A simple introduction toScience at ISIS

Robert McGreevy

ISIS Facility, CCLRC Rutherford Appleton Laboratory,

Chilton, Didcot, OX11 0QX, UK.

RAL December 5th 2005

RAL December 5th 2005

RAL December 5th 2005

RAL December 5th 2005

RAL December 5th 2005

To see small things – you need a big thing …

RAL December 5th 2005

’Neutrons (and muons) tell you where atoms are and what atoms do’

What can neutrons and muons do?

RAL December 5th 2005

Diamond

Graphite

Fullerene

RAL December 5th 2005

0 2 4 6 8 10-1

0

1

2

3

4

5

6

F(Q

)

Q/Å-1

NeutronDiffraction

RAL December 5th 2005

RAL December 5th 2005

InelasticNeutron

Scattering 0,00,2

0,4

0,6

0,8

0,4 0,6 0,81,0

1,2 Q/n

m-1

/ps-1

RAL December 5th 2005

Time of flight method

ParticleMomentum – k (velocity)Energy - E

Wave Wavelength – λ (length scale)

1000 m/s 20 m

μs 20 ms

10-10 m

RAL December 5th 2005

RAL December 5th 2005

RAL December 5th 2005

Neutrons see the world in a uniqueunique way

Length and time scales

10-11 – 10-6 m 10-14 – 10-6 s

From hydrogen … … to hydrogenase

RAL December 5th 2005

Neutrons see the world in a uniqueunique way

Length and time scales

10-11 – 10-6 m 10-14 – 10-6 s

From hydrogen … … to hydrogenase

RAL December 5th 2005

10-8

10-7

10-6

10-5

10-4

10-3

10-2

10-1

100

101

102

103

104

10-4

10-3

10-2

10-1

100

101

102

E /

meV

Q / Å-1

108

107

106

105

104

103

102

101

100

10-1

10-2

10-3

104

103

102

101

100

10-1

r / Å

t / p

s

Spin Echo

Backscattering

Chopper

I nelasticX-ray

Multi-Chopper

I nelastic Neutron Scattering

Brillouinscattering

Ramanscattering

UT3

Photoncorrelation

VUV-FELIn

fra-

red

uSRNMR

Q (Å-1)

0.10 0.12 0.14 0.16 0.18 0.20 0.22 0.24 0.26 0.28 0.30

Tim

e (

ms)

0

1000

2000

3000

4000

5000

2.0e-7 4.0e-7 6.0e-7 8.0e-7 1.0e-6 1.2e-6 1.4e-6 1.6e-6

Neutrons see the world in a uniqueunique way

RAL December 5th 2005

Neutrons see the world in a uniqueunique way

Penetration

Large samples, buried interfaces, non-destructive

RAL December 5th 2005

Neutrons see the world in a uniqueunique way

Magnetism

The neutron has a magnetic moment but no charge

RAL December 5th 2005

Neutrons see the world in a uniqueunique way

+ + =

Sensistivity and selectivity

Isotopic substitution/contrast variation

RAL December 5th 2005

Neutrons see the world in a uniqueunique way

a(4K) = 14.04212(2) Å 18th order spherical harmonic

c18,1 = -0.020; c18,2 = 0.077

Precision

Weak interaction, simple interaction

RAL December 5th 2005

RAL December 5th 2005

Crystallography

Powder diffraction

HRPDPOLARISGEMHiPr(ROTAX)WISH (TS2)

Single crystal diffraction

SXD

Engineering diffraction

ENGIN-X

RAL December 5th 2005

Single crystal diffraction - SXD

RAL December 5th 2005

Anticancer drug studied on SXD in 2005

C. K. Broder et al.

RAL December 5th 2005

Anticancer drug studied on SXD in 2005

C. K. Broder et al.