a physiological in vitro model of intervertebral disc tissue · a physiological in vitro model of...

A physiological in vitro model of intervertebral disc tissue

van Dijk, B.G.M.

DOI:10.6100/IR754354

Published: 01/01/2013

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Download date: 20. Jul. 2018

https://doi.org/10.6100/IR754354

https://research.tue.nl/en/publications/a-physiological-in-vitro-model-of-intervertebral-disc-tissue(3fa179c1-e3d9-423a-934f-29a6c145dbb9).html

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=6 Ih"xkj{iky"VMK8 ot"g"sujkr"ul"joyi"nkxtogzout

!

A

B

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OR3<

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;49"Xky{rzy =7

OR37＝"gtj"ZTL

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*

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3 14 21 28

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(µ

M)

Days

Microspheres 1 µM

Gel 1 µM

Bolus 10 µM

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=8 Ih"xkj{iky"VMK8 ot"g"sujkr"ul"joyi"nkxtogzout

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;4:"Joyi{yyout =9

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=484: Gvvroigzout"jusgotGy"znk"sujkr" oy"¦grojgzkj"zu"zoyy{k"gtj"ikrr{rgx"hkng¦oux"vgxgskzkxy2 oz" oy" lkgyohrkzu"{yk"oz"zu"zkyz"hourumoigr"znkxgvoky4 Znoy"otir{jky"mxu}zn"lgizuxy2 ikrr"znkxgv’"gtjinksoigr"gmktzy4 G ykiutj"gvvroigzout"jusgot" oy"zu"{yk"znk"sujkr"zu" ot¦kyzomgzkvgznuvn’yourumoigr" vxuikyyky" gz" znk" ikrr{rgx" rk¦kr" j{xotm" joyi" jkmktkxgzout" gtjnkxtogzout4 G lk}"vuyyohorozoky"gxk@ i’zuqotk"vxuj{izout"j{xotm"jollkxktz"yzgmky"uljkmktkxgzout2 znk"xkyvutyk"ul"jkmktkxgzkj"zoyy{k"zu"lgizuxy"}noin"gxk"vxuvuykj"zuhk"ot¦ur¦kj"ot"jkmktkxgzout2 gtj"znk"vxuikyy"ul"nkxtogzout"{yotm"y}krrotm"zoyy{k"gtjiu3i{rz{xk"}ozn"sutui’zky4

=484; Xkvxkyktzotm"znk"joykgykZnk"zxgtyrgzout"lxus"sujkr"zu"joykgyk"oy"gt"osvuxzgtz"vgxz"ul"¦grojgzout"gtj"ngy"k¦ktxkginkj"znk"skjog"¦kx’"xkiktzr’"a?:c4 G yz{j’"ynu}kj"zngz"znk"vgznuvn’yourum’"ulsu{yk"sujkry"ul"zxg{sg2 h{xty2 gtj"ykvyoy"}kxk"l{tjgsktzgrr’"jollkxktz"lxus"znkiuxxkyvutjotm" n{sgt" iutjozouty" a7<?c4 Znk" g{znuxy" iussktzkj" zngz" znoy"somnzkvrgot" }n’" tkgxr’" 7;6" irotoigr" zxogry" zkyzotm" igtjojgzk" gmktzy" otzktjkj" zu" hruiqznk" otägssgzux’" xkyvutyk" ot" ixozoigrr’" orr" vgzoktzy" lgorkj4 Znk’" l{xznkx" y{mmkyzkjzngz" gtosgr" sujkry" ynu{rj" hk" suxk" iruykr’" ¦grojgzkj" gz" znk" surki{rgx" rk¦kr" zusgqk" y{xk" zngz" znk" joykgyk" xkvxkyktzy" znk" n{sgt" iutjozout4 Gtosgr"sujkry" luxjoyi" jkmktkxgzout" ulzkt" ng¦k" otj{ikj" jkmktkxgzout2 {yotm" gt" gtt{rgx" v{tiz{xkux"jomkyzout"ul" znk"TV2"}noin" oy"jollkxktz" lxus" znk"tgz{xgr" uii{xxotm"jkmktkxgzoutot" n{sgty" a<c4 Zxkgzsktzy" zngz" gxk" y{iikyyl{r" ot" znkyk"sujkry" gxk" znkxkluxk" tuztkikyygxor’" y{iikyyl{r" ot" n{sgty4 Znk" kzktz" ul" znk" jollkxktiky" hkz}kkt" znkyk

=49"Yktyozo¦oz’"gtgr’yoy ?;

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Znk"vxkrosotgx’"xky{rzy"lxus"ingvzkx"<"ynu}"zngz"znk"gxzoãiogr"gtt{r{y"}gy"ghrk"zuqkkv"n{sgt"kvrgtzy"iruyk"zu"znkox"ot"¦o¦u"yzgzk2 grznu{mn"znkxk"vgxzogr"VM ruyy"}gyuhykx¦kj4 Znoy" otjoigzky" zngz" znk" gvvxugin2 znu{mn"}uxqotm" lux" nkgrzn’" hu¦otk2iu{rj"tuz"hk"joxkizr’"zxgtylkxxkj"zu"znk"n{sgt"kgxr’"jkmktkxgzkj"yoz{gzout4 Oz"oy"roqkr’zngz"znk"VMy"gxk"suxk"lxgmsktzkj"ot"kgxr’"jkmktkxgzout"a7<6c2 gtj"igt"rkgin"u{z"ulznk"skshxgtk"gy"joyi{yykj" ot"ingvzkx"<4 ]nkt"znkyk" oyy{ky"gxk"gjjxkyykj2 znkgvvxugin"oy"roqkr’"zu"hk"y{iikyyl{r"lux"n{sgt"kgxr’"jkmktkxgzkj"zoyy{k4

Znk" nkxtogzout" sujkr" .ingvzkx" ;/" xkvxkyktzy" znk" y}krrotm" zngz" oy" ykkt" }nkt" TVzoyy{k"kzx{jky"lxus"znk"joyi4 Znk"gj¦gtzgmk"ul"znoy"yosvroãkj"gvvxugin"oy"zngz"znkiutzxoh{zout"ul"y}krrotm"igt"hk"joyzotm{oynkj"lxus"uznkx"kllkizy"h’"{yotm"znk"gxzoãiogrgtt{r{y"gy"g"iutzxur4 Znk"sujkr"}orr"xkvxkyktz"znk"joykgyk"suxk"iruykr’"}nkt"kgxr’jkmktkxgzkj"n{sgt"zoyy{k"oy"{ykj2 gtj"znk"huj’"oss{tk"xkyvutyk".k4m4 iu3i{rz{xk}ozn"sutui’zky"a7==c/"oy"gjjkj4 Gy"sktzoutkj"hkluxk2 znk"gxzoãiogr"gtt{r{y"i{rz{xkot"ingvzkx"<"tkkjy"zu"hk"osvxu¦kj"hkluxk"znoy"gvvxugin"ngy"g"¦grojgzkj"iutzxur4

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Hohroumxgvn’ 77;

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77< Hohroumxgvn’

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