Sebastián Rivera Pérez 3rd Semester

Medicine StudentUniversidad Pontificia Bolivariana

CANCERApoptosis

Hepatocelullar Carcinoma

If the cell can’t repair the damages on the DNA, the cell will suffer apoptosis. When the cell doesn’t suffer apoptosis, it can reproduce with the damages and produce CANCER

The daughter cells of the cell with damages in the DNA doesn’t suffer apoptosis too. So, the number of cells with damages grow.

Recognize if 8-bromo-7-methoxycrysin-induce apoptosis of Recognize if 8-bromo-7-methoxycrysin-induce apoptosis of hepatocellular carninoma celss involves ROS and jnkhepatocellular carninoma celss involves ROS and jnk

Este resultado indica que BrMC induce selectivamente la apoptosis celular de HCC.

Activacion de las JNK

Expresión de la fosforilacion de JNK con BrCM, inhibido por NAC, SP600125 y GW9662.

Author ¿ What did she/ he said? Agree / Disagree

Kitazawa M et al.

ROS have been associated with carcinogenesis but also, paradoxically, with mitochondrial-mediated cell death in cancer cells. The overproduction of ROS as a central event in mitochondrial-mediated apoptosis is now well documented.

AGREE

Torres M et al.Intracellular ROS mediate multiple cellular responses, including protein kinase activation. AGREE

Sánchez Y et al.

NAC is an antioxidant agent and mainly known as a ROS scavenger. It reduces ROS generation and protects the cells from oxidative stress. BrMCinduced apoptosis of HepG2 cells was accompanied by ROS generation. It has been reported that arsenic trioxide induced ROS generation was inhibited by NAC treatment

AGREE

Malhotra JD et al.JNK is implicated in mediating endoplasmic reticulum stress-induced apoptosis. AGREE

This study has shown that BRMC promotes the production of ROS and these lead to apoptosis in HCC.

N-acetylcystine (NAC) is an antioxidant and inhibits the action of BrMC

The research is very useful to science because thanks to these findings may make new therapies against HCC.

The activation of JNK by BrMC has a proapoptotic effect