achieving world’s standards through …cii.in/webcms/upload/global ayurveda summit...
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![Page 1: ACHIEVING WORLD’S STANDARDS THROUGH …cii.in/WebCMS/Upload/GLOBAL AYURVEDA SUMMIT COCHIN.pdfACHIEVING WORLD’S STANDARDS THROUGH QUALITY IN RAW MATERIALS BY DR. C.I.JOLLY (Former](https://reader031.vdocuments.site/reader031/viewer/2022030507/5ab5873a7f8b9a1a048cf357/html5/thumbnails/1.jpg)
ACHIEVING WORLD’S STANDARDS THROUGH QUALITY IN RAW
MATERIALS
BY
DR. C.I.JOLLY(Former Professor of Phytochemistry, Bombay University)
Scientific AdvisorKerala Ayurveda Ltd., Aluva & Amala Ayurvedic Research Centre,
Thrissur
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One Needs To ConclusivelyProve The Testing Procedures
To Identify The Specific Species
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RHIZOMA ZINGIBERIS
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GEOGRAPHICAL DISTRIBUTION
• Native to south-east Asia• Commonly grown in Africa, China, India,
Japan and Jamaica• India is the world’s largest producer
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GINGER FINDS PLACE IN• WHO monographs• Chinese herbal pharmacopoeia• United States herbal pharmacopoeia• British herbal pharmacopoeia• British herbal compendium• Japanese standards for herbal medicine• Ayurvedic Pharmacopoeia of India
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DEFINITION• Dried rhizome of Zingiber officinale
Roscoe
SYNONYMS• Zingiber blanco Massk• Amomum zingiber L.
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CHINESE QA FOR CRUDE DRUGS
• Chinese pharmacopoeia grade ginger rhizome collected in winter containing not less than 0.8mg of volatile oils.
• Good Agricultural Practice for Chinese crude drug for 2002
• Ecological environment of production site
• Germplasam and propagation material
• Species, subspecies and varieties • Management of rearing • Collection and primary processing
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SELECTED VERNACULAR NAMES
• Adrak• Inji• African ginger• Cochin ginger• Common ginger• Ginger
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DESCRIPTION• A perennial herb with a subterranean,
digitately branched rhizome• Each flower shows reddish to orange
corolla
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GENERAL APPEARANCE• Ginger is a large tuberous perennial plant• Ginger occurs in horizontal, laterally
flattened, irregularly branching pieces
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• The material of commerce is peeled (Jamaica), partially scraped (India,Nigeria, Australia and Japan) or unpeeled rhizomes (China) .
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ORGANOLEPTIC PROPERTIES
• Odour-Characteristic aromatic
• Taste-Pungent and Aromatic
• Colour-Internally Pale Yellow To Brown
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MACRO AND MICROSCOPIC EXAMINATION
• Scattered bundles of the leaf-traces accompanied by fibers
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POWDERED PLANT MATERIAL
• nonlignified scalariform, reticulate and spiral vessels and starch
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CHRACTERIZATION & STANDARDIZATION OF EACH
HERBAL INGREDIENT
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FOREIGN ORGANIC MATTER• Not more than 2.0%
TOTAL ASH• Not more than 6.0%
ACID-INSOLUBLE ASH• Not more than 2.0%
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EXTRACTIVE VALUES
WATER-SOLUBLE EXTRACTIVE• Not less than 10%
ALCOHOL-SOLUBLE EXTRACTIVE• Not less than 4.5%
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Qualitative & Quantitative Chemical Evaluation
• Volatile oil content – 1 to 4% essential oil• Oleoresin content – 4 to 7.5% (Non volatile pungent
principles, gingerols and shogaols)• Australian Pharmacopoeia and German Pharmacopoeia
require not less than 1.5% volatile oil
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REFERENCE STANDARDS TO DETERMINE PURITY, SIMPLICITY
AND REPRODUCIBILITY
CRUDE DRUG GINGER, EXTRACTS
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British herbal pharmacopoeia, American herbal pharmacopoeia & German commission E have prescribed certain specifications regarding herbal drugs
These includes• ''The herbal drug or herbal preparation in
its entirety is regarded as the active substance''.
• Constituents with known activity ''are chemically defined substances or group of substances which are generally accepted to contribute substantially to the therapeutic activity of a herbal drug or of a preparation.''
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• Markers ''are chemically defined constituents of a herbal drug, which are of interest for control purposes.
• Standardization refers to '' adjusting the herbal drug preparation to a defined content of a constituent or a group of substances with known therapeutic activity
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CHEMICAL ASSAYS• Not less than 2%v/w of volatile oil • Qualitative analysis by TLC• Quantitative analysis by GC and HPLC
• Gingerols• Shogaols• Zingiberine• Bisabolene• Curcumene
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MAJOR CHEMICAL CONSTITUENTS
• 1-4% essential oil and an oleoresin
ZingibereneShogaols
Gingerols
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CONCERN IS MORE ON THE IMPURITY LEVELS RATHER THAN
ON THE PURITY LEVELS
SAFETY MORE THAN EFFICACY
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German Pharmacopoeia and Austrian Pharmacopoeia specifies purity tests
for absence of bleaching agents (Calcium carbonate)
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TOXICOLOGICAL STUDIES
MICROBIAL PURITY• Aerobic bacteria- not more than 107 /g• Fungi- not more than 105 /g
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PESTICIDE RESIDUES• Established in accordance with national
requirements• Maximum residue limit of Aldrin and
Dieldrin is not more than 0.05mg/kg
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HEAVY METAL CLEARANCE• Lead – Not more than 10ppm• Mercury – Not more than 1ppm• Arsenic – Not more than 3ppm• Cadmium - Not more than 0.3mg/kg
RADIOACTIVE RESIDUES• Strontium-90• Iodine-131• Caesium-137
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DOSAGE FORMS• Dried root powder, extract, tablets
MEDICINAL USESUses supported by clinical data• Prophylaxis of nausea and vomiting associated with
motion sickness• Treatment of dyspepsia, flatulence, colic, vomiting,
diarrhoea, spasms, colds, flu and to stimulate appetite
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Uses described in folk medicine, not supported by experimental or clinical data
• Cataracts, toothache, insomnia, baldness, and hemorrhoids
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PHARMACOLOGY• EXPERIMENTAL PHARMACOLOGY• ANTIEMETIC ACTIVITY• ANTI-INFLAMMATORY ACTIVITY• ANTINAUSEA AND ANTIEMETIC
ACTIVITIES
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CONTRAINDICATIONS• With gallstones, first consult a physician
SIDE EFFECTS• None known but European Commission
Contraindicates Ginger during pregnancy and lactation
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PRECAUTIONS
• Anticoagulant drugs or those with blood coagulation disorders
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DRUG INTERACTIONS• Ginger may affect bleeding times and
immunological parameters owing to its ability to inhibit thromboxane synthase and to act as a prostacyclin agonist
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ADVERSE REACTIONS• Contact dermatitis of the finger tips has
been reported in sensitive patients.
• Ref: Indian journal of dermatology, 1987, 53:328
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TRADITIONAL CONCEPTS AND PROCEDURES
• Conduct the selection of ayurvedic crude drugs as per the scriptures
• Ginger (Crude drug)
• Fresh Ginger –• Dry Ginger –• White Ginger –
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• Vettumaran Gulika (INJINEERU)• (Antipyretic)
• Water Extract (Kashayam) of Dry Ginger• Amruthotharam Kashayam• (Bring in increased blood flow to the surface
of the skin, reduce elevated BP, Works as Antipyretic)
• Total powder• Trikatu (Gingerols are pain relievers close to
capsaicin action on specific receptor sites (Vanilloid receptor) normally reacts to heat . Antiinflammatory on COX I and COX II like ibuprofen
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• Injineeru (Ginger juice) act by suppressing the appetite, reducing fat absorption and fat deposition, and increasing the metabolic “burning off” of fat.
• Researchers world wide are trying to understand the mystery of taste buds (2000-10000 Taste Buds convey the signals to the nerve cells)
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Amino acids (It decreases the nausea and vomiting)
Flavanoids (Pinostrobin-powerful antioxidant thanquercetin and myricetin, contains more than broccoli)
ALAKALOIDS (Berberin)
Volatile oils (gingerberine, capsaicinin, bisabolene)
Oleoresins (Gingerol and shogaol pungent principles,They are anti-inflammatory, diuretic, anti nausea)
GINGER
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Conduct the finger printing process and characterization process and treat this as an Active Ayurvedic Ingredient
(AAI) and taken for finished formulations
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CHROMATOGRAM• Juice contains amino acids• Kashaym contains phenols, saponins,
flavonoids, inorganic compounds -Calcium, Iron, Potassium & Phosphorous,Vitamin A and B and Fibers
• Total methanolic extract contains resins, and Volatile oil (DCM extract)
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GINGER AMINO ACIDS
Rf Colour
Visible light
0.15
0.29
Pink
Pink
Pink0.43
Solvent: n Butanol: Acetic acid: water (4:0.1:0.1)
FRESH JUICE
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GINGER-FLAVANOIDS• FRESH JUICE (Methanol Ext)
Solvent: Toluene: Ethyl acetate: Formic acid (5:3:1)
Rf Colour0.86 Yellow fluorescent
LONG UV
GINGER KASHAYAM (Methanol Ext)No band
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GINGER-DCM Ext-Volatile oils
Rf Colour
Visible light
0.10
0.15
0.64
Violet
Violet
Blue
Solvent: Toluene: Ethyl acetate (93:7)
Rf Colour
Visible light
0.11
0.25
Violet
Blue
Fresh Juice (DCM extract) Ginger Kashayam (Dcm Ext)
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GINGER-RESINS
Rf Colour
Visible light
0.19
0.25
0.43
0.60
0.66
Violet
Violet
Blue
Blue
Blue
Solvent: Toluene: Ethyl acetate (88:12)
Fresh juice (alcohol ext) Ginger kashayam (alc ext)
Rf Colour
Visible light
0.14
0.19
Blue
Violet
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GINGER PHENOLS
Rf Colour
Visible light
0.170.420.480.520.570.610.670.790.92
ALL BLUE
Solvent: Toluene: EA: Formic acid (5:3:1)
FRESH JUICEGINGER KASHAYAM (Methanol Ext)
Rf Colour
Visible light
0.440.520.570.62
ALL BLUE
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• Intellectual Property Rights and assessment of raw materials used in Indian system of medicine, 2002
• TRIPS (Trade related aspects of intellectual property rights) agreement and status of crude drugs in ISM&H
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ALCOHOL ABUSE• The water extracted Ginger has
detoxifying and antioxidant effect is recommended even for alcohol toxin (Phenols)
• Antibacterial activity of kashaym• It inhibits E.coli, Salmonella,
Staphylococcus and Aspergillus
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IR SPECTROSCOPY• Oleoresin• Water extract (Kashayam)• Alcoholic extract • DCM extract
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GINGER-DCM extract IR
756.
30
896.
71
1266
.45
1426
.54
2992
.54
3055
.66
-10
0
10
20
30
40
50
60
70
80
90
100
%T
1000 1500 2000 2500 3000 3500 4000 Wavenumbers (cm-1)
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GINGER-OLEORESIN IR
686.
0480
8.63
879.
68
1043
.38
1085
.74
1271
.22
1378
.29
1449
.40
1515
.85
1653
.11
1707
.60
1920
.09
2926
.52
2969
.8933
71.0
6
-10
0
10
20
30
40
50
60
70
80
90
100
%T
500 1000 1500 2000 2500 3000 3500 4000 Wavenumbers (cm-1)
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GINGER- ALCOHOLIC EXTRACT IR
661.
75878.
20
1043
.30
1085
.56
1326
.64
1383
.91
1649
.00
1922
.28
2127
.83
2888
.66
2974
.36
3323
.83
3844
.01
-10
0
10
20
30
40
50
60
70
80
90
100
%T
1000 1500 2000 2500 3000 3500 4000 Wavenumbers (cm-1)
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GINGER- WATER EXTRACT IR
693.
091638
.25
2115
.88
3378
.22
-10
0
10
20
30
40
50
60
70
80
90
100
%T
1000 1500 2000 2500 3000 3500 4000 Wavenumbers (cm-1)
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GINGER-OVERLAPING IR
GIN
GE
R O
LEO
RE
SIN
EX
TRA
CT
GIN
GE
R D
CM
EX
TRA
CT
GIN
GE
R A
LCO
HO
L E
XTR
AC
T
GIN
GE
R W
ATE
R E
XTR
AC
T-10
0
10
20
30
40
50
60
70
80
90
100
%T
1000 1500 2000 2500 3000 3500 4000 Wavenumbers (cm-1)
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693.09661.75686.0418
808.63756.317
878.2879.68896.716
1043.31043.3815
1085.561085.7414
1326.64 (Volatile oil)1271.221266.4513
1383.91 (Volatile oil)1378.2912
1449.411
1515.8510
1638.25 (Alkenes)16491653.111426.549
1707.68
1922.281920.097
2115.88 (Alkynes)2127.836
2888.66 (Resins)2926.525
2974.36 (Resins)2969.892992.544
3055.663
3378.22 (Phenol)3323.833371.062
3844.011
Alcohol ext.
Ginger - Water extractGinger - Alcohol ext.Ginger oleoresin -Ginger DCM extractSl.No.
IR SPECTRUM COMPARISON
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STABILITY OF CRUDE DRUGS• 4 to 8 months storage• Resulted changes from the conversion of
geranyl acetate to geraniol, geranial and neral successively.
• Components of fresh ginger oil are Zingiberene and β-sesquiphellandrene.
• On storage deposits of Ar-curcumene are seen in the oil.
• Its presents indicates of its long storage.
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SHELF LIFE OF CRUDE DRUG• Ginger is ideal to store maximum of 3 to 4
months.• Changes of chemical constituents are
observed • Fresh ginger, powder or its extracts are
used for treating gastric ulcer and enhances secretion of bile and decreases gastric secretion.
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“Stones are only thrown that bear fruits. Take constructive criticism on our side”
“We want Ayurveda to be a medium to talk about issues of health care”
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