6-marco - emergencies-may s-2010 - ti.ubc.ca
TRANSCRIPT
![Page 1: 6-Marco - EMERGENCIES-may S-2010 - ti.ubc.ca](https://reader033.vdocuments.site/reader033/viewer/2022042804/626848b92b48686a3a6bb38e/html5/thumbnails/1.jpg)
1
![Page 2: 6-Marco - EMERGENCIES-may S-2010 - ti.ubc.ca](https://reader033.vdocuments.site/reader033/viewer/2022042804/626848b92b48686a3a6bb38e/html5/thumbnails/2.jpg)
2
![Page 3: 6-Marco - EMERGENCIES-may S-2010 - ti.ubc.ca](https://reader033.vdocuments.site/reader033/viewer/2022042804/626848b92b48686a3a6bb38e/html5/thumbnails/3.jpg)
3
![Page 4: 6-Marco - EMERGENCIES-may S-2010 - ti.ubc.ca](https://reader033.vdocuments.site/reader033/viewer/2022042804/626848b92b48686a3a6bb38e/html5/thumbnails/4.jpg)
4
![Page 5: 6-Marco - EMERGENCIES-may S-2010 - ti.ubc.ca](https://reader033.vdocuments.site/reader033/viewer/2022042804/626848b92b48686a3a6bb38e/html5/thumbnails/5.jpg)
5
![Page 6: 6-Marco - EMERGENCIES-may S-2010 - ti.ubc.ca](https://reader033.vdocuments.site/reader033/viewer/2022042804/626848b92b48686a3a6bb38e/html5/thumbnails/6.jpg)
6
Coronary atherosclerosis/ Thrombous formationobstruction
ischemia
Compensatory /physiologic mechanisms -NO, bradykinin,histamin, thromboxane A2
-sympathetic activation, RAAS
Physiological changes: HR (oxygen demand) Vascular Resistances
DBP(coronary BF), SBP (wall tension)
Corornary atherosclerosis/ Thrombous formationobstruction
ischemia
![Page 7: 6-Marco - EMERGENCIES-may S-2010 - ti.ubc.ca](https://reader033.vdocuments.site/reader033/viewer/2022042804/626848b92b48686a3a6bb38e/html5/thumbnails/7.jpg)
7
CBF= Cerebral perfusion pressure (CPP) / cerbrovascular resistance (CVR)
CBF= 50 ml /100 g / min
CPP= MAP - ICP
AUTOREGULATION
If auto-reg is impaired and ICP is increase; small changes in MAP CPP
![Page 8: 6-Marco - EMERGENCIES-may S-2010 - ti.ubc.ca](https://reader033.vdocuments.site/reader033/viewer/2022042804/626848b92b48686a3a6bb38e/html5/thumbnails/8.jpg)
8
![Page 9: 6-Marco - EMERGENCIES-may S-2010 - ti.ubc.ca](https://reader033.vdocuments.site/reader033/viewer/2022042804/626848b92b48686a3a6bb38e/html5/thumbnails/9.jpg)
9
![Page 10: 6-Marco - EMERGENCIES-may S-2010 - ti.ubc.ca](https://reader033.vdocuments.site/reader033/viewer/2022042804/626848b92b48686a3a6bb38e/html5/thumbnails/10.jpg)
10
All-cause Mortality
![Page 11: 6-Marco - EMERGENCIES-may S-2010 - ti.ubc.ca](https://reader033.vdocuments.site/reader033/viewer/2022042804/626848b92b48686a3a6bb38e/html5/thumbnails/11.jpg)
11
Num
ber o
f R
CTs
Number of RCTs
0
1
2
3
4
5
65-6
7 68
-70
71-7
3 74
-76
77-7
9 80
-82
83-8
5 86
-88
89-9
1 92
-94
95-9
7 98
-00
01-0
3 04
-06
07-0
9
15 RCTS (N=869)
Hypertensive emergencies
0 2 4 6 8 10
ACE-inhibitors
B-blockers
Calcium CB
Nitrates
Alpha-1 blockers
Diuretics
Direct VD
Dopamine agonist
Class of Drug
Hypertensive emergencies
![Page 12: 6-Marco - EMERGENCIES-may S-2010 - ti.ubc.ca](https://reader033.vdocuments.site/reader033/viewer/2022042804/626848b92b48686a3a6bb38e/html5/thumbnails/12.jpg)
12
![Page 13: 6-Marco - EMERGENCIES-may S-2010 - ti.ubc.ca](https://reader033.vdocuments.site/reader033/viewer/2022042804/626848b92b48686a3a6bb38e/html5/thumbnails/13.jpg)
13
![Page 14: 6-Marco - EMERGENCIES-may S-2010 - ti.ubc.ca](https://reader033.vdocuments.site/reader033/viewer/2022042804/626848b92b48686a3a6bb38e/html5/thumbnails/14.jpg)
14
Nitrates vs. dopamine agonist: decrease in SBP of 14 mm Hg
CCB vs. ACE-I: decrease in DBP of 8 mm Hg
increase in HR of 22 bpm. CCB vs. nitrates:
increase in HR of 11 bpm
![Page 15: 6-Marco - EMERGENCIES-may S-2010 - ti.ubc.ca](https://reader033.vdocuments.site/reader033/viewer/2022042804/626848b92b48686a3a6bb38e/html5/thumbnails/15.jpg)
15
![Page 16: 6-Marco - EMERGENCIES-may S-2010 - ti.ubc.ca](https://reader033.vdocuments.site/reader033/viewer/2022042804/626848b92b48686a3a6bb38e/html5/thumbnails/16.jpg)
16
![Page 17: 6-Marco - EMERGENCIES-may S-2010 - ti.ubc.ca](https://reader033.vdocuments.site/reader033/viewer/2022042804/626848b92b48686a3a6bb38e/html5/thumbnails/17.jpg)
17
![Page 18: 6-Marco - EMERGENCIES-may S-2010 - ti.ubc.ca](https://reader033.vdocuments.site/reader033/viewer/2022042804/626848b92b48686a3a6bb38e/html5/thumbnails/18.jpg)
18
![Page 19: 6-Marco - EMERGENCIES-may S-2010 - ti.ubc.ca](https://reader033.vdocuments.site/reader033/viewer/2022042804/626848b92b48686a3a6bb38e/html5/thumbnails/19.jpg)
19