700103 department of chemistry revised syllabi for

1

RAMAKRISHNA MISSION RESIDENTIAL COLLEGE (AUTONOMOUS)

NARENDRAPUR, KOLKATA- 700103

DEPARTMENT OF CHEMISTRY

Revised Syllabi

for

3 year 6 semester B. Sc. Honours Course in Chemistry

(August 30, 2013)

COURSE STRUCTURE

HONOURS COURSE

\

Semester Duration Marks Examination

Theoretical(T) Practical(P) Total

Semester I July-Dec. 75 25 100 January

Semester II Jan.-June 75 25 100 June

Semester III July-Dec. 75 25 100 January

Semester IV Jan.-June 75 25 100 June

Semester V July-Dec. 150 50 200 January

Semester VI Jan.-June 100 100 200 June

Total 550 250 800

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SEMESTER-WISE DISTRIBUTION OF SUBJECTS

CHEMISTRY HONOURS

SEMESTER – I: 100 Marks

TWO PAPERS OF 50 (M) EACH

Paper Group Subjects Marks

A Inorganic Theoretical 25

I B Organic Theoretical 25

A Physical Theoretical 25

II B Practical 25

SEMESTER –II: 100 Marks




III B Organic Theoretical 25

IV A Physical Theoretical 25

B Practical 25

SEMESTER – III: 100 Marks




V B Organic Theoretical 25

VI A Physical Theoretical 25

B Practical 25

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SEMESTER – IV: 100 Marks




VII B Organic Theoretical 25

VIII A Physical Theoretical 25

B Practical 25

SEMESTER – V: 200 Marks

FOUR PAPERS OF 50 (M) EACH

Paper Subjects Marks

IX Inorganic Theoretical 50

X Organic Theoretical 50

XI Physical Theoretical 50

XII Practical 50

SEMESTER – VI: 200 Marks

FOUR PAPERS OF 50 (M) EACH


XIII A Inorganic Theoretical 25

B Organic Theoretical 25

A Physical Theoretical 25

XIV B Chemistry of Materials &

Biomolecules

25

XV Practical 50

XVI Practical 50

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CHEMISTRY HONOURS

SEMESTER – I (100 M)

(Theoretical 75 and Practical 25)

PAPER – I

GROUP – A ( 25 M )

INORGANIC CHEMISTRY

Unit -1 : ( 9 M )

Extranuclear Structure of atom

Bohr’s theory to hydrogen like atoms and ions: spectrum of hydrogen atom Quantum

numbers.Introduction to the concept of atomic orbitals; shapes, radial and angular probability diagrams of s, p

and d orbitals (qualitative idea). Many electron atoms and ions: Pauli’s exclusion principle. Hund’s rule,

exchange energy. Aufbau principle and its limitation. Electronic energy level diagram and electronic

configurations of hydrogen-like and polyelectronic atoms and ions. Term symbols of atoms and ions for atomic

numbers <30.

Unit – 2 : ( 8 M )

Chemical Bonding and Structure - 1

Ionic bonding: Size effects, radius ratio rules and their limitations, Packing of ions in crystals, lattice

energy. Born-Lande equation and its applications. Born-Haber cycle and its applications. Solvation energy,

polarizing power and polarizability, ionic potential, Fajan’s rules. Defects in solids (elementary idea).

Covalent bonding: Lewis structures, formal charge. Valence Bond Theory, directional character of

covalent bonds, hybridizations, equivalent and non-equivalent hybrid orbitals. Bent’s rule.

Unit – 3 : ( 8 M )

Chemical periodicity

Periodic table, group trends and periodic trends in physical properties. Classification of elements on the

basis of electronic configuration. Modern IUPAC Periodic table. General characteristic of s. p. d and f block

elements. Position of hydrogen and noble gases in the periodic table.

Effective nuclear charges, screening effects. Slater’s rules, atomic radii, ionic radii (Pauling’s univalent),

covalent radii, Ionization potential, electron affinity and electronegativity (Pauling’s, Mulliken’s and Allred-

Rochow’s scales) and factors influencing these properties. Inert pair effect, Group trends and periodic trends in

these properties in respect of s-. p- and d-block elements.

5

GROUP – B ( 25 M )

ORGANIC CHEMISTRY

Unit – 1 : ( 9 M )

Acyclic stereochemistry

Representation of molecules in saw horse, Fischer, flying-wedge and Newman formulae and their inter

translations, symmetry elements, molecular chirality.

Configuration: stereogenic units i) stereocentres: systems involving 1, 2, 3 centres, stereogenicity,

chirotopicity. pseudoasymmetric (D/L and R/S descriptor, threo/erythro and syn/anti nomenclatures (for aldols)

ii) stereoaxis: chiral axis in allenes & biphenyls, R/S descriptor; cis/trans, syn/anti, E/Z descriptors (for C=C,

C=N).

Optical activity of chiral compounds: specific rotation, optical purity (enantiomeric

excess), racemic compounds, racemisation (through cationic and anionic and radical

intermediates), resolution of acids, bases and alcohols via diastereomeric salt formation.

Topicity of ligands and faces (elementary idea): Pro-R, Pro-S and Re /Si descriptors.

Conformation: Conformational nomenclature, eclipsed, staggered, gauche and anti; dihedral angle, torsion

angle, energy barrier of rotation, relative stability of conformers on the basis of steric effect, dipole-dipole

interaction, H-bonding; conformational analysis of ethane, propane, n-butane, haloethane, 1,2-haloethane, 1,2-

glycol, 1,2-halohydrin; invertomerism of trialkylamines.

Unit – 2 ( 8 M )

Bonding and physical properties

Valence bond theory: concept of hybridisation, resonance (including hyperconjugation), orbital pictures

of bonding (sp3, sp2, sp: C-C, C-N & C-O system).

Inductive effect, bond polarization and bond polarizability, steric effect, steric inhibition of resonance.

Physical properties: bond distance, bond angles, mp/bp & dipole moment in terms of structure and

bonding (covalent & non covalent). Heat of hydrogenation and heat of combustion.

Unit – 3 : ( 8 M )

MO theory

MO theory: sketch and energy levels of MOs of i) acyclic p orbital system (C=C, conjugated diene and

allyl systems) ii) cyclic p orbital system (neutral system: [4], [6] annulenes; charged system: 3,4,5-ring system);

Frost diagram, Huckel’s rules for aromaticity & antiaromaticity; homoaromaticity bis homoaromaticity.

6

PAPER – II

GROUP – A ( 25 M )

PHYSICAL CHEMISTRY

Unit – 1: ( 9M )

Thermodynamics – I :

Importance and scope, definition of system and surroundings: type of systems. Extensive and intensive

properties. Steady state and equilibrium state. Concept of thermal equilibrium and the zeroth-law of

thermodynamics, thermodynamic coordinates, state of system, equation of state, state functions and path

functions. Partial derivatives and cyclic rule, concept of heat and work (IUPAC convention). Graphical

explanation of work done during expansion and compression of an ideal gas. Reversible and irreversible process

and work done in isothermal and adiabatic processes.

First law of thermodynamics, internal energy (U) as a state function. enthalpy as a state function. heat changes at

constant volume and constant pressure; relation between CP and CV using ideal gas and van der Waals equation.

Joule’s experiment and its consequence. Explanation of term (δU / δV)T.

Thermochemistry: heat changes during physicochemical process at constant pressure / volume and their relation,

Kirchoff’s relation. Bond dissociation energies. Changes of thermodynamic properties in different chemical

changes, maximum flame temperature.

Unit – 2: ( 8M )

Transport properties - I:

Flux, force, phenomenological coefficients & their inter-relationship (general form), different examples of

transport properties.

Conductance and measurement of conductance, cell constant, specific conductance and molar conductance.

Variation of specific and equivalent conductance with dilution for strong and weak electrolytes. Kohlrausch’s law

of independent migration of ions, ion conductance and ionic mobility. Equivalent and molar conductance at

infinite dilution and their determination for strong and weak electrolytes. Ostwald’s dilution law. Debye-Huckel

model (physical idea only). Application of conductance measurement (determination of solubility product and

ionic product of water). Conductometric titrations, Transport number. Determination of transport number by

moving boundary method.

Unit – 3: ( 8M )

Deviation of gases from ideal behaviour and kinetic Theory -I:

Compressibility factor: Andrew’s and Amagat’s plots: van der Waals equation and its characteristic features.

Existence of critical state. Critical constants in terms of van der Waals constants. Law of corresponding state and

significance of second virial coefficient. Boyle temperature. Intermolecular forces (Debye, Keesom and London

interactions: Lennard-Jones potential - elementary idea).

Molecular kinetic theoretical interpretation of pressure,temperature and ideal gas laws. Collision of gas

molecules, collision diameter, collision number and mean free path.

7

GROUP – B ( 25 M )

CHEMISTRY HONOURS PRACTICAL

U -1) Qualitative analysis of organic compounds - 20 M

U -2) Lab. Quiz / viva - 5 M

(number of classes per week = 7 – 8)

Examination: 4 hours

8

SEMESTER – II (100 M)


PAPER – III

GROUP – A ( 25 M )

INORGANIC CHEMISTRY

Unit – 1: ( 9 M )

Chemical Bonding and Structures - 2

VSEPR theory, shapes of molecules and ions containing lone pairs and bond pairs (examples from main

groups chemistry), Partial ionic Character of covalent bonds, bond moment, dipole moment and electronegativity

differences. Concept of resonance, resonance energy, resonance structures.

Molecular orbital concept of bonding (elementary pictorial approach): sigma and pi-bonds, multiple

bonding. MO diagrams of H2, F2 , O2, C2 , B2 , CO, NO, CN- , HF, and H2O : bond orders, bond lengths. Walsh

Diagram.

Hydrogen bonding and its effects on the physical properties of compounds of the main group elements.

Metallic bonding: qualitative idea of band theory, conducting, semi conducting and insulating properties

with examples from main group elements.

Unit – 2 : ( 8 M )

Nucleus, Nuclear Reactions and Isotopes :

Nuclear stability and nuclear binding energy. Nuclear forces: meson exchange theory. Nuclear models

(elementary idea): Concept of nuclear quantum number, magic numbers. Nuclear Reactions: Artificial

radioactivity, transmutation of elements, fission, fusion and spallation. Nuclear energy and power generation.

Separation and uses of isotopes. Radio chemical methods; principles of determination of age of rocks and

minerals, radio carbon dating, hazards of radiation and safety measures. Isotope Labelling and tracer study.

Unit -3 : ( 8 M )

Acid-Base reactions and Solvent Systems in Inorganic Chemistry :

Acid-Base concept: Arrhenius concept, theory of solvent system (in H2O, NH3 SO2 and HF), Bronsted-

Lowry’s concept, relative strength of acids : Oxoacids and Hydracids, Pauling’s rules. Amphoterism, Lux-Flood

concept, Lewis concept, Superacids, HSAB principle, Acid-base equilibria in aqueous solution and pH, [Acid-

base neutralization curves, indicator, choice of indicators]. Gas phase acidity and proton affinity; B-strain, F-

strain.

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GROUP – B ( 25 M )

ORGANIC CHEMISTRY

Unit-1: ( 9 M)

General treatment of reaction mechanism:

Mechanistic classification: ionic, radical and pericyclic; heterolytic bond cleavage and heterogenic bond

formation, homolytic bond cleavage and homogenic bond formation; representation of mechanistic steps using

arrow formalism.

Reactive intermediates: carbocations (cabenium and carbonium ions), carbanions, carbon radicals,

carbenes – structure using orbital picture, electrophilic/nucleophilic behaviour, stability, generation and fate

(elementary idea)

Reaction thermodynamics: free energy and equilibrium, enthalpy and entropy factor, intermolecular &

intramolecular reactions. Application of thermodynamic principles in tautomeric equilibria [keto-enol

tautomerism, composition of the equilibrium in different systems (simple carbonyl, 1,3 and 1,2- dicarbonyl

systems,

phenols and related system), substituent and solvent effect].

Concept of acids and bases: effect of structure, substituent and solvent on acidity and basicity.

Reaction kinetics: transition state theory, rate const and free energy of activation, free energy profiles for

one step and two step reactions, catalyzed reactions, kinetic control and thermodynamic control of reactions,

isotope effect , primary kinetic isotopic effect (kH/kD), principle of microscopic reversibility, Hammond

postulate.

Unit-2: ( 8 M )

Nucleophilic substitution reactions I:

Sustitution at sp3 centre - Mechanism: SN1, SN2, SN2’, SNi mechanisms, effect of

solvent, substrate structure, leaving group, nucleophiles including ambident nucleophiles

(cyanide & nitrite) substitution involving NGP; relative rate & stereochemical features

[systems: alkyl halides, allyl halides, alcohols, ethers, epoxides].

Unit-3: ( 8 M)

Nucleophilic substitution reactions II:

Halogenation of alkanes and carbonyls.

Substitution at sp2 carbon (carbonyl system) - Mechanism: BAC2, AAC2, AAC1, AAL1 (in

connection to acid and ester). Systems: amides, anhydrides & acyl halides [formation and

hydrolysis]

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PAPER – IV

GROUP – A ( 25 M )

PHYSICAL CHEMISTRY

Unit – 1: ( 9M )

Thermodynamics – II:

Second law of thermodynamics, need of second law. Concept of heat reservoirs and heat engines. Carnot

cycle and refrigerator. Kelvin – Planck(KP) and Clausius(CL) statements and equivalence of the two statements.

Carnot’s theorem; thermodynamic scale of temperature.

Physical concept of entropy. Entropy as a measure of the microscopic but not macroscopic disorder. Clausius

inequality. Entropy change of systems and surroundings for various processes and transformations. Entropy

change during the isothermal mixing of ideal gases. Entropy and unavailable work. (i) validity of KP & CL

statements, (ii) |Wrev|>|Wirr| and (iii) ηcarnot (maximum) for entropic point of view. T,S; P,T; U,V; S,V and other

diagrams of different thermodynamic processes. Auxiliary state functions (G and A) and their variation with T,P

and V. Criteria for spontaneity and equilibrium.

Thermodynamic relations: Maxwell’s relations, thermodynamic equation of state. Gibbs-Helmholtz

equation, Joule-Thomson experiment and its consequences; inversion temperature. Joule-Thomson coefficient for

a van der Waals gas. General heat capacity relations. Nernst heat theorem, Towards absolute zero and adiabatic

demagnetization.

Unit – 2: ( 8M )

Liquid State:

Nature of the liquid state (short range order and long range disorder). Vapor pressure. Surface tension,

surface energy, excess pressure, capillary rise and measurement of surface tension. Work of cohesion and

adhesion, spreading of liquid over other surface. Vapour pressure over curved surface. Temperature dependence

of surface tension.

Transport properties -II: (fluid flow):

General features of fluid flow (streamline flow and turbulent flow). Reynold number, nature of viscous

drag for streamline motion. Newton’s equation, viscosity coefficient. Poiseuille’s equation (with derivation),

temperature dependence of viscosity,principle of determination of viscosity coefficient of liquids by falling

sphere method, Ostwald’s viscometer.

Viscosity of gases vs. liquids.

Unit – 3: ( 8M )

Kinetic theory -II and the gaseous state:

Nature of distribution of velocities in one,two and three dimentions. Maxwell’s distribution of speeds.

Kinetic energy distribution in one, two and three dimentions, calculation of average, root mean square and most

probable values in each case: calculation of molecules having energy ≥ε, Principle of equipartition of energy and

its application to calculate the classical limit of molar heat capacity of gases,Variation with temperature.

Collision diameter, collision number and mean free path and frequency of binary collisions (similar and different

molecules), wall collision frequency and rate of effusion, kinetic theory of gas viscosity.

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GROUP – B ( 25 M )


U -1) Simple Chemical preparations - 10 M

U -2) Simple Chemical estimations - 10 M




12

SEMESTER – III ( 100 M )

( Theoretical 75 and Practical 25 )

PAPER – V

GROUP – A ( 25 M )

INORGANIC CHEMISTRY

Unit – 1 : ( 9 M )

Coordinate Bond and coordination compounds :

Coordinate bonding: Lewis acid-base adducts (examples), double salts and complex salts. Werner’s

theory of coordination compounds. Ambidentate and polydentate ligands, chelate and inner metallic complexes,

IUPAC nomenclature of coordination compounds (up to two metal centers). Coordination numbers,

constitutional isomerism, Stereoisomerism and optical isomerism in square planar and octahedral complexes.

Complex stability

Unit – 2 : ( 8 M )

Vertical Trends for s and p block elements :

Trends in chemistry of elements and simple compounds from the point of view of structure, bonding and

thermodynamics: Properties of isolated atoms, Physical and chemical properties of elements, Structural and

bonding aspects of elements and compounds, Physical and chemical properties of compounds (Hydrides, oxides,

oxy acids, halides).Trends in pπ-pπ, dπ-pπ, sigma vs. π-bond, complex formation, condensation, redox behaviour

of different usual and unusual oxidation states. Polyhalides, interhalogens, pseudohalogens and inert gas

compounds.

Unit – 3 : ( 8 M )

Horizontal Trends for s and p block elements :

Trends in variation of atomic properties, Physical and chemical properties of elements, Ionic covalent

transitions, oxides, oxy acids, hydrides, halides, common oxidizing and reducing agents, catenation, lone pairs

and empty orbitals. Trends in pπ-pπ, dπ-pπ, sigma vs. π-bond, complex formation, condensation, redox behaviour

of different oxidation states

13

GROUP – B ( 25 M )

ORGANIC CHEMISTRY

Unit-1: ( 9 M )

Elimination and aromatic substitution:

Elimination - Mechanisms: E1, E2 and E1cB; reactivity, orientation (Saytzeff/Hofmann) and

stereoselectivity; substitution vs elimination,

Electrophilic aromatic substitution: Mechanisms, orientation and reactivity.

Reactions: nitration, nitrosation, sulfonation, halogenation, Friedel-Crafts reactions, onecarbon

electrophiles (reactions: chloromethylation, Gatterman-Koch, Gatterman, Hoesch, Vilsmeier-Haack reaction,

Reimer-Tiemann, Kolbe-Schmidt).

Nucleophilic aromatic substitution: Addition-elimination mechanism, SN1 mechanism, benzyne

mechanism.

Unit-2: ( 8 M )

Addition reactions I:

Electrophilic addition to C=C: Mechanism, reactivity, regioselectivity and

stereoselectivity. Reactions: halogenations, hydrohalogenation, hydration, hydrogenation,

epoxidation, hydroxylation, ozonolysis, electrophiilic addition to diene (conjugated dienes and allenes). Radical

addition: HBr addition. Dissolving metal reduction of alkynes and bezenoid aromatics (Birch). Pericyclic

addition: Diels-Alder reaction. Addition of singlet and triplet carbenes.

Unit-3: ( 8 M )

Addition reactions II:

Nucleophilic addition to C=O: Mechanism, reactivity, equilibrium and kinetic control.

Reactions with alcohols, amines, thiols, HCN, bisulfate, Wittig reaction.

Carbonyl Reduction: hydride addition, Wolff-Kishner reduction, dissolving metal

(Bouveault-Blanc reduction, Clemmensen Reduction), Cannizzaro reaction, Tischenko

reaction, aldol condensation, benzoin condensation. Hydrolysis of nitriles and isonitriles.

Nucleophilic addition to α,β-unsaturated carbonyl system (general principles).

14

PAPER – VI

GROUP – A ( 25 M )

PHYSICAL CHEMISTRY

Unit – 1: ( 9M )

Thermodynamics III and Equilibrium:

Open system, chemical potential and activity, partial molar quantities, chemical potential in terms of

Gibbs’ free energy and other thermodynamic state functions and its variation with temperature and pressure.

Gibbs- Duhem equation; fugacity of gases and fugacity coefficient, activity coefficient of non-electrolytes,

concept of standard state in various scales and Raoult’s law. ∆Gmixture, ∆Smixture, criteria of ideality.

Thermodynamic conditions for equilibrium, degree of advancement, van’t Hoff’s reaction isotherm

(deduction from chemical potential). Explanation of the free energy versus degree of advancement plot.

Equilibrium constant and standerd Gibbs free energy change. Definitions of KP, KC and Kx, van’t Hoff’s reaction

isobar and isochore from different standard states. Shifting of equilibrium due to change in external parameters

e.g. temperature and pressure. Effect of inert gas, Le Chatelier’s principle and degree of advancement –

thermodynamic treatment, Nernst distribution law.

Activity and activity coefficients of electrolyte ions in solution. Debye- Huckel limiting law. Solubility

product principle and its application in qualitative analysis. Ionic product of water, acid-base indicators. pH (in

details), buffer solution, buffer capacity, salt hydrolysis (detailed treatment).

Unit – 2: ( 8M )

Chemical kinetics -I:

Introduction of reaction rate in terms of extent of reaction: rate constants, order and molecularity of

reactions. Reactions of zero order, first order, second order and fractional order. Derivation of working formula

of some practical examples. Pseudo-first order reactions (example using acid catalyzed hydrolysis of methyl

acetate). Determination of order of a reaction by half-life and differential method. Rate-determining step and

steady-state approximations - explanation with suitable examples.

Opposing reactions, consecutive reactions and parallel reactions (with explanation of kinetic and

thermodynamic control of products: all steps first order); chain reactions.

Temperature dependence of rate constant: Arrhenius equation, energy of activation.

Unit – 3: ( 8M )

Quantum Mechanics:

Wave-particle duality, and the de Broglie hypothesis. Elementry concepts of operators, eigenfunctions

and eigenvalues, Linear operators, Commutation of operators, fundamental commutator and uncertainty relation

(without proof). Expectation value. Schrodinger equation and its time-independent form; nature of the equation,

acceptability conditions imposed on the wave functions and probability interpretations of wave function.

Quantum Free-Particle (Normalisation of wave function excluded). Particle in a box: setting up of

Schrodinger equation for one-dimensional box and its solution. Comparison with free particle eigenfunctions and

eigenvalues. Properties of PB wave functions (normalization, orthogonality, probability distribution). Expectation

values of x, x2, px and p2

x and their significance in relation to the uncertainty principle. Classical Limit and

Correspondence Principle. Extension of the problem to two and three dimensions and the concept of degenerate

energy levels.

15

GROUP – B ( 25 M )


U -1) Qualitative inorganic analysis - 20 M




16

SEMESTER – IV ( 100 M )


PAPER – VII

GROUP – A ( 25 M )

INORGANIC CHEMISTRY

Unit – 1: ( 9 M )

Inorganic Chains, Rings & Cages and Reagents:

Compounds with multicentre bonds (B2H6 and boranes ); Poly acids of main group elements ; Inorganic chains,

rings and cages; Zintle ions; Crown ethers, cryptates and cryptands. Peracids and persalts, carbides.

Reagents: Hydrazoic acid and azide, hydrazine, hydroxylamine, arsenious oxide, phosphorous pentachloride,

phosphorous pentoxide, SbF5 Hypophosphorous acid, phosphorous acid, phosphoric acid, SiCl4, silicon nitride,

and silicon carbide, SnCl2, SnCl4, lead tetraacetate, PbO2, Na2SO3, Na2S2O5, Na2S2O3, Na2S2O4, Na2S2O6,

Na2S4O6, telluric acid, KBrO3, KIO3, periodic acids and periodates, KHF2, SF6, NaBiO3, Freons, perchloric acid.

Unit -2: ( 8 M )

Statistical methods in chemical analysis and Classical Analytical Methods:

Errors in chemical analysis: Accuracy and precision of measurements, determinate indeterminate, systematic and

random errors in chemical analysis with examples, absolute and relative errors: source, effect and detection of

systematic errors: distribution of random errors, normal error curve, standard deviations, standard deviation of

calculated results- sum or difference, product or quotient, significant figures, rounding and expressing results of

chemical computations.

Classical analytical methods with typical examples and underlying physicochemical principles: Titrimetry –

Acid-base, Redox, Complexometry, precipitation titration and Gravimetry.

Unit -3: ( 8 M )

Chemistry of d and f block elements- I:

3d, 4d and 5d elements: General features, electronic configurations, periodic trends, oxidation states, aqueous

chemistry, coordination numbers, simple and complex compounds, redox properties, catalytic properties,

lanthanide contraction and unusual oxidation states. Comparison of d and f block elements in the context of

oxidation states.

17

GROUP – B ( 25 M )

ORGANIC CHEMISTRY

Unit-1: ( 9 M )

Nitrogen compounds and Organometallics:

Nitrogen compounds: amines (aliphatic & aromatic) [preparation, separation and

identification of primary, secondary and tertiary amines], E. Clarke reaction, enamines,

Mannich reaction, diazomethane, diazoacetic ester, aromatic nitro compounds, aromatic

diazonium salts, nitrile and isonitrile.

Organometallics: preparation of Grignard reagent and organo lithium. Reactions:

addition of Grignard and organo lithium to carbonyl compounds, substitution on -COX,

conjugate addition by Gilman cuprates, Reformatsky reaction.

Unit-2: ( 8 M )

Reactions: Rearrangements I:

1,2-shift: Rearrangement to electron-deficient carbon (Wagner-Meerwein

rearrangement, pinacol rearrangement, dienone-phenol; Wolff rearrangement in Arndt-

Eistert synthesis, benzil-benzilic acid rearrangement).

Electron-deficient nitrogen (Beckmann rearrangement, Schmidt rearrangement,

Hofmann rearrangement, Lossen rearrangement, Curtius rearrangement).

Unit-3: ( 8 M )

Reactions: Rearrangements II

Electron-deficient oxygen (Baeyer-Villiger oxidation, hydroperoxide rearrangement (cumene

hydroperoxide-phenol rearrangement), Dakin reaction.

Aromatic rearrangements [migration from oxygen to ring carbon (Fries rearrangement, Claisen

rearrangement); migration from nitrogen to ring carbon (Hofmann-Martius rearrangement, Fischer-Hepp

rearrangement, N-azo to C-azo rearrangement, Bamberger rearrangement, Orton rearrangement, benzidine

rearrangement.

18

PAPER – VIII

GROUP – A ( 25 M )

PHYSICAL CHEMISTRY

Unit – 1: ( 9M )

Electro- chemical cells:

Types of electrochemical cells and examples, cell reactions, concept of electrode potential, emf and change in

free energy, ∆H and ∆S of cell reactions from emf measurements. Thermodynamic derivation of Nernest

equation. Standerd cells, Half-cells electrodes, different types of electrodes (with examples). Definition of emf,

Standard electrode potential (IUPAC convention) and principles of its determination. Types of concentration

cells. Liquid junction potential and its minimization.

Glass electrode and determination of pH of a solution. Potentiometric titrations (acid- base and redox).

Determination by emf method of (i) Standard electrode potential, (ii) Activity solubility product, (iii) Ionic

product, (iv) mean activity coefficient, (v) transport number.

Redox potential diagram (Latimer, Purbaix and Frost diagrams) of common elements and their applications.

Disproportionation and comproportionation reactions (typical examples).

Unit – 2: ( 8M )

Chemical kinetics -II & Catalysis:

Collision theory (detailed treatment), transition state theory (thermodynamic treatment), Lindmann theory of

unimolecular reactions.

Catalysis: Homogeneous catalysis, mechanism of catalytic actions, acid- base catalysis, primary kinetic salt

effect, Enzyme Catalysis: Michaelis – Menten equation, Lineweaver – Burk plot, turnover number, significance

of Km.

Electrical properties of molecules:

Polarizability of atoms and molecules, dielectric constant and polarization, molar polarization for polar and non-

polar molecules. Clausius-Mosotti equation and Debye equation (both without derivation) and their application in

determination of dipole moments.

Unit – 3: ( 8M )

Quantum Chemistry – II:

Simple Harmonic Oscillator: setting up of the Schrodinger stationary equation, energy expression (without

derivation), expression of wave function for n=0 and n=1 (without derivation), and their characteristic features.

Stationary Schrodinger equation for the H- atom in polar coordinates, separation of radial and angular (θ, φ)

parts, Solution of φ- part and emergence of quantum number ‘m’; energy expression (without derivation),

degeneracy, Hydrogenic wave functions up to n= 2 (expression only); real wave function. Concept of orbitals,

radial and angular plots and probability plots of s, p and d orbitals, shape of orbitals.

19

GROUP – B ( 25 M )


U -1) Experiments based upon physico-chemical principles - 20 M




20

SEMESTER – V ( 200 M )


PAPER – IX ( 50 M )

INORGANIC CHEMISTRY

Unit – 1: (10 M)

Bonding in Coordination Compounds:

VB description and its limitations, Elementary Crystal Field Theory; spitting of dn configurations in octahedral

square planar and tetrahedral fields, crystal field stabilization energy in weak and strong fields: pairing energy,

Jahn-Teller distortion. Metal-ligand bonding (MO concept, elementary idea), sigma- and pi- bonding in

octahedral complexes (qualitative pictorial approach) and their effects on the oxidation states of transitional

metals (examples).

Unit – 2: (10M)

Magnetic and Spectroscopic Properties:

Orbital and spin magnetic moments, spin only moments of dn ions and their correlation with effective magnetic

moments, including orbital contribution; quenching of magnetic moment; super exchange and antiferromagnetic

interactions (elementary idea with examples only) ; d-d transitions : L-S coupling : qualitative Orgel diagrams for

3d1-3d

9 ions and their spectroscopic ground states ; selection rules for electronic spectral transitions;

spectrochemical series of ligands ; charge transfer spectra (elementary idea). Spectral and magnetic properties of

lanthanides

Unit – 3 : (10M)

Organometallic Compounds and Catalysis:

18-electron rule and its applications to carbonyls (including carbonyl hydrides and carbonylates),

nitrosyls, cyanides and nature of bonding involved therein. Simple examples of metal-metal bonded compounds

and metal clusters. Metal-olefin complexes: Zeise’s salt (preparation, structure and bonding). Ferrocence

(preparation, structure and reactions). Hapticity (η) of organometallic ligands, examples of mono and penta-hapto

cyclopentadienyl complexes. Simple examples of fluxional molecules, Coordinative unsaturation: oxidative

addition and insertion reactions, Homogeneous catalysis by organometallic compounds: Hydrogenation,

hydroformylation and polymerization of alkenes (Ziegler-Natta catalysis).

21

Unit – 4: (10M)

Chemistry of d and f block elements- II (Special Features):

Comparative chemistry with respect to following compounds/ complexes of:

(a) V(III), VO(IV) & VO(V); (b) Cr(III) & Cr(VI); (c) Mn(III), Mn(IV) & Mn(VI); (d) Fe(II), Fe(III), Fe(IV) &

Fe(VI); (e) Co(II) & Co(III); (f) Ni(I), Ni(II) & NI(III); (g) Cu(I), Cu(II) & Cu(III); (h) Mo(VI) & W(VI); (i)

Ru(II), Ru(III), Os(II) & Os(III); (j) Pd(II), Pt(II) & Pt(IV) and (k) Rh(I), Rh(III), Ir(I) & Ir(III).

Unit – 5: (10M)

Methods of Instrumental Analysis and Separation Techniques:

Thermogravimetry, Electrogravimetry, Coulometry, Spectrophotometry : Principle of spectrophotometric

estimation of iron, manganese and phosphorous, Principles and instrumentations of atomic absorption and atomic

emission spectrometry; estimation of sodium and potassium in water samples.

Ion exchange resins and their exchange capacities, principle and simple applications of ion exchange

separation. Chromatographic separations ; General description and classification of chromatographic methods,

thin layer, paper and column chromatographic techniques and their simple applications, Rf-values and their

significance, elution in column chromatography, migration rates of solutes, band broadening and column

efficiency, column resolution.

22

PAPER – X (50 M)

ORGANIC CHEMISTRY

Unit-1:

(10M)

Carbanion chemistry and cyclic stereochemistry:

Carbanions: formation of enols and enolates (metal), alkylation of enolates, reactions of enolates with

carbonyls (aldehydes, ketones and esters), conjugate addition of enolates.

Cyclic Stereochemistry: Baeyer strain theory.

Conformational analysis: cyclohexane, mono and disubstituted cyclohexane, symmetry properties and

optical activity. Conformation & reactivity in cyclohexane system: elimination (E2), rearrangement, nucleophilic

substitution (SN1, SN2, NGP), oxidation of cyclohexanol, esterification, saponification, lactonisation.

Unit-2: (10M)

Spectroscopy UV, IR:

UV Spectra: Electronic transition (ζ-ζ*, n-ζ*, π-π* and n-π*), relative positions

of λmax considering conjugative effect, steric effect, solvent effect, red shift (bathochromic shift), blue shift

(hypsochromic shift), hyperchromic effect, hypochromic effect (typical examples).

IR Spectra: Modes of molecular vibrations, application of Hooke’s law, characteristic stretching

frequencies of O-H, N-H, C-H, C-D, C=C, C=N, C=O functions; factors effecting stretching frequencies (H-

bonding, mass effect, electronic factors, bond multiplicity, ring size).

Unit-3: (10M)

Spectroscopy NMR (elementary):

PMR Spectra: Nuclear spin, NMR active nuclei, principle of proton magnetic resonance, equivalent and

non-equivalent protons, chemical shift δ), shielding /deshielding of protons, up-field and down-field shifts. NMR

peak area (integration), diamagnetic anisotropy, relative peak positions of different kinds of protons (alkyl

halides, olefins, alkynes, aldehyde H), substituted benzenes (toluene, anisole, nitrobenzene, halobenzene,

dinitrobenzenes, chloronitrobenzene), first order coupling (splitting of the signals: ordinary ethanol, bromoehane,

dibromoehanes), coupling constants.

23

Unit-4: (10M)

Synthetic strategies and Asymmetric synthesis:

Retrosynthetic analysis: disconnections, synthons, donor and acceptor synthons,

functional group interconversion, C-C disconnections and synthesis [one group and twogroup

(1,2 to 1,6-dioxygenated], reconnection (1,6-di carbonyl), natural reactivity and umpolung, protection-

deprotection strategy [alcohol, amine, carbonyl, acid]

Strategy of ring synthesis: thermodynamic factor, synthesis through enolate anion chemistry and carbonyl

condensation reactions (including acetoaceticester & malonic ester synthesis) ,synthesis through rearrangement

(including pinacol, Favorski), synthesis of large rings, high dilution technique and acyloin reaction, Stobbe

condensation.

Asymmetric synthesis: stereoselective and stereospecific reactions, diastereoselectivity

and enantioselectivity (only definition), diastereoselectivity: addition of nucleophiles to C=O, adjacent to a

stereogenic centre (Felkin-Anh model).

Unit-5: (10M)

Carbohydrate chemistry:

Monosaccharides: Aldoses upto 6 carbons, structure of D-glucose & D-fructose

(configuration & conformation), anomeric effect, mutarotation.

Reactions: osazone formation, bromine – water oxidation, stepping–up (Kiliani method)

and stepping–down (Ruff’s & Wohl’s method)of aldoses.

Disaccharides: glycosidic linkages, structure of sucrose.

24

PAPER – XI (50 M)

PHYSICAL CHEMISTRY

Unit – 1: (10M)

Colligative properties:

Vapour pressure of solution, Ideal solutions, ideally dilute solutions and colligative properties. Raoult’s law,

Thermodynamic derivation of colligative properties of solution (using chemical potential) and their inter-

relationships. Abnormal colligative properties, Deviation from Raoult’s law for binary liquid mixture. Henry’s

law. Standard states for solutes (both non electrolyte and electrolyte in molal scale).

Unit – 2: (10M)

Surface Chemistry (Adsorption, Surfactants, Heterogeneous Catalysis & Colloids):

Physical and chemical adsorption. Freundlich and Langmuir adsorption isotherms, Surface films on liquid,

Langmuir film balance, force-area plot, two-dimensional equation of surface film, Langmuir-Blodgett film,

Determination of surface area of adsorbent, Gibbs adsorption isotherm and surface excess, Surface active and

surface inactive agents. Surfactants including Bio-surfactants, Micellisation of surfactants, Kraft Point & cloud

point, Micellar catalysis, Liquid crystals.

Heterogeneous catalysis (single reactant).

Colloids: lyophobic and lyophilic sols, Origin of charge and stability of lyophobic colloids, Coagulation and

Schultz-Hardy rule, Zeta potential and Stern double layer (qualitative idea), Tyndall effect, Electrokinetic

phenomenon (qualitative idea only), Determination of Avogadro Number by Perrin’s method.

Unit – 3: (10M)

Molecular Spectroscopy – I:

B.O.approximation (mention only), Characteristic features of spectral lines (spacing and intensity), selection

rules, Lambert- Beer’s Law & population effect. Rotational spectroscopy of diatomic molecules: rigid rotor

model, determination of bond length, effect of isotopic substitution, effect of nuclear spin (mention only).

Vibrational spectroscopy of diatomic molecules: SHO model, selection rules, spectra: anharmonicity and its

consequences on energy levels, overtones, hot bands.

Raman Effect, Characteristic features and conditions of Raman activity with suitable illustrations. Rotational and

vibrational Raman spectra. Rule of mutual exclusion with examples.

25

Unit – 4: (10M)

Molecular Spectroscopy – II:

Potential energy curves (diatomic molecules). Frank-Condon principle and vibrational structure of electronic

spectra. Bond dissociation and principle of determination of dissociation energy. Decay of excited states by

radiative and non-radiative paths. Fluorescence and phosphorescence. Jablonsky diagram.

Chemical analysis by electronic spectroscopy. Elementry idea polarization of light and optical rotation; circularly

polarized light and circular dichroism, application of CD spectra to distinguish between enantiomeric pairs

(elementary idea).

Photochemistry: Stark- Einstein law of photochemical equivalence, quantum yield and its measurement for a

photochemical process, actinometry, Photostationary state. Photosensitized reactions. Kinetics of HI

decomposition,dimerisation of anthracene.

Unit – 5: (10M)

Phase equilibrium:

Definitions of phase, component and degrees of freedom. Phase rule and its derivations. Definition of phase

diagram. First order phase transition and Clapeyron equation: Clausius- Clapeyron equation – derivation and use.

Phase Equilibria for one component system – Water, CO2 and sulphur.

Liquid- vapour equilibrium for two component systems. Ideal solution at fixed temperature and pressure.

Deviation of Raoult’s law and boiling point composition diagram. Principle of fractional distillation. Duhem-

Margules equation, Henry’s law, Konowaloff’s rule. Positive and negative deviations from ideal behaviour,

Azeotropic solution. Liquid- liquid phase diagram using phenol-water system. Solid- liquid phase diagram,

Eutectic mixture. Systems having congruent and in-congruent melting points. Nernst distribution law. Solvent

extraction.

26

PAPER – XII ( 50M )


U -1) Experiments based upon physico-chemical principles - 30 M

U -2) Methods of separation and identification - 10 M


(number of classes per week = (12 – 16)

Examination: 6 + 4 hours

27

SEMESTER – VI ( 200 M )


PAPER – XIII

GROUP – A ( 25 M )

INORGANIC CHEMISTRY

Unit – 1: ( 9 M )

Distribution, Extraction and Purification of Elements/ compounds:

Distribution and General methods of extraction of elements, Pyrometallurgy, Electrometallurgy Ellingham

Diagram, Hydrometallurgy, Zone Refining referring Ti, Cr, Ni, Pt, Ag, U, Li, Si and Ge as representative

examples.

Separation of lanthanide elements: Solvent extraction and ion exchange methods.

Separation of geometrical and optical isomers (with some specific examples).

Unit – 2: ( 8 M )

Environmental Chemistry:

Atmosphere, Lithosphere, Hydrosphere: Composition, Structure.

Chemical and photochemical reactions in atmosphere: Ozone-oxygen, SO2, NOx, CFC, Greenhouse gases and

Green house effect: Acid rains.

Soil: Inorganic and organic components, acid-base and ion-exchange reactions and NPK of soil.

Monitoring of pollution: Sampling and preservation;

Analysis of air for CO, NOx and particulates

Monitoring of water quality: Analysis of NH3, NO3- , NO2

- , F

-, As, Cd, Hg, Cr, BOD, DO and COD.

Unit – 3: ( 8 M )

Reactions of coordination compounds:

Stability, Lability and Inertness of coordination complexes; Factors influencing lability/inertness in main group

and transition metal complexes.

Reactions of coordination complexes: Substitution, Electron transfer and Racemisation reactions in coordination

complexes and coordination polymers.

Substitution in square planar complexes: Trans Effect – Definition, theories (elementary idea) and applications.

28

GROUP – B ( 25 M )

ORGANIC CHEMISTRY

Unit-1: (9M)

Heterocycles:

.

Heterocyclic compounds: reactivity, orientation and important reactions of furan,

pyrrole, pyridine, indole, synthesis (including retrosynthetic approach) pyrrole: Knorr

pyrrole synthesis and Hantzsch synthesis. Hantzsch pyridine synthesis. Indole: Fischer,

Madelung and Reissert synthesis, Skaurp quinoline and Bischler-Napieralski Synthesis of

isoquinoline.

Unit-2: (8M)

Carbocycles:

Polynuclear hydrocarbons: syntheses and reactions of naphthalene, anthracene

and phenanthrene

Unit-3: (8M)

Amino acids, peptides :

Amino acids: Synthesis: (Strecker, Gabriel, acetamido malonic ester, azlactone);

isoelectric point, ninhydrin reaction.

Peptides: peptide linkage, syntheses of peptides using N-protection & Cprotection,

solid phase synthesis; peptide sequence: C–terminal and N–terminal unit determination (Edmann, Sanger &

dansyl chloride).

29

PAPER – XIV

GROUP – A ( 25 M )

PHYSICAL CHEMISTRY

Unit 1:

( 9M )

NMR & ESR Spectroscopy:

Introduction, basis of magnetic resonance spectroscopy, nmr active nuclei, the nmr spectrometer (Principle and

schematic representation); chemical shift and δ scale, Shielding constant and its dependence on different

contributions (Elementary physical idea only ). Qualitative discussion of spin-spin coupling and line structure

splitting, example, Equivalent nuclei (in respect of two protons) and simple consequences.

Elementary qualitative idea of electron spin resonance spectroscopy.

Unit 2: ( 8M )

Solid state:

Types of solid, Lattice, space lattice, unit cell, symmetry in crystals, crystal planes, indexing of lattice planes, law

of rational indices, distance between the lattice planes, packing of uniform hard spheres, close packed

arrangements (fcc & hcp), tetrahedral & octahedral voids, percentage of void space in simple 2D and 3D

structures, density of cubic crystals, Bragg’s Law and its application, powder method.

Heat capacity of solids:

Equipartition principle and Dulong- Petit Law, Einstein’s theory of heat capacity of solids and its limitations,

Debye’s T3- Law.

Unit 3: ( 8M )

Statistical thermodynamics:

Macrostates and microstates, thermodynamic probability, Equilibrium state is the state with max. thermodynamic

probability, entropy and probability, Boltzmann distribution formula (with derivation). Applications to

barometric distribution, molecular partition function and thermodynamic properties, Maxwell’s speed distribution

and Third Law of Thermodynamics.

30

GROUP – B ( 25 M )

CHEMISTRY OF MATERIALS & BIOMOLECULES

Unit 1: ( 9M )

Chemistry of Materials :

Nanomaterials: Elementary introduction about nano- science and technology and their importance, self-

assembly and structure, classification of nanomaterials and their preparation by various techniques, properties,

applications & toxicity of nanomaterials, biomaterials (elementary idea).

Polymers: Classification, methods of polymerization, kinetics of addition polymerization, number average and

mass average molar masses & their determination by different methods, Donan equilibrium

Unit 2: ( 8M )

Proteins:

Classification, structure (secondary, tertiary and quaternary structures), classification of enzymes, coenzymes

(simple examples).

Nucleic Acids:

Structure of nucleosides and nucleotides (structure elucidation excluded nomenclature of nucleosides ), DNA and

RNA, complementary base pairing, elementary idea of double helical structure of DNA (Watson – Crick model).

Properties of DNA and RNA in solution.

Bio- energetics:

Electron transport chain, oxidative phosphorylation & ATP cycle.

Unit 3:

( 8M )

Bioinorganic Chemistry:

Elements of life; essential major, trace and ultra trace elements,. Basic chemical reactions in the biological

systems and the role of metal ions (specially Na+ , K

+ , Mg

2+ ,Ca

2+ , Fe

3+/2+ , Cu

2+/+ , and Zn

2+). Metal ion

transport across biological membrane Na+-ion pump, ionpphores, Biological functions of hemoglobin and

myoglobin, cytochromes and ferrodoxins, carbonate, bicarbonate buffering system and carbonicanhydrase,

Biological nitrogen fixation, Photosynthesis : Photosystem-1 and Photosystem-II, Toxic metal ions and their

effects, chelation therapy (examples only), Pt and Au complexes as drugs (examples only), metal dependent

diseases.

31

CHEMISTRY HONOURS PRACTICAL (100M)

Paper: XV – (50M)

Unit 1) Quantitative Inorganic Analysis – 40M

Unit 2) Lab Quiz / Viva – 10M

Paper: XVI – (50M)

Unit 1) Synthesis, characterization and / or study of properties of some chemical compounds

– 20M

Unit 2) Internal assessment – 30M

EXAMINATION HOURS:

i) Unit – 1 of the paper XV : 6 hrs (one day)

ii) Unit – 1 of the paper XVI and the Unit – 2 of the paper XV : 6 hrs (one day)

32

RAMAKRISHNA MISSION RESIDENTIAL COLLEGE (AUTONOMOUS)

NARENDRAPUR, KOLKATA- 700103

DEPARTMENT OF CHEMISTRY

Revised Syllabi

for

2 year 4 semester B. Sc. General Course in Chemistry

(AUGUST 30, 2013)

COURSE STRUCTURE

GENERAL COURSE

Semester

Duration

Marks

Examination Theoretical

(T)

Practical (P) Total

Semester I July-Dec. 50 25 75 January

Semester II Jan.-June 50 25 75 June

Semester III July-Dec. 50 25 75 January

Semester IV Jan.-June 50 25 75 June

Total 200 100 300

SEMESTER-WISE DISTRIBUTION OF SUBJECTS

CHEMISTRY GENERAL

SEMESTER – I: 75 Marks


I

General Theoretical 20

A Organic Theoretical 20

Physical Theoretical 10

B Chemistry Practical 25

33

SEMESTER – II: 75 Marks

Theoretical – 50M; Practical – 25M


II

General Theoretical 10




SEMESTER – III: 75 Marks



III

Organic Theoretical 10




SEMESTER – IV: 75 Marks



IV

Organic Theoretical 20




34

SYLLABI

B.Sc. GENERAL (THEORETICAL)

Semester – I

PAPER – I, GROUP – A (50 M)

Unit 1: Structure of Atoms (Nuclear & Extra- nuclear). - 10

Unit 2: Chemical periodicity & Redox reactions. - 10

Unit 3: Thermodynamics (I). - 10

Unit 4: Reaction mechanism & Stereochemistry. - 10

Unit 5: ( a) Organo-metallic compounds.

(b) Compounds with active methylene group - 10

Semester – II

PAPER – II, GROUP – A (50 M)

Unit 1: Acids - Bases & Ionic equilibrium. - 10

Unit 2: Thermodynamics (II). - 10

Unit 3: Chemical kinetics & Catalysis. - 10

Unit 4: s and p block of elements & their compounds – comparative study. - 10

Unit 5: (a) s and d block of elements & their compounds – comparative study.

(b) Some analytical reactions - 10

Semester – III

PAPER – III, GROUP – A (50 M)

Unit 1: Bonding (Ionic, Covalent & Metallic bonds) and structure. - 10

Unit 2: Coordinate bonds & Coordination compounds. - 10

Unit 3: Aliphatic compounds. - 10

Unit 4: Gaseous state of matter. - 10

Unit 5: Liquid & Solid states of matter and Conductance in solution. - 10

Semester – IV

PAPER – IV, GROUP – A (50 M)

Unit 1: Colligative properties and Phase rule. - 10

Unit 2: Electromotive force. - 10

Unit 3: (a) Extraction, purification & uses of Li, Cr, Ni, Ag, Au.

(b) Preparation, properties and uses of some important compounds. - 10

Unit 4: Aromatic compounds. - 10

Unit 5: Carbohydrates, Lipids, Nucleic acids & Proteins. - 10

35

CHEMISTRY GENERAL

COURSE DETAILS

SEMESTER – I (75 M) (Theoretical 50 and Practical 25)

PAPER – I

GROUP – A (50 M)

CHEMISTRY GENERAL THEORETICAL

Unit – 1: (10M)

Structure of Atoms and Chemical Periodicity :

(a) Extra Nuclear Structure of Atoms : 8 – 10 (L)

Qualitative idea on black body radiation. Planck’s Quantum Equation, Atomic spectra of Hydrogen,

Bohr’s atomic model, Bohr’s theory for Hydrogen atom (simple mathematical treatment), Sommerfeld’s

model, Quantum numbers and their significance, Pauli’s Exclusion Principle, Hund’s Rule ; wave nature

of electron, idea of atomic orditals and their shapes, electronic configuration of many electron atoms,

Aufbau principle and its limitations.

(b) Radioactivity and Nuclear Structure of Atoms :

Natural Radioactivity : Radioactive disintegration series, group displacement law, law of radioactive

decay, half-life and average life of radioelements, radioactive equilibrium, measurement of radioactivity.

Atomic Nucleus : Stability of atomic nucleus, n/p ratio, nuclear binding energy, mass defect, Einsten’s

mass-energy relation, nuclear forces, Nuclear reactions : fission, fusion and spallation; transmutation of

elements, artificial radioactivity; radioisotopes and their applications ; radiocarbon dating, medicinal and

agricultural uses of isotopes, Hazards of radiation and safety measures.

Unit – 2:

(10M)

(a) Chemical Periodicity :

Classification of elements on the basis of electronic configuration : General characteristics of s-, p-, d- and

f-block elements, Positions of Hydrogen and noble gases, Atomic and ionic radii, ionization

potential,electron affinity and electronegativity : periodic and group-wise variation of these properties in

respect of s- and p- block of elements.

(b) Redox Reactions : Balancing of equations by oxidation number and ion- electron methods Oxidimetry-

reductimetry.

36

Unit – 3 : (10M)

Chemical Thermodynamics - I:

(a) Definition of Thermodynamic terms; Intensive and extensive variables isolated, closed, open and cyclic

systems, reversible and irreversible processes. Thermodynamic functions and their differentials, Zeroth

Law of Thermodynamics, concept of heat (q) and work (w).

(b) First Law of Thermodynamics, internal energy (U) and enthalpy (H); relation between Cp and Cv,

calculation of w, q, dU and dH for expansion of ideal gas under isothermal and adiabatic conditions for

reversible and irreversible processes including free expansion. Joule-Thomson Coefficient and inversion

temperature.

(c) Application of First Law of Thermodynamics : Standard state, standard enthalpy of formation, standard

enthalpy changes of physical and chemical transformations : fusion, sublimation, vaporization, solution,

dilution,neutralization, ionization. Hess’s Law of constant heat summation. Bond-dissociation energy,

Kirchoff’s equation, relation between ΔH and ΔU of a reaction.

Unit – 4: (10M)

Reaction mechanism & Stereochemistry:

(a) Inductive effect , electromeric effect, conjugation, resonance and resonance energy, hyperconjugation,

homolytic and heterolytic bond breaking, electrophiles and nucleophiles; carbocations, carbanions and

radicals (stability and reactivity of).

(b) Constitution and nomenclature of carbon compounds (IUPAC and trivial systems). Stereochemistry of

carbon compounds : Different types of isomerism, geometrical and optical isomerism, optical activity,

asymmetric carbon atom, elements of symmetry, chirality, enantiomers and diastereoisomers : E and Z

nomenclature, D and L nomenclature (for carbohydrates and aminoacids only). R and S nomenclature,

Fischer and Newman Projection formulae of simple molecules containing one and two asymmetric carbon

atom (s).

Unit – 5: (10M)

(a) Organometallic Compounds :

Grignard Reagents – Preparation and reactions, Application of Grignard reagents in organic synthesis.

(b) Compounds with active methylene group; Synthetic uses of D.E.M. and E.A.A.

37

GROUP – B ( 25 M )

CHEMISTRY GENERAL PRACTICAL

1. Qualitative analysis of a single solid organic compound:

(a) Solubility classification (in water, dil HCl, Dil. NaOH, NaHCO3 solution). 4M

(b) Tests to detect presence/absence of the following functional groups: 10M

Ar-NH2, Ar-NO2, Ar-OH, -COOH, >CO

(distinction of aldehyde and ketone excluded),

© Reporting of functional groups 1M

2. Viva voce / Lab quiz 5M

3. Laboratory Note Book 5M


38

SEMESTER – II (75 M)


PAPER – II

GROUP – A (50 M)


Unit – 1: (10M)

Acids-Bases and Ionic Equilibria:

Modern concepts of acids and bases: Arrhenius theory, theory of solvent system, Bronsted and

Lowry’s concept, Lewis concept with typical examples, applications and limitations. Strenghts of acids

and bases (elementary idea). Ionisation of weak acids and bases in aqueous solution, application of

Ostwald’s dilution law, ionization constants, ionic product of water, pH-scale, buffer solutions and their

pH values, buffer actions; hydrolysis of salts, solubility product principle and it’s applications.

Unit – 2: (10M)

Thermodynamics (II):

Spontaneous processes, heat engine, Carnot cycle and its efficiency, Second Law of Thermodynamics,

Entropy (S) as a state function, molecular interpretation of entropy, entropy changes on simple

transformations. Free energy: Gibbs function (G) and Helmholtz function (A), Gibbs-Helmholtz equation,

criteria for thermodynamic equilibrium and spontaneity of processes.

Chemical Equilibria of homogeneous and heterogeneous systems, derivation of expression of equilibrium

constants; temperature, pressure and concentration dependence of equilibrium constants (Kp, Kc, Kx); Le

Chatellier’s Principle of dynamic equilibrium.

Unit – 3: (10M)

Chemical Kinetics and Catalysis:

Order and moleculatiry of reactions, rate laws and rate equations for first order and second order reactions

(differential and integrated forms); Pseudo first order reactions. Zero order reactions. Determination of

order of reactions. Temperature dependence of reaction rate, energy of activation.

Different types of Catalytic Reactions.

Unit – 4 : (10M)

p-Block Elements and Their Compounds:

Comparative Study : Group trends in electronic configuration, modification of pure elements, common

oxidation states, inert pair effect, chemical properties and reactions of common hydrides, halides, oxides

and oxyacids (if any) in respect of following groups of elements : (i) B-AI, (ii) C-Si-Ge-Sn-Pb, (iii) N-P-

As-Sb-Bi, (iv) O-S-Se-Te and (v) F-Cl-Br-I.

Unit – 5: (10M)

(a) s- and d-block elements and their compounds : Comparative Study : Group trends in electronic

configurations, oxidation states, chemical properties and reactions in respect of following groups

elements : (i) Li-Na-K, (ii) Be-Mg-Ca-Sr-Ba (iii) Cr-Mn-Fe-Co-Ni, (iv) Cu-Ag-Au, (v) Zn-Cd-Hg.

(b) Analytical reactions leading in detection of : carbonate, bicarbonate, lead, ammonia, nitrate, nitrite,

phosphate, sulphide, sulphite, thiosulphate, sulphate, halides, borate, boric acid, borax bead test.

39

GROUP – B (25 M)


1. Qualitative analysis of a mixture of two inorganic acid radicals from: 15M

Cl-, Br

-, I

-, NO3

-, NO2

-, SO4

=, BO3

3-, PO4

3-, F

-, S

=, SO3

=, S2O3

=, CrO4

=

(insoluble samples, CO3=, HCO3

- are excluded)




40

SEMESTER – III (75 M) (Theoretical 50 and Practical 25)

PAPER – III

GROUP – A (50 M)


Unit – 1: (10M)

Chemical Bonding and Structure :

(a) Ionic Bonding : General characteristics of ionic compounds, Sizes of ions, radius ratio rule and its

limitation, packing of ions in crystals, Lattice energy, Born Haber Cycle.

(b) Covalent Bonding : General Characteristics of covalent compounds, valence-bond approach, directional

character of covalent bond, hybridization involving s-, p- and d- orbitals, multiple bonding. Valence shell

Electron Pair Repulsion (VSEPR) concept, shapes of simple molecules and ions (examples from main

groups chemistry). Molecular orbital (elementary idea), sigma and pi bonds, bond length, bond order,

bond energy. Bond moment and dipole moment, partial ionic character of covalent bonds. Fajan’s Rules.

Hydrogen bonding and its effect on physical and chemical properties.

(c) Metallic bonding: Elementary idea of metallic bond.

Unit – 2: (10M)

Coordinate bonds and Coordination compounds :

Formation of coordinate bonds, difference between covalent & coordinate bonds, Complex salts and

double salts, Werner’s theory of coordination, chelate complexes, Isomerism, stereochemistry of

coordination numbers 4 and 6. IUPAC nomenclature of coordination complexes (mononuclear complexes

only).

41

Unit – 3: (10M)

Chemistry of Organic Compounds (I):

(a) Alkanes, alkenes and alkynes : Isomerism, synthesis and chemical reactivity of alkanes, mechanism of

free-redical halogenation of alkanes, Sulphonation of alkanes, detergents. General methods of synthesis of

alkenes, heat of hydrogenation and stability of alkenes, Electrophilic addition reactions, mechanism of

bromination and hydrohalogenation; Markownikoff’s addition, peroxide effect. Hydration, hydroboration,

ozonololysis, epoxidation, hydroxylation polymerization reactions of alkenes (definition and examples

only). General methods of synthesis, acidity, hydration and substitution reactions of alkynes.

(b) Aldehydes and Ketones :

The nature of carbonyl group, methods of synthesis, physical properties, derivatives of carbonyl

compounds, nucleophilic addition, Cannizzaro’s reaction, Reformatsky’s reaction, Relative reactivities and

distinction of aldehydes and ketones, formation and reactions of enolates-aldol condensation (with

mechanism), Perkin reaction, Knoevenagel reaction, Benzoin Condensation, Claisen Condensation,

Oxidation and Reducation reactions, Aliphatic and aromatic aldehydes.

(c) Carboxylic Acids and Their Derivatives :

Acidity of carboxylic acids and effects of substituents on acidity, chemical reactivity, mechanism of

esterification of carboxylic acids and hydrolysis of ester (BAc2 and AAc2 only); methods of synthesis and

reactions of acyl halides, amides, esters and acid anhydrides.

Unit – 4: (10M)

Gaseous State of Matters :

Gas Laws, Kinetic theory of gas, collision and gas pressure, derivation of gas laws from kinetic theory,

average kinetic energy of translation, Boltzman constant and absolute scale of temperature, Maxwell’s

distribution law of molecular speeds (without derivation), most probable, average and root mean square

speeds of gas molecules, principle of equipartition of energy (without derivation), Mean free path and

collision frequencies, Heat capacity of gases (molecular basis of); Viscosity of gases,

Real gases, compressibility factor, deviation from ideality, van der Waals’ equation of state, critical

phenomena, continuity of states critical constants, intermolecular forces, liquefaction of gases.

Unit – 5: (10M)

Liquid & solid states of matter; conductance in solution.

(a) Liquid State:

Physical properties of liquids and their measurements, Vapour pressure, surface tension, viscosity,

refractive index and dipole moment

(b) Crystalline State:

Type of bonding in solids, law of constancy of angles, concept of unit cell, law of rational indices, Miller

indices, symmetry elements in crystals, seven crystal systems, density of cubic crystal.

(c) Solutions of Electrolyte (conductance in solutions):

Electrolytic conductance, specific conductance, equivalent conductance and molar conductance of

electrolytic solutions. Influence of temperature and dilution on conductance of weak electrolytes.

Measurement of conductance, conductimetric titration: acid-base and precipitation titrations as examples.

42

GROUP – B (25 M)


1. Qualitative analysis of a mixture of two inorganic basic radicals from: 15M

Cu++

, Fe++

/Fe3+

, Al3+

, Cr3+

, Mn++

, Ni++

, Co++

, Zn++

, Ba++

, Sr++

, Ca++

, Na+,

K+, NH4

+ (insoluble samples are excluded)




43

SEMESTER – IV (75 M) (Theoretical 50 and Practical 25)

PAPER – IV

GROUP – A (50 M)


Unit – 1: (10M)

(a) Solution of Non-Electrolytes (Colligative properties):

Colligative properties of solution, Henry’s Law and Roult’s Law, relative lowering of vapour pressure,

osmosis and osmotic pressure; elevation of boiling point and depression of freezing point of solvents ;

Determination of molecular mass of solutes from measurement of Colligative properties of solutions.

(b) Phase rule:

Phase, component, system, degrees of freedom, The phase rule. Phase diagram of one component

systems: water, carbondioxide and sulphur.

Heterogeneous systems: Nernst Distribution Law, miscibility and distillation of binary liquid mixtures,

azeotroic mixtures, critical solution temperature, steam distillation. eutectic mixtures, congruent and

incongruent melting points, solid solutions.

Unit – 2: (10M)

Electromotive force:

(a) Electrode potentials, Nernst Equation, Reference electrodes: Normal Hydrogen Electrode and calomel

electrodes, emf of electrochemical cells and its measurement, Electrode potential series and its

applications, Potentiometric titrations : (Fe (II)-permanganace, Fe (II)-dichromate titrations as examples) :

measurement of hydrogen ion concentration (pH) using glass-calomel electrode-pH meter, concentration

cells.

Unit – 3: (10M)

(a) Extraction and purification of elements from natural sources : Li, Cr, Ni, Ag, Au.

(b) Preparation, properties and uses of some important compounds: KMnO4 , K2Cr2O7, and Mohr’s salt,

Hydrazine, Hydroxylamine, Perchloric acid, Sodium Thiosulphate, Hypo phosphorous acid, LiAlH4 &

NaBH4.

44

Unit – 4: (10M)

(a) Chemistry of organic compounds - II :

Resonance structure of benzene, General mechanism of electrophilic substitution reactions of benzene,

Synthesis of aromatic compounds using nitration sulphonation, halogenation, Friedel-Craft alkylations and

acylation reactions, Nuclear and side-chain halogenation of toluene.

(b) Alkyl and Aryl halides :

Methods of synthesis, SN1, SN2, E1, E2 reactions (elementary methanistic aspects), Saytzeff and Hofmann

elimination reactions, reactivity of aromatic halides, nucleophilic aromatic substitution reactions.

Synthesis of DDT.

(c) Alcohols and Ethers:

Methods of synthesis, physical properties, distinction of primary, secondary and tertiary alcohols and their

chemical reactions. Ethers Williamson’s ether synthesis, physical properties chemical reactions an uses of

ethers.

(d) Phenols :

Synthesis, acidic character and chemical reactions of phenols. Kolbe reactions, Reimer-Tiemann reaction,

Fries rearrangement. Claise, rearrangement, Houben-Hoesch reaction, Manasse reaction, Cresols,

nitrophenols.

(e) Organic Compounds Containing Nitrogen :

Aromatic nitro-compounds – their synthesis and reduction under different conditions, Methods of

synthesis of aliphatic amines, Heinsberg’s method of amine separation, Hofmann degration, Gabriel’s

phthalimide synthesis, distinction of primary, secondary and tertiary amines. Methods of synthesis of

aromatic amines, basicity of aliphatic and aromatic amines, Diazotisation and coupling reactions and their

mechanisms, synthetic applications of diazonium salts.

Unit – 5: (10M)

(a) Carbohydrates:

Introduction, occurrence and classification of carbohydrates; constitution of glucose, Osazone formation,

Reactions of glucose and fructose,mutarotation. Cyclic structures – pyranose and furanose forms

determination of ring size excluded, epimerization, chain-lengthening and chain-shortening in aldoses.

(b) Amino Acids, Proteins and Nucleic Acids :

Methods of synthesis of α-amino acids (glycine and alanine using Gabriel’s phthalamide synthesis and

Strecker synthesis, Physical properties : Zwitterion structures , isoelectric point; peptide synthesis

(elementary idea), Nucleic acids : compounds, nucleosides and nucleotide, structures and functions (basic

idea).

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GROUP – B (25 M)


1. Qualitative analysis of an inorganic sample containing three radicals

as included in semester II (CEMG 2P) and Semester III (CEMG 3P) courses. 15M




700103 department of chemistry revised syllabi for

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