6. farmasi fisik-rheologi
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STTIF BOGOR 2012
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PENDAHULUAN SISTEM NEWTON SISTEM NON NEWTON THIKSOTROPIK PENENTUAN SIFAT-SIFAT RHEOLOGI VISKOELASTISITAS PSIKORHEOLOGI PENERAPAN DI BIDANG FARMASI
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RHEOLOGI : ALIRAN CAIRAN DAN DEFORMASI PADATAN
VISKOSITAS : TAHANAN CAIRAN UNTUK MENGALIR
RHEOLOGI PENTING DALAM FORMULASI DAN ANALISIS
RHEOLOGI UNTUK KUALITAS KONSISTENSI SEDIAAN
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HUKUM ALIRAN NEWTON VISKOSITAS KINEMATIS KETERGANTUNGAN TEMPERATUR
DAN TEORI VISKOSITAS
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: VISKOSITAS
: FLUIDITAS
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ALIRAN PLASTIS ALIRAN PSEUDOPLASTIS ALIRAN DILATAN
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TIDAK MELALUI (0,0)
MEMOTONG SUMBU SHEARING STRESS
HARGA YIELD (EKSTRAPOLASI KE SUMBU X)
PARTIKEL YANG TERFLOKULASI DALAM SUSPENSI PEKAT
SHEAR STRESS DIATAS YIELD VALUE : ALIRAN NEWTON
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MELALUI (0,0) TIDAK ADA YIELD VALUE VISKOSITAS BERKURANG DENGAN
MENINGKATNYA RATE OF SHEAR
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PENINGKATAN VISKOSITAS/DAYA HAMBAT DENGAN PENINGKATAN RATE OF SHEAR
VOLUME BERTAMBAH DENGAN SHEARING STRESS MENINGKAT
SUSPENSI DENGAN KONSENTRASI TINGGI (50%)
PARTIKEL YANG MENGALAMI DEFLOKULASI
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PENGUKURAN THIKSOTROPIK BULGE DAN SPUR THIKSOTROPIK NEGATIF THIKSOTROPIK DALAM FORMULASI
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SISTEM NEWTON GRAFIK PENINGKATAN DAN PENURUNAN RATE OF SHEAR BERIMPIT
SISTEM NON NEWTON• GRAFIK PENINGKATAN RATE OF SHEAR
KANAN• GRAFIK PENURUNAN RATE OF SHEAR KIRI• TERJADI PEMECAHAN STRUKTUR (SHEAR OF
THINNING)
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BULGE (KEMBUNG)• BENTONIT 10-15%• MEMBENTUK STRUKTUR RUMAH KARTU
SPUR (TAJI)• GEL PENISILIN• SEDIAAN TAHAN LAMA SETELAH DIINJEKSI
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KENAIKAN RATE OF SHEAR DI KIRI PENURUNAN RATE OF SHEAR DI
KANAN KENAIKAN VISKOSITAS THIKSOTROPIK NEGATIF DILANTAN
• THIKSOTROPIK NEGATIF 1-10%• DILANTAN 50%
MAGMA MAGNESIA
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KONSISTENSI TINGGI, DAPAT DITUANG DAN TERSEBAR MUDAH
PROKAIN PENISILIN-G• TERJADI PEMECAHAN STRUKTUR MELALUI
JARUM SUNTIK• TERBENTUK DEPO OBAT DI OTOT POLOS
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PEMILIHAN VISKOMETER VISKOMETER KAPILER VISKOMETER BOLA JATUH VISKOMETER MODEL MEKANIKA ALIRAN PLUG (SUMBAT) VISKOMETER KERUCUT DAN
LEMPENG
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SEMUA VISKOMETER DAPAT DIGUNAKAN UNTUK SISTEM NEWTON
SISTEM NON NEWTON HARUS ADA SHEAR STRESS YANG BERVARIASI
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HUKUM POISEUILLE
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VISKOMETER SEARLE VISKOMETER ROTOVISKO VISKOMETER STORMER
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KERUGIAN VISKOMETER MANGKUK DAN ROTOR ADALAH BERBEDA SHEAR STRESS MELEWATI SAMPEL ANTARA ROTOR DAN MANGKUK
SHEAR STRESS DIBAWAH YIELD VALUE TERJADI ALIRAN SUMBAT ALIRAN SUMBAT PENTING PADA
ALIRAN PASTA DAN SUSPENSI PEKAT MELALUI LUBANG PENGELUARAN
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KEUNTUNGAN VISKOMETER:
RATE OF SHEAR KONSTAN DI SLEURUH SAMPLE SHEAR
MENCEGAH SUMBAT
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SHEAR CONTINU• DEFORMASI DAN PERUBAHAN BAHAN SELAMA
PENGUKURAN VISKOELASTISITAS
• TIDAK MERUSAK STRUKTUR• BERDASARKAN SIFAT MEKANIS
KEKENTALAN UNTUK CAIRAN ELASTISITAS UNTUK PADATAN
SEDIAAN FARMASI : KRIM, LOTION, SALEP, SUPPOSTORIA, SUSPENSI, EMULSI
BIOLOGI : DARAH, SALIVA, SERVIKS
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SIFAT FARMASETIKAN DAN FARMAKOLOGI
RASA, DAYA SEBAR,WARNA DAN SIFAT-SIFAT PSIKOLOGIS DAN ORGAN SENSOR LAIN
KELEMBUTAN, KETIPISAN DAN KEHANGATAN
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CAIRAN QUASISOLID PADATAN PEMROSESAN