144

5158758

P R O D U C T I O N O F S I L I C A H A V I N G H I G H S P E C I F I C

S U R F A C E A R E A

PATENT ABSTRACTS

measuring system is operated to obtain a measurement of modified sample material, the measurements of modified and unmodified sam- ple material then being used to provide an in- dication of the amount of the constituent of interest in the sample material.

Paul C Chieng, Deborah J Brame, Alexander H T Chu assigned to International Minerals & Chemical Corp

A method for production of high specific surface area silica gel by hydrolysis of silicon tetrahalide, wherein a solution of silicon tetrahalide in a non- reactive solvent such as alcohol is mixed with water to produce silica gel having a high surface area and narrow pore diameter distribution especially suited for use as normal phase packing material in high performance chromatography columns. The water contains fluoride ions if the halide is chloride. Reverse phase packing material can be prepared by reacting the normal phase silica gel with organochlorosilanes to pre- pare bonded reverse phase material for use in high performance liquid chromotagraphy sys- tems.

5158868

M E T H O D O F S A M P L E A N A L Y S I S

Caroly Bergkuist, Yvonn Fraticelli, Theodore S (3eiselman assigned to Iniziative Marittime 1991 S r l

A system for analyzing a biological fluid or the like for a constituent of interest comprises struc- ture defining a sample inlet port, structure defining an analysis region, a measuring system connected in sensing relation to the analysis re- gion, and structure defining a reaction chamber that has an immobilized enzyme capable of modifying the constituent of interest. Control means operates liquid flow means in a unidirec- tional sample flow mode to initially flow a sam- ple of material to be analyzed from the sample inlet port to the reaction chamber and to the analysis region for a measurement of unmodified sample material, and then operates the liquid flow means in a bidirectional sample flow mode to oscillate the sample material in the reaction chamber and facilitate modification by the im- mobilized enzyme of the constituent of material in the sample. Modified sample material is then introduced into the analysis region and the

5158870

D I A G N O S T I C M E T H O D S F O R M Y C O P L A S M A G E N I T A L I U M

I N F E C T I O N S

Joel B Baseman, Janice Morrison-Plummer as- signed to Board of Regents The University of Texas System

Monoclonal antibodies binding Mycoplasma genitalium more strongly than Mycoplasma pneumoniae, Mycoplasma hominis, Mycoplasma orale, Mycoplasma salivarium and Acholeplasm laidlawii are described herein. These monoclonal antibodies are utilized in immunoassays directed toward the detection of M. genitalium infections. Hybridomas pro- ducing the above-described monoclonal anti- bodies have been created and isolated. These monoclonal antibodies are directed toward M. genitalium antigens. Certain antibodies bind protein antigens, while others bind lipid anti- gens. In one case a particular antibody ap- parently has binding affinity for both protein and lipid antigens of M. genitalium.

5158873

M E T H O D A N D R E A G E N T F O R D E T E R M I N I N G L D - I I S O E N Z Y M E

William Abbott, David Yost, Rita Byrne as- signed to Abbott Laboratories

A rapid and specific method and reagent for determining LD- 1 isoenzyme in biological fluids by incorporating a chaotropic agent, such as sodium perchlorate, into an LDH assay reagent system. The chaotropic agent produces an im- mediate inactivation of the LDH isoenzymes containing one or more M type subunits while the LTD-1 isoenzyme remains stable and is simultaneously measured.