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ABSTRACT BOOK

ONE DAY NATIONAL LEVEL CONFERENCE

“Pharmacovigilance: Current Scenario and Emerging Trends”

(3rd August, 2019)

Organized ByShree Naranjibhai Lalbhai Patel College of Pharmacy

Sponsored byGUJCOST

Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh,Bardoli, Surat

website : www.snlpcp.ac.in

ABOUT TRUST

The Vidyabharti Trust was registered as Public Education Trust under theBombay Public Trust Act, 1950 in 18/09/1980, registration no. E-1852-Surat,with a pious aim to impart quality education and training to the children fromPrimary to the terminal of higher education and allied research. The trust alsoreceived exemption under section 80(G) of the income-tax act for acceptingdonations.

The Vidyabharti Trust campus is in the vicinity of Bardoli, the nucleus ofthe political activity during our freedom struggle and ship anchor of the wellknown Bardoli Satyagraha of Shri Sardar Vallabhbhai Patel. The campus issituated in an area of 38 acres of land. It catalyses and manifests educationalactivities in a peaceful natural environment.

The Vidyabharti Trust has fulfilled many motives pertaining to educationin the present arena. Currently, the Trust has obtained recognizable position inthe society.

SHREE NARANJIBHAI LALBHAI PATEL COLLEGE OF PHARMACYVidyabharti Campus, At & Po Umrakh

Ta: Bardoli, Dist: Surat, Gujarat, India, Pin: [email protected]

MESSAGE

Vidyabharti Trust is a leading organization offering variety of coursesranging from School studies to Doctorate research. VBT group of Colleges hasmade a constant endeavor to provide quality education and a platform foroverall development to its students.

To provide rich and complete study experience to its students throughcutting – edge amenities, research and innovation that will assist students inbuilding a successful professional path, Shree N L Patel College of Pharmacy,Umrakh has once again organized National seminar in sponsorship with GujaratCouncil of Science and Technology (GUJCOST).

I sincerely welcome and thank all speakers, invited guests and delegatesfor participating whole heartedly in the seminar. Inspired and encouraged byyour good wishes we will continue to contribute towards progress andprosperity of Pharmacy education.

Shri Kiritbhai N. Patel

Secretary,

Vidyabharti Trust, Umrakh

MESSAGE





Secretary,


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Secretary,


MESSAGE

I extend my warm welcome to one and all who have accepted ourinvitation and marked their presence here today or registered as delegates/partners with National Seminar at Shree N L Patel College of Pharmacy,Umrakh. This seminar is crossing another mile stone towards its journey toaccomplish the Vision and Mission.

I wish to express my profound thanks and gratitude to our Principal Dr.Dhiren Shah, teaching and non-teaching staff members and students to make itsuccessful.

I wish this seminar a grand success.

Shri Ashwinbhai H. Patel

Joint Secretary,


MESSAGE

I take this opportunity to appreciate the dynamic and spirited efforts putin by the entire team of Shree N L Patel College of Pharmacy, Umrakh underthe leadership of Dr. Dhiren Shah for organizing a National seminar. SNLPCP,Umrakh, has successfully hosted national level seminar in past, and now, thisNational seminar adds another feather in the cap of Shree N L Patel College ofPharmacy, Umrakh. I congratulate our principal, Dr. Dhiren Shah, his staffmembers for this mile stone achievement.

My good wishes to all and wish Shree N L Patel College of Pharmacy,Umrakh, to contribute towards progress and prosperity of Pharmacy education.

Dr. Ajay V. Shah

Campus Director,


MESSAGE

On the eve of this unique event of National Seminar at Shree N L PatelCollege of Pharmacy, Umrakh, sponsored by Gujarat Technological University,Ahmedabad, I would like to extend my greetings to all of you.

We are all grateful to our esteemed speakers for having accepted ourinvitation and the overwhelming support received from the pharmaceuticalfraternity and the event sponsors to make the seminar a success story.

All my teaching, non-teaching and administrative staff at Shree N L PatelCollege of Pharmacy, Umrakh, deserves a special applause for carving out thisbeautiful event and working hard for its success.

I am sure the seminar will help our pharmaceutical professionals todesign the strategy for their future.

Let us all join hands together to make a great professional organizationwhose ultimate aim is to improve the quality in various field ofPharmaceuticals.

Dr. Dhiren Shah

Principal,

Shree N L Patel College of Pharmacy, Umrakh.

It is my proud privilege to state that our institute Shree NaranjibhaiLalbhai Patel College of Pharmacy is organizing a one-day National Conferenceon “Pharmacovigilance: Current Scenario and Emerging Trends” in sponsorshipwith Gujarat Council of Science and Technology (GUJCOST). The idea ofholding such a conference is to bring academicians, researchers, industryleaders, pharmacy consultants, pharma experts and students on a commonplatform to discuss the various concepts, fundamentals and prospective ofpharmacovigilance. Pharmacovigilance (PV) plays a key role in the healthcaresystem through assessment, monitoring and discovery of interactions amongstdrugs and their effects in human. Pharmaceutical and biotechnologicalmedicines are designed to cure, prevent or treat diseases; however, there arealso risks particularly adverse drug reactions (ADRs) can cause serious harm topatients. Thus, for safety medication ADRs monitoring required for eachmedicine throughout its life cycle. Pharmacovigilance is still in its infancy inIndia and there exists very limited knowledge about the discipline. There is animmense need to understand the importance of pharmacovigilance and how itimpacts the life cycle of the product.

I am sure that these scientific discussions and deliberations would providea good information and knowledge of current scenario and future trends inpharmacovigilance. I am thankful to the management for their full support fororganizing the conference. I would like to express my gratitude to Dr. DhirenShah for his valuable guidance and direction. I would like to place on recordthe constant cooperation extended by the Registration committee, ScientificCommittee, Stage Committee, Multimedia and graphics committee, Foodcommittee, Finance committee and Hospitality committee.

I also deliver my thanks to the GUJCOST for their sponsorship andtimely support.

MESSAGE

Organizing Secretary

Dr. Vijay B. Lambole

Dr. V. AddepalliDirector

SVKM’s Shri C. B. Patel Research CentreVile Parle (West), Mumbai – 400 056. Maharashtra, IndiaPh. + 91 22 4235 5961

Pleased to note that Shree Naranjibhai Lalbhai Patel College ofPharmacy, Umrakh (SNLPCP) (Formerly known as Vidyabharti Trust Collegeof Pharmacy, Umrakh), a self-finance college is organising one day nationalconference on Pharmacovigilance: current Scenario & Future Trends on 3rdAugust, 2019 sponsored by Gujarat Council of Science & Technology(GUJCOST). The seminar will provide an important platform forpharmacovigilance stakeholders to discuss and share best practices inexpediting Pv and its further development. It is indeed a need of the hour andwish the seminar a great success

Title of Talk : Pharmacovigilance - Present status and future perspective.

Abstract:

Drug development has undergone a drastic change in recent times. Theera is witnessing rapid revolution as exemplified by targeted therapies andpersonalized therapies for disease management. Every patient who is taking adrug of any system of medicine is at high risk for developing Adverse DrugReactions (ADR). Pharmacovigilance has therefore had an important impact onthe public health environment. The talk will throw light upon the role ofPharmacovigilance and its importance in Healthcare, present status in India andfuture perspective.





Abstract:






Abstract:


Mr. Bharat B. DoshiFounder,BioDev Services, Ahmedabad

Message for Abstract

Back in 1990s - career options after a Pharmacy graduation or post-graduation were limited to Manufacturing, Marketing and rarely a R&D job.However, over the years many more job-roles have become prominent. Withthis change, one of the most common ambition shown by students of Pharmacy(i.e. after completion of their course); is to get into a profession that allows themto sit in a corporate environment, work on computers, earn possibly in dollars &build a career in MNC company.

Pharmacovigilance is one such career option - that possibly meets theabove vague definition narrated by pharma career aspirants. Unfortunately,everyone knows what they want (as narrated above) - but they don't know how;Nor do they know the deeper nuances of PV activities.

The proposed discussion will give students an overview ofPharmacovigilance industry under following points:

What happens in a PV set-up as on today, Why those activities are done

What it is? R&D? Marketing? How PV activities are linked to other activities

PV as a business: Economic drivers for PV industry

What's new? what are the upcoming trends?

PV in India

Skills required for a career in PV industry

Mr Nayan Prajapati

Head Training.

Cliantha Research, Ahmadabad.

Email: [email protected]

Topic: How shall I Perform best in Pharmacovigilance!!

Abstract:

Pharmacovigilance has been accepted as an important public healthfunction which which aims at reducing the medicine related harms. Intensiveefforts are currently ongoing in the country to strengthen the system ofPharmacovigilance Programme of India (PvPI) to ensure safety of medicines.

The objective of seminar was to provide transformative professionaldevelopment experience. As the entire professionals are important stakeholdersin Pharmacovigilance, the session was conducted to train and educate studentson various aspects of Pharmacovigilance. Two major points were covered insession. First part was about basics of Pharmacovigilance. This portion helpedstudents to understand basics of Pharmacovigilance, terminologies, essentialelements, various activities and role of each profile in Pharmacovigilance.Students found second portion of great use to understand skill and knowledgerequired to perform best in each profile. What all shall One endure in his/herpersonality to perform best, not only survive but to grow in Pharmacovigilanceindustry was explained in an effective way to get practical knowledge with hugeexperience of industry people.

This presentation was overall aimed to provide the understanding andimportance of Skill and Attitude along with Knowledge required to performexcellent.

Mr Nayan Prajapati

Head Training.




Abstract:




Mr Nayan Prajapati

Head Training.




Abstract:




LOCAL ORGANIZING COMMITTEE

Chief Patron Shri Manharbhai L. Patel(Managing Trustee)

Patrons Shri Kiritbhai N. Patel(Secretary, VBT)

Shri Ashwinbhai H. Patel(Co-Secretary, VBT)

Dr. Ajay V. Shah(Campus Director)

Chairman Dr. Dhiren P. Shah(Principal)

Coordinator Dr. Vijay B. Lambole

Registrationcommittee

Dr. Dixit C. ModiMr. Vipul G. GajeraMr. Tejas PatelMrs. Pooja Chaudhari

Scientificcommittee

Dr. Rumit ShahDr. Jitendra Singh YadavMr. Sagar PatelMrs. Rachita Desai

Stage Committee Mrs. Sonal SolankiMrs. Jasmina SuratiMiss. Sonia J PatelMr. Bhumin Pathak

Hospitality andTransportCommittee

Dr. Biren ShahDr. Dipansu Sahu

FinanceCommittee

Dr. Ashok Akbari

Multimediacommittee

Dr. Hemal Bhuva

SCIENTIFIC COMMITTEE

Dr. Rumit Shah Dr. Jitendra SinghYadav Mr. Sagar Patel Mrs. Rachita Desai

REGISTRATION COMMITTEE

Dr. Dixit Modi Mr. Vipul Gajera Mr. Tejas Patel Mrs. PoojaChaudhari

HOSPITALITY AND TRANSPORT COMMITTEE FINANCECOMMITTEE

MULTIMEDIACOMMITTEE

Dr. Biren Shah Dr. Dipansu Sahu Dr. Ashok Akbari Dr. Hemal Bhuva

STAGE COMMITTEE

Mrs. Sonal Solanki Mrs. Jasmina Surati Miss. Sonia J Patel Mr. BhuminPathak

GUJCOST SponsoredOne Day National Level Conference

““Pharmacovigilance: Current Scenario and Emerging Trends”(3rd August, 2019)

Organized byShree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh

INDEX

Poster Code Department Page No

PCT-01 to PCT-25

Pharmaceutics /Pharmaceutical Technology

/NDDS / Microbiology/ Bio – Technology

15 - 26

PCO-01 to PCO-38

Pharmacology / Clinical /Pharmacovigilance/Pharmacy Practice

27 - 43

PQA-01 to PQA-02

Pharmaceutical Chemistry/Pharmaceutical Analysis /

Quality Assurance /Regulatory Affairs

44

PCG-01 to PCG-06Pharmacognosy / Herbal DrugTechnology/ Phyto-Chemistry 45 - 48

Pharmacovigilance: Current Scenario and Emerging Trends

15 Organized byShree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh

PCT-01FORMULATION, OPTIMIZATION AND CHARACTERIZATION OF

TRANSDERMAL FILM BASED ON NANOPARTICLES OF CHOLINESTERASEINHIBITORS FOR THE TREATMENT OF ALZHEIMER’S.

Kapoor Devesh UmeshDr. Dayaram Patel Pharmacy College, Sardar Baug, Station Road, Bardoli

Solid lipid nanoparticles play vital role for delivering drugs to the brain because of theirenormous potential for the transport of numerous drugs to the brain which are not able tocross blood brain barrier (BBB). The nanoparticles can be fabricated to enhance the growthand release of numerous pharmacological agents at the diverse pathological sites, enhance thehealing effectiveness by superior bioavailability, water solubility and betterpharmacokinetics. The aim of current research to fabricate donepezil hydrochloridetransdermal film by using full factorial design. The design expert software (version 10) isemployed for the fabrication of different formulations. Modified solvent emulsificationmethod employing surface active agent, lipid, permeation enhancer and diverse solvents forthe fabrication of nanoparticles. The solvent casting method is employed for the fabricationof transdermal films having plasticizer, polymers, permeation enhancer and solvents. Thesefilms are characterized for in-vitro release studies, drug content, flatness, tensile strength andex vivo skin permeation study. All the formulation of films was found to be flat. The range ofdrug content and tensile strength was 97.49±1.4 to 97.76±2.2% and 5.67±0.54 to 12.23±0.97N/mm2 (Newton/millimeter2) respectively. The in vitro release of drug and ex vivo skinpermeation study after 24 hrs was 88.45±1.34 to 97.23±1.11% and 87.54±0.97 to98.12±0.34%. On the basis of outcome it can be suggested that transdermal films ofdonepezil hydrochloride can be employed for human applications. It is a safe, convenient,painless and cost effectual drug delivery system for patients of Alzheimer’s.

PCT - 02BIOSENSORS: PRINCIPLE, TYPES AND APPLICATIONS

Patel Anjali, Patel JaimiShree Naranjibhai Lalbhai Patel College Of Pharmacy, Umrakh

Biosensor is a device, probe or electrode having immobilized biocatalyst which, upon makingcontact with an appropriate sample, converts the presence of the desired analyte into aphysical, chemical or electrical signals which can be measured. Biosensor consists of threeparts: a component that recognizes the analyte and produces a signal, a signal transducer, anda reader device. In comparison with any other currently available diagnostic device,biosensors are much higher in performance in terms of sensitivity and selectivity both. Typesof biosensors based on tansducer are: Calorimetric biosensor, Potentiometric biosensor,Piezoelectric biosensor, Amperometric biosensor and Optical biosensor. Biosensors havefound potential applications in the general healthcare monitering, screening for diseases,clinical analysis and diagnosis of diseases, industrial processing and monitoring,environmental pollution control, also in agricultural and food industries. Important featuresfor commercialization of the biosensors are selectivity, sensitivity, stability, reproducibility



and low cost. This poster reviews the basic principle, the various types of biosensorsavailable and its applications.Keyword: - Biosensors, Principle, Types and Applications.

PCT – 03BIONIC EYE

Modi Preet, Mistry ParthShree Naranjibhai Lalbhai Patel College Of Pharmacy, Umrakh

Retinitis pigmentosa(RP) is group of genetic eye conditions that leads to incurable blindness.it further result in tunnel vison ,people pigmentosa are notr legally blind untill their 40s or50s ,while in some cases patients may become blind due to ROP as early as in their childhood.however ,patient who gone blind because of retinitis pigmentosa are a step closer toperhaps.....device exemption to conduct a clinical studty of the new decvice -dybbed theargus II bionic retinal system .apart from these there have been breakthroughs in devlopmentof bionic eye in number of institutions throghout the world .this review paper deals thetechnology & the working of the device which of the device which would help in eradicatingblindness in the near futureKEYWORDS:BIONIC EYE ,RETINITIS PIGMENTOSA,ARGUS II

PCT - 04PLASTIC EATING BACTERIA- IDEONELLA SAKAIENSIS

Gamit ZeelShree Naranjibhai Lalbhai Patel College Of Pharmacy, Umrakh

A Gram-stain-negative, aerobic, non-spore-forming, rod-shaped bacterium, designed strain201-F6T, was isolated from a microbial consortium that degrades poly(ethyleneterephthalate) (PET) collected in Sakai city, Japan, and was characterized on the basis of apolyphasic taxonomic study. The cells were motile with a polar flagellum. The straincontained cytochrome oxidase and catalase. It grew within the pH range 5.5-9.0 (optimally atpH 7-7.5) and at 15-42 ºC (optimally at 30-37 ºC). Phylogenetic analysis using the 16S rRNAgene sequences showed that strain 201-F6T was affiliated to the genus Ideonella, and wasclosely related to Ideonella dechloratans LMG 28178T (97.7 %) and Ideonella azotifigensJCM 15503T (96.6 %). Strain 201-F6T could be clearly distinguished from the relatedspecies of the genus Ideonella by its physiological and biochemical characteristics as well asby its phylogenetic position and DNA-DNA relatedness. Therefore, the strain represents anovel species of the genus Ideonella, for which the name Ideonella sakaiensis sp. nov. (typestrain 201-F6T=NBRC 110686T=TISTR 2288T) is proposed.



PCT - 053D PRINTING OF DRUGS

Prajapati ManishShree Naranjibhai Lalbhai Patel College Of Pharmacy, Umrakh

Three-dimensional (3D) printing is a manufacturing method in which objects are made byfusing or depositing materials in successive layers laid down under computer control. Todevelop a standard conventional solid dosage form like tablets it include the operationsinvolving like milling, mixing, granulation, drying and compression which able to result indifferent qualities of the final products concerning the loading of the drug, the release of thedrug, stability of the drug and pharmaceutical dosage form stability. To overcome somechallenges of conventional pharmaceutical unit operations, 3DP is gaining more attention inthe pharmaceutical formulation in the future. 3DP can successfully overcome the issuesrelating to the drug delivery of peptides, potent drugs, water-soluble drugs, and the release ofmulti-drugs, etc. The ideal opportunity of this technology is the preparation of personalizeddoses to state individual patient needs. 3D printing in pharmaceuticals has been used toproduce many novel dosage forms like microcapsules, Complex Drug-Release Profiles, nano-suspensions, and multilayered drug delivery devices. From industrial point of view, it alsooffers important advantages like, cost-effectiveness, increased productivity, democratizationof design and manufacturing, and enhanced collaboration. Keeping in view the recentapproval given by USFDA to the first 3D printed antiepileptic drug the focus has now shiftedto the personalized medicine as it offers an important benefit to patients who needmedications that have narrow therapeutic indices or a higher predilection to be influenced bygenetic polymorphisms. 3D printer is now seen as a valuable, efficient and economical tool tomanufacture individualized medications, tailored to specific patients based on their needs andthereby change the future of pharmacy practice in general and pharmaceutical care. Here, wepresent an outline and the perspective of 3DP in the development of novel drug deliverysystems.

PCT - 06POLYMERASE CHAIN REACTION AND ITS APPLICATION

Patel Jaimi, Patel AnjaliShree Naranjibhai Lalbhai Patel College Of Pharmacy, Umrakh

"The Polymerase Chain Reaction (PCR) has revolutionised molcular biology and DNAtechnology. Invented in the 1980s by kary b muliis, it enables us to produce large quantites ofDNA from very small samples in a remarkably short time. This in turn makes it possible forus to analyse tiny samples of DNA and unravel the mysteries of the individual genes. Thepolymerase chain reaction (PCR) is a scientific technique in molecular biology to amplify asingle or a few copies of a piece of DNA across several orders of magnitude, generatingthousands to millions of copies of a particular DNA sequence. PCR is now a common andoften indispensable technique used in medical and biological research labs for a variety ofapplications. There are three major steps involved in the PCR technique: denaturation,annealing, and extension. PCR is useful in the investigation and diagnosis of a growing



number of diseases. Qualitative PCR can be used to detect not only human genes but alsogenes of bacteria and viruses. PCR is also used in forensics laboratories and is especiallyuseful because only a tiny amount of original DNA is required. PCR can identify genes thathave been implicated in the development of cancer. Molecular cloning has benefited from theemergence of PCR as a technique. The present poster is an attempt to review basics of PCR.KEY WORDS: PCR, Principles, Application

PCT - 07B.HEALTHY ONE STOP SOLUTION

Parekh Brijesh, Jain Kevil, Modi Preet, Patel Nil, Patel SagarkumarShree Naranjibhai Lalbhai Patel College Of Pharmacy, Umrakh

These days, the life style of the people gets hectic; therefore, they do not have much time. Ifthey get everything at home; they might not prefer to go out. Considering this scenario, Wehave a thought to improve health of a person by providing everything from consultation todelivering of medicine through a new and modified online platform, which deals with healthrelated issues and diseases. This system also deals with the loopholes of existing onlineplatforms. This platform provides the facility of online consultation from the physician,which becomes huge convenience for the patient and if they need any laboratory support orreports, the platform can provide it. Online pharmacy is the emerging field in our nation.There are some loopholes in the existing system of online pharmacy, like lack of qualifiedstaff in the delivery of drugs and time consuming. The platform also addresses the issues ofonline pharmacy. Some the features of B healthy are Consultation with medical practitioner,All health related issues and their solution on single platform and Fast delivery of medicinesby registered Pharmacist

PCT - 08NANOPARTICLE LOADED HYDROGEL: A PROMISING APPROACH FOR

LOCALIZED DRUG DELIVERY (REVIEW ARTICLE)Patel Dhruvkumar, Patel Tejas

Shree Naranjibhai Lalbhai Patel College Of Pharmacy, UmrakhNanoparticles have offered a unique set of properties for drug delivery including high drugloading capacity, combinatorial delivery, controlled and sustained drug release, prolongedstability and lifetime, and targeted delivery. To further enhance therapeutic index, especiallyfor localized application, nanoparticles have been increasingly combined with hydrogels toform a hybrid biomaterial system for controlled drug delivery. Herein, we review recentprogresses in engineering such nanoparticle hydrogel hybrid system with a particular focuson its application for localized drug delivery. Specifically, we highlight four research areaswhere NP-gel has shown great promises, including passively controlled drug release, stimuli-responsive drug delivery, site-specific drug delivery, and detoxification. Overall, integratingtherapeutic nanoparticles with hydrogel technologies creates a unique and robust hybridbiomaterial system that enables effective localized drug delivery.



PCT - 09ORALLY DISINTEGRATING FILMS: A MODERN EXPENSION IN DRUG

DELIVERY SYSTEMChaudhary Priyavanda, Singh Neha, Modi Dixit

Shree Naranjibhai Lalbhai Patel College Of Pharmacy, UmrakhOver the past few decades, tendency toward innovative drug delivery systems has majorlyincreased attempts to ensure efficacy, safety and patient acceptability. As discovery anddevelopment of new chemical agents is a complex, expensive and time consuming process,so recent trends are shifting toward designing and developing innovative drug deliverysystems for existing drugs. Out of those, drug delivery system being very eminent amongpediatrics and geriatrics is orally disintegrating films (ODFs). These fast disintegrating filmshave superiority over fast disintegrating tablets as the latter are associated with the risks ofchoking and friability. This drug delivery system has numerous advantages over conventionalfast disintegrating tablets as they can be used for dysphasic and schizophrenic patients andare taken without water due to their ability to disintegrate within a few seconds releasingmedication in mouth. Various approaches are employed for formulating ODFs and amongwhich solvent casting and spraying methods are frequently used. Generally, hydrophilicpolymers along with other excipients are used for preparing ODFs which allow films todisintegrate quickly releasing incorporated active pharmaceutical ingredient (API) withinseconds. Orally disintegrating films have potential for business and market exploitationbecause of their myriad of benefits over orally disintegrating tablets. This present reviewattempts to focus on benefits, composition, approaches for formulation and evaluation ofODFs. Additionally, the market prospect of this innovative dosage form is also targeted.

PCT - 10DESIGN & DEVELOPMENT OF SYRINGEABLE THERMOSENSITIVE IN SITU

MUCOADHESIVE GEL DELIVERY SYSTEM FOR PERIODONTITIS”Master Ruchi, Patel Asmi, Dalal Mittal, Barot TularamRofel, Shri G. M. Bilakhia College Of Pharmacy, Vapi

A new concept of in situ gel was developed to overcome the shortcomings of conventionalformulations which deal with Periodontitis. In situ mucoadhesive gel of Chlorhexidinegluconate & Lidocaine hydrochloride was prepared using the cold method using PluronicF127 & PVP K30 for their thermosensitive gelation and mucoadhesive nature respectively.The optimized formulation was subjected to stability study and from data fits it wasconcluded that PVP K30 showed good mucoadhesion and also provides desired drug releasefrom in situ gel. Further, our results also suggest no evidence of interaction between the twodrugs or with the excipients. Hence we can conclude that the above formulation can be usedfor the treatment of periodontitis.



PCT - 11DESIGN DEVELOPMENT AND CHARACTERIZATION OF KETOPROFEN

MICROSPHERES LOADED GEL FOR TOPICAL DRUG DELIVERYThakor Heli, Patel Harsh, Shah Rumit

Shree Naranjibhai Lalbhai Patel College Of Pharmacy, UmrakhThe present work was aimed to prepare Ketoprofen Microspheres for topical delivery byusing Ethyl cellulose as a polymer with the purpose of developing a dosage form for controlrelease characteristics of the therapeutic effect by continuously releasing medication over anextended period of time. The objective in designing topical gel based control release deliverysystem is to reduce the frequency of dosing or to increase the effectiveness of drug bylocalizing at the site of action, and to improve the bioavailability and to localize drug withinthe epidermis by reducing its transdermal penetration which may increase residence time intothe body without being absorbed into systemic compartment, hence may avoid the systemicside effects. To give control and modify release characteristics of the drug and hence todecrease dose and dose frequency which may improve patient compliance.

PCT - 12FORMULATION AND IN-VITRO EVALUATION OF COLON SPECIFIC DRUG

DELIVERY SYSTEM USING NATURAL GUM CONTAINING METHOTREXATEPatel Mohini1, Garasiya Sujit 1, Yadav Jitendra Singh1, Gupta Arti 2

1Shree Naranjibhai Lalbhai Patel College Of Pharmacy, Umrakh2Maliba Pharmacy College, Uka Tarsadia University

The present research work was aimed to prepare colon specific matrix tablets of Methotrexatewith the purpose of developing a dosage form for prolonged therapeutic effect bycontinuously releasing medication over an extended period of time. The objective indesigning oral sustained delivery systems to reduce the frequency of the dosing or to increasethe effectiveness of drug by localizing at the site of action, reducing the dose required orprovide uniform drug delivery, thereby also improving patient compliance using naturaipolymers.

PCT – 13DESIGN DEVELOPMENT ABD CHARACTERIZATION OF NANOSTRUCTURED

LIPID CARRIERS FOR PREVENTIVE THERAPY OF BREAST CANCER.Mistry Stuti, Solanki Sonal

Shree Naranjibhai Lalbhai Patel College Of Pharmacy, UmrakhPresent study was to Design, Development and Characterization of Nanostructured lipidcarrier for preventive therapy of Breast cancer. Nanostructured lipid carrier can be made upusing stearic acid, oleic acid and poloxamerl88 by Melt emulsification and solventevaporation method. It was found that the Curcumin release 75% and 63% from NLCs andNLC based gel respectively within 24 hr (in-vitro). The NLC based gel gives 53.17% drugrelease after 12 hrs (Ex-vivo). It showed sustained release of Curcumin over 24 hrs in NLCs



and NLCgel. It can be concluded that the optimized NLCs and NLC-gel exhibit faster onsetand prolonged action. Curcumin Loaded NLC Shows good cytotoxicity profile against MCF-7 Breast cancer cell line. Which suggest that it can be used in Breast cancer.

PCT - 14DESIGN DEVELOPMENT AND CHARACTERIZATION OF BUCCAL

FORMULATION OF RIZATRIPTAN BENZOATPatel Sejalkumari, Patel Tejas

Shree Naranjibhai Lalbhai Patel College Of Pharmacy, UmrakhRizatriptan benzoate is an anti migraine drug and belong to BCS class 2 and is absorbs orallyand having 45% bioavailability. The present research work was aimed to prepare buccal filmof the drug rizatriptan benzoatr with the purpose of developing a dosage form for a quickonset of action and to enhance the bioavailability to the and dissolution rate of a drug, whichis beneficial in management of migraine to the patient with swallowing difficutiies ortravelling patient not having the access of water and as a result it increase the patientcompliance. The pre formulation work was fist carried out FTIR studies were carried out forchecking the interaction between drug and polymer. Fiml forming polymer, superdisintrgrantand plasticizer were screemed and selected. The film were prepared by solvent castingmethod using HPMC E10 as a polymer, PEG-400 as plasticizer, kyron as a super disintegrant, SLS permeation enhancer, citric acid as a saliva stimulating agent, sodi. Saccharine assweetener and peppermint oil as flavoring agent. The optimize batch was subjected for thestability studies and also the compression between the optimize batch and marketedformulation was done. The pre formulation studies showed no interaction between drug andexcipient. The optimize formulation F10 was obtaine from the 32 Factorial design wassubjected for various evalution such as content uniformity, uniformity of weight, surfacepH,folding endurance, disintegration time, tensile strength, and % elongation stabilityanalysis was done which show no significant change in the formulation.It was conclude thatbuccal film of rizatriptan benzoate can be prepare using suitable polymer for the treatment ofmigrane for the quick onset of action which is beneficial in management of migrane to thepatient with swallowing difficulties and in emergency condition.

PCT - 15NANOSPONGES: A NOVEL DRUG DELIVERY SYSTEM AND ITS ROLE IN

TARGETED DELIVERY AND DETOXIFICATIONDevadiga Bhagyashree, Gupta Garima, Yadav JayhindRofel, Shri G. M. Bilakhia College Of Pharmacy, Vapi

Nanosponge is an innovative technology, capable of safely removing a broad class ofdangerous toxins from the blood stream and can also be employed as effective drug deliverysystems. Nanosponge consist of polymeric nanoparticle core surrounded by red blood cellmembrane, just one cell membrane can make thousands of nanosponge, material used arepolymer, co-polymer and cross-linker. Nanosponges form a three dimensional network that is



biodegradable, having a mesh like structure. They are solid in nature and each sponge has asize less than 1 micrometer. Nanosponges can be formulated in oral, I.V, topical andinhalation dosage form. Toxins produce by MRSA (methicillin-resistant staphylococcusaureus), E. coli, snake venom and bees or pore forming toxins in the blood stream can beeasily entrapped into the porous structure of nanosponge and then metabolized in the liver.Nanosponges are also effective in targeted drug delivery and can be used to carry medicationinto specific part of body (e.g., site of tumor) and release drug in controlled manner, thus alsoreducing adverse effects on other tissues.

PCT - 16FORMULATION AND IN-VITRO EVALUATION OF IMMEDIATE RELEASE

SOFTGEL OF NAPROXEN SODIUMSwain Soumya Ranjan Swain, Mishra Amiya Bhusan Mishra, Badatya Ashish Kumar

Badatya, Mahanty Rakesh MahantyRoland Institute Of Pharmaceutical Sciences Brahmapur, Odisha, India

Oral drug delivery has been known for decades as the most widely utilized route ofadministered among all the routes that have been employed for the systemic delivery of drugvia various pharmaceutical products of different dosage forms. The reasons that the oral routeachieved such popularity may be in part attributed to its ease of administration and the beliefthat oral administration of the drug is well absorbed. One such area of research is design ofSoftgel technology. Softgel technology is one of the most attractive and promising approachfor increasing oral bioavailability by means of increasing solubility of the poorly solubledrug. Naproxen Sodium is one of the most important Non-steroidal anti-inflammatory agentsused in the treatment of acute to chronic pains, inflammation and it belongs to BCS class-IIdrug so as to increase its aqueous solubility for enhancing the bioavailability, it is formulatedas a liquid filled soft gelatin capsules.

PCT - 17BIODEGRADABLE POLYMER-CLAY-HYDROXYAPATITE NANOCOMPOSITES

AS NOVEL DRUG DELIVERYUmate Minal, Yengade Mayuri, Roul Jyotiranjan

Institute Of Pharmaceutical Education And Research, Borgaon Meghe, WardhaBiodegradable polymer based nanocomposites have been used for various drug deliverysystems and biomedical applications as compared to synthetic polymer composites becauseof the biocompatible and biodegradable behavior of natural polymers. These nanocompositesalso possess improved mechanical properties, swelling behavior, drug loading efficiency andcontrolled release behavior as compared to polymer matrices. The objective of the presentstudy was to design and characterize nanocomposites based on hydroxyapatite andbiodegradable polymer chitosan and montmorillonite clay. The nanocomposites weresuccessfully prepared and their structures were characterized by powder x-ray diffraction(XRD), particle size analyzer (Beckman coulter), scanning electron microscopy (SEM), and



fourier transmission infrared spectroscopy (FT-IR) techniques. FT-IR studies provided theevidence of molecular interaction among the constituents of the nanocomposite. SEMprovided the shapes and surface topography of polymer nanocomposites. Particle sizeanalyzer provides the intensity distributions and average size and polydispersity index ofparticles. XRD provided the information on the degree of hybrid structure generated andcrystal size. The average diameters of particles in the nanocomposites were found to bebelow 300nm. This work represents the design of novel clay–chitosan–hydroxyapatitenanocomposite with improved properties that has potential applications in novel drugdelivery.

PCT - 18BIOPOLYMER/RECTORITE NANOCOMPOSITE BEADS: STRUCTURE, AND

DRUG DELIVERY BEHAVIOURYengade Mayuri, Roul Jyotiranjan, Umate Minal

Institute Of Pharmaceutical Education And Research, Borgaon Meghe, WardhaThe present study aims at the formulation development of rectorite nanocomposite beads asdrug delivery carrier and its evaluation. Nanocomposite beads were prepared by gelationmethod. Prepared samples were evaluated and compared simultaneously by Powder X-RayDiffraction, scanning electron microscope, Fourier transform infrared spectroscopy andParticle size analyzer (zeta sizer). For all batches of nanocomposite beads, there was novariation of their bead size. The large size of wet beads suggested high swelling and waterretention capability. The average particle diameter of the optimized nanocomposite beads wasfound to be around 90nm, whereas polydispersity index of particles was found to be 0.674.By applying Scherrer equation, the crystallite size of the optimized nanocomposite beads wasfound to be around 150 nm. From the in vitro release study, it is confirmed that addition ofclay decreases the release of drug at basic pH. It also confirmed that prepared polymer/claynanocomposite beads showed extended release period of drug as compared to the pristinesodium alginate.

PCT - 19A COMPREHENSIVE REVIEW ON CRYSTALLO CO-AGGLOMERATION

Bode Harshita, Dewani SunilInstitute Of Pharmaceutical Education And Research, Borgaon Meghe, Wardha

Crystallo-co-agglomeration is a novel particle engineering/design technique developed toovercome the limitations of spherical crystallization. It is a type of spherical agglomerationtechnique, which enables both crystallization and agglomeration to be done simultaneously oftwo or more drugs to yield complex agglomerates of drug and excipients. Basically, it’ssingle step process used for size enlargement of single, two or more, small dose or large dosedrugs, in combination with or without diluent. This process involves simultaneouscrystallization and agglomeration of drug/s with/without excipients/s from good solventand/or bridging liquid by addition of a non-solvent. These techniques are useful to yield



directly compressible crystal/agglomerates to achieve fast dissolving tablet as well as modifythe drug release for controlled release dosage form.

PCT - 20SOLID DISPERSION TECHNIQUES FOR IMPROVEMENT OF ORAL

BIOAVAILABILITY OF POOR WATER SOLUBLE DRUGS: A COMPREHENSIVEREVIEW

Parshuramkar Trupti, Dewani SunilInstitute Of Pharmaceutical Education And Research, Borgaon Meghe, Wardha

The poor solubility and low dissolution rate of poorly water soluble drugs in the aqueousgastro-intestinal fluids often cause insufficient bioavailability. This may be achieved byincorporating the drug in a hydrophilic carrier material obtaining products called soliddispersions. Solid dispersions are one of the most promising strategies to improve the oralbioavailability of poorly water soluble drugs. By reducing drug particle size to the absoluteminimum, and hence improving drug wettability, bioavailability may be significantlyimproved. They are usually presented as amorphous products, mainly obtained by two majordifferent methods, for example, melting and solvent evaporation. Recently, surfactants havebeen included to stabilize the formulations, thus avoiding drug recrystallization andpotentiating their solubility. So this presentation highlights various approaches for thepreparation of solid dispersion, technology involved, detail description of poorly watersoluble drugs & carriers.

PCT - 21A COMPREHENSIVE REVIEW ON USE OF MONTMORILLONITE CLAY IN

NANOPARTICULATE DRUG DELIVERYSarode Madhuri, Roul Jyotiranjan, Hadke J

Institute Of Pharmaceutical Education And Research, Borgaon Meghe, WardhaIn the preparation of final dosage form of a drug, it is necessary to disperse the drug in abiologically inert matrix such as polymeric matrices or clay particles, for improved drugdelivery. In these cases it is necessary to produce systems that not only release the drug anappropriate rate but also have suitable mechanical properties for the particular application. Tooptimize biological activity and therapeutic effect of the drug, the drug delivery compositionswith modified release systems are developed where the drug is released at a controlled ratesuch as the controlled release oral drug delivery systems. Clay minerals like montmorillonite,rectorite find wide range of applications, in various areas of science, like drug deliverysystems due to their natural abundance and the propensity with which they can be chemicallyand physically modified to suit practical technological needs. Montmorillonite has beenextensively applied for prolonged release of drugs as it can retain large amounts of drug dueto its high cation exchange capacity. It may interact with active drug molecules, but also withinactive components like polymers. On the basis of these interactions, montmorillonite and itsmodified forms can be effectively used to modify drug delivery systems. This review



emphasizes the modifications of montmorillonite clay, its interactions with drug moleculesand its applications in novel nanoparticulate drug delivery systems.

PCT - 22FORMULATION OPTIMIZATION AND CHARACTERIZATION OF

NANOSUSPENSION OF ACYCLOVIRPoojari Anusha, S Mounika

Jayamukhi College of PharmacyAcyclovir, BCS class III drug, shows only 20% bioavailability, very low permeability andhigh onset of action. Direct nanoparticle uptake is one of the promising methods ofimproving the bioavailiability for such compounds. Transcytosis of the nanoparticle takesplace with the help of Microfold cells(M CELLS) of peyer patches in the small intestine. But,the problem is these M cells represent typically less than 1% of the total intestine area, whichmakes the selective delivery to these sites more difficult. So, surface modification technologywas incorporated which includes the use of Eudragit Coating nanosuspension of Acyclovirwas prepared by emulsification solvent evaporation method with Eudragit EPO as polymericstabilizer and Tween 80 as surfactant stabilizer. 32 full factorial design was applied foroptimization of the formulation parameters. The prepared formulation were evaluated forparticle size and zeta potential, % entrapment efficiency, % drug release, ex- vivo diffusionstudy, Transmission Electron Microscopy etc.were performed and best batch was optimized.The results showed that nanosuspension containing Acyclovir higher bioavailability ascompared to the marketed product and can be used as best alternative to the viral diseases.

PCT - 23NEED OF BIOAVAILABILITY STUDIES IN PAEDIATRIC DOSAGE FORM

Singaram MounikaJayamukhi College of Pharmacy

The bioavailability (BA) studies explains rate of absorption of drug availability in body.Paediatrics has immature organ and body system so paediatric dosage forms have to complywith specific regulation. The paediatric use marketing authorisation (PUMA) helps underarticle 45& article 46 for the development of expired or going to expire patent medicines forchildren trials. It also creates support measures to manage the operation of the paediatricregulation including the paediatric committee within the European medicinal agency, USFood and Drugs Administration and other regulatory authorities. The BA studies are done toformulate requirements for their design, conduct, and evaluation for Patient/ volunteer rangesbetween 0-14 years i.e. under 1 year (Infants) system & organ are not developed &immatured;1-4 years (Toddlers) organs are developing but not matured ;5-9 years (EarlyChildhood) organs & system are developed ; 10-14 years (Middle Childhood)similar to adult.



PCT – 24FORMULATION TECHNIQUES FOR HIGH DOSE DRY POWDERS

Gomathi JoshiJayamukhi Institute Of Pharmaceutical Sciences

Delivery of drugs to the lungs via dry powder inhaler (DPI) is a promising approach for thetreatment of both local pulmonary conditions and systemic diseases. Though DPIs are widelyused for the pulmonary deposition of potent bronchodilators, anticholinergics, andcorticosteroids, there is growing interest in the utilization of this delivery system for theadministration of high drug doses to the lungs, as made evident by recent regulatoryapprovals for anti-microbial, anti-viral and osmotic agents. However, the formulation of highdose DPIs carries several challenges from both a physiological and physicochemicalstandpoint. This review describes the various formulation techniques utilized to overcome thebarriers associated with the pulmonary delivery of high dose powders.

PCT - 25FORMULATION AND DEVELOPMENT OF MICROSPHERES TO STUDY THE

EFFECT OF PH ON PARTICLE SIZE AND ENTRAPMENT EFFICIENCYBhoyar Milind, Sathe Bhushankumar, Roul Jyotiranjan

Institute Of Diploma In Pharmacy, Borgaon (Meghe), WardhaThe aim of present study was to formulate microspheres of ‘ibuprofen’ to provide controlledrelease as well as to minimize local side effect associated with upper gastrointestinal tract bymodifying the release of drug. The lipid polymer, modifier and dispersant were used for theformulation of microspheres by melt dispersion method which is more beneficial than thesolvent evaporation method because of total absence of organic solvents during thepreparation process. The main objective of this research work was to study the effect of pHon the particle size, entrapment efficiency as well as evaluation characteristics ofmicrospheres. Effect of different variables on evaluation parameters and in-vitro release ofibuprofen were also studied. The effect of pH showed maximum entrapment efficiency andsize optimization at pH 3.5 as compare to other pH range. The microspheres form the lumpsat low pH 1.2 to 3.0 and shows less entrapment efficiency at higher pH 5.0 to 6.5. Theoptimized batch of lipid microspheres was formulated with drug-lipid ratio (1:2), at pH 4.5 ofaqueous medium and suitable modifier. The obtained results showed the highest entrapmentefficiency (about 84.27%) of ibuprofen and drug loading (18.91%). Here from the result, itwas observed that the pH of external phase affecting directly the entrapment efficiency,release and morphology of the microspheres.



PCO-01A BRIEF REVIEW ON INTERNATIONAL NON-PROPRIETARY NAME : UNIQUE

IDENTITY OF PHARMACEUTICAL DRUGS

Mulla Kaynat*, Kalan Maitri, Merai AnkitRofel, Shri G. M. Bilakhia College Of Pharmacy, Vapi

The International Non-Proprietary Name (INN) is an official generic & non- proprietaryname given to a pharmaceutical drug or an active ingredient. There are different namingstandard followed in several countries for INN. Having standard names for each drug isessential, as the drug may be sold by various brand names or branded medication may containmore than one drug. Each INN is unique and contains a word stem shared with other drugs ofthe same class. This review provides a brief idea on the various naming systems followed byseveral countries as per INN. It also provide the guidelines for naming medicines, differentbrands & generic names across world-wide.

Keywords :- International Non-Proprietary Name, Pharmaceutical drug, Brand name, Genericname.

PCO-02ONLINE ADR REPORTING TOOL’S : AN ADVANCE STEP TO

PHARMACOVIGILANCEKalan Maitri*, Mulla Kaynat, Merai Dr. Ankit

Rofel, Shri G. M. Bilakhia College Of Pharmacy, Vapi

Adverse Drugs Reaction (ADR) is one of the cause for morbidity & mortality. At present,there are various tools available to report ADRs, yet there is low rate of reporting world-wide. The rate limiting factors in reporting are legal aspect, complacency, diffidence,indifference, ignorance, lack of time period etc. Along with that major hurdle is, theconfusion regarding which kind of information have to report in ADRs reporting. So, thisinclude information regarding a brief view on ADRs reporting process, the data flows of thereported cases, the various form available to report & the various tool’s available to reportADRs (such as Vigiflow, Aris G, Argus) with their special feature, benefits and compatibilitywith respective ADRs reporting forms and the limitations of it. Thus, mainly emphasis onpromoting ADRs reporting via online process which may serve, less tedious & time saving tohealthcare stake-holder’s and add up to improve health-care system status regarding safety &safe use of medicine.

Keywords: Adverse Drug Reaction, ADRs reporting tools, ADRs reporting forms.

PCO-03STUDY ON EFFECTIVENESS AND SAFETY OF THRICE WEEKLY

SUBCUTANEOUS ADMINISTRATION OF RECOMBINANT ERYTHROPOIETININ TREATMENT OF CHRONIC RENAL ANAEMIA IN NON-DIALYSIS PATIENTS

Lakhani Ruchita*, Menon Megha, Dalal Mittal, Bhatti HanifRofel, Shri G. M. Bilakhia College Of Pharmacy, Vapi

To assess effectiveness and safety, by subcutaneous administration, of recombinanterythropoietin (Rh-EPO) in treatment of chronic renal anaemia in non-dialysis patients.



Single arm open label study design was used for this study. The study involved the evaluationof demographics, past medical history, etiology of CKD, blood pressure and pulse rate ofpatients suffering from chronic renal anaemia and receiving Rh-EPO (subcutaneous) dose of50 IU/kg. Further for efficacy of Rh-EPO, Hb and haematocrit were evaluated every 4 weeksand for safety other hematological parameters and any reported adverse events wereevaluated in these patients. After administering Rh-EPO mean change in Hb conc. (g/dl) wasanalysed by using paired t-test.

The therapeutic strategy used in this study was found to produce a significant increase in Hbvalue (p<0.05). The few adverse events reported, include hypertension, hypotension,diarrhoea, constipation, upper respiratory tract infection, headache, back pain and cough.However, no causal association could be established with Rh-EPO.

Conclusion : The results of this program indicated that the thrice weekly dose of the drugmaintains the Hb level above 11 and also improves the quality of life of patient.

PCO-04EVALUATION OF STATIN THERAPY IN TYPE 2 DIABETES MELLITUS

PATIENTS OF AGE BETWEEN 35-75 YEARS : A RETROSPECTIVE STUDYDavda Bhakti*, Kumar Santhana, Dalal Mittal


In type 2 Diabetes Mellitus (T2DM) patient usage of Statin therapy is recommended by mostclinical guidelines as prophylaxis for Cardiovascular disease (CVD) and seems to be effectivefor primary or secondary CVD prophylaxis. This research article points to summarize thecurrent evidence confirming the role of statins and respective dose regimen which is effectivein T2DM patients based on prescriptions and also considers the factors affecting clinicalpractices. Results from our study indicate a widespread prophylactic use of statins byphysicians in study population. Also, Atorvastatin and Rosuvastatin was found to be mostprescribed statin. Ensuring proper statin prescribing and utilization can help in achievingbetter clinical outcomes of statin therapy in T2DM Patients.It was found that the intensity ofstatin therapy was empirical and there is a need in inclusion of use of statins in primaryprevention of ASCVD in patients with T2DM.

PCO-05COMPARISON OF HEALTH CARE COST IN END STAGE RENAL DISEASE

PATIENTS UNDERGOING PERITONIAL DIALYSIS OR HEMODIALYSISTandel Divya*, Dalal Mittal, Mehta Neha


Hemodialysis (HD) and Peritoneal dialysis (PD) are the main modalities for dialysis inpatients with end stage renal disease (ESRD), involving complete failure of kidney function.This study was done with an aim to compare the COST of patients with ESRD undergoingHD or PD. A randomised, open labelled, observational clinical study was conducted inpatients undergoing HD or PD. As expected, cost of the therapy of HD was found to be morein private hospitals over civil hospitals. Results from our study suggest a higher direct cost ofPD compared to HD but a lower indirect cost of PD compared to HD. Further, the total cost



of therapy was found to be higher in PD. It was also noted that the convenience attributed tothe procedure, as reported by patients was more in PD.

PCO-06Effect of Chronic DHT exposure in pre-pubertal rats on histological presentation of

uterus and its reversal by Bauhinia purpurea and Anetheum graveolensTailor Shivangi*, Dalal Mittal


Androgen receptor agonist can affect the hypothalamic-pituitary-ovarian (HPO) axis inseveral ways, producing alterations in the female reproductive tract that may be detectedhistologically. Potent Androgen receptor agonist such as Dihydrotestosterone typically causeovert histological changes in the vagina, uterus and ovary. This study was aimed to evaluatethe effect of chronic administration of 83 µg/day Dihydrotestosterone (DHT) in prepubertalrats on the histological presentation in uterus. The rats treated with DHT cause oestrusacyclicity and destruction of follicular cells and absence of corpus luteum in the ovaries. Inthe uterus, DHT was found to produce morphological alterations, characterized by presenceof vacuolated epithelium and endometrial stroma fibrosis. There was also evidence ofincreased angiogenesis. Treatment of Bauhinia and Anetheum was found to reverse some ofthese effects, though not all. Further studies are necessary to evaluate the mechanism of theseeffects.

Keywords:Dihydrotestosterone, uterus, histology, Bauhinia purpurea, Anetheum graveolens

PCO-07RHEUMATOID ARTHRITIS- WITH HOPE AND CHALLENGES

Patel Het*, Pathan Shahbaz, Patel Anish, Tarafdar DipayanC. K. Pithawalla Institute Of Pharmaceuticalscience & Research, Surat

Rheumatoid arthritis (RA) is a chronic inflammatory disorder which affects the joints bydestroying body tissues. Pain and fatigue are very common and often reported symptoms forRA. The progress of pain and fatigue in RA is related with problematic moods, psychosocialresources and burdens. Current therapies tend to treat symptoms or slow down the diseaseprogression but no cure exists at the moment. Recent research creates a hope for new inthis autoimmune disease with the knowledge of the effect of genetic, environment,epigenetics. With advances of therapy, clinical outcomes have improved dramatically andremission is possible for many patients. These advances have come with many challenges,prompting consideration of strategies to improve diagnosis and treatment and implementmore cost-effective care. The present discussion is an attempt to explore the pros and cons ofnew therapies with a hope for better clinical outcomes.



PCO-08ANTI FUNGAL RESISTANCE AND ITS EVOLUTION : AN INCREASING

CONCERNMalek Kavsar*, Patel Sahina, Dipayan Tarafder

C. K. Pithawalla Institute Of Pharmaceuticalscience & Research, Surat

Fungal infections are an issue of increasing concern, and it is necessary to develop newstrategies in order to mitigate mortality rates caused by these types of pathogens. Fungiexhibit different resistance mechanisms, ranging from genetic mutations to metabolicadaptations to the action of several anti-fungal compounds available for clinical treatments.However, some anti-fungal resistance are no-evident and need to be studied in order to avoidrising of new resistant fungal strains. Moreover, it is well known that drug resistance is linkedto fungal evolution. For this reason, it is important to understand adaptation mechanismscarried out by fungi to resist anti-fungal action, such as amino acid mutations or differentmetabolic responses of fungal species to several anti-fungal drugs. In order to design bothnew anti-fungal compounds or strategies for treating fungal infections. The present discussionis an attempt to explore the effects of evolution in fungi in order to evade anti fungal effects.

PCO-09CLINICAL ORGAN TRANSPLANTATION AND ITS BARRIER : AN EMERGENT

CONCERNPatel Minu*, Patel Tulsi, Patel Mili, Bharatia Rishi, Tarafder DipayanC. K. Pithawalla Institute Of Pharmaceuticalscience & Research, Surat

Clinical organ transplantation has been recognized as one of most gripping medicaladvantage of century in the way of giving gift of life to vital organ failure patients. Globalshortage of organ is cause of countless fatalities across the world. Major source of organdeceased donor after brain death, many from liver donation and from non-heart-beatingdonor. Immunological barrier remain main obstacle to widespread use of transportation asreplacement therapy for terminal organ failure. With the development of faster, larger drones,long-distance drone organ shipment may result in substantially reduced cold ischemia times,subsequently improved organ quality, and thousands of lives saved.

PCO-10ARTIFICIAL BLOOD - A GAME CHANGER WITH CHALLENGES

Patil Bhumika*, Shahani Priti, Singh Mamta, Tarafder DipayanC. K. Pithawalla Institute Of Pharmaceuticalscience & Research, Surat

Artificial blood is a new concept of biotechnology used to mimic and fulfil some functions ofbiological blood. Biological blood is essential for transport of essential nutrients and oxygento cells and to remove waste product away from those cells. When natural blood is notavailable in case of cardiac surgery, trauma or any other emergency conditions with hugeblood loss, artificial blood can be used. The present discussion is an attempt to explore thepros and cons using artificial blood.



PCO-11EBOLA VIRUS - OUTBREAK

Nishad Vandana*, Yahya MoollaC. K. Pithawalla Institute Of Pharmaceuticalscience & Research, Surat

Ebola virus are pathogenic agent which cause severe, fatal disease in humans and animals. Inequatorial Africa 4 species of this virus have been identified. The transmission will occur bycontact to body fluid which results in major epidemics. This happens mostly in unresourcedsettings. This disease can characterised by following symptoms, immune suppression,inflammatory responses, deficiency of major electrolytes and fluids in body. Despite ofprogress in the treatment of this virus the mortality rate is high. Case management isnecessarily supportive, which manages severe multiple organ failure because of immunemediated cell damage. In 2013-16 outbreak, WHO classified it as public health emergency ofinternational concerns, questioning scientific, clinical and societal preparation to handlefuture activities.

PCO-12HER-2 BIOMARKER PROBE: A REVIEW

Mansuri Anjuman*,Desai JitalSmt. B. N. B. Swaminarayan Pharmacy College, Salvav,Pardi, Vapi.

Chemical probes are becoming more vital reagents to investigate the pathological andbiological mechanisms with its etiological reason in major diseases like cancer. As we knowbreast and gastric cancer are among the highest prevailing types in cancer in world. In thisstudy, we will discuss regarding brief review on involvement of chemical probes in breastand gastric cancer. DNA probe is nucleic acid molecule (single stranded DNA) having astrong affinity towards specific target. Hybridization of nucleic acid probes has been a keytechnique used in exploration of the molecular biology of the cell. Coupling of hybridizationwith amplification of nucleic acids in vitro, will results in extremely sensitive detection ofspecific nucleic acids. As we know precise monitoring of human epidermal growth factorreceptor 2 (HER2) status is important for most favorable patient management withtrastuzumab (Herceptin). HER2 DNA probe is a biomarker which is mainly used in detectionof breast and gastric cancer. A literature review of published studies explained that there aremore than 50 DNA probes available vital biomarker, amongst this, HER2 DNA probe is morepopular. The HER2 gene and Chr17 centromere were detected using the HER 2 Probe and itsmechanism is briefly summarized in this content. How the HER2 probes helps in determinethe HER2 gene status within the morphological context of the tumour. How the HER2 DNAprobe used in detection of amplification by light microscopy of the HER2 gene. This reviewhelps in increasing the information regarding the mechanism and application of latest HER2probes as biomarker in breast and gastric cancer.Keywords: Breast cancer, gastric cancer, HER gene, HER2 Probe, DNA Probe

PCO-13PHANTOM VIBRATION SYNDROME(PVS): AN EMERGING PHENOMENON

Panchal Nikita*, Patel Chandni, Patel Pinesh, Lambole VijayShree Naranjibhai Lalbhai Patel College Of Pharmacy, Umrakh

Mobile phones are innovation of new era’s technology. Around 5 billion people are usingmobile phone worldwide. Mobile phone is an essential part of urban life. People spent moretime on cell phones and it is affecting their physical and mental health. mobile phone is



causing serious health issues related to psychology and social behavior. Newly reporteddisorders, like Phantom Vibration Syndrome, Nomophobia and possible risk for sleepdisorders and infertility among medical. A phenomenon known as ‘‘phantom vibrationsyndrome’’ This refers to when phone users perceive their device to vibrate, indicating that acall or text is incoming, when in fact the phone did not vibrate at all. They might beconsidered as a normal brain mechanism. People are using vibration alert mode in silencezone and its frequent use lead towards phantom vibration syndrome (PVS). In 2003, Mr.Robert D. Jones described the term Phantom vibration syndrome. Phantom vibrationsyndrome is an emerging disorder due to excessive use of mobile phones. PVS is concernwith psychological or neurological changes. Prevalence of Phantom vibration syndrome ismore than 70% among the medical students. This tactile hallucination causes by repeated useof cell phone, vibration alert mode and using same location for carrying mobile phone. PVSmay lead toward anxiety, depression and affective disorders. Phantom vibration syndromecan manage by changing habits towards utilization and carrying of cell phone. By usingmobile phones in proper way, one can avoid these syndromes, or at least can ameliorate thesymptoms. It is also avoided by turning off the vibration, cell phone fast or by reducingvolume of ring.

PCO-14CRISPR-THE GENETIC TECHNIQUE AGAINST THE HIV

Patel Heli*, Trivedi Milind, Mistry ParthShree Naranjibhai Lalbhai Patel College Of Pharmacy, Umrakh

HIV (Human Immunodeficiency Virus) which can lead to AIDS ( AcquiredImmunodeficiency Syndrome) . AIDS is not curable by drugs due to its direct effect on thegenetics factor of immune CD4+ T cells. We can suppress the HIVs replication by the ARTdrugs (Anti-Retro Viral Therapy) – Protease inhibitors, Integrase inhibitors, Nucleosidereverse transcriptase inhibitors. If they are stopped, HIV rebounds, renewing replication andfueling the development of AIDS. But now the new genetic technique namely CRISPR(Clustered Regularly Interspaced Short Palindromic Repeats) is emerged as powerfultechnology to edit the genomes and is now widely used in basic biomedical research toexplore gene function in combination with LASER ART (Long acting slow effecting releaseantiretroviral therapy) which is developed by the researchers at the Temple university andThe university of Nebraska medical center. According to the study, the potential of CRISPRtechnology to edit the HIV genome and block the expressions, has opened new door toremove the HIV.

PCO-15HORMONE REPLACEMENT THERAPY

Patel Reema*, Patel Nil, Patel Jaimi, Shah GunjanShree Naranjibhai Lalbhai Patel College Of Pharmacy, Umrakh

Hormone Replacement Therapy is supplementing women with hormones that are lost duringthe menopausal transition. To relieve the symptoms associated with menopause, conventionalHRT includes an estrogen and progesterone components to mimic the hormones created byhuman ovary. It can also be used in male hormonal therapy and treatment for individuals whoundergo a sex change. The role of hormone replacement therapy has been debated. Duringmenopause, the estrogen levels fall. From the recent trials held by Women’s health initiative



(WHI), if HRT is initiated soon after menopause, consistent reduction is observed inCoronary Heart Disease, improve muscle function and mortality. It may help to keep skinyoung but it can not reverse delay the overall effect of aging. It also significantly decrease theincidence of various symptoms of menopause like hot flashes, weight gain, hair loss,osteoporosis, insomnia, etc. It has side effects like vaginal dryness, blood clot, breast cancer,stroke, heart disease. To avoid the risks, HRT should be primarily estrogen based. Use ofonly estrogen is associated with reduced onset of young-onset of breast cancer. Use of bothestrogen and progesterone was not associated with increased risk. It can delivered by creamsor gels, vaginal rings, tablets and skin patches.

PCO-16A NEW APPROACH TO TREATMENT OF PROSTATE CANCER

PARMAR RAJATKUMAR*, DEVDHARA FORAM, LAMBOLE VIJAYShree Naranjibhai Lalbhai Patel College Of Pharmacy, Umrakh

The Prostate is a gland in the male reproductive system located just below the bladder and infront of rectum.The main function of prostate gland is to produce and store fluid which comesout from man’s penis during ejaculation.There are various types of prostate cancer likeadecarcinomas, prostatic interaepithelia neoplasia (PIN), prostate carcinoma, benign prostatichyperplasia(BPH) and prostate enlarges.It is mainly occurs in the man with a high fat diet,tire plant workers & who has been exposed to cadmium.The main symptoms of prostatecancer(PCa) is dribbling, slow urination & blood in urine.Prostate cancer (PCa) is the secondmost common cause of cancer and the sixth leading cause of cancer death among menworldwide.PCa is treated by surgery and various therapies like radiation & hormonetherapy.The new approved drugs for treatment of prostate cancer like apalutamide andenzalutamide having a good result against PCa.These drugs are previously used in the laststage of prostate cancer, but researchers applied it into the first stage of cancer which shownextremely beneficial results in first stage of prostate cancer.Use of those drugs in early stagesby giving it along with the other androgen depressive drugs can decrease the death rate.It isanalysed that lives of about 72% patient’s have been saved with the help of this newandrogen depression therapy.

PCO-17STEM CELL TRANSPLANT

Jain Kevil*, Parekh Brijesh, Modi Preet, Patel NilShree Naranjibhai Lalbhai Patel College Of Pharmacy, Umrakh

Cancer is an incurable disease, which arises due to uncontrollable growth of normal cells andinfection of carcinogenic agents .Various types of cancer are based on the site at which thecells show tumor formation, such as breast cancer, colon cancer, lung cancer, melanoma,leukemia etc. There are various types of therapies used for the treatment of cancer. One of thetherapies used is stem cell transplant. Stem cell transplant is the therapy in which the patientis provided with stem cells as they are deficient in normal cells due to disease condition orradiation therapy. Stem cells are the primitive cells that have the ability of totipotency andcan differentiate into various cells that aid into normal functioning of the body. Stem celltransplant can be done by following ways: Autologous transplantation, allogeneic, reduced-intensity stem cell transplantation, syngeneic transplantation.



PCO-18ANTI-HIV DRUG SUPRESSES HIV VIRUS FOR ALMOST TWO YEARS WHEN

OTHER ANTI-RETROVIRAL TREATMENTS FAIL.Chaudhari Falguni*, Lambole Vijay

Shree Naranjibhai Lalbhai Patel College Of Pharmacy, Umrakh

Human immunodeficiency virus-1 (HIV-1) infection currently requires lifelong therapy withdrugs that are used in combination to control HIV infection. Even in the era of modernHAART regimen, antiretroviral (ARV) therapy gets failure and emergence of drug resistanceis still a problem worldwide. New classes with different mechanisms of action are needed toovercome this challenge. After the integrase inhibitors were launched, more than a decadeago, no new classes were added to the ARV.

A first-in-class HIV treatment developed by the UK company ViiV Healthcare hassuppressed the virus in people who have become resistant to other antiretroviral drugs,providing protection for at least 96 weeks. The phase III trial tested by ViiV Healthcare’sfirst-in-class drug fostemsavir in 272 HIV-infected people who had failed to respond toapproved antiretroviral drugs. Given twice per day, the drug was able to suppress the HIVvirus in 60% of the patients for at least 96 weeks. Fostemsavir is a prodrug that ismetabolised to the active compound, temsavir, a first-in-class attachment inhibitor that bindsto glycoprotein 120 (gp120) on the envelope of the HIV, locking gp120 in a conformationalstate that inhibits initial interaction between the virus and host immune cells, preventing viralattachment and entry into the host CD4+ T-cell.

PCO-19AN INNOVATIVE NUTRITION BASED APPROACH TO MANAGE KIDNEY

STONEPatel Charmi*, Lambole Vijay

Shree Naranjibhai Lalbhai Patel College Of Pharmacy, Umrakh

Kidney stones arise from an excessive urinary excretion of oxalate or hyperoxaluria. Dietaryoxalate can become actively harmful when too much of it is absorbed; oxalate is a componentof the most common type of kidney stones. 75% kidney stones in patients in the United Statesconsist of calcium oxalate. Oxalate can cause complications in patients who haveinflammatory bowel disease and short-bowel syndrome however as oxalate is contained inmany different foods, often at different levels in a single food, avoiding oxalate consumptionwhile maintaining a balanced diet is difficult. Up to approximately 25 percent of the oxalateconsumed in the diet is absorbed into the human bloodstream through the intestines.captozyme has developed enzyme products that degrade oxalate, thereby promoting itsremoval from both diet and the body. captozyme has taken the innovative approach ofreducing the oxalate concentration in food through adding an oxalate degrading enzyme.captozyme has addressed these problems by using oxalate degrading enzymes to removeoxalate in the digestive tract and reduces the oxalate concentration in food.



PCO-20EFFECT OF POLYHERBAL PREPARATION ON HIGH FAT DIET INDUCED

HYPERLIPIDEMIA IN FEMALE SPRAGUE DAWLEY RATS.Patel Sonia*, Vyas Bhavin

Shree Naranjibhai Lalbhai Patel College Of Pharmacy, UmrakhFrom time immemorial plants have been used as a source for health care by human society.In this study, a polyherbal preparation was prepared using extracts of five medicinal plantssuch as Commiphora mukul hook ex stocks., Cedrus deodar roxb- loud., Bauhinia variegate.,Achyranthes aspera linn. And Picrorrhiza kurroa royle ex. Benth.. The present study isundertaken to evaluate Anti-hyperlipidemic potentials through in-vivo methods of thepolyherbal preparation prepared in-house. The rats were fed with high fat diet for theinduction of hyperlipidemia for 4 weeks. Upon confirmation of disease induction the animalexperiments were conducted as per standard protocols. The hyperlipidemic rats wereadministered two graded doses of polyherbal preparation and the standard control group wastreated with Atorvastatin (10 mg/kg) orally for 14 days. After treatment blood samples fromnormal/positive control/control (HFD) /standard/polyherbal preparation (low/high) dose werecollected and lipid profile, atherogenic index, serum biochemistry examination of liver andrenal function were determined. After sacrificing the animal, histopathological studysuggested that polyherbal preparation produced significant hypocholesterolemic effect.Keywords: High fat diet, Hyperlipidemia, Lipid profile, Polyherbal formulation.

PCO 24CHRONIC USE OF PPIs: - CAUSE FOR CONCERN

Qadri Misbah*, Vyas Bhavin, Desai BhargaviMaliba Pharmacy College

Proton pump inhibitors (PPIs) are the most potent acid suppressing drugs available andmillions of individuals are currently using these medications. Hence, risk of potential long-term side effects associated with the use of PPIs is increasing. Events like nephritis, tetany,anaemia, pneumonia, osteoporosis and increased the risk of birth defects if taken for a longerperiod of time during pregnancy. Even its frequent use increases the risk of C. Diffuleinfection. The treatment with proton pump inhibitors was associated with increased risk forpneumonia in stroke patients. On March 2, 2011, the US FDA informed the public of the riskof hypomagnesaemia associated with prolonged usage of PPIs. The use of proton pumpinhibitors has been associated with the several events causing hypomagnesaemia leading tohypocalcaemia further leads to risk of fracture by interfering with calcium absorption throughinduction of hypochlorhydria but they also may reduce bone resorption through inhibition ofosteoclastic vacuolar proton pumps. The researchers also used laboratory parameters to lookat the risk of kidney diseases progression; they found that patients in the PPI group weremore likely to experience a doubling of serum creatinine level. In recent years, concerns havebeen raised about potential adverse drug events (ADEs) associated with chronic PPI use bydoing clinical studies on several patients (approx. 1,00,000). This review aimed to investigatethe longitudinal studies published in the last years on the relationship between PPIs and itsside effects.



PCO 25SAFETY ASSESSMENT OF BEVACIZUMAB IN PATIENT WITH DIFFERENT

TYPES OF CANCERSPatel Drashti*,Manjarawala Kinjal, Vyas Bhavin

Maliba Pharmacy CollegeBavacizumab is a recombinant humanised monoclonal antibody that selectively binds to andneutralises the biological activity of human vascular endothelial growth factor. Bevacizumabis the 1st line targeted therapy which is use in case of frontline treatment, platinum sensitiverecurrent diseases or platinum resistant disease or persistent, recurrent or metastaticcarcinoma. The main objective of this study was to assess the safety of Bevacizumab byevaluating different parameters like ECG pattern for cardiac abnormalities and comparisonbetween laboratory values and blood pressure at screening visit and after 2 follow up (after21 days of dosing). A total number of 86 patients were enrolled in study having differenttypes of cancer in age group of 18 to 65 years belonging to both genders. According to datathere is no significant effect on ECG interval and blood pressure due to chosen dose ofBevacizumab. Data shows that there are minor changes observed in laboratory values like Hblevel, SGPT, SGOT, Absolute neutrophil count, Platelet counts, Total Bilirubin, SerumCreatinine, Direct and Indirect Bilirubin, Total Protein. From present study it can beconcluded that the chosen dose of Bevacizumab is safe in all type of cancer.

PCO 26PHARMACOVIGILANCE: SAFETY AND EFFICACY OF FIXED DOSE

COMBINATIONSBhikadiya Vishal*, Khadela Avinash, Vyas Bhavin

Maliba Pharmacy CollegePharmacovigilance is the science associated with the detection, understanding, monitoringand prevention of adverse drug reactions. In the present scenario, where the development andmarketing of an ever-growing array of medicines has rendered their safety and therapeuticefficacy, which is a key to determine the success of a drug. The rationality of a fixed dosecombination (FDC) is the most controversial and debated issue in today’s clinical practice.The FDC is a formulation of two or more active ingredients combined in a single dosageform available in certain fixed doses. Though there are many advantages of fixed-dosecombinations, namely simplification of therapy, increased patient compliance, reduction oftotal daily dose and side effects, reduction of overall cost of therapy, there are severaldisadvantages too. The safety of FDCs are justifiable only when they have been developedaccording to rational pharmacokinetic and pharmacodynamic criteria. The pharmacovigilanceshould ensure the safety and efficacy of FDCs in clinical practice. Adverse Event MonitoringCenters (AMCs) under Pharmacovigilance Programme of India can be optimally utilized forconducting education and awareness programs on periodic screening of FDCs by consideringthe latest scientific evidence.



PCO 27CICHRIUMINTYBUS IN METABOLIC SYNDROME: A PARALLEL

ALTERNATIVE TO STATINSDesai Priya*, Rathod Mohini, Vaidya Rutvi

Maliba Pharmacy CollegeCichriumintybus in Metabolic Syndrome: A Parallel Alternative to StatinsINTRODUCTION: Metabolic Syndromeis constellation of an interconnected physiological,biochemical, clinical, and metabolic factors directly increasing risk of cardiovascular disease,Type2 diabetes, and all-cause mortality. Sinister intake of carbohydrate as well as saturatedfatrich diet induces complications including MetS, CVD and non-alcoholic fatty liver disease.Absence of monotherapy and adverse effect on chronic use of Statins have led to need ofalternatives. AIM AND OBJECTIVE: To identify effect of synthetic and plant based lipidlowering agent in the treatment of MetS induced by high carbohydrate high fat diet in rat.MATERIAL METHODS: High-Carbohydrate-High-Fat diet (15 gm/day)was fed to Wistaralbino rat of wither sex for 112 days to induce MetS.Either Atorvastatin (10mg/kg)andAqueous root extract of Cichoriumintybus (200and400mg/kg)were used as treatment for 28days once daily p.o. To ensure the induction of clustering factors of MetS parameters such ascardiovascular, biochemical, molecular parameter were measured. RESULT Synthetic-atorvastatin and plant based – aqueous root extract of Cichoriumintybus showed significantlipid lowering and pleiotropic effect in treatment of MetS induced by HCHF diet.Conclusion: Atorvastatin and CI extract have effectiveness in treatment of metabolicsyndrome.

PCO 28DEVELOPMENT AND EVALUATION OF ANTISTRESS ACTIVITY OF NOVEL

HEALTH PROMOTING TEA FORTIFIED WITH HERBSMarathe Dipika*, Rajpurohit Kirthi, Pal Roy Samaresh, Vyas Bhavin

Maliba Pharmacy CollegeThe present study was designed to develop and evaluate antistress property of a healthpromoting tea comprising of poly herbal formulation containing ethanolic extracts of fourplant Withania somnifera (ashwagandha), Justicia adhatoda (vasaka), Trigonella foenum(methi), Vitis vinifera (grape seed). The antistress activity was evaluated with the adult ratsby swimming endurance test (SET), anoxia tolerance test (ATT) and immobilization stresstest (IST). Here, five group of animal six in each were taken and rats were subjected tochronic unpredictable stress (CUS) like restraint stress, ether anesthesia, tilted cage, tail pinchfor 14 days depending on study design. The treatment was given for 21 days depending onstudy design. The efficacy of the different doses of Poly herbal extract (PHE) 200 mg/kg; 400mg/kg) was evaluated as compared with the standard drug and marketed herbal preparationMentat from Himalayan herbals. The level of neurotransmitters serotonin and dopamine andnor epinephrine were estimated in brain homogenate of rats using spectrofluorimeter. Inswimming endurance test our poly herbal extract showed a dose dependent significant resultby decreasing in immobility time on rat which is almost comparable to standard Mentat. In



the similar fashion in anoxia tolerance test PHE increased the convulsion time on rat whichwas again statistically significant. In case of immobilization stress test the estimatedbiochemical parameters (Cortisol, Glucose, triglyceride and Cholesterol) showed significantdose dependant antistress activity of polyherbal extract. The level of neurotransmittersserotonin and dopamine and nor epinephrine were found to be increase when treated with thePHE as compare to stress control group. So, the present study reveals that poly herbal extractpossesses significant anti-stress activity in different experimental animal models. Thereforeby using these four ethanolic extract of the herbs we have prepared polyherbal tea for themanagement of stress.

PCO 29A PROSPECTIVE STUDY OF CLINICAL PROFILE AND DRUG PRESCRIBING

PATTERN FOR OSTEOPOROSIS IN A MULTI SPECIALITY HOSPITALTailor Neelam*, Pavagadhi Divya, Pal Roy Samaresh

Maliba Pharmacy CollegeThe purpose of the present investigation was to study the trends in utilization of drug patternand evaluate risk factor as well as cost of treatment for the management of osteoporosis. APropective observational study was carried out in which subjects were enrolled within theduration of 6 months at Hospital, who were diagnosed with osteopenia and osteoporosis andalso vitamin D3 deficiency. A total of 120 subjects were enrolled out of which 47.5% weremen and 52.5% were women. The ratio of men and women was 4:5. Out of them, 69.1%patients were having osteopenia and 30.8% patients were osteoporotic. The majority ofosteoporosis and osteopenia was prevalent in the age group of 41-60 being 22.5% in 41-50and 27.5% in 51-60. Hypertension was the most common co-morbid condition found amongthe osteoporosis subjects being 27%. Most common clinical feature among them was jointpain followed by low back pain. A positive correlation was found among the socio economicand socio personal variables like menopausal status, dietary habits, BMI with severity ofdisease except for age. The most commonly prescribed medicines were vitamin D andcalcium supplements being 60% followed by analgesics, muscle relaxants andbiphosphonates being 22% and 9% respectively. The ratio of men and women in our studywas found to be 4:5. Cost benefit analysis could be done through long term studies tomeasure quality of life of the subjects.

PCO 30A SEARCH FOR PROTEINS INVOLVED INTO THE PATHOGENESIS OF

RHEUMATOID ARTHRITISSarangi Deepak Kumar*, Sarangi, Sriwastawa Keshari Kumar, Tarini Charan

TripathyRoland Institute of Pharmaceutical Sciences Brahmapur, Odisha, India

Rheumatoid arthritis (RA) is a chronic autoimmune disease. Certain autoantigens have beenimplied to contribute to the induction and maintenance of inflammatory reactions against the



host tissue(s). Therefore the identification of novel autoantigens in RA appears to be veryimportant for a better understanding of specific disease mechanisms. SEREX (SerologicalAnalysis of Recombinant cDNA Expression Libraries) is a valuable tool widely used insearching for autoantigens. The method is based on screening gene expression librariesconstructed from tissue samples to find potential proteins triggering the production ofautoantibodies. We used a modified SEREX method with synovial fluid from RA patient assource of antibodies. We found numerous novel autoantibodies. There were reports thatfibromodulin is a newly defined autoantigen in RA. We were also able to identify decorin,vimentin, aldolase A and eEF1A-1 as autoantigens in RA which have been previouslyidentified to be involved into the immune response in rheumatoid arthritis. Our resultsconfirm the validity of results obtained using the SEREX system and that the SEREXtechnique is useful for the identification of novel autoantigens that play a potential role in thepathogenesis of the disease. Such proteins identified as autoantigens might help to betterunderstand the pathophysiology of RA.

PCO 31MYRISTOYL COA: PROTEIN N-MYRISTOYL TRANSFERASE: A TARGET FOR

STRUCTURE-AIDED DESIGN IN THE DEVELOPMENT OF A NOVEL ANTI-MALARIAL DRUG

Sahoo Priti Ranjan*, Upadhyaya Sangram, Keshari Upadhyaya, Jain AnandRoland Institute of Pharmaceutical Sciences Brahmapur, Odisha, India

Malaria, an illness caused by protozoan parasites of the genus Plasmodium, continues to be akey global health issue; around 40% of the world’s populations are at risk and more than 1million people are killed each year. It is transmitted via bites of infected female mosquitoes(Anopheles) and its severest form, falciparum malaria, can cause blocked blood vessels,cerebral malaria, coma, and death if left untreated. There is a variety of drugs available tocounter malarial infection, however effective malarial treatment is complex due tointerweaved factors such as drug resistance and socioeconomic development. We haveidentified an enzyme from the parasite, myristoyl CoA:protein N-myristoyl transferase(NMT), which if inhibited will lead to parasite death. NMT catalyses the co-translationaltransfer of myristic acid to an N terminal glycine of certain substrate proteins and it is knownthat this enzyme is essential for viability of these protozoa. Initial screening using in vitrotests of enzyme activity as well as P. falciparum infected erythrocytes has allowed us toidentify a series of specific benzothiazole compounds that act as inhibitors of P. falciparumNMT. It is known that these benzothiazoles compete with binding of the peptide substratewithin the NMT enzyme-binding cleft. We are currently following a strategy of structure-based drug design where we will exploit slight differences in the peptide binding pockets ofP. falciparum and human NMTs to produce selective and potent inhibitors, which we hopewill lead to effective new anti-malarial treatments.



PCO 32A ROLE FOR LIPID RAFTS IN CERAMIDE-INDUCED INSULIN RESISTANCE

Padhi Ansik Kumar*, Priyadarshini Tabassum, Swain Priyanka.Roland Institute of Pharmaceutical Sciences Brahmapur, Odisha, India

Type II diabetes is characterised by a loss in responsiveness of both muscle and adiposetissue to insulin, the main hormone that regulates the body’s energy stores. Although theprecise mechanisms that underlie this pathogenesis still remain unclear there is strongevidence that suggests that an increase in circulating free fatty acids may play a role in theobserved reduction in insulin sensitivity in tissues such as skeletal muscle. We investigate themechanisms by which fatty acids such as ceramide, a main intermediate in the sphingomyelinpathway, trigger insulin resistance and impair insulin signalling in cultured skeletal musclecells and adipocytes. Ceramide activates an atypical Protein Kinase C zeta (PKCz) andpromotes its association with the protein kinase B (PKB), a key protein in the insulinsignalling, which in turn become inhibited. Whether the complex is targeted to a specificcellular compartment has been unknown. We investigated whether lipids rafts within theplasma membrane could serve to sequester and retain PKB in its inactive state. We show thatlipid rafts elicit increased abundance of both PKCz and PKB following cell treatment withceramide. Lipid rafts dispersion by cholesterol depletion of cells reduces the ceramide-mediated increase of both kinases. As a consequence the insulin-dependent activation of PKBis restored. Our findings indicate that ceramide inhibits the hormonal activation of PKB by itsassociation with PKCz and retention in specialised microdomains of the plasma membrane.This implies that therapeutic manipulation of PKCz activity or lipid raft composition mayprovide opportunities for enhancing insulin sensitivity of tissues such as skeletal muscle andfat.

PCO 33NEPHROPROTECTIVE EFFECT OF TABERNAEMONTANA DIVARICATA

FLOWER EXTRACT AGAINST DICLOFENAC INDUCED RENAL DAMAGE INRATS

Syeda Nishat*Jayamukhi College of Pharmacy

The present study was carried out to evaluate the beneficial nephroprotective effect ofethanolic extract of Tabernaemontana divaricata flower against diclofenac induced renaldamage. In the present study wistar albino rats were divided into four groups containing 6animals in each group. Group-I was treated as Normal Control group, Group II was treated asNephotoxic group (diclofenac sodium 50 mg/kg), Group-III was treated as Nephroprotectivegroup (silymarin 150 mg/kg)and Group-IV was treated as Test group (Tabernaemontanadivaricata flower extract 500 mg/kg) being treated with diclofenac sodium for 14 days. On15th day blood samples were collected by retro orbital plexus and biochemical renalfunctional tests urea, creatinine as well as lipid peroxidation and antioxidant activities such assuperoxide dismutase (SOD) and superoxide catalase (CAT) were assessed. Results of thisstudy revealed that the serum markers in the animals treated with diclofenac alone were



significantly increased indicating severe renal damage by diclofenac, whereas the bloodsamples from the animals treated with ethanolic extract of Tabernaemontana divaricataflower showed significant reduction in the serum markers indicating the effect of the plantextract in restoring the normal functional ability of the nephrons. The present study revealsthat the ethanolic extract of Tabernaemontana divaricata flower could afford a significantprotection against diclofenac induced renal damage as it can normalized the oxidative stress.

PCO 34PHARMACOLOGICAL EVALUATION OF IN-VITRO ANTI-INFLAMMATORYACTIVITY OF ETHANOLIC BAUHINIA SEMLA ROOT EXTRACT AGAINST

CARRAGEENAN INDUCED PAW EDEMA IN RATSGadegoni Hemalatha*

Jayamukhi College of PharmacyBauhinia semla has widely been used in the indigenous and traditional systems of medicinebecause of its wide therapeutic profile. Traditionally the flowers are used for management ofgout, biliousness, dropsy, epilepsy, convolutions and hysteria. The present study was carriedout to evaluate the effect of ethanolic Bauhinia semla flower extract against carrageenaninduced paw edema in Rats using Indomethacin as standard drug. Acute oral toxicity study asper ICH Topic S7A guidelines and OECD 423 guidelines was carried out and 250 mg/kgbody weight of dose was selected for further study. The extract showed significant reductionin paw volume after carrageenan Injection. Thereby it can be concluded that ethanolicBauhinia semla flower extract has potential anti-inflammatory property.

PCO 35BETA CATENIN – A NOVEL APPROACH IN TREATMENT OF STRESS AND

DEPRESSIONHajira Ummay*, Syeda Nishat Fathima

Jayamukhi College of PharmacyDepression is a common mental disorder, affecting as many as 1 in 4 people in the course oftheir lifetime. Moreover, between 5% and 10% of the population suffer from thispsychological disorder at some point, to varying degrees. All current antidepressants activatenorepinephrine or serotonin in the brain. They are very nonspecific, so the drugs are usefulfor a wide range of disorders, not specifically depression. A single brain protein beta-cateninappears to mediate resilience to stress and susceptibility to depression that may offer targetsfor novel and more effective antidepressants. Beta-catenin activity in D2-type dopaminereceptor neurons in the nucleus accumbens plays a central role in the ability to deal withstress and be resilient to depression. Moreover, activity is reduced in the brains of depressedpatients. By targeting β-catenin, we just might be able to come up with a new cure fordepression that is also much more effective than current treatment. The focus is on addressingthe negative impacts of stress, but, the new way of treating depression might instead involvescientists activating beta-catenin resilience mechanisms in order to stave off depression.



PCO 36FIBROBLAST GROWTH FACTOR: CONNOTATION IN ANGIOGENESIS

Vankudothu Ganapathi*, Syeda Nishat FathimaJayamukhi College of Pharmacy

Angiogenesis is the growth of blood vessels from the existing vasculature. Angiogenictherapies are designed to control the growth and regression of blood capillaries can be used toimprove the survival of poorly perfused tissues that are essential to the body (heart, brain,skeletal muscle, etc.) and to rid the body of unwanted tissues (tumors). FGFs are homeostaticfactors and function in tissue repair and response to injury. When inappropriately expressed,some FGFs can contribute to the pathogenesis of cancer. A subset of the FGF family,expressed in adult tissue, is important for neuronal signal transduction in the central andperipheral nervous systems. Fibroblast growth factors (FGFs) are potent mitogens forvascular and capillary endothelial cells and can stimulate the formation of blood capillaries(angiogenesis). Basic FGF can stimulate processes that are characteristic of angiogenesis,including endothelial cell migration, proliferation of capillary endothelial cells, invasion, andproduction of plasminogen activator. They, thus promote Angiogenesis represents anexcellent therapeutic target for the treatment of cardiovascular disease.Basic and acidic fibroblast growth factors are prototypes of the family of fibroblast growthfactors. They stimulate the proliferation of fibroblasts and endothelial cells that give rise toangiogenesis and developing granulation tissue; both increase blood supply and fill up awound space/cavity early in the wound-healing process. Early clinical studies with protein-based therapeutics largely focused on the intravenous or intracoronary administration of aparticular growth factor to stimulate angiogenesis in the affected tissue or organ. This reviewhighlights the therapeutic importance of fibroblast growth factors in cardiovascular disorders.Most of the clinical trials reveal that the treatment especially with a single agent was not aviable option to treat ischemic cardiovascular success. The clinical protocols give renewedhope that Angiogenesis therapy will be a treatment choice for sufferers of CVS diseases. Thislead to a resurgence of interest in returning to protein based therapy especially fibroblast tostimulate angiogenesis.

PCO 37ANTIMICROBIAL ACTIVITY OF NOVEL CHITOSAN/CLOISITE 10A

NANOCOMPOSITE: PREPARATION, OPTIMIZATION, CHARACTERIZATIONAND DRUG DELIVERY BEHAVIOR

Roul Jyotiranjan*Institute of Pharmaceutical Education And Research, Borgaon (Meghe), Wardha

The objectives of the present research project were to formulate, evaluate and performantimicrobial study and drug delivery behavior of nanocomposite material based onbiopolymer chitosan and organically modified montmorillonite clay; i.e. cloisite 10A. In thepresent study, chitosan / cloisite 10A nanocomposite material was formulated by solutionmixing and optimized. The nanocomposite material was characterized by FTIR, zeta sizer,XRD, and SEM. Polymer/clay nanocomposite material is evaluated for its antimicrobial



activity against both gram- negative and gram- positive bacteria. It was also studied forpotential drug carrier system using diclofenac sodium as a model drug. Drug incorporationefficiency and drug content were also determined. SEM provided the composite shape and itssurface topography. XRD data revealed the nanocrystalline composition and crystallite size.The average diameters of particles in the nanocomposite were found to be around 80 nm fromboth XRD report, calculated by applying Scherrer equation and zeta sizer. The antimicrobialactivity report revealed that nanocomposite exhibited stronger inhibition against themicroorganisms as compared to that of pure chitosan. From the in vitro drug-release study, itis observed that biopolymer/clay nanocomposite exhibited extended release period of drug ascompared to the pristine chitosan. This research work provides a platform for further researchon the polymer/clay nanocomposites for biomedical and drug delivery applications.

PCO 38PHARMACOVIGILANCE: INDIAN PROSPECTIVE

Mishra Bhawna*Institute of Pharmaceutical Education And Research, Borgaon (Meghe), Wardha

Pharmacovigilance is the science dealing with the detection, assessment, collection andprevention of adverse reaction related to the pharmaceutical product in context ofpharmacology. This study holds a wide horizon of scope as it deals with the safety patientcare and public health. This can be used to promote understanding, clinical training andeffective communication to healthcare professionals and the public. In a nutshellpharmacovigilance is concerned with the detection of hazards linked with pharmaceuticalproducts and reduce the risk of any potential harm that may occur. Pharmacovigilanceprogramme of India (PvPI), started by AIIMS, New Delhi on 14th July 2010 is one of theleading pharmacovigilance facility in India. The sector has been expanding in recent yearsdue to the stringent rules of regulatory authorities regarding the drug safety. Clearlypharmacovigilance is increasingly important worldwide, especially to avoid the reoccurrencesof serious problems that are damaging to the health care system and the industry. This isdesigned to provide crucial data on the effects of the drugs which can aid in drugdevelopment and marketing if harnessed properly, being a boon than the hindrance.



PQA 01THE MODERN ROLE OF SMARTPHONE IN ANALYTICAL CHEMISTRY

Zaveri Sufiyan*,Patel KuldeepShree Naranjibhai Lalbhai Patel College Of Pharmacy, Umrakh

Main trends in development of analytical instrumentation involve design a measuringinstruments, which are able to provide the largest possible amount of analytical informationabout analyzed material, but simultaneously also simplification and scaling-downanalytical instruments towards a possible use directly by users without specializedtraining. Both those development trends are associated with another important tendency,which is the elimination of direct human effort in carrying out different operations inchemical analytical procedures by design of measuring systems, which are mechanized,robotized, or even completely automated involving various contributions of artificialintelligence. One of elements used also for further instrumental progress, is in recentdecade the application of mobile phones in further modification of analytical devicesfor remote and personal use. The potential utility value of a concept to equip mobile-phones in chemical sensors can be considered as a very efficient way for improvingthe access to a personal analytical devices for instance in bioanalytical applications,smartphone-based biosensors, and integration of microfluidic devices and smartphones.

PQA 02DISCOVERY OF NOVEL ANTIBACTERIAL AGENTS

Ahirrao Damini*, Bhuva HemalShree Naranjibhai Lalbhai Patel College Of Pharmacy, Umrakh

The need for novel antimicrobials become essential to face the increasing resistance towardsolder ones. This review summarises the discovery of some recently approved antimicrobialagents. In 2018, eravacycline (first fully synthetic fluorocycline) and omadacycline (C-9substituted derivative of minocycline) were approved in an order to be active againsttetracycline resistance mechanism.In 2017, delafloxacin (to increase activity in acidicmedium by lacking strong basic heterocyclie ring and to increase stability) and ozenoxacin(to be effective topically in impetigo) were approved.Rapidly increasing the resistancetocarbapenemsdue toKlebsiellapneumoniaecarbapenemase enzyme and with reports thatboronic acids inhibit β-lactamase enzyme, new β-lactamase inhibitorVaborbactam wasdiscovered with cyclic boronic acid pharmacophore. Its combination with meropenem wasapproved in 2017. In an order to find covalent, reversible β-lactamase inhibitor, avibactamwith diazabycyclooctane nucleus was discovered and its combination with ceftazidime wasapproved in 2015.



PCG 01CONCEPT OF PHARMA RESTAURENT

Chaudhari Umesh*, Shah BirenShree Naranjibhai Lalbhai Patel College Of Pharmacy, Umrakh

Let the food be your medicine".The main aim for the establishment of the pharma restaurentis to serve the qualitative meal according to the disease of the person.For the prevention andthe cure of the disease. We provide the hygine food with proper nutritional requirement. Thismay help the person to develop the strong immunity and help to produce ressistant for thedisease.For the diabetic patient we have proper recipe like Jamun ka jalwa and other recipekiwi ki masti etc.They are most probably rich in fibers and vitamins which reduces bloodsugar level in the body and they are poor in carbohydrates. The most of the food is coockedin olive oil which contain omega-3 fatty acids(which reduce the risk of heart disease and alsopromote healthy skin).They are also used along the diet and exercise to help lowerlevels of acertain blood fat(triglyceride)and rise the level of HDL( good cholestrol).

PCG 02Jalkumbhi: A polluting monster or a therapeutic boon?

Salunke Snehal*, Vashi Jainee, Dalal MittalRofel, Shri G. M. Bilakhia College Of Pharmacy, Vapi

Jalkumbhi with the scientific name Pistia stratiotes, is an aquatic plant that is widely found inlakes, rivers and other stagnant water bodies. It is distributed in the tropical and subtropicalregion of Asia, Africa and America. The plant spreads on the surface of water. It has mostlybeen portrayed as a water pollutant but it also has various medicinal uses, which are yet to beexplored. It is propagated by seeds or more rapidly by stolons. It forms a dense mass on thewater surface and causes serious clogging of water ways. A large number of medicinalproperties are attributed to the plant, particularly the leaves. Leaves are rich in vitamin A andC, and also contain vitamin B. The ash is rich in potassium and other minerals. Otherbiologically active chemical constituents of P. stratiotes are alkaloids, glycosides, flavonoids,and steroids. The plant is considered antiseptic, antitubercular, and antidysentric. Thiscommonly available economical plant has a lot more to offer, in terms of its therapeuticproperties.Keyword: A Sea monster, boon, clogging water, dense mass, medicinal plant.

PCG 03ANIMAL SELF-MEDICATIONParmar Bhumika*, Shah Biren

Shree Naranjibhai Lalbhai Patel College Of Pharmacy, UmrakhThe consumption of plants, insects, dirt and microbes by animals for prophylactic ortherapeutic use by themselves in illness or to improve their own health is termed as ZooPharmacognosy or animal self-medication. Different species of animals use differentsubstances derived from nature which possesses therapeutic properties. Zoo Pharmacognosy



can show us the solutions quicker. We must now take responsibility of our mismanagement,overuse and disregard of the species of this world. Once we are able to unlock all thepotential benefits of Zoo Pharmacognosy and its positive implications for conservation, thenand only then, can we revolutionize our world. The mechanism underlying the selection byanimals of specific plants during illness is still unclear. The reasons of self-medication byanimals include parasitism, indigestion, stomach upset, infections, neutralize toxins, etc. Thisparticular behavior of animal self-medication like fur rubbing with plants, resins, citrus fruits,ant-eating, eating dirt, etchas driven attention to study further in order to discover new drugs.This paper describes various types, methods and reasons of Zoo Pharmacognosy by variousanimals.

PCG 04GOMUTRA (COW URINE): A MULTIDIMENSIONAL DRUG THERAPY

Patel Nil*, Jain Kevil, Modi Preet, Parekh BrijeshShree Naranjibhai Lalbhai Patel College Of Pharmacy, Umrakh

Gomutra is important part of Indian tradition. It is not only holy but also has variousimportant medicinal uses. Classical treatises in Ayurved i.e. Charka, Sushruta and VagbhataSamhita has described Ashta mutra (eight types of urine) along with their properties,indication and formulations. Cow urine is one of them. Cow urine is one of the five contentsof Panchagavya which are obtained from cow (urine, milk, ghee, curd and dung). Cow basedtreatment is called as Panchagavya Chikitsa (Cowpathy). Panchagavya is a term used inAyurveda to describe five important substances obtained from cow namely Urine, Dung,Milk, Ghee and Curd. Many people use Panchgavya in some rituals (puja) and for medicinalpurposes. In this modern era, the diseases related to life style like cancer, autoimmunediseases, diabetes, AIDS etc. are increasing day by day. A work carried out on modernapproaches has showed that cow urine has different activities like antioxidant, anti-diabetic,wound healing property, immunomodulator also act as bioenhancer to increase the efficacy ofantibiotics, nutrients and anticancer drugs like taxol. Irrational use of antibiotics is alsoresponsible for increase in antibiotic resistant infectious diseases. Various actions andresearches on cow urine are summarized in this article. However, more studies experimentalas well as clinical can throw better light on it.

PCG 05A BRIEF REVIEW ON REGULATORY GUIDELINE ON HERBAL MEDICINES IN

INDIASingh Diksha*, Mithani Namira, Rohit Vrushti

Smt. B. N. B. Swaminarayan Pharmacy College, Salvav,Pardi, Vapi.Herbal medicines have gained enormous popularity throughout the world now, and alsogained popularity throughout India. This enormous spread now brings up a huge question forthe safety, efficacy and reliability of the drugs being used. There is as such no specificguideline available regarding herbal, poly herbal and herbo mineral products. The



manufacturer claims them to be safe and effective but it always need a regulatory body tocheck on. The clinical and preclinical trials which has been carried on for some herbalproducts also demand for a specific guideline, as there is no clarification regarding clinicalguidelines. The department of AYUSH and D&C Act 1945 are regulating the herbalmedicines and related regulatory guidelines but still it limits at the point of rationality many atimes. There is a major drawback regarding the specific criteria to undergo animal studies,which needs great modifications so only approved drugs undergo studies and reducepreclinical load in country. A regulatory rule regarding drugs which can proceed for trial, itstrial period needs to be established. Pharmacovigilant data and studies need to be taken underconsideration when the drugs are intended to be used for a long period. Hence, developmentof a body which solely governs the herbal medicine is necessary . With the aid of AYUSHthis can be established even quicker and efficiently. Else the guidelines provided by thedepartment needs constant reassessment and specifications.

Keywords: Herbal drugs, AYUSH, D&C ACT, Pharmacovigilant data, Regulatory rule.

PCG 06PHARMACOGNOSTIC PROFILING OF POGOSTEMON AURICULARIS L. HusskAND DEVELOPMENT OF NOVEL TOPICAL ANTI INFLAMMATORY GEL WITH

ITS QUALITY CHECKMaheshwari Kinara*, Jat Rakesh, Shah Biren, Ishwar, Pushpa

T. John college of pharmacyExpectedly a quarter of current prescription medications are derived from plant sources ex.aspirin. In ancient time herbal medicine in different-different forms incorporating plantextracts or powders of crude drugs for medicinal purposes. It is the creation’s most ancientform of soothing. Considerably this age-old knowledge is still useful and gives effectiveresults in modern clinical testing. Our ancestors had profusive familiarity towards herbs andtheir curing ability. Contrary to that they had modest information about active chemicalconstituents of primary and secondary metabolites. Conventional COX inhibitors come withdeleterious effects like, Risk of hemorrhage, renal insufficiency, alteration of hepaticenzymes, bone marrow depression etc. where herbs produce laser side effects and comparableeffectiveness. Pogostemon auricularis L. Hussk belonging to the family Lamiaceae. It ishabitat to Bellary, Mysore, Chikamagalur, Assam, south India, Kodagu, Maharashtra, westBengal and fully-fledged naturally in wastelands.

Methodology: Pogostemon auricularis L. Hussk was evaluated for Macroscopical,Anatomical features. Physical, chemical make-up was investigated along with TLC study assupportive parameter towards confirmation of findings. From the findings of primarysecondary metabolites further pharmacological study was conducted. Anti-inflammatorystudy of methanolic extract was checked using Plethysmometer. Carrageenan induced pawoedema model was executed under standard lab condition. Novel pharmaceuticalformulation, poly herbal gel was developed and standardized for its quality check.



Results: Pogostemon auricularis leaves found covered with hairs on both the plane andlathery feel. It is dorsiventral leaf with presence of dicytic epidermal openings, cuticle layerto the epidermis, uniseriate covering trichomes, spongy parenchyma, vascular bundle at themidrib and most distinguish character cystoliths in epidermis. Chemical analysis depictedpresence of alkaloids, cardiac & saponin glycoside, tannins, phenols, steroids and flavonoidspresence. Pulverized leaves showed 17 % w/w extractives with methanol. So, the sameextracts used for further pharmacological study and poly herbal gel preparation. Methanolicextract exhibited 73 % reduction in rat paw oedema volume compared to standard treatmentDiclofenac which is 79 %. Gel preparation passed thee quality tests which are pH, viscosity,Spreadability, irritability, swelling ability, drug content, in-vitro drug diffusion and drugrelease kinetic model study.

abstract book book_conference_03.08.… · abstract book one day national level conference...

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