5.1 abamectin (177) toxicology · 2016-03-25 · susceptibility of cf-1 mice and neonatal rats to...

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Page 1: 5.1 ABAMECTIN (177) TOXICOLOGY · 2016-03-25 · susceptibility of cf-1 mice and neonatal rats to abamectin ,q pdppdov dedphfwlq lv d vxevwudwh iru 3 jo\frsurwhlq zklfk lv d phpehu

5.1 ABAMECTIN (177)

TOXICOLOGY

Susceptibility of CF-1 mice and neonatal rats to abamectin

Page 2: 5.1 ABAMECTIN (177) TOXICOLOGY · 2016-03-25 · susceptibility of cf-1 mice and neonatal rats to abamectin ,q pdppdov dedphfwlq lv d vxevwudwh iru 3 jo\frsurwhlq zklfk lv d phpehu

Biochemical aspects

Toxicological data

Page 3: 5.1 ABAMECTIN (177) TOXICOLOGY · 2016-03-25 · susceptibility of cf-1 mice and neonatal rats to abamectin ,q pdppdov dedphfwlq lv d vxevwudwh iru 3 jo\frsurwhlq zklfk lv d phpehu
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.

Toxicological data on metabolites and/or degradates

Page 5: 5.1 ABAMECTIN (177) TOXICOLOGY · 2016-03-25 · susceptibility of cf-1 mice and neonatal rats to abamectin ,q pdppdov dedphfwlq lv d vxevwudwh iru 3 jo\frsurwhlq zklfk lv d phpehu

Human data

Toxicological evaluation

Levels relevant to risk assessment of abamectin and 8,9-Z isomer of abamectin

Page 6: 5.1 ABAMECTIN (177) TOXICOLOGY · 2016-03-25 · susceptibility of cf-1 mice and neonatal rats to abamectin ,q pdppdov dedphfwlq lv d vxevwudwh iru 3 jo\frsurwhlq zklfk lv d phpehu

Z

Page 7: 5.1 ABAMECTIN (177) TOXICOLOGY · 2016-03-25 · susceptibility of cf-1 mice and neonatal rats to abamectin ,q pdppdov dedphfwlq lv d vxevwudwh iru 3 jo\frsurwhlq zklfk lv d phpehu

Critical end-points for setting guidance values for exposure to abamectin

Page 8: 5.1 ABAMECTIN (177) TOXICOLOGY · 2016-03-25 · susceptibility of cf-1 mice and neonatal rats to abamectin ,q pdppdov dedphfwlq lv d vxevwudwh iru 3 jo\frsurwhlq zklfk lv d phpehu

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Summary

RESIDUE AND ANALYTICAL ASPECTS

Page 9: 5.1 ABAMECTIN (177) TOXICOLOGY · 2016-03-25 · susceptibility of cf-1 mice and neonatal rats to abamectin ,q pdppdov dedphfwlq lv d vxevwudwh iru 3 jo\frsurwhlq zklfk lv d phpehu

Avermectin B1a

8,9-Z isomer of avermectin B1a

Avermectin B1b

O

OOH

OH

O

OH

OO

O

O

OO

O

H

H

O

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OOH

OH

O

OH

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HO

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OH

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O

OH

OO

O

O

OO

O

H

H

O

O

OH

Page 10: 5.1 ABAMECTIN (177) TOXICOLOGY · 2016-03-25 · susceptibility of cf-1 mice and neonatal rats to abamectin ,q pdppdov dedphfwlq lv d vxevwudwh iru 3 jo\frsurwhlq zklfk lv d phpehu

Plant metabolism

Page 11: 5.1 ABAMECTIN (177) TOXICOLOGY · 2016-03-25 · susceptibility of cf-1 mice and neonatal rats to abamectin ,q pdppdov dedphfwlq lv d vxevwudwh iru 3 jo\frsurwhlq zklfk lv d phpehu
Page 12: 5.1 ABAMECTIN (177) TOXICOLOGY · 2016-03-25 · susceptibility of cf-1 mice and neonatal rats to abamectin ,q pdppdov dedphfwlq lv d vxevwudwh iru 3 jo\frsurwhlq zklfk lv d phpehu

Animal metabolism

Methods of residue analysis

Page 13: 5.1 ABAMECTIN (177) TOXICOLOGY · 2016-03-25 · susceptibility of cf-1 mice and neonatal rats to abamectin ,q pdppdov dedphfwlq lv d vxevwudwh iru 3 jo\frsurwhlq zklfk lv d phpehu

Stability of residues during storage

Residue definition

Page 14: 5.1 ABAMECTIN (177) TOXICOLOGY · 2016-03-25 · susceptibility of cf-1 mice and neonatal rats to abamectin ,q pdppdov dedphfwlq lv d vxevwudwh iru 3 jo\frsurwhlq zklfk lv d phpehu

Residues resulting from supervised residue trials on crops

Page 15: 5.1 ABAMECTIN (177) TOXICOLOGY · 2016-03-25 · susceptibility of cf-1 mice and neonatal rats to abamectin ,q pdppdov dedphfwlq lv d vxevwudwh iru 3 jo\frsurwhlq zklfk lv d phpehu
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Page 17: 5.1 ABAMECTIN (177) TOXICOLOGY · 2016-03-25 · susceptibility of cf-1 mice and neonatal rats to abamectin ,q pdppdov dedphfwlq lv d vxevwudwh iru 3 jo\frsurwhlq zklfk lv d phpehu
Page 18: 5.1 ABAMECTIN (177) TOXICOLOGY · 2016-03-25 · susceptibility of cf-1 mice and neonatal rats to abamectin ,q pdppdov dedphfwlq lv d vxevwudwh iru 3 jo\frsurwhlq zklfk lv d phpehu
Page 19: 5.1 ABAMECTIN (177) TOXICOLOGY · 2016-03-25 · susceptibility of cf-1 mice and neonatal rats to abamectin ,q pdppdov dedphfwlq lv d vxevwudwh iru 3 jo\frsurwhlq zklfk lv d phpehu
Page 20: 5.1 ABAMECTIN (177) TOXICOLOGY · 2016-03-25 · susceptibility of cf-1 mice and neonatal rats to abamectin ,q pdppdov dedphfwlq lv d vxevwudwh iru 3 jo\frsurwhlq zklfk lv d phpehu
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Fate of residues in processing

Residues in animal commodities

Page 22: 5.1 ABAMECTIN (177) TOXICOLOGY · 2016-03-25 · susceptibility of cf-1 mice and neonatal rats to abamectin ,q pdppdov dedphfwlq lv d vxevwudwh iru 3 jo\frsurwhlq zklfk lv d phpehu

RECOMMENDATIONS

DIETARY RISK ASSESSMENT

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Long-term intake

Short-term intake

Page 24: 5.1 ABAMECTIN (177) TOXICOLOGY · 2016-03-25 · susceptibility of cf-1 mice and neonatal rats to abamectin ,q pdppdov dedphfwlq lv d vxevwudwh iru 3 jo\frsurwhlq zklfk lv d phpehu