This is a repository copy of A prenylated dsRNA sensor protects against severe COVID-19.

White Rose Research Online URL for this paper:https://eprints.whiterose.ac.uk/179044/

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Wickenhagen, A, Sugrue, E, Lytras, S et al. (420 more authors) (2021) A prenylated dsRNA sensor protects against severe COVID-19. Science. ISSN 0036-8075

https://doi.org/10.1126/science.abj3624

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Cite as: A. Wickenhagen et al., Science

10.1126/science.abj3624 (2021).

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Use of think article is subject to the Terms of service

Science (ISSN 1095-9203) is published by the American Association for the Advancement of Science. 1200 New York Avenue NW,Washington, DC 20005. The title Science is a registered trademark of AAAS.Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to

original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

A prenylated dsRNA sensor protects against severe COVID-19

Arthur Wickenhagen, Elena Sugrue, Spyros Lytras, Srikeerthana Kuchi, Marko Noerenberg, Matthew L. Turnbull, Colin Loney,Vanessa Herder, Jay Allan, Innes Jarmson, Natalia Cameron-Ruiz, Margus Varjak, Rute M. Pinto, Jeffrey Y. Lee, Louisa Iselin,Natasha Palmalux, Douglas G. Stewart, Simon Swingler, Edward J. D. Greenwood, Thomas W. M. Crozier, Quan Gu, EmmaL. Davies, Sara Clohisey, Bo Wang, Fabio Trindade Maranhão Costa, Monique Freire Santana, Luiz Carlos de Lima Ferreira,Lee Murphy, Angie Fawkes, Alison Meynert, Graeme Grimes, , Joao Luiz Da Silva Filho, Matthias Marti, Joseph Hughes,Richard J. Stanton, Eddie C. Y. Wang, Antonia Ho, Ilan Davis, Ruth F. Jarrett, Alfredo Castello, David L. Robertson, MalcolmG. Semple, Peter J. M. Openshaw, Massimo Palmarini, Paul J. Lehner, J. Kenneth Baillie, Suzannah J. Rihn, Sam J. Wilson,J. Kenneth Baillie, Malcolm G. Semple, Peter J. M. Openshaw, Gail Carson, Beatrice Alex, Benjamin Bach, Wendy S. Barclay,Debby Bogaert, Meera Chand, Graham S. Cooke, Annemarie B. Docherty, Jake Dunning, Ana da Silva Filipe, Tom Fletcher,Christopher A. Green, Ewen M. Harrison, Antonia Ying Wai Ho, Peter W. Horby, Samreen Ijaz, Saye Khoo, Paul Klenerman,Andrew Law, Wei Shen Lim, Alexander J. Mentzer, Laura Merson, Alison M. Meynert, Mahdad Noursadeghi, Shona C. Moore,Massimo Palmarini, William A. Paxton, Georgios Pollakis, Nicholas Price, Andrew Rambaut, David L. Robertson, Clark D.Russell, Vanessa Sancho-Shimizu, Janet T. Scott, Thushan de Silva, Louise Sigfrid, Tom Solomon, Shiranee Sriskandan,David Stuart, Charlotte Summers, Richard S. Tedder, Emma C. Thomson, A. A. Roger Thompson, Ryan S. Thwaites, LanceC. W. Turtle, Rishi K. Gupta, Carlo Palmieri, Olivia V. Swann, Maria Zambon, Marc-Emmanuel Dumas, Julian L. Griffin,

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Siddharth Bakshi, Samantha L. Barlow, Laura Booth, Benjamin Brennan, Katie Bullock, Benjamin W. A. Catterall, Jordan J.

Clark, Emily A. Clarke, Sarah Cole, Louise Cooper, Helen Cox, Christopher Davis, Oslem Dincarslan, Chris Dunn, Philip Dyer,

Angela Elliott, Anthony Evans, Lorna Finch, Lewis W. S. Fisher, Terry Foster, Isabel Garcia-Dorival, William Greenhalf, Philip

Gunning, Catherine Hartley, Rebecca L. Jensen, Christopher B. Jones, Trevor R. Jones, Shadia Khandaker, Katharine King,

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Prince, Will Reynolds, P. Matthew Ridley, Debby Sales, Victoria E. Shaw, Rebecca K. Shears, Benjamin Small, Krishanthi S.

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Science, Ahead of Print • DOI: 10.1126/science.abj3624

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