74_ΕΓΚΕΦΑΛΟΣ ΚΑΙ ΑΝΤΙΒΑΡΥΤΗΤΑ_gr
TRANSCRIPT
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XEI
& EARN
SAVE,NOSTRESS,
WEALTHY 2010
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EARN SAVE NOSTRES WEALTHY
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1 - . . ( -REM), REM.
EEG= , EMG = ( Szymusiak
,15
).
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, .14, 15 , , D2, 1 [growth hormone releasinghormone]. 16 , , NREM, ,
. - o REM. ,
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, NREM . - NREM REM, NREM REM.8, 16
NREM. , , .
()
[excitatory/inhibitory postsynapticpotentials: EPSPs/IPSPs] . [sleep spindles] . Steriade,McCormick 17-22 , , .
GABA- . 7 14 Hz, , , . , , . GABA , . IPSPs
, . , EPSPs IPSPs , . , .
, ,
. , NREM, REM.
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[locus coeruleus], [raphe nuclei] , 23-26 .16 ( GABA- )
NREM . , GABA, GABA- , .16, 27-29 , , . , , ,
.30 , , [ascending activating system], , .31-35
REM
REM
. 2 REM. , . REM. 24 REM ( ), (). . 36 (.. ) ,
.37 , .38 REM [tonic] .
.39 , , -- [ponto-
geniculooccipital
(PGO) spikes]. , 30 REM .
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REM, 3 10 , . -- , REM. , , , . ,
, .40 , REM. REM, REM, . . ,
PGO . , .41-43 REM [phasic] .
-----------------------------------------------------
2 : - . : 4 - . REM = , G =- , EOG =, OLF= , LGN= , HIPP= , EMG= , PGO=-- .
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-----------------------------------------------------
3 L= 1,6 Berman [BermanAtlas] . RN
= , LC = , 6 = , 7= , = . H() - () .
-----------------------------------------------------
4 . . EMG = , EKG
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= , RESP = . = 50 mV ( Siegel 49)
-----------------------------------------------------
, REM ,
.47 , REM. ( 3, ). , .48 , REM- REM,
, REM ( 4).49 , , , REM , REM.
, REM ( 2 , 5). 50 PGO PGO REM REM .
-
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-----------------------------------------------------
5 : (), () (LGN) - . 1 . ,
. ( Siegel.51)
-----------------------------------------------------
, PGO, REM. 49, 51
, , ,
REM, , , REM. REM , REM. Matsuzaki . 52 ,
, PGO , REM .
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REM. REM. , PGO , ( 6, ). 63 PGO
REM.
. REM , REM , PGO, . , , ( 6,). 64, 65 REM ,
, . , . REM . 53,66-69
.
Sylvious [periaqueductal gray] ( - ) REM, REM . , GABAA REM , .70 71 .35 ,
[deep mesencephalic nucleus].
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-----------------------------------------------------
6 - REM , . () REM ( ). , , -- (PGO) REM. , REM
PGO REM. ( Shouse& Siegel,63 Elsevier Science.)
-----------------------------------------------------
GABA ( [pontine oralis] ) REM GABA , .72, 73
, GABA, GABA
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. GABA REM .74
REM, George . 75
REM . REM REM, REM . . , , REM
. 76-78 PGO, PGO , , . , REM ,79-81 , .82
REM . . 31, 48, 83 , .31, 84-86
REM .34, 87 , REM,88 , .
,
, REM , .
-
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, . [unit recording] REM.
, REM REM. 41, 42, 58, 89, 90 REM , REM. REM . ,
, , , . , . , REM, REM , REM. REM
,59, 91 92 .
REM. [microdialysis studies] REM, REM, .93 .
REM (REM- [REM-on cells]). , REM.94 , REM- . 95
REM 96, .35 Fos [tract tracing]
REM. 31, 34, 35, 48, 8486, 97
---------------------------------------------------
-
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7 REM- [REM sleep-off] . EEG = , EOG=, LGN= , EMG =.
-------------------------------------------------
. , 98,98 100 , 25 , NREM, REM ( 7). , REM, REM. REM GABA , 27-29, 101 REM- GABA- . 102, 103 GABA REM, 28 REM.
PGO. 104, 105 , . PGO .106-108 ,
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NREM REM PGO REM.
REM Fos 20 . Quattrochi
PGO - . . 108-110
Fos REM . Verret 111 -
Fos REM. , Fos - , -, Sylvious . , REM. and , [paragigantocellular] 112
[raphe obscurus]. , GABA- REM.29 Verret 83 Sylvious , GABA- , REM. Maloney GABA- Fos REM.
REM , Sylvious GABA- GABA- , 28, 113 .
Fos , REM.
, REM Fos REM, REM ,
-
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NREM .8 Fos [melanin concentrating hormone neurons] , Fos REM REM .114, 115
REM .
. NREM . REM , .116
NREM REM . REM REM. REM .
REM
. 116, 117 GABA, .118 , . REM [magnocellularis] -
[paramedianus] ,117 . 31
[ambiguous] . REM .
,
. 119 , GABA , ,
-
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, REM [disfacilitation].
[facilitatory] . [pontine inhibitory area, ] , 31 .
, . 120
. REM (REM- ) , , ( 8).
GABA REM .85, 86 , ( 9). 31, 84 , , ( 9). 48, 121
. 122, 123
, . , - (
REM) - , . 122
[jawappliances] . ,
[bruxism]. ,
-
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.124 , , NREM. , REM. , GABA NREM,
125 REM.126 , REM. NREM. REM. , REM, --D-
(NMDA) -NMDA REM. 127
, , REM. REM
. 128 , - , . (. ). 24 ,
, , .
-
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-
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9. .
. . (
-
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