration, sickle cells, monensin, 1074Hydrogen peroxide, secretion by mono-

cytes, enhanced capacity, lym-phokine effects, 1042

3-Hydroxy-3-methyl-glutaryl coenzymeA, apoliprotein E in abetalipopro-teinemia, 1157

25-Hydroxyvitamin D3-la-hydroxylase,suppression with metabolic aci-dosis, 135

Hypercalciuria, spontaneous, tubularmechanism for, 835

Hyperchlorous acid, generation by neu-trophils, 598

Hypercholesterolemia, familial, fibroblastreceptor affinity and low densitylipoprotein, 823

Hyperlipoproteinemia, type V, apolipo-protein E4, 474

Hyperoxia, neutrophil-induced injury,lung cells, 342

Hyperplasia, somatotroph, growth hor-mone-releasing factor-secretingpancreatic tumor removal, 965

Hypertensioncardiac overload, physiologic and path-

ologic cardiac hypertrophy and,1300

essential, captopril and angiotensinsuppression of renin, 335

Hypertriglyceridemia, very low density li-poproteins, triglyceride synthesisand accumulation, 168

Hypertrophy, cardiac, physiologic andpathologic, 1300

Hypothalamus, neurons, immunoreactivesomatostatin biosynthesis by, 1101

Hypothyroidism, congenital, brain adap-tation to, neonate, 1110

Ibuprofen, endotoxic shock and, 536IgA, monomeric and polymeric, selective

transport in bile, 230IgG

antigranulocyte antibody, activation ofcomplement by, 1137

light chains and/or Fab fragments, rec-ognition of determinants by pe-ripheral T lymphocytes, 329

Immune complexescirculating

bacterial antigens in, infective endo-carditis, 271

serum level after vasectomy, 33Immunity, viral, Epstein-Barr virus neu-

tralization, 1081Immunobiology, aging, null cell senes-

cence and, 201Immunochemotherapy, sensitization to 5-

fluorouracil, enhancement of sys-temic antitumor effect, 558

Immunopathology, autoimmunity pre-vented by xid gene, polyclonalstimulation or immunization withDNA, 587

Infantslipid transport in, 262liver, tyrosine aminotransferase and p-

hydroxyphenylpyruvate dioxygen-ase activities, 198

preterm, hemoglobin synthesis, 50Insulin

differential effects of, splanchnic andperipheral glucose disposal, 117

effects on glucose, Michaelis constant,1310

glucose and, very low density lipopro-tein triglyceride secretion, effectson, 63

postprandial response, suppression, ef-fects on hypertriglyceridemia,1225

regulation of leucine kinetics, 1031resistance, glucose transport activity,

adipose cell, 780Intensive care, neonatal, hemoglobin syn-

thesis, 50Interleukin- 1monokine requirement on histamine-

induced suppressor activity, 393T lymphocytes and, Interleukin-2 pro-

duction, 470Interleukin-2, production by lympho-

cytes, OKT4 or OKT8 phenotype,470

Intestinal cells, isolated, heme and biliru-bin metabolism in, 23

Intestinal perfusion, antidiarrheal effectsof codeine, 989

Intestine, small, mucosa, heme and biliru-bin metabolism in, 23

lodothyronine 5'deiodinase, thyroid-hor-mone-dependent enzyme activities,cerebral cortex, neonate, 1110

Iron, plasma, exchange, 769Ischemia, oxygen supply and consump-

tion, improvement with proprano-lol, 320 -

Islet cells: see Pancreatic isletsIsoferritin, acidic, control of granulocyte

and macrophage production, Ia-like antigens, 568

JJejunum, blood flow, local regulation,

1329

KKallikrein, digestion of Hageman factor,

effects, 627

1356 Subject Index * Volume 11, 1982

Keratinocytes, cell surface glycoproteinsynthesis by, identification withpemphigus antibodies, 281

Kidney, collecting duct, ammoniumshunting, I

Kidney medulla, potassium recycling in,219

Kidney tubulescortical collecting

potassium secretion, dietary modula-tion after adrenalectomy, 579

prostaglandin-vasopressin interac-tions, 1193

proximaldefect, spontaneous hypercalciuria,

835inorganic phosphate metabolic re-

quirement, 53proximal convoluted, determinants of

bicarbonate reabsorption in, 639Killer cells, Chediak-Higashi patients,

numbers, function, and morphol-ogy, 193

Kininase II, induction by glucocorticoids,endothelium and lung, 684

Krabbe disease, fatty acid-labeled cere-broside sulfate uptake, diagnosisafter, 89

L

Labeling, surface, normal and abnormalplatelet membrane glycoproteins,Bernard-Soulier syndrome, 304

Lactateturnover, measurement, fetus, 179uptake, umbilical, fetus, 179

Lactic acidosis, treatment with dichloro-acetate, 853

Lactoferrin, membrane-bound, polymor-phonuclear leukocyte surfaceproperty alteration by, 1049

Leishmaniasis, human, parasite-monocyteinteractions, 82

Leucine, kinetics, insulin role in regula-tion, 1031

Leukemiaacute lymphoblastic, non-T cell, B cell

antigen induction in, 433chronic lymphocytic, pure red cell

aplasia in, 1148hairy cell, monoclonal antibodies spe-

cific for, 254promyelocytic cells, cyclic nucleotide-

induced maturation of, 953Leukocytespolymorphonuclearenhancement of cytotoxicity media-

tion in lung cells, 342leukotriene B4 synthesis, 1058receptor-mediated modulation by

phorbol diesters, 699surface property alteration by lacto-

ferrin, 1049Leukotriene, generation by purified lung

mast cells, 747Leukotriene B4, synthesis in leukocytes,

acetyl glyceryl ether phosphoryl-choline effects, 1058

Light chains

Bence Jones proteins and, amyloidosis,453

determinants on, peripheral T lympho-cytes, rheumatoid arthritis, 329

Linkage, analysis, familial isolatedgrowth hormone deficiency type I,489

Lipasecharacterization of activities, obese

Pima Indians, 791hepatic triglyceride, inhibition, lipopro-

tein metabolism during, 1184pancreatic, hydrolysis of milk fat glob-

ules by, 30Lipid, digestion, pancreatic lipase, 30Lipopolysaccharide, Salmonella typhimu-

rium, extracted and native forms,877

Lipoproteinapoliprotein E-containing, role in apo-

liproteinemia, 1157high and low density

cholesterol metabolism analysis, 863plasma-free cholesterol metabolism

and, 105high density

binding density, 877Tangier disease, 934

low densityproduction, plasma cholesterol and,

13receptor, familial hypercholesterole-

mia, 823very low density

hypertriglyceridemia, triglyceridesynthesis and accumulation, 168

metabolism, hepatic triglyceride li-pase inhibition, 1184

triglyceride secretion, insulin andglucose effects on, 63

Lipoxygenase, leukotriene B4 synthesis,acetyl glyceryl ether phosphoryl-choline effects, 1058

Liverbile formation, ion substitution effects

on, 505bile salt transport in, regulation by

cholic acid receptors, 401deoxycorticosterone and deoxycorticos-

terone sulfate metabolism in, sexdifferences, 312

leucine kinetics, insulin role in regula-tion, 1031

microcirculation, assessment in cirrho-sis, 1234

triglyceride lipase, inhibition, lipopro-tein metabolism during, 1184

uptake, bile acids, 724Loop of Henle: see Henle's loopLung

angiotensin-converting enzyme produc-tion, induction by glucocorticoids,684

purified mast cells, leukotriene genera-tion by, 747

shock, burns, alternative complementpathway activation and, 1170

surfactant, abnormality, respiratoryfailure, 673

Lung cells, neutrophil-induced injury, hy-peroxia, 342

Lupus erythematosus, systemic, antibod-ies from, cellular RNA-proteinbinding, 141

Lymphocytes: see also B cell, T cellautologous mixed reaction

cancer patients, 98Interleukin, 470

dysfunction, congenital hypoplasticanemia, 619

function, receptor-mediated modula-tion by phorbol diesters, 699

monoclonal, spontaneous differentia-tion, IgM gammopathy, 1292

spontaneous activation of latent cyto-megalovirus, spleen explants, 762

volume regulation by, 632Lymphokines, enhancement of monocyte

capacity to secrete reactive oxygenintermediates, 1042

Lymphoma, cutaneous T-cell, diagnosisusing monoclonal antibodies, 1205

Ma2-Macroglobulin, plasminogen activator

reaction with, 412Macromolecule clearances, glomerulone-

phritis and, 732Macrophages: see also specific type

alveolar, growth factor for fibroblasts,806

bone resorption mediation, differentialaction of biphosphonates on, 927

granulocyte, colony-forming units and,568

peritoneal, triglyceride synthesis andaccumulation, lipoprotein effects,168

secretion of reactive oxygen intermedi-ates, enhanced capacity, lymphok-ine effects, 1042

spontaneous activation of latent cyto-megalovirus, spleen explants, 762

Malariabredinin effects, 461Plasmodiumfalciparum-infected eryth-

rocytes, attachment of, 369Marfan syndrome, abnormal elastin in

aorta, 1245Marrow, transplantation, hematopoietic

stem cell concentration in, 242Mast cells, lung, purified, leukotriene

generation by, 747Maturation, growth-plate cartilage, stim-

ulation with triiodothyronine, 496Meal, stimulation after, plasma neuroten-

sinlike immunoreactivity eleva-tion, 74

Melanoma cells, Plasmodiumfalciparum-infected, malaria, 379

Mesenchyme-epithelial interaction, endo-metrium, 798

Metabolic acidosis: see Acidosis, meta-bolic

Metabolism, C5a and C5a des arginine,1177

Metabolites

The Journal of Clinical Investigation 1357

neurotensin, elevation of immunoreac-tivity after meal, 74

oxygen, neutrophil-induced injury,lung cells, 342

Metachromatic leukodystrophy, fattyacid-labeled cerebroside sulfateuptake, diagnosis after, 89

Methotrexate, polyglutamates, synthesis,retention, and biological activity,breast cancer cells, 351

Milk fat globules, hydrolysis by pan-creatic lipase, colipase, phospholi-pase A2, bile salts, 30

Mineralocorticoids, effects on proopiome-lanocortin, pituitary and neuroin-termediate lobe, 443

Minerals, vitamins and, pills, presenceand formation of cobalamin ana-logues, 889

Molecular variant, spectrin /-chain, he-reditary elliptocytosis, 707

Monensin, sickle cell hydration using,1074

Monoclonal antibodies: see Antibodies,monoclonal

Monoclonal autoantibodies: see Autoanti-bodies, monoclonal

MonocytesFactor VII and VIla binding to, 526function, receptor-mediated modula-

tion by phorbol diesters, 699interaction with parasite, human leish-

maniasis, 82secretion of reactive oxygen intermedi-

ates, enhanced capacity, lymphok-ine effects, 1042

Monokine, requirement on histamine-in-duced suppressor activity, 393

Multimeric structure, aberrant, von Wil-lebrand's disease, 1124

Multiple sclerosis, cerebrospinal fluid, Tcell subsets in, 387

Mycosis fungoides, diagnosis, monoclonalantibodies and, 1205

Myeloid differentiation, cyclic nucleotide-induced maturation of promyelo-cytic leukemia cells, 953

Myeloperoxidase, oxidative metabolism,hypochlorous acid generation,neutrophils, 598

Myelopoiesis, Ia-antigen and control ofcolony-forming unit-granulocytemacrophage proliferation, 568

Myoinositol, plasma, lung surfactant ab-normality in respiratory failure,673

Myo-inositol, sodium- and energy-de-pendent uptake, peripheral nerve,1009

Myosin, exercise effects, physiologic andpathologic cardiac hypertrophy,1300

N

Naloxone, electrolyte absorption and, an-tidiarrheal effects of codeine, 989

Natural killer cells, Chediak-Higashi pa-tients, numbers, function, andmorphology, 193

1358 Subject Index * Volume 11, 1982

Neisseria gonorrhoeae, serum resistanceof, 157

Nephronisolated, 25-hydroxyvitamin D3-la-hy-

droxylase, metabolic acid effects,135

superficial and juxtamedullary, ammo-nium handling by, I

Nerveperipheral, myo-inositol metabolism,

1009phrenic, activity, reflex effects of aero-

solized histamine on, 424Neural cultures, hypothalamic, immuno-

reactive somatostatin biosynthesisby, 1101

Neurointermediate lobe, pituitary and,steroid effects on proopiomelano-cortin in, 443

Neuropathy, myo-inositol uptake, periph-eral nerve, 1009

Neurotensin, plasma immunoreactivity,elevation after meal, 74

Neutrophilsaggregation, acetyl glyceryl ether phos-

phorylcholine effects, 1058C5a and C5a des arginine, role in tis-

sue distribution, 1177chlorination of taurine by, hypochlo-

rous acid generation, 598energy metabolism of, phagocytosis,

550function, receptor-mediated modula-

tion by phorbol diesters, 699proteolysis by, 845secretory compartment of, gelatinase

release from, 518Nifedipine, binding, smooth muscle and

cardiac membranes, 209Nitrendipine, binding, smooth muscle

and cardiac membranes, 209Nuclear antigen: see Antigens, nuclearNucleotide, cyclic, promyelocytic leuke-

mia cell maturation and, 953Null cell, senescence, immunobiology of

aging and, 201

0

Obesityenlarged adipose cell, insulin-resistant

glucose transport activity in, 780lipase activities, Pima Indians, 791

Opiates, antidiarrheal effects, 989Osteoporosis, bone mineral density

changes, aging, 716Oxidants

lung cell injury, neutrophil-induced,hyperoxia, 342

neutrophil-derived proteolysis, protein-ases and inhibitors, 845

Oxidative metabolismhypochlorous acid generation, neutro-

phils, 598inorganic phosphate, proximal tubule,

53Oxygen

metabolites, neutrophil-induced injury,lung cells, 342

radicals, spontaneous generation bysickle erythrocytes, 1253

supply and consumption, myocardialischemia, propranolol effects, 320

p

Palmitate flux, glycerol flux and, new-born, 262

Pancreas, exocrine, enzyme secretion, di-abetes effects, 148

Pancreatic isletssuperoxide dismutase, diabetogenic

drugs, protective role, 650surface antibodies, diabetes binding to

pancreatic B-cells, 41tumor, growth hormone-releasing fac-

tor-secreting, acromegaly treat-ment by removal, 965

Parasiteinteraction with monocyte, human

leishmaniasis, 82Schistosoma mansoni, destruction by T

lymphocytes, 369Parathyroid hormones, 25-hydroxyvi-

tamin D3- a-hydroxylase, regula-tion, 135

Pemphigus, antibodies, cell surface glyco-protein identification by, 281

Phagocytosis, energy metabolism of neu-trophils during, 550

Phorbol diesters, receptor-mediated ef-fects on blood cells, 699

Phosphate, transport, renal tubule, 53Phosphatidylinositol, metabolism, activa-

tion in platelets, 1205Phospholipase A2, hydrolysis of milk fat

globules, pancreatic lipase, 30Phospholipase C, phosphatidylinositol-

specific, collagen-stimulated acti-vation, 1205

Phospholipids, bronchoalveolar lavage,lung surfactant abnormality in res-piratory failure, 673

Phrenic nerve, activity, reflex effects ofaerosolized histamine on, 424

p-Hydroxyphenylpyruvate dioxygenase,development, fetal and neonatalliver, 198

Pima Indians, obese, characterization oflipase activities, 791

Pituitaryanterior, corticosterone binding and

glucocorticoids, 899neurointermediate lobe and, steroid ef-

fects on proopiomelanocortin in,443

Plasmacells, binding of polysaccharides by,

1292membrane

hepatic bile salt transport regulationby cholic acid receptors, 401

thymocytes, triiodothyronine bindingsites, 919

plasminogen activator isolation, uroki-nase and, 1320

Plasmin, streptokinase and, catabolicpathways, 412

a2-Plasmin inhibitor, plasminogen activa-tor complex and, 412

Plasminogen activatorprotein C activation in vivo, 127urokinase and, isolation from plasma,

1320Platelets

function, receptor-mediated modula-tion by phorbol diesters, 699

interaction with drugs and antibodies,thrombocytopenia, 989

membrane glycoprotein abnormalities,Bernard-Soulier syndrome, 304

phospholipase activation, 15-hydroxy-9a, I la-peroxidoprosta-5,13-dien-oic acid and collagen, 1216

protease, Factor V activation by, 1092surface modifications, Tn-syndrome,

1281thrombospondin, complex formation

with fibrinogen, 542Polyglutamate, methotrexate, synthesis,

retention, and biological activity,breast cancer cells, 351

Polymers, IgA and IgM, selective trans-port in serum, bile, and saliva, 230

Polysaccharides, bacterial, binding withmonoclonal IgM proteins, 1292

Postprandial state, serum bile acids, he-patic uptake, 724

Potassiuminteraction with angiotensin II, stim-

ulation of aldosterone secretion,667

permeability, mechanisms, urinarybladder, 832

recycling, consequences, renal medulla,219

secretion, dietary modulation of, corti-cal collecting tubule, 579

Potassium ionspermeability, lymphocytes, 632transport, mechanisms in isolated uri-

nary bladder, 832Progesterone, conversion to deoxycorti-

costerone, sex differences, 312Proopiomelanocortin, steroid effects on,

pituitary and neurointermediatelobe, 443

Propranolol, oxygen supply and con-sumption, ischemic heart, 320

Prostacyclincholesteryl ester hydrolysis modulation

by, cyclic adenosine monophos-phate, 479

increased secretion by Clara cells, nor-mally ventilated lungs, 608

Prostaglandinsynthesis, mesenchyme-epithelial inter-

actions, endometrium, 798vasopressin regulation by, cortical col-

lecting tubule, 1193Prostaglandin E, control of granulocyte

and macrophage production, Ia-like antigens, 568

Prostaglandin H2, activation of plateletphospholipases, 1205

Protease, platelet, Factor V activation by,1092

ProteinBence Jones, light chains of immuno-

globulins and, 453contractile, abnormalities, correction

with cardiac hypertrophy, 1300entry into cerebrospinal fluid, encepha-

litis, 289erythrocyte membrane, permeability,

potassium and sodium, 1273Protein C

activation in vivo, 127inhibitor, combined Factor V/VIII de-

ficiency disease, 1260Proteinase, inhibitor, neutrophil-derived

proteolysis and, 845Proteinuria, mechanisms in glomerulone-

phritis, 732Proteolysis, neutrophils and, 845Prothrombin activator, Factor V activa-

tion by platelet protease, 1092Protoporphyrin, light-induced release of

erythrocytes, erythropoietic proto-porphyria, 693

Pulmonary alveolar proteinosis, lung sur-factant abnormality in, 673

Purines, host-parasite metabolism, anti-malarial properties of bredinin,461

QQuinidine, thrombocytopenia induction

by, drug-antibody-platelet interac-tion in, 989

Quinine, thrombocytopenia induction by,drug-antibody-platelet interactionin, 989

R

Receptorschemotactic, cyclic nucleotide-induced

maturation of promyelocytic leu-kemia cells, 953

cholic acid, regulation of bile salttransport with, 401

fibrinogen, platelet thrombospondinformation, 542

fibroblast, increased affinity, familialhypercholesterolemia, 823

glucocorticoid, anterior pituitary, 899Red blood cells: see also Erythrocytes

pathophysiology, SC disease, 1315sickle, oxygen radical generation by,

1253Reflexes, pulmonary vagal, histamine

and phrenic nerve activity, 424Renin, suppression by angiotensin and

captopril, essential hypertension,335

Respiratory burst, gelatinase release, ef-fects on, 518

Restriction endonuclease, polymorphism,genetic analysis of familial isolatedgrowth hormone deficiency type I,489

Ribonucleoprotein, antigen, analysis ofspeckled fluorescent antinuclearantibody antisera, 296

RNA particles, small cytoplasmic and

nuclear, binding, connective tissuedisease antibodies and, 141

SSaliva, monomeric and polymeric pro-

teins in, selective transport of, 230Salmonella typhimurium, lipopolysaccha-

ride, extracted and native forms,877

SC disease, high intracellular hemoglobinconcentration, pathophysiologicconsequences, 1315

Schistosoma mansoni, destruction by Tlymphocytes, 369

Secretory organelle, neutrophils, gelati-nase release and, 518

Selectivity, transport, proteins in serum,bile, and saliva, 230

Senescence, null cell, immunobiology ofaging and, 201

Serotonin, local blood flow, jejunum,1329

Sezary syndrome, diagnosis, monoclonalantibodies and, 1205

Shockbums, mortality, alternative comple-

ment pathway activation and,1170

endotoxin, ibuprofen and, 536Shock lung syndrome, lung surfactant ab-

normality in, 673Shunt, intrahepatic, liver microcirculation

in cirrhosis, 1234Sickle cellshemoglobin concentration, pathophysi-

ologic consequences, 1315hydration, monensin, 1074

Sickle cell anemia, oxygen radical gener-ation by erythrocytes, 1253

Size-selective barrier, glomerulonephritisand, 732

Small cytoplasmic RNA-protein particles,binding, connective tissue diseaseantibodies and, 141

Small nuclear RNA-protein particles,binding, connective tissue diseaseantibodies and, 141

Sodium-coupled transport, bile forma-tion, liver, 505

Sodium ionophore, monensin, sickle cellhydration using, 1074

Sodium-potassium ATPase, bile forma-tion, liver, 505

Sodium-potassium pump, basolateral, in-hibition, potassium ion movement,832

Somatostatinimmunoreactive, biosynthesis by hy-

pothalamic neurons, 1101induced suppression of postprandial in-

sulin response, hypertriglyceride-mia, 1225

Somatotroph hyperplasia, growth hor-mone-releasing factor-secretingpancreatic tumor, removal, 965

Spectrinfl-chain variant, hereditary elliptocyto-

sis, 707

The Journal of Clinical Investigation 1359

molecular defect, hereditary pyropoik-iocytosis, 1019

Sperm, antibodies and antigens, serumlevels after vasectomy, 33

Spine, vertebral fracture, bone mineraldensity changes, aging, 716

Splanchnic glucose uptake, intravenousglucose load, differential insulineffects, 117

Spleen, explants, spontaneous activationof latent cytomegalovirus, 762

Stem cellshematopoietic, high proliferative po-

tential, 242hemopoietic, multipotential progeni-

tors, umbilical cord blood, 1324Stomatocytosis, hereditary, erythrocyte

membrane permeability to potas-sium and sodium, 1273

Streptokinase, plasminogen activatorcomplex and, catabolic pathways,412

Streptokinase-plasmin, catabolic path-ways, 412

Streptozotocin, protective role of super-oxide dismutase against, 650

Substance P, endoluminal, local bloodflow, jejunum, 1329

Superoxide anion, secretion by mono-cytes, enhanced capacity, lym-phokine effects, 1042

Superoxide dismutase, protective roleagainst diabetogenic drugs, 650

Surface antigens, islet cell, monoclonalantibody binding, 659

Surfactant, lung, abnormality, respiratoryfailure, 673

Synthetic rate, plasma cholesterol regula-tion, 13

Systemic lupus erythematosus: see Lupuserythematosus, systemic

TTangier disease, high density lipoprotein

deficiency, abnormal apoliproteinA-I, defective metabolism, 934

T celllymphoma, cutaneous, 1205subsets, multiple sclerosis cerebrospinal

fluid, 387suppressor, histamine- and concana-

valin A-induced, 393

Ty cells, growth suppression of erythroidcolony-forming units, pure red cellaplasia, chronic lymphocytic leu-kemia, 1148

Tetanus, toxin, protective hybridoma an-tibody to, 1306

Thrombocytopenia, quinine- and quini-dine-induced, drug-antibody-platelet interaction in, 989

Thrombosis, protein C activation in vivo,127

Thrombospondin, platelet, complex for-mation with fibrinogen, 542

Thromboxane, mediation, cardiopulmo-nary effects of embolism, 361

Thymocytes, plasma membrane of, spe-cific binding sites for triiodothyro-nine, 919

Thyroid hormone, glycosaminoglycanregulation, 1066

Thyroid hormone-dependent enzyme,congenital hypothyroidism, cere-bral cortex, neonate, 1110

T lymphocytesB lymphocytes and, volume regulation

by, 632destruction of Schistosoma mansoni by,

369macrophage-depleted, Interleukin I

and 2, 470peripheral, rheumatoid arthritis, IgG

determinants, 329Tn-syndrome, platelet surface modifica-

tions in, 1281Toxin, neutralization, hybridoma anti-

body and, 1306Transferrin, plasma iron exchange, 769Triglycerides

postprandial insulin response suppres-sion and, hypertriglyceridemia,1225

synthesis and accumulation, inductionby hypertriglyceridemic very lowdensity lipoproteins, 168

very low density lipoprotein, secretion,insulin and glucose effects, 63

Triiodothyroninegrowth plate cartilage maturation,

stimulation by, 496specific binding sites for, thymocyte

plasma membrane, 919

Tropoelastin, chemotactic responses of fi-broblasts to, 614

Tumor promoters, phorbol diesters, re-ceptor-mediated effects on bloodcells, 699

Tyrosine aminotransferase, development,fetal and neonatal liver, 198

Tyrosinemia, transient neonatal, liver,198

UUltraviolet light, induced protoporphyrin

release, erythropoietic protopor-phyria, 693

Urea cycle, argininosuccinate synthetasedeficiency, molecular analysis,1334

Urokinase, high molecular weight, plas-minogen activator and, isolationfrom plasma, 1320

VVagotomy, cholinergic blockade, secre-

tion by Clara cells, 608Vascular disease, Marfan syndrome, ab-

normal elastin in aorta, 1245Vasectomy, recent, sperm-related antigen,

antibody, and immune complexserum level after, 33

Vasopressin, regulation by prostaglan-dins, cortical collecting tubule,1193

Verapamil, daunorubicin responsiveness,Ehrlich ascites carcinoma, 1131

Viral neutralization, Epstein-Barr virus,nonimmune human serum and,1081

Vitamin B12, presence and formation ofanalogues, multivitamin-mineralpills, 889

Vitamins, minerals and, pills, presenceand formation of cobalamin ana-logues, 889

von Willebrand factor, aberrant multi-meric structure, 1124

von Willebrand's disease, variant, aber-rant multimeric structure of vonWillebrand factor, 1124

WW/W' mice, marrow of, hematopoietic

stem cell concentration in, 242

1360 Subject Index * Volume 11, 1982

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