a b s. cerevisiae a s. cerevisiae b10.1186... · por1 swi4 chd1 rtf1 sds3 arp4 swi3 yku80 isw2...
TRANSCRIPT
A
0 5 10 15
−5
0
5
Mean final abundance
Mea
n gr
owth
rate
CBR1
COX5BPOR2
COX12
XDJ1
AAC1
POR1
SWI4
CHD1RTF1
SDS3
ARP4SWI3
YKU80
ISW2
cytoplasmic translation∆ haploinsufficient genesmitochondrialchromatin
C
RTG3RTG2RTG1
−40
4Z Score
YPD
Sorbito
lHea
t
YPD + EtO
H
YP + EtO
H YPD
Sorbito
lHea
t
YPD + EtO
H
YP + EtO
H
S. cerevisiae Hybrid
D
0 20 40 60 80 100 120 1400
5
10
15
20
25
30
Hours
Gen
erat
ions
WTdMKS1dRTG2TDH3−RTG2
3.5 14.5 22 3.5 14
.5
−5 0 5 10
Generations
Barcode reads(normalized,log2)
23
essentialhaploinsufficient
Mitochondrial import and oxydative phosphorylation
Chromatin remodelers
Cytoplasmic translation and/or haploinsufficient genes
S. cerevisiae A S. cerevisiae B
RPO26SEC23SUI3RPL33ARPL5NOG1RPL20BRPS10ANOG2RPS3NIP1RPL20ARPL13BRNA14RPS18BRPL6BRPS1ARPS28BUTP13RPL10RPS4ASUI2IST3CCT2THS1RPL34BUTP9NMD3RPP1RPS20RPS24ARPL12BRPS13RPS11ASSB1RPL21ARPB5FES1RPL32RPL19B
YTA7NHP10YKU80GCN5SDS3CHD1RTF1ISW2ARP4SWI4SWI3NOP1
QCR10CIR1AIM11GPG1MSS18MRP51RSM25RSM22CBR1COX5BCOX12TIM12AAC1XDJ1POR2POR1
BFIGURE S4