VIII PatentsALERT

This invention involves a chemically transformed chicken hepatocyte derived cell line which is capable of efficiently supporting replication of infectious laryngotracheitis virus (ILTV) and methods for cultivating ILTV using this hepatocellular carcinoma cell line. The virus harvested from these continuous cell culture methods can be used as a vaccine against ILTV infection.

5443984

METHOD FOR CULTURING MAMMALIAN CELLS IN A MEDIUM

CONTAINING FISH SERUM

Sawyer Evelyn S; Sawyer Philip J Kennebunkport, ME, UNITED STATES Assigned to Sea Run Holdings Inc

A method for culturing mammalian cells using fish serum. The method uses serum extracted from the blood of fishes to culture mammalian cells for various purposes. The technique has the key advantages of 1) freedom from mammalian infectious agents that could contaminate cell lines or endanger researchers or recipients of therapeutants derived from mammalian cell culture; 2) consistent and reproducible serum content and quality; 3) low cross-reactivity; and 4) provision of the appropriate serum nutrients to maintain the growth of mammalian cells. Fish serum is used together with designated defmed media to allow mammalian cells to grow and populations of these cells to be maintained. Blood serum is derived from captive stocks of fish raised under controlled conditions such that the diet, habitat, genetics, life history, and reproductive status of the fish remains substantially consistent and reproducible.

5451210

SYSTEM AND METHOD FOR RAPID VASCULAR DRUG DELIVERY

Kramer George C; Spoon Herbert H; Miller Larry J; Collette David J; Zamorano Ruben G; Jenkinson Joel P Galveston, TX, UNITED STATES Assigned to Lifequest Medical Inc; Board of Regents Univ of TX System

A rapid vascular drug delivery device, system and method is provided having a releasibly extending and retracting needle necessary for injecting and withdrawing fluid into and from a physiological or non-physiological cavity. Accordingly, the needle can be releasibly extended with sufficient momentum at a

point of impact to penetrate a hard substance such as bone. The needle is slideably placed within an aperture configured at the forward end of a main housing, wherein a trigger needle can be arranged proximate to the forward end in order to detect tissue thickness or bone depth necessary for ensuring accurate placement of the bone-piercing needle within the bone marrow. The needle can receive fluids interspersed by parallel-placed or series-placed fluid containers configured within the main housing. Thus, more than two dissimilar types of fluids or medicants can be pre-loaded into the device and delivered to the subject in order to enhance dissemination of, for example, a resuscitating drug deep within and throughout the bone marrow.

5453278

LAMINATED BARRIERS FOR TISSUE IMPLANTS

Chan Eddie K M; Pauley Robin G; Brauker James H; Woo Lecon Round Lake Beach, IL, UNITED STATES Assigned to Baxter International Inc

Improved Implant assemblies and methodologies provide immuno-protection for implanted allografts, xenografis, and isografts. The assemblies and methodologies establish an improved boundary between the host and the implanted cells. The boundary structure is laminated, combining elements having different characteristics beneficial to the survival of the implanted cells. Filaments of adhesive material lay in between the elements. The filaments of adhesive material have been melted in place by the application of heat and solidified in place by cooling to secure the elements together into a composite laminated structure.

5456267

BONE MARROW HARVESTING SYSTEMS AND METHODS AND BONE

BIOPSY SYSTEMS AND METHODS

Stark John G Deephaven, MN, 55391, UNITED STATES

The invention relates to systems and methods for harvesting bone marrow and biopsy sections of bone. A hollow screw is attached to the bone and then a negative pressure is applied to the screw to withdraw the bone marrow through the hollow portion of the screw. One system and method includes inserting a pin into the bone and then positioning the screw on the pm. A guide cannula may be used to insert the pin. The screw is