Review Article: 200th Anniversary Article A Tale of Coronary Artery Disease and Myocardial

Infarction

Elizabeth G. Nabel, M.D., and Eugene Braunwald, M.D.

N Engl J MedVolume 366(1):54-63

January 5, 2012

Summary

• In this review of heart disease, Nabel and Braunwald focus on two themes — coronary artery disease and myocardial infarction — and explain how our understanding has evolved over the past two centuries.

• The authors consider therapies that have led to improved survival.

Decline in Deaths from Cardiovascular Disease in Relation to Scientific Advances.

Nabel EG, Braunwald E. N Engl J Med 2012;366:54-63

Percutaneous Coronary Angiography and Intervention in the Treatment of Arterial Stenosis.

Nabel EG, Braunwald E. N Engl J Med 2012;366:54-63

Discoveries in Vascular Biology Pertaining to Atherosclerosis.

Nabel EG, Braunwald E. N Engl J Med 2012;366:54-63

The LDL-Receptor Pathway and Treatment with LDL Cholesterol–Lowering Drugs, which Improves Cardiovascular Outcomes.

Nabel EG, Braunwald E. N Engl J Med 2012;366:54-63