Benzothiazolyl Substituted Iminothiazolidinones and Benzamido-oxothiazolidines as Potent

and Selective Aldose Reductase Inhibitors

Aamer Saeeda, Yildiz Tehseenb, Hummera Rafiquea, Norbert Furtmannc,d, Jürgen Bajorathc,

Ulrich Flörkee and Jamshed Iqbalb

a Department of Chemistry, Quaid-i-Azam University,1slamabad, Pakistanb Centre for Advanced Drug Research, COMSATS Institute of Information Technology,

Abbottabad, Postal Code 22060, Pakistan c Department of Life Science Informatics, B-IT, LIMES Program Unit Chemical Biology and

Medicinal Chemistry, Rheinische Friedrich-Wilhelms-Universität, Dahlmannstr. 2, D-53113

Bonn, Germany.d Pharmaceutical Institute, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germanye Department Chemie, Fakultät für Naturwissenschaften, Universität Paderborn,

Warburgerstrasse 100, D-33098 Paderborn, Germany

Methyl-2-[3-(benzo[d]thiazol-2-yl)-2-(4-methylbenzamido)-4-oxo-thiazolidin-5-ylidene]acetate (2c)

Electronic Supplementary Material (ESI) for Medicinal Chemistry Communications.This journal is © The Royal Society of Chemistry 2014

Ethyl 4-[5-(2-methoxy-2-oxoethylidene)-2-(4-methylbenzamido)- 4-oxo-thiazolidin-3-yl]benzoate (3d)