7 things every woman should know about cervical cancer

1 Cervical cancer is caused by human papillomavirus Cervical cancer is the 3rd most common cancer afﬂicting women worldwide 1 cervical cancer 7 References: 1. Ferlay et al. GLOBOCAN 2012. World Cancer Population fact sheet. Available at: http://globocan.iarc.fr/Pages/fact_sheets_population.aspx. Last updated 2012. Accessed 21 May 2014. 2. WHO/ICO HPV Information Center. Human Papilloma Virus and Related Cancers. Summary Report Update. Nov 15, 2010. p8. 3. Ikenberg et al., Screening for Cervical Cancer Precursors With p16/Ki-67 Dual-Stained Cytology: Results of the PALMS Study. J Nat’l Cancer Inst. 2013;105(20):1550-1557. 4. Bergeron C, Ordi J, Schmidt D, Trunk MJ, Keller T, Ridder R; European CINtec Histology Study Group. Conjunctive p16INK4a testing signiﬁcantly increases accuracy in diagnosing high-grade cervical intraepithelial neoplasia. Am J Clin Pathol. 2010;133(3):395-406. 5. Leyden WA, Manos MM, Geiger AM, et al. Cervical cancer in women with comprehensive health care access: attributable factors in the screening process. J Natl Cancer Inst. 2005;97(9):675-683. doi:10.1093/jnci/dji115. 6. Andrae B, Kemetli L, Sparén P , et al. Screening-preventable cervical cancer risks: evidence from a nationwide audit in Sweden. J Natl Cancer Inst. 2008;100(9):622-629. doi:10.1093/jnci/djn099. 7. WHO/ICO HPV Information Center. Human Papilloma Virus and Related Cancers. Summary Report Update. Nov 15, 2010. p.25. 8. Wright TC Jr, Stoler MH, Sharma A, et al. Evaluation of HPV-16 and HPV-18 genotyping for the triage of women with high-risk HPV+ cytology-negative results. Am J Clin Pathol. 2011;136(4):578-586. doi:10.1309/AJCPTUS5EXAS6DKZ. 530,000 new cases/year mostly in developing countries 1 Nearly 1 in 7 women that are Pap cytology negative but are HPV genotype 16 positive can have Approximately 270,000 (51%) will die from it 1 of cervical cancers occur in screened women with a Up to 1 / 3 with vaccination, screening and treatment 2, 3, 4 high-grade cervical disease 8 negative Pap cytology test 5, 6 will cause 99.7 % of cervical cancers 7 HPV genotypes 16 & 18 are responsible for 70 % of cases 7 PREVENTABLE 100 % Cervical cancer is nearly Tell someone you love about HPV cervical screening !!! 18 16 today! 2 3 4 5 6 7 should know about things every woman Combined with 12 other high-risk HPV genotypes

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Page 1: 7 Things every woman should know about cervical cancer

1Cervical cancer is caused byhuman papillomavirus

Cervical cancer is the 3rd most common cancer afflicting women worldwide1

cervical cancer7

References:

1. Ferlay et al. GLOBOCAN 2012. World Cancer Population fact sheet. Available at: http://globocan.iarc.fr/Pages/fact_sheets_population.aspx. Last updated 2012.

Accessed 21 May 2014.

2. WHO/ICO HPV Information Center. Human Papilloma Virus and Related Cancers. Summary Report Update. Nov 15, 2010. p8.

3. Ikenberg et al., Screening for Cervical Cancer Precursors With p16/Ki-67 Dual-Stained Cytology: Results of the PALMS Study. J Nat’l Cancer Inst. 2013;105(20):1550-1557.

4. Bergeron C, Ordi J, Schmidt D, Trunk MJ, Keller T, Ridder R; European CINtec Histology Study Group. Conjunctive p16INK4a testing significantly increases accuracy in

diagnosing high-grade cervical intraepithelial neoplasia. Am J Clin Pathol. 2010;133(3):395-406.

5. Leyden WA, Manos MM, Geiger AM, et al. Cervical cancer in women with comprehensive health care access: attributable factors in the screening process.

J Natl Cancer Inst. 2005;97(9):675-683. doi:10.1093/jnci/dji115.

6. Andrae B, Kemetli L, Sparén P, et al. Screening-preventable cervical cancer risks: evidence from a nationwide audit in Sweden. J Natl Cancer Inst. 2008;100(9):622-629.

doi:10.1093/jnci/djn099.

7. WHO/ICO HPV Information Center. Human Papilloma Virus and Related Cancers. Summary Report Update. Nov 15, 2010. p.25.

8. Wright TC Jr, Stoler MH, Sharma A, et al. Evaluation of HPV-16 and HPV-18 genotyping for the triage of women with high-risk HPV+ cytology-negative results.

Am J Clin Pathol. 2011;136(4):578-586. doi:10.1309/AJCPTUS5EXAS6DKZ.

530,000 new cases/year mostly in developing countries1

Nearly 1 in 7 women that are Pap cytology negative but are HPV genotype 16 positive can have

Approximately 270,000 (51%) will die from it1

of cervical cancers occur in screened women with a

Up to

1/3

with vaccination, screening and treatment 2, 3, 4

high-grade cervical disease8

negative Pap cytology test5, 6

will cause 99.7% of cervical cancers7

HPV genotypes 16 & 18 are responsible for 70% of cases